Publications 2019

Original articles

Piechulek A, Scharf A, Berwanger L, von Mikecz A: Life span-resolved nanotoxicology identifies nuclear amyloid, altered metabolism and neurodegenerative processes in the nematode Caenorhabditis elegans. Biopolym Cell 35(3): 194-195, 2019. doi: 10.7124/bc.0009CB

Piechulek A, Berwanger L, Scharf A, von Mikecz A: The cell nucleus as sensor of environmental pollution: Amyloid, neurodegeneration and aging. Biopolym Cell 35: 195-196, 2019. doi: 10.7124/bc.0009CC

Vogeley C, Esser C, Tüting T, Krutmann J, Haarmann-Stemmann T: Role of the aryl hydrocarbon receptor in environmentally induced skin aging and skin carcinogenesis. Int J Mol Sci 20(23): 6005, 2019. doi: 10.3390/ijms20236005

Haupeltshofer S, Leichsenring T, Berg S, Pedreiturria X, Joachim SC, Tischoff I, Otte J-M, Bopp T, Fantini MC, Esser C, Willbold D, Gold R, Faissner S, Kleiter I: Smad7 in intestinal CD4+ T cells determine autoimmunity in a spontaneious model of multiple sclerosis. PNAS 116(51): 25860-25869, 2019. doi: 10.1073/pnas.1905955116

Cossarizza A, … Esser C, … Zychlinsky A: Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49(10): 1457-1973, 2019. doi: 10.1002/eji.201970107

Zhao T, Markevych I, Standl M, Schikowski T, Berdel D, Koletzko S, Jörres RA, Nowak D, Heinrich J: Short-term exposure to ambient ozone and inflammatory biomarkers in cross-sectional studies of children and adolescents: Results of the GINIplus and LISA birth cohorts. Environ Pollut 255(Pt 2): 113264, 2019. doi: 10.1016/j.envpol.2019.113264

Liu Y, Gao W, Koellmann C, Le Clerc S, Hüls A, Li B, Peng Q, Wu S, Ding A, Yang Y, Jin L, Krutmann J, Schikowski T, Zagury JF, Wang S: Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. J Dermatol Sci 96(1): 42-49, 2019. doi: 10.1016/j.jdermsci.2019.08.010

Walter KM*, Dach K*, Hayakawa K*, Giersiefer S, Heuer H, Lein PJ#, Fritsche E#: Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Plos One 14(9): e0221230, 2019. doi: 10.1371/journal.pone.0221230

Jorcano A, Lubczyńska MJ, Pierotti L, Altug H, Ballester F, Cesaroni G, El Marroun H, Fernández-Somoano A, Freire C, Hanke W, Hoek G, Ibarluzea J, Iñiguez C, Jansen PW, Lepeule J, Markevych I, Polańska K, Porta D, Schikowski T, Slama R, Standl M, Tardon A, Vrijkotte TGM, von Berg A, Tiemeier H, Sunyer J, Guxens M: Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts. Environ Int 2019 131: 104927, 2019. doi: 10.1016/j.envint.2019.104927

Harris CP, von Berg A, Berdel D, Bauer CP, Schikowski T, Koletzko S, Heinrich J, Schulz H, Standl M: Dietary saturated fat and low-grade inflammation modified by accelerometer-measured physical activity in adolescence: results from the GINIplus and LISA birth cohorts. BMC Public Health 19(1): 818, 2019. doi: 10.1186/s12889-019-7113-6

Soppa VJ, Shinnawi S, Hennig F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B: Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness – a randomized sham-controlled exposure study. Int J Hyg Environ Health 222(8): 1115-1132, 2019. doi: 10.1016/j.ijheh.2019.08.002

Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N: Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11(16): 6535-6554, 2019. doi: 10.18632/aging.102208

Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H, Wang CC: Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines. Reprod Toxicol 89: 45-53, 2019. doi: 10.1016/j.reprotox.2019.06.001

Granger C, Krutmann J, Bustos J, Sola Y, Hosenally M, Trullàs C, Andres P, Passeron T: New methodology to evaluate sunscreens under outdoor conditions: A double-blind, randomized intra-individual clinical study of a water-based broad-spectrum SPF50+ versus SPF15 (P3) and SPF50+. Dermatol Ther  9(3): 589-599, 2019. doi: 10.1007/s13555-019-00315-4

Piechulek A, Berwanger L, von Mikecz A: Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium. Nanotoxicology 13(8): 1133-1148, 2019. doi: 10.1080/17435390.2019.1643048

Esser C, Hochrath K, Teichweyde N, Krutmann J, Chang H-D: Beyond sequencing: fast and easy microbiome profiling by flow cytometry. Arch Toxicol 93(9): 2703-2704, 2019. doi: 10.1007/s00204-019-02527-1

Fiala GJ, Schaffer AM, Merches K, Morath A, Swann J, Herr LA, Hils M, Esser C, Minguet S, Schamel WWA: Proximal Lck promoter-driven Cre function is limited in neonatal and ineffective in adult γδ T cell development. J Immunol 203(2): 569-579, 2019. doi: 10.4049/jimmunol.1701521

Ishihara Y, Haarmann-Stemmann T, Kado N, Vogel CFA: Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages. Toxicol Sci 170(2): 404-414, 2019. doi: 10.1093/toxsci/kfz114

Piechulek A, von Mikecz A: Aging by pollutants: Introducing the aging dose (AD)50. Environ Sci Eur 31: 23, 2019. doi: 10.1186/s12302-019-0205-1

Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T*, Homey B*, Meller S*: Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events. Allergy 74(12): 2437-2448, 2019. doi: 10.1111/all.13972

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee J, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T: The toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Archiv Toxicol 93(7): 1917-1926, 2019. doi: 10.1007/s00204-019-02488-5

Fuks KB, Wigmann C, Altug H, Schikowski T: Road traffic noise at the residence, annoyance, and cognitive function in elderly women. Int J Environ Res Public Health 16(10): 1790, 2019. doi: 10.3390/ijerph16101790

Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I, Bogatyrova O, Kaucher S, Bermejo JL, Leung SY, Chan TL, Lasitschka F, Bohrer MH, Marx A, Haußen RH, Herold-Mende C, Dyckhoff G, Boukamp P, Delank KW, Hörmann K, Lippert BM, Baier G, Dietz A, Oakes CC, Plass C, Becher H, Schmezer P, Ramroth H, Popanda O: DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. Clin Epigenetics 11(1): 67, 2019. doi: 10.1186/s13148-019-0666-5

Masjosthusmann S, Siebert C, Hübenthal U, Bendt F, Baumann J, Fritsche E: Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense. Chemosphere 235: 447-456, 2019. doi: 10.1016/j.chemosphere.2019.06.123

Vogel CFA, Ishihara Y, Campbell C, Kado S, Nguyen-Chi A, Sweeney C, Pollet M, Haarmann-Stemmann T*, Tuscano JM*: A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth. Cancers 1(5): 589, 2019. doi: 10.3390/cancers11050589 (*equal contribution)

El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR: Genetic compensation triggered by mutant mRNA degradation. Nature 568(7751): 193-197, 2019. doi: 10.1038/s41586-019-1064-z

Yang BY, Markevych I, Harris C, Standl M, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Dong GH, Heinrich J: High-sensitivity C-reactive protein and allergic endpoints in German adolescents. Int Arch Allergy Immunol 179(2): 152-157, 2019. doi: 10.1159/000497320

Guo Q, Liang F, Tian L, Schikowski T, Liu W, Pan X: Ambient air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing: a time-stratified case-crossover analysis. Environ Sci Process Impacts 21(1): 163-173, 2019. doi: 10.1039/c8em00494c

Groten K, Marini A, Grether-Beck S, Jaenicke T, Ibbotson SH, Moseley H, Ferguson J, Krutmann J: Tomato phytonutrients balance UV response: Results from a double blind, randomized, placebo controlled study. Skin Pharmacol Physiol 32(2): 101-108, 2019. doi: 10.1159/000497104

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F: The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun 10(1): 651, 2019. doi: 10.1038/s41467-019-08555-w

Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M: Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake. Sci Rep 9(1): 2913, 2019. doi: 10.1038/s41598-019-39770-6

Çakmak G, Ertürk Ari P, Emerce E, Arı A, Odabası M, Schins RPF, Burgaz S, Gaga EO: Investigation of spatial and temporal variation of particulate matter in vitro genotoxicity and cytotoxicity in relation to the elemental composition. Mutat Res Gen Tox En 842: 22-34, 2019. doi: 10.1016/j.mrgentox.2019.01.009

Hüls A, Sugiri D, Abramson MJ, Hoffmann B, Schwender H, Ickstadt K, Krämer U, Schikowski T: Benefits of improved air quality on aging lungs - Impacts of genetics and obesity. Eur Respir J 53: 1801780, 2019. doi: 10.1183/13993003.01780-2018

Tran B-H, Dao V-A, Bilstein A, Unfried K, Shah-Hosseini K, Mösges R: Ectoine-containing inhalation solution versus saline inhalation solution in the treatment of acute bronchitis and acute respiratory infections: A prospective, controlled, observational study. Biomed Res Int 2019: 7945091, 2019. doi: 10.1155/2019/7945091

Fuks K*, Hüls A*, Sugiri D, Altug H, Vierkötter A, Abramson M, Goebel J, Wagner G, Demuth I, Krutmann J*, Schikowski T*: Tropospheric ozone and skin aging: results from two German cohort studies. Environ Int 124: 139-144, 2019. doi: 10.1016/j.envint.2018.12.047 (* equal contribution)

Zhao T, Markevych I, Standl M, Schulte-Körne G, Schikowski T, Berdel D, Koletzko S, Bauer CP, von Berg A, Nowak D, Heinrich J: Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts. Environ Res 170: 73-81, 2019. doi: 10.1016/j.envres.2018.12.014

Steinbrenner H, Micoogullari M, Hoang NA, Bergheim I, Klotz L-O, Sies H: Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes. Redox Biol 20: 489-495, 2019. doi: 10.1016/j.redox.2018.11.004

Markevych I, Feng X, Astell-Burt T, Standl M, Sugiri D, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Heinrich J: Residential and school greenspace and academic performance: Evidence from the GINIplus and LISA longitudinal studies of German adolescents. Environ Pollut 245: 71-76, 2019. doi: 10.1016/j.envpol.2018.10.053

Hüls A*, Abramson MJ*, Sugiri D, Fuks K, Krämer U, Krutmann J, Schikowski T: Non-atopic eczema in elderly women - Impact of air pollution and genes. J Allergy Clin Immunol 143(1): 378-385.e9, 2019. doi: 10.1016/j.jaci.2018.09.031 (* equal contribution)

Kühne BA, Puig T, Ruiz-Martínez S, Crous-Masó J, Planas M, Feliu L, Cano A, Garcia ML, Fritsche E, Llobet JM, Gómez-Catalán J, Barenys M: Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres. Food Chem Toxicol 123: 195-204, 2019. doi: 10.1016/j.fct.2018.10.055

Hüls A, Sugiri D, Fuks K, Krutmann J*, Schikowski T*: Lentigines formation in Caucasian women - Interaction between particulate matter and solar UVR. J Invest Dermatol 139(4): 974-976, 2019. doi: 10.1016/j.jid.2018.09.034 (* equal contribution)

Ali AAH, Schwarz-Herzke B, Mir S, Sahlender B, Victor M, Görg B, Schmuck M, Dach K, Fritsche E, Kremer A, von Gall C: Deficiency of the clock gene Bmal1 affects neural progenitor cell migration. Brain Struct Funct 224(1): 373-386, 2019. doi: 10.1007/s00429-018-1775-1

Reviews, contributions to books, etc.

Sies H, Reichert AS: Selectively addressing mitochondrial glutathione and thioredoxin redox systems. Cell Chem Biol 26: 316-318, 2019. doi: 10.1016/j.chembiol.2019.02.017

Penzel T, Krämer U, Höger R, Zimmermann S, Wichmann HE: Aktueller Wissensstand zu Fluglärm und Gesundheit - einschließlich WHO-Reviews und neuer Literatur bis Ende 2018. Umweltmed - Hygiene - Arbeitsmed 24(4): 187-218, 2019.

Krebs A, … , Fritsche E, …, Leist M: Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data. ALTEX 36(4): 682-699, 2019. doi: 10.14573/altex.1909271s

Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins RPF, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F: The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity? Part Fibre Toxicol 16(1): 32, 2019. doi: 10.1186/s12989-019-0315-3

Solecki R, Rauch M, Gall A, Buschmann J, Kellner R, Kucheryavenko O, Schmitt A, Delrue N, Li W, Hu J, Fujiwara M, Kuwagata M, Mantovani A, Makris SL, Paumgartten F, Schönfelder G, Schneider S, Vogl S, Kleinstreuer N, Schneider M, Schulze F, Fritsche E, Clark R, Shiota K, Chahoud I: Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol 89: 124-129, 2019. doi:

Bernard JJ, Gallo RL, Krutmann J: Photoimmunology: how ultraviolet radiation affects the immune system. Nat Rev Immunol 19(11): 688-701, 2019. doi: 10.1038/s41577-019-0185-9

Bruckmann P, Krämer U, Wichmann HE: Wissenschaft trifft Politik - die Basis der europäischen Grenzwerte für Stickstoffdioxid und Feinstaub. Umwelt - Hygiene – Arbeitsmed 24(2): 83-100, 2019.

Krutmann J: Luftverschmutzung und Haut. Hautarzt 70(3): 156-157, 2019. doi: 10.1007/s00105-018-4349-5

Krämer U, Behrendt H: Luftverschmutzung und atopisches Ekzem. Hautarzt 70(3): 169-184, 2019. doi: 10.1007/s00105-018-4330-3

Schikowski T, Krutmann J: Luftverschmutzung (Feinstaub, Stickstoffdioxid) und Hautalterung. Hautarzt 70(3): 158-162, 2019. doi: 10.1007/s00105-018-4338-8 (Leitthema)

Fuks KB, Woodby B, Vallacchi G: Hautschäden durch troposphärisches Ozon. Hautarzt 70(3): 163-168, 2019. doi: 10.1007/s00105-018-4319-y (Leitthema)

Reinke H, Asher G: Crosstalk between metabolism and circadian clocks. Nat Rev Mol Cell Biol 20: 227-241, 2019. doi: 10.1038/s41580-018-0096-9