The Genome Engineering and Model Development lab (GEMD) is offering a position for a Cell Biologist (f/m/d) (Post-doc position).
The position is to be filled at IUF as of October 1st, 2021.
The project is focused on the potential risk of particles exposure:
- Development and validation of 3D lung culture systems, including lung-on-a-chip, for mechanistic and toxicological research
- Identification of the molecular pathways underlying pathogenesis of human diseases induced by exposure to airborne xenobiotics
- Generation of genetically engineered human cells by genome editing of newly identified key regulators
The project aims to the understanding of the underlying mechanisms and their genetic susceptibility involved in the development of pulmonary disease associated with particle exposure. The candidate will work on improving various aspects of existing techniques as well as developing novel models for the investigation of pathogenic effects after air liquid interphase exposure to particles as well as on the generation of genetically modified human lung cells and organoids.
We seek a highly motivated candidate (f/m/d) with a strong background in cell biology. Experience in advanced in vitro culture systems combining different cell types is appreciated. Expertise in standard molecular biology techniques and cell culture is critical. Previous work with lung models is a plus.
- The individual should apply significant expertise in cell biology, cell culture, and molecular biology-based techniques.
- Participate in the development and qualification of assays. Independently analyze data and provide conclusions. Critically evaluate own and others results and offer insights based on process and product understanding to help solve problems.
- Contribute to patents, regulatory documents or manuscript as required.
- Read scientific and technical literature in order to bring new and improved procedures to the laboratory, and to broaden understanding of disciplines outside area of training. Utilizes all appropriate experimental design methods needed for work in area of specialization. Conduct literature searches and apply knowledge to the approaches taken.
- Participate in scientific discussion with colleagues through informal and formal scientific seminars and meetings.
EDUCATION AND EXPERIENCE
- Ph.D. in Molecular Biology, Biology, Physiology, Biochemistry, or related field.
- Minimum 3 years of experience with cell culture, ex-vivo models, organoids is highly preferred.
- In depth understanding of lung physiology, cell types and co-culture systems.
- Demonstrated competency in immunohistochemistry, western blotting and DNA cloning.
- Demonstrated proficiency in Microsoft Office, including Word, Excel, and PowerPoint.
The candidate is required to have strong skills in English and German and proven abilities to publish at a high international level with at least one first author publication. Motivation to work independently and be responsible for the daily management of the research project in coordination with other members of the group is expected. The candidate will also be actively involved in the training and co-supervision of other group members and students.
Based at the heart of North Rhine-Westphalia in Dusseldorf, within close vicinity to the Netherlands and Belgium, our institute hosts a vibrant community of international researchers with access to state-of-the-art technology (Illumina sequencers, Oxford Nanopore, 10x Genomics).
The position is limited for 2 years with the option to be extended. The weekly working time totals 39 hours and 50 minutes. Remuneration is given in accordance with the provisions of the collective agreement for the employees of the states (TV-L).
Please address your application (incl. letter of motivation, CV, references, qualification certificates), preferably electronically, to firstname.lastname@example.org:
Dr. Andrea Rossi
IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.