Publications of Thomas Haarmann-Stemmann's group

2022

Yusuf N, Haarmann-Stemmann T, Nakamura M: Editorial: Environment and skin cancer. Front Oncol 12: 924225, 2022. doi: 10.3389/fonc.2022.924225

Vogeley C, Rolfes KM, Krutmann J, Haarmann-Stemmann T: The Aryl Hydrocarbon Receptor in the pathogenesis of environmentally-induced squamous cell carcinomas of the skin. Front Oncol 12: 841721, 2022. doi: 10.3389/fonc.2022.841721

Ishihara Y, Kado SY, Bein KJ, He Y, Pouraryan AA, Urban A, Haarmann-Stemmann T, Sweeney C and Vogel CFA: Aryl hydrocarbon receptor signaling synergizes with TLR/NF-κB-signaling for induction of IL-22 through canonical and non-canonical AhR pathways. Front Toxicol 3: 787360, 2022. doi: 10.3389/ftox.2021.787360

Fehsel K, Schwanke K, Kappel BA, Fahimi E, Meisenzahl-Lechner E, Esser C, Hemmrich K, Haarmann-Stemmann T, Kojda G, Lange-Asschenfeldt C: Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction. J Psychopharmacol 36(2): 191-201, 2022. doi: 10.1177/02698811211055811

2021

Vogeley C, Sondermann NC, Woeste S, Momin AA, Gilardino V, Hartung F, Heinen M, Maaß SK, Mescher M, Pollet M, Rolfes KM, Vogel CFA, Rossi A, Lang D, Arold ST, Nakamura M, Haarmann-Stemmann T: Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response. Environ Int 158: 106989, 2022. doi: 10.1016/j.envint.2021.106989

Faßbender S, Sondenheimer K, Majora M, Schindler J, Opitz FV, Pollet M, Haarmann-Stemmann T, Krutmann J, Weighardt H: Keratinocytes counteract UVB-induced immunosuppression in mice via HIF1a signaling. J Invest Dermatol 142(4):1183-1193, 2022. doi: 10.1016/j.jid.2021.07.185

Rolfes KM, Sondermann NC, Vogeley C, Dairou J, Gilardino V, Wirth R, Meller S, Homey B, Krutmann J, Lang D, Nakamura M, Haarmann-Stemmann T: Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity. Redox Biol 46: 102110, 2021. doi: 10.1016/j.redox.2021.102110

Vogel CFA, Lazennec G, Kado SY, Dahlem C, He Y, Castaneda A, Ishihara Y, Vogeley C, Rossi A, Haarmann-Stemmann T, Jugan J, Mori H, Borowsky AD, La Merrill MA, Sweeney C: Targeting the aryl hydrocarbon receptor signaling pathway in breast cancer development. Front Immunol 12: 62534, 2021. doi: 10.3389/fimmu.2021.625346

Haarmann-Stemmann T, Sutter TR, Krutmann J, Esser C: The mode of action of tapinarof may not only depend on the activation of cutaneous aryl hydrocarbon receptor signaling but also on its antimicrobial activity. J Am Acad Dermatol 85(1): e33-e34, 2021. doi: 10.1016/j.jaad.2021.01.103

Fritsche E, Haarmann-Stemmann T, Kapr J, Galanjuk S, Hartmann J, Mertens PR, Kämpfer AAM, Schins RPF, Tigges J, Koch K: Stem cells for next level toxicity testing in the 21st century. Small 17(15): e2006252, 2021. doi: 10.1002/smll.202006252

Ghashghaei O, Pedrola M, Seghetti F, Martin VV, Zavarce R, Babiak M, Novacek J, Hartung F, Rolfes KM, Haarmann-Stemmann T, Lavilla R:  Extended multicomponent reactions with indole aldehydes: Access to unprecedented polyheterocyclic scaffolds, ligands of the Aryl Hydrocarbon Receptor. Angew Chem Int Edit 60(5): 2603-2608, 2021. doi: 10.1002/anie.202011253

2020

Dahlem C, Kado SY, He F, Bein K, Wu D, Haarmann-Stemmann T, Kado NY, Vogel CF: AHR signaling interacting with nutritional factors regulating the expression of markers in vascular inflammation and atherogenesis. Int J Mol Sci 21(21): 8287, 2020. doi: 10.3390/ijms21218287

Esser C, Hochrath K, Schikowski T, Haarmann-Stemmann T: COVID-19 research: toxicological input urgently needed! Arch Toxicol 94(7): 2547-2548, 2020. doi: 10.1007/s00204-020-02803-5

Vogel CFA, Van Winkle LS, Esser C, Haarmann-Stemmann T: The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses. Redox Biol 34: 101530, 2020. doi: 10.1016/j.redox.2020.101530

2019

Vogeley C, Esser C, Tüting T, Krutmann J, Haarmann-Stemmann T: Role of the aryl hydrocarbon receptor in environmentally induced skin aging and skin carcinogenesis. Int J Mol Sci 20(23): 6005, 2019. doi: 10.3390/ijms20236005

Ishihara Y, Haarmann-Stemmann T, Kado N, Vogel CFA: Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages. Toxicol Sci 170(2): 404-414, 2019. doi: 10.1093/toxsci/kfz114

Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T*, Homey B*, Meller S*: Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events. Allergy 2019. doi: 10.1111/all.13972 (* equal contribution)

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee J, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T: The toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Archiv Toxicol 93(7): 1917-1926, 2019. doi: 10.1007/s00204-019-02488-5

Vogel CFA, Ishihara Y, Campbell C, Kado S, Nguyen-Chi A, Sweeney C, Pollet M, Haarmann-Stemmann T*, Tuscano JM*: A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth. Cancers 1(5): 589, 2019. doi: 10.3390/cancers11050589 (*equal contribution)

2018

Pollet M*, Shaik S*, Mescher M*, Frauenstein K, Tigges J, Braun S, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CF, Krutmann J, Haarmann-Stemmann T: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 25: 1823-1836, 2018. doi: 10.1038/s41418-018-0160-1 (* equal contribution)

Pollet M, Krutmann J, Haarmann-Stemmann T: Commentary: Usage of mitogen-activated protein kinase small inhibitors: More than just inhibition!” Front Pharmacol 9: 935, 2018. doi: 10.3389/fphar.2018.00935

Mescher M, Haarmann-Stemmann T: Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options. Pharmacol Ther 187: 71-87, 2018. doi: 10.1016/j.pharmthera.2018.02.012

Esser C, Haarmann-Stemmann T, Hochrath K, Schikowski T, Krutmann J: AHR and the issue of immunotoxicity. Curr Opinion Toxicol 10: 91-97, 2018. doi: 10.1016/j.cotox.2018.03.001

Nakamura M*, Haarmann-Stemmann T*, Krutmann J, Morita A: Alternative test models for skin aging research. Exp Dermatol 27: 495-500, 2018. doi: 10.1111/exd.13519 (* equal contribution)

2017

Vogel CFA, Haarmann-Stemmann T: The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AHR signaling: Clues for its role in inflammation and cancer. Current Opinion Toxicol 2: 109-119, 2017. doi: 10.1016/j.cotox.2017.02.004

Merches K, Haarmann-Stemmann T, Weighardt H, Krutmann J, Esser C: AHR in the skin: From the mediator of chloracne to a therapeutic panacea? Current Opinion Toxicol 2: 79-86, 2017. doi: 10.1016/j.cotox.2017.02.002

2016

Brandstätter O*, Schanz O*, Vorac J*, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H*, Förster I*: Balancing intestinal and systemic inflammation through cell typespecific expression of the aryl hydrocarbon receptor repressor. Sci Rep 6: 26091, 2016. doi: 10.1038/srep26091 (* equal contribution)

Vogel CFA, Chang WLW, Kado S, McKulloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang GX, Leung PSC, Matsumura F, Gershwin ME: Transgenic overexpression of aryl hydrocarbon receptor repressor (AhRR) and AhR-mediated induction of CYP1A1, cytokines and acute toxicity. Environ Health Perspect 124(7): 1071-1083, 2016. doi: 10.1289/ehp.1510194

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J: The aryl hydrocarbon receptor promotes aging phenotypes. Sci Rep 6: 19618, 2016. doi: 10.1038/srep19618.

Dittmann KH, Rothmund MC, Paasch A, Mayer C, Fehrenbacher B, Schaller M, Frauenstein K, Fritsche E, Haarmann-Stemmann T, Braeuning A, Rodemann HP: The nuclear aryl hydrocarbon receptor is involved in regulation of DNA-repair and cell survival following treatment with ionizing radiation. Toxicol Lett 240(1): 122-129, 2016. doi: 10.1016/j.toxlet.2015.10.017

2015

Haarmann-Stemmann T, Esser C, Krutmann J: The Janus-faced role of Aryl Hydrocarbon Receptor (AHR) signaling in the skin: Consequences for prevention and treatment of skin disorders. J Invest Dermatol 135(11): 2572-2576, 2015. [pubmed]

Nakamura M, Haarmann-Stemmann T, Krutmann J: COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn. Exp Dermatol 24(10): 734-735, 2015. [pubmed] (open access)

Bekki K, Vogel H, Li W, Ito T, Sweeney C, Haarmann-Stemmann T, Matsumura F, Vogel CF: The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells. Pestic Biochem Physiol 120: 5-13, 2015. [pubmed]

Frauenstein K*, Tigges J*, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CFA, Haarmann-Stemmann T: Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol 89(8): 1329-1336, 2015 (* equal contribution) [pubmed]

Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J: Environment-Induced Lentigines (EILs): Formation of solar lentigines beyond ultraviolet radiation. Exp Dermatol 24(6): 407-411, 2015. [pubmed]

Bruhs A, Haarmann-Stemmann T, Frauenstein K, Krutmann J, Schwarz T, Schwarz A: Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells. J Invest Dermatol 135(2): 435-444, 2015. [pubmed]

2014

Tigges J*, Haarmann-Stemmann T*, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J*, Fritsche E*: The new arylhydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2): 556-559, 2014. (* equal contribution) [pubmed] (open access)
Vogel CFA, Kahn EM, Leung P, Gershwin ME, Chang WLW, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS: Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for NF-κB. Journal of Biological Chemistry 289(3): 1866-1875, 2014. [pubmed] (open access)

2013

Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J, Haarmann-Stemmann T: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. [pubmed] (open access)

Haarmann-Stemmann T, Boege F, Krutmann J: Adaptive and maladaptive responses in sSkin: Mild heat exposure protects against UVB-induced photoaging in mice. J Invest Dermatol 133(4): 868-871, 2013. [pubmed]

Tigges J*, Weighardt H*, Wolff S, Goetz C, Foerster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E: Arylhydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. J Invest Dermatol 133(1): 87-96, 2013. (*equal contribution) [pubmed] (open access)

Esser C, Bargen I, Weighardt H, Haarmann-Stemmann T, Krutmann J: Functions of the Aryl Hydrocarbon Receptor in the skin. Seminars in Immunopathology 35(6): 677-691, 2013. [pubmed]

Stobbe-Maicherski N, Wolff S, Wolff C, Abel J, Sydlik U, Frauenstein K, Haarmann-Stemmann T: The IL-6-type cytokine oncostatin M induces AHR expression in a STAT3-dependent manner in human HepG2 hepatoma cells. FEBS Journal 280(24): 6681-6690, 2013. [pubmed]

Vrzal R*, Frauenstein K*, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T: Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One 8(9): e74917, 2013. (*authors contributed equally) [pubmed]

Ono Y, Torii K, Fritsche E, Shintani Y, Nishida E, Nakamura M, Shirakata Y, Haarmann-Stemmann T, Abel J, Krutmann J, Morita A: Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression.Exp Dermatol 22(5): 349-353, 2013. [pubmed]

2012

Haarmann-Stemmann T, Abel J, Fritsche E, Krutmann J: The AhR-Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention? J Invest Dermatol 132 (1): 7-9, 2012. [pubmed]

2011

Bothe H*, Gassmann K*, Götz C, Fritsche E, Abel J, Haarmann-Stemmann T: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. Toxicology Letters 203(3): 258-264, 2011. (*equal contribution) [pubmed]

Haarmann-Stemmann T, Abel J: Influence of HIF-1a and Nrf2 on AHR mediated gene expression, toxicity and biological functions. In: The AH Receptor in Biology and Toxicology. Raimo Pohjanvirta (ed). Wiley-VCH, Weinheim 2011, ISBN 978-0-470-60182-2

2010

Gassmann K, Abel J, Bothe H, Haarmann-Stemmann T, Merk HF, Quasthoff KN, Rockel TD, Schreiber T, Fritsche E: Species-specific differential AhR-expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. Environ Health Perspect 118(11): 1571-1577, 2010.

Haarmann-Stemmann T, Sendker J, Götz C, Krug N, Bothe H, Fritsche E, Proksch P, Abel J: Regulation of human dioxin receptor function by different beta-carboline alkaloids. Archives of Toxicology 84 (8): 619-629, 2010.

Bothe H, Götz C, Stobbe-Maicherski N, Fritsche E, Abel J, Haarmann-Stemmann T: Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Archives of Biochemistry and Biophysics 498 (2): 111-118, 2010.

Abel J, Haarmann-Stemmann T: An introduction to the molecular basics of Arylhydrocarbon Receptor biology. Biological Chemistry 391(11):1235-48, 2010.

2009

Haarmann-Stemmann T, Bothe H, Abel J: Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochemical Pharmacology 77 (4): 508-520, 2009.

2007

Haarmann-Stemmann T, Bothe H, Kohli A, Sydlik U, Abel J, Fritsche E: Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines. Drug Metabolism and Disposition 35: 2262-2269, 2007.

2006

Haarmann-Stemmann T, Abel J: The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function. Biological Chemistry 387: 1195-1199, 2011.

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