Publications of Thomas Haarmann-Stemmann's group


Faßbender S, Sondenheimer K, Majora M, Schindler J, Opitz FV, Pollet M, Haarmann-Stemmann T, Krutmann J, Weighardt H: Keratinocytes counteract UVB-induced immunosuppression in mice via HIF1a signaling. J Invest Dermatol S0022-202X(21)02217-X, 2021. doi: 10.1016/j.jid.2021.07.185

Rolfes KM, Sondermann NC, Vogeley C, Dairou J, Gilardino V, Wirth R, Meller S, Homey B, Krutmann J, Lang D, Nakamura M, Haarmann-Stemmann T: Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity. Redox Biol 46: 102110, 2021. doi: 10.1016/j.redox.2021.102110

Vogel CFA, Lazennec G, Kado SY, Dahlem C, He Y, Castaneda A, Ishihara Y, Vogeley C, Rossi A, Haarmann-Stemmann T, Jugan J, Mori H, Borowsky AD, La Merrill MA, Sweeney C: Targeting the aryl hydrocarbon receptor signaling pathway in breast cancer development. Front Immunol 12: 62534, 2021. doi: 10.3389/fimmu.2021.625346

Haarmann-Stemmann T, Sutter TR, Krutmann J, Esser C: The mode of action of tapinarof may not only depend on the activation of cutaneous aryl hydrocarbon receptor signaling but also on its antimicrobial activity. J Am Acad Dermatol 85(1): e33-e34, 2021. doi: 10.1016/j.jaad.2021.01.103

Fritsche E, Haarmann-Stemmann T, Kapr J, Galanjuk S, Hartmann J, Mertens PR, Kämpfer AAM, Schins RPF, Tigges J, Koch K: Stem cells for next level toxicity testing in the 21st century. Small 17(15): e2006252, 2021. doi: 10.1002/smll.202006252

Ghashghaei O, Pedrola M, Seghetti F, Martin VV, Zavarce R, Babiak M, Novacek J, Hartung F, Rolfes KM, Haarmann-Stemmann T, Lavilla R:  Extended multicomponent reactions with indole aldehydes: Access to unprecedented polyheterocyclic scaffolds, ligands of the Aryl Hydrocarbon Receptor. Angew Chem Int Edit 60(5): 2603-2608, 2021. doi: 10.1002/anie.202011253


Dahlem C, Kado SY, He F, Bein K, Wu D, Haarmann-Stemmann T, Kado NY, Vogel CF: AHR signaling interacting with nutritional factors regulating the expression of markers in vascular inflammation and atherogenesis. Int J Mol Sci 21(21): 8287, 2020. doi: 10.3390/ijms21218287

Esser C, Hochrath K, Schikowski T, Haarmann-Stemmann T: COVID-19 research: toxicological input urgently needed! Arch Toxicol 94(7): 2547-2548, 2020. doi: 10.1007/s00204-020-02803-5

Vogel CFA, Van Winkle LS, Esser C, Haarmann-Stemmann T: The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses. Redox Biol 34: 101530, 2020. doi: 10.1016/j.redox.2020.101530


Vogeley C, Esser C, Tüting T, Krutmann J, Haarmann-Stemmann T: Role of the aryl hydrocarbon receptor in environmentally induced skin aging and skin carcinogenesis. Int J Mol Sci 20(23): 6005, 2019. doi: 10.3390/ijms20236005

Ishihara Y, Haarmann-Stemmann T, Kado N, Vogel CFA: Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages. Toxicol Sci 170(2): 404-414, 2019. doi: 10.1093/toxsci/kfz114

Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T*, Homey B*, Meller S*: Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events. Allergy 2019. doi: 10.1111/all.13972 (* equal contribution)

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee J, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T: The toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Archiv Toxicol 93(7): 1917-1926, 2019. doi: 10.1007/s00204-019-02488-5

Vogel CFA, Ishihara Y, Campbell C, Kado S, Nguyen-Chi A, Sweeney C, Pollet M, Haarmann-Stemmann T*, Tuscano JM*: A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth. Cancers 1(5): 589, 2019. doi: 10.3390/cancers11050589 (*equal contribution)


Pollet M*, Shaik S*, Mescher M*, Frauenstein K, Tigges J, Braun S, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CF, Krutmann J, Haarmann-Stemmann T: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 25: 1823-1836, 2018. doi: 10.1038/s41418-018-0160-1 (* equal contribution)

Pollet M, Krutmann J, Haarmann-Stemmann T: Commentary: Usage of mitogen-activated protein kinase small inhibitors: More than just inhibition!” Front Pharmacol 9: 935, 2018. doi: 10.3389/fphar.2018.00935

Mescher M, Haarmann-Stemmann T: Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options. Pharmacol Ther 187: 71-87, 2018. doi: 10.1016/j.pharmthera.2018.02.012

Esser C, Haarmann-Stemmann T, Hochrath K, Schikowski T, Krutmann J: AHR and the issue of immunotoxicity. Curr Opinion Toxicol 10: 91-97, 2018. doi: 10.1016/j.cotox.2018.03.001

Nakamura M*, Haarmann-Stemmann T*, Krutmann J, Morita A: Alternative test models for skin aging research. Exp Dermatol 27: 495-500, 2018. doi: 10.1111/exd.13519 (* equal contribution)


Vogel CFA, Haarmann-Stemmann T: The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AHR signaling: Clues for its role in inflammation and cancer. Current Opinion Toxicol 2: 109-119, 2017. doi: 10.1016/j.cotox.2017.02.004

Merches K, Haarmann-Stemmann T, Weighardt H, Krutmann J, Esser C: AHR in the skin: From the mediator of chloracne to a therapeutic panacea? Current Opinion Toxicol 2: 79-86, 2017. doi: 10.1016/j.cotox.2017.02.002


Brandstätter O*, Schanz O*, Vorac J*, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H*, Förster I*: Balancing intestinal and systemic inflammation through cell typespecific expression of the aryl hydrocarbon receptor repressor. Sci Rep 6: 26091, 2016. doi: 10.1038/srep26091 (* equal contribution)

Vogel CFA, Chang WLW, Kado S, McKulloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang GX, Leung PSC, Matsumura F, Gershwin ME: Transgenic overexpression of aryl hydrocarbon receptor repressor (AhRR) and AhR-mediated induction of CYP1A1, cytokines and acute toxicity. Environ Health Perspect 124(7): 1071-1083, 2016. doi: 10.1289/ehp.1510194

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J: The aryl hydrocarbon receptor promotes aging phenotypes. Sci Rep 6: 19618, 2016. doi: 10.1038/srep19618.

Dittmann KH, Rothmund MC, Paasch A, Mayer C, Fehrenbacher B, Schaller M, Frauenstein K, Fritsche E, Haarmann-Stemmann T, Braeuning A, Rodemann HP: The nuclear aryl hydrocarbon receptor is involved in regulation of DNA-repair and cell survival following treatment with ionizing radiation. Toxicol Lett 240(1): 122-129, 2016. doi: 10.1016/j.toxlet.2015.10.017


Haarmann-Stemmann T, Esser C, Krutmann J: The Janus-faced role of Aryl Hydrocarbon Receptor (AHR) signaling in the skin: Consequences for prevention and treatment of skin disorders. J Invest Dermatol 135(11): 2572-2576, 2015. [pubmed]

Nakamura M, Haarmann-Stemmann T, Krutmann J: COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn. Exp Dermatol 24(10): 734-735, 2015. [pubmed] (open access)

Bekki K, Vogel H, Li W, Ito T, Sweeney C, Haarmann-Stemmann T, Matsumura F, Vogel CF: The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells. Pestic Biochem Physiol 120: 5-13, 2015. [pubmed]

Frauenstein K*, Tigges J*, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CFA, Haarmann-Stemmann T: Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol 89(8): 1329-1336, 2015 (* equal contribution) [pubmed]

Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J: Environment-Induced Lentigines (EILs): Formation of solar lentigines beyond ultraviolet radiation. Exp Dermatol 24(6): 407-411, 2015. [pubmed]

Bruhs A, Haarmann-Stemmann T, Frauenstein K, Krutmann J, Schwarz T, Schwarz A: Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells. J Invest Dermatol 135(2): 435-444, 2015. [pubmed]


Tigges J*, Haarmann-Stemmann T*, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J*, Fritsche E*: The new arylhydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2): 556-559, 2014. (* equal contribution) [pubmed] (open access)
Vogel CFA, Kahn EM, Leung P, Gershwin ME, Chang WLW, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS: Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for NF-κB. Journal of Biological Chemistry 289(3): 1866-1875, 2014. [pubmed] (open access)


Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J, Haarmann-Stemmann T: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. [pubmed] (open access)

Haarmann-Stemmann T, Boege F, Krutmann J: Adaptive and maladaptive responses in sSkin: Mild heat exposure protects against UVB-induced photoaging in mice. J Invest Dermatol 133(4): 868-871, 2013. [pubmed]

Tigges J*, Weighardt H*, Wolff S, Goetz C, Foerster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E: Arylhydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. J Invest Dermatol 133(1): 87-96, 2013. (*equal contribution) [pubmed] (open access)

Esser C, Bargen I, Weighardt H, Haarmann-Stemmann T, Krutmann J: Functions of the Aryl Hydrocarbon Receptor in the skin. Seminars in Immunopathology 35(6): 677-691, 2013. [pubmed]

Stobbe-Maicherski N, Wolff S, Wolff C, Abel J, Sydlik U, Frauenstein K, Haarmann-Stemmann T: The IL-6-type cytokine oncostatin M induces AHR expression in a STAT3-dependent manner in human HepG2 hepatoma cells. FEBS Journal 280(24): 6681-6690, 2013. [pubmed]

Vrzal R*, Frauenstein K*, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T: Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One 8(9): e74917, 2013. (*authors contributed equally) [pubmed]

Ono Y, Torii K, Fritsche E, Shintani Y, Nishida E, Nakamura M, Shirakata Y, Haarmann-Stemmann T, Abel J, Krutmann J, Morita A: Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression.Exp Dermatol 22(5): 349-353, 2013. [pubmed]


Haarmann-Stemmann T, Abel J, Fritsche E, Krutmann J: The AhR-Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention? J Invest Dermatol 132 (1): 7-9, 2012. [pubmed]


Bothe H*, Gassmann K*, Götz C, Fritsche E, Abel J, Haarmann-Stemmann T: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. Toxicology Letters 203(3): 258-264, 2011. (*equal contribution) [pubmed]

Haarmann-Stemmann T, Abel J: Influence of HIF-1a and Nrf2 on AHR mediated gene expression, toxicity and biological functions. In: The AH Receptor in Biology and Toxicology. Raimo Pohjanvirta (ed). Wiley-VCH, Weinheim 2011, ISBN 978-0-470-60182-2


Gassmann K, Abel J, Bothe H, Haarmann-Stemmann T, Merk HF, Quasthoff KN, Rockel TD, Schreiber T, Fritsche E: Species-specific differential AhR-expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. Environ Health Perspect 118(11): 1571-1577, 2010.

Haarmann-Stemmann T, Sendker J, Götz C, Krug N, Bothe H, Fritsche E, Proksch P, Abel J: Regulation of human dioxin receptor function by different beta-carboline alkaloids. Archives of Toxicology 84 (8): 619-629, 2010.

Bothe H, Götz C, Stobbe-Maicherski N, Fritsche E, Abel J, Haarmann-Stemmann T: Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Archives of Biochemistry and Biophysics 498 (2): 111-118, 2010.

Abel J, Haarmann-Stemmann T: An introduction to the molecular basics of Arylhydrocarbon Receptor biology. Biological Chemistry 391(11):1235-48, 2010.


Haarmann-Stemmann T, Bothe H, Abel J: Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochemical Pharmacology 77 (4): 508-520, 2009.


Haarmann-Stemmann T, Bothe H, Kohli A, Sydlik U, Abel J, Fritsche E: Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines. Drug Metabolism and Disposition 35: 2262-2269, 2007.


Haarmann-Stemmann T, Abel J: The arylhydrocarbon receptor repressor (AhRR): structure, expression, and function. Biological Chemistry 387: 1195-1199, 2011.