Publications of Jean Krutmann's group

2022

Wei Q, Li Z, Gu Z, Liu X, Krutmann J, Wang, Xia J: Shotgun metagenomic sequencing reveals skin microbial variability from different facial sites. Front Microbiol 13: 933189, 2022. doi: 10.3389/fmicb.2022.933189

Plitta-Michalak B, Stricker N, Pavez Loriè E, Chen I, Pollet M, Krutmann J, Volkmer B, Greinert R, Boukamp P, Rapp A: Development and characterisation of an irradiation device for biomedical studies covering the solar spectrum with individual regulated spectral bands. Photochem Photobiol Sci, 2022. doi: 10.1007/s43630-022-00252-w

Duteil L, Queille-Roussel C, Aladren S, Bustos X, Trullas C, Granger C, Krutmann J, Passeron T: Prevention of polymorphic light eruption afforded by a very high broad-spectrum protection sunscreen containing Ectoin. Dermatol Ther (Heidelb) 12(7): 1603-1613, 2022. doi: 10.1007/s13555-022-00755-5

Nguyen T, Ramachandran H, Martins S, Krutmann J, Rossi A: Identification of genome edited cells using CRISPRnano. Nucleic Acids Res, 2022. doi: 10.1093/nar/gkac440

Surber C, Krutmann J: Sonnenschutz: Wichtiger denn je! [Sun protection measures: more important than ever!]. Hautarzt 73(4): 249-250, 2022. doi: 10.1007/s00105-022-04964-z

Wolf P, Krutmann J: Sonnenschutz der Zukunft: Herausforderungen und Möglichkeiten [Sunscreens of the future: challenges and opportunities]. Hautarzt 73(4): 257-265, 2022. doi: 10.1007/s00105-022-04959-w

Vogeley C, Rolfes KM, Krutmann J, Haarmann-Stemmann T: The Aryl Hydrocarbon Receptor in the pathogenesis of environmentally-induced squamous cell carcinomas of the skin. Front Oncol 12: 841721, 2022. doi: 10.3389/fonc.2022.841721

Liu W, Jie L, Liu D, Makino ET, Krutmann J, Mehta RC: Protective effects of a day/night dual-antioxidant serum on skin: a randomized, regimen-controlled study in Chinese women exposed to air pollution. J Cosmet Dermatol, 2022. doi: 10.1111/jocd.14839

Neves JR, Grether-Beck S, Krutmann J, Correia P, Gonçalves Junior JE, Sant'Anna B, Kerob D: Efficacy of a topical serum containing l-ascorbic acid, neohesperidin, pycnogenol, tocopherol and hyaluronic acid in relation to skin aging signs. J Cosmet Dermatol, 2022. doi: 10.1111/jocd.14837

2021

Li B, Cheng Y, Tan Y, Wang F, Hu W, Wang X, Liu W, Krutmann J, Wang S, Zou Y: Analysis of factors influencing skin reactions to sunscreens, skin whitening products, and deodorants: Results from a large-scale patch test dataset in China. J Cosmet Dermatol, 2021. doi: 10.1111/jocd.14699

Vogeley C, Sondermann NC, Woeste S, Momin AA, Gilardino V, Hartung F, Heinen M, Maaß SK, Mescher M, Pollet M, Rolfes KM, Vogel CFA, Rossi A, Lang D, Arold ST, Nakamura M, Haarmann-Stemmann T: Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response. Environ Int 158: 106989, 2022. doi: 10.1016/j.envint.2021.106989

Faßbender S, Sondenheimer K, Majora M, Schindler J, Opitz FV, Pollet M, Haarmann-Stemmann T, Krutmann J, Weighardt H: Keratinocytes counteract UVB-induced immunosuppression in mice via HIF1a signaling. J Invest Dermatol 142(4):1183-1193, 2022. doi: 10.1016/j.jid.2021.07.185

Piquero-Casals J, Morgado-Carrasco D, Granger C, Trullàs C, Jesús-Silva A, Krutmann J: Urea in dermatology. A review of its emollient, moisturizing, keratolytic, skin barrier enhancing and antimicrobial properties. Dermatol Ther (Heidelb) 11(6): 1905-1915, 2021. doi: 10.1007/s13555-021-00611-y

Rolfes KM, Sondermann NC, Vogeley C, Dairou J, Gilardino V, Wirth R, Meller S, Homey B, Krutmann J, Lang D, Nakamura M, Haarmann-Stemmann T: Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity. Redox Biol 46: 102110, 2021. doi: 10.1016/j.redox.2021.102110

Grether-Beck S, Marini A, Jaenicke T, Brenden H, Felsner I, Aue N, Brynjolfsdottir A, Krutmann J: Blue Lagoon Algae improve uneven skin pigmentation: Results from in vitro studies and from a monocentric, randomized, double-blind, vehicle-controlled, split-face study. Skin Pharmacol Physiol 35(2): 77-86, 2022. doi: 10.1159/000518781

Breuckmann P, Meinke MC, Jaenicke T, Krutmann J, Rasulev U, Keck CM, Müller RH, Klein AL, Lademann J, Patzelt A: Influence of nanocrystal size on the in vivo absorption kinetics of caffeine after topical application. Eur J Pharm Biopharm 167: 57-64, 2021. doi: 10.1016/j.ejpb.2021.07.006

Martins S, Hacheney I, Teichweyde N, Hildebrandt B, Krutmann J, Rossi A: Generation of an induced pluripotent stem cell line (IUFi001) from a Cockayne syndrome patient carrying a mutation in the ERCC6 gene. Stem Cell Res 55: 102456, 2021. doi: 10.1016/j.scr.2021.102456

Li B, Cheng Y, Tan Y, Wang F, Hu W, Wang X, Liu W, Krutmann J, Wang S, Zou Y: Analysis of factors influencing patch test reactions: Results from a large- population-based study in Chinese. J Cosmet Dermatol 21(5): 2183-2188, 2022. doi: 10.1111/jocd.14338

Granger C, Ong G, Andres P, Trullàs C, Hosenally M, Lai W, Liu W, Krutmann J, Passeron T, Lim HW: Outdoor Sunscreen Testing with High-intensity Solar Exposure in a Chinese and Caucasian Population. Photodermatol Photoimmunol Photomed 38(1): 19-28, 2022. doi: 10.1111/phpp.12710

Krutmann J, Granger C, Trullàs C, Passeron T: Daily Photoprotection: What Does it Really Mean? Photodermatol Photoimmunol Photomed 37(6): 569-570, 2021. doi: 10.1111/phpp.12707

Passeron T, Zouboulis CC, Tan J, Andersen ML, Katta R, Lyu X, Aguilar L, Kerob D, Morita A, Krutmann J, Peters EMJ: Adult skin acute stress responses to short-term environmental and internal aggression from exposome factors. J Eur Acad Dermatol Venereol 35(10): 1963-1975, 2021. doi: 10.1111/jdv.17432

Lim H, Kohli I, Granger C, Trullas C, Piquero-Casals J, Narda M, Masson P, Krutmann J, Passeron T: Photoprotection of the skin from visible light-induced pigmentation: Current testing methods and proposed harmonization. J Invest Dermatol 141(11): 2569-2576, 2021. doi: 10.1016/j.jid.2021.03.012

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer A-K, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl L-C, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery Cell Biol Toxicol 2021. doi: 10.1007/s10565-021-09603-2

Budden T, Gaudy-Marqueste C, Porter A, Kay E, Gurung S, Earnshaw CH, Roeck K, Craig S, Traves V, Krutmann J, Muller P, Motta L, Zanivan S, Malliri A, Furney SJ, Nagore E, Virós A: Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nat Commun 12(1): 2742, 2021. doi: 10.1038/s41467-021-22953-z

Grether-Beck S, Felsner I, Brenden H, Marini A, Jaenicke T, Aue N, Welss T, Uthe I, Krutmann J: Air pollution-induced tanning of human skin. Br J Dermatol 185(5): 1026-1034, 2021. doi: 10.1111/bjd.20483

Baswan SM, Klosner AE, Weir C, Salter-Venzon D, Gellenbeck KW, Leveret J, Krutmann J: Role of ingestible carotenoids in skin protection: A review of clinical evidence. Photodermatol Photoimmunol Photomed 37(6): 490-504, 2021. doi: 10.1111/phpp.12690

Ramachandran H, Martins S, Kontarakis Z, Krutmann J, Rossi A: Fast but not furious: a streamlined selection method for genome edited cells. Life Sci Alliance 4(6): e202101051, 2021. doi: 10.26508/lsa.202101051

Krutmann J, Schalka S, Watson REB, Liu W, Morita A: Daily photoprotection to prevent photoaging. Photodermatol Photoimmunol Photomed 37(6): 482-489, 2021. doi: 10.1111/phpp.12688

Passeron T, Lim HW, Goh CL, Kang HY, Ly F, Morita A, Ocampo Candiani J, Puig S, Schalka S, Wei L, Dréno B, Krutmann J: Photoprotection according to skin phototype and dermatoses: Practical recommendations from an expert panel. J Eur Acad Dermatol Venereol 35(7): 1460-1469, 2021. doi: 10.1111/jdv.17242

Li Z*, Xia J*, Jiang L, Tan Y, An Y, Zhu X, Ruan J, Chen Z, Zhen H, Ma Y, Jie Z, Xiao L, Yang H, Wang J, Kristiansen K, Xu X, Jin L, Nie C, Krutmann J*, Liu X*, Wang J*: Characterization of the human skin resistome and identification of two microbiota cutotypes. Microbiome 9(1): 47, 2021. doi: 10.1186/s40168-020-00995-7 (*equal contribution)

Haarmann-Stemmann T, Sutter TR, Krutmann J, Esser C: The mode of action of tapinarof may not only depend on the activation of cutaneous aryl hydrocarbon receptor signaling but also on its antimicrobial activity. J Am Acad Dermatol 85(1): e33-e34, 2021. doi: 10.1016/j.jaad.2021.01.103

Zhao H, Wu J, Wang N, Grether-Beck S, Krutmann J, Wei L: Oral Pycnogenol^® intake benefits the skin in urban Chinese outdoor workers: A randomized, placebo-controlled, double blind, and crossover intervention study. Skin Pharmacol Physiol 34: 135-145, 2021. doi: 10.1159/000514323

Krutmann J, Schikowski T, Morita A, Berneburg M: Environmentally-induced (extrinsic) skin aging: Exposomal factors and underlying mechanisms. J Invest Dermatol 141(4S): 1096-1103, 2021. doi: 10.1016/j.jid.2020.12.011

Krutmann J, Berneburg M: Photodermatologie. Hautarzt 72(1): 1, 2021. doi: 10.1007/s00105-020-04746-5

Krutmann J, Berneburg M: Lichtalterung (Photoaging) der Haut: Was gibt es Neues? Hautarzt 72(1): 2-5, 2021. doi: 10.1007/s00105-020-04747-4

2020

Passeron T, Krutmann J, Andersen ML, Katta R, Zouboulis CC: Clinical and biological impact of the exposome on the skin. J Eur Acad Dermatol Venereol 34 (Suppl 4): 4-25, 2020. doi: 10.1111/jdv.16614

Baswan SM, Marini A, Klosner AE, Jaenicke T, Leverett J, Murray M, Gellenbeck KW, Krutmann J: Orally administered mixed carotenoids protect human skin against ultraviolet A-induced skin pigmentation: A double-blind, placebo-controlled, randomized clinical trial. Photodermatol Photoimmunol Photomed 36(3): 219-225, 2020. doi: 10.1111/phpp.12541

Altuğ H, Fuks KB, Hüls A, Mayer AK, Tham R, Krutmann J, Schikowski T: Air pollution is associated with depressive symptoms in elderly women with cognitive impairment. Environ Int 136: 105448, 2020. doi: 10.1016/j.envint.2019.105448

Tan Y, Wang F, Fan G, Yan Z, Li B, Li N, Liu Y, Wang X, Liu W, Krutmann J, Zou Y, Wang S: Identification of factors associated with minimal erythema dose variations in a large-scale population study of 22 146 subjects. J Eur Acad Dermatol Venereol 34(7): 1595-1600,2020. doi: 10.1111/jdv.16206

Lademann J, Richter H, Patzelt A, Meinke MC, Gross I, Grether-Beck S, Krutmann J, Frazier L, Darvin ME: Laser scanning microscopy for control of skin decontamination efficacy from airborne particulates using highly absorbent textile nanofiber material in combination with PEG-12 dimethicone. Skin Res Technol 26(4): 558-563, 2020. doi: 10.1111/srt.12830

Krutmann J, Passeron T, Gilaberte Y, Granger C, Leone G, Narda M, Schalka S, Trullas C, Masson P, Lim HW: Photoprotection of the future: Challenges and opportunities. J Eur Acad Dermatol Venereol 34(3): 447-454, 2020. doi: 10.1111/jdv.16030

Grether-Beck S, Marini A, Jaenicke T, Goessens-Rück P, McElwee KJ, Hoffmann R, Krutmann J: Autologous cell therapy for aged human skin: a randomized, placebo-controlled, phase-I study. Skin Pharmacol Physiol 33: 9-16, 2020. doi: 10.1159/000502240

Trullàs C, Granger C, Lim HW, Krutmann J, Masson P: Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing. Photodermatol Photoimmunol Photomed 36(5): 351-356, 2020. doi: 10.1111/phpp.1250

2019

Vogeley C, Esser C, Tüting T, Krutmann J, Haarmann-Stemmann T: Role of the aryl hydrocarbon receptor in environmentally induced skin aging and skin carcinogenesis. Int J Mol Sci 20(23): 6005, 2019. doi: 10.3390/ijms20236005

Liu Y, Gao W, Koellmann C, Le Clerc S, Hüls A, Li B, Peng Q, Wu S, Ding A, Yang Y, Jin L, Krutmann J, Schikowski T, Zagury JF, Wang S: Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. J Dermatol Sci 96(1): 42-49, 2019. doi: 10.1016/j.jdermsci.2019.08.010

Granger C, Krutmann J, Bustos J, Sola Y, Hosenally M, Trullàs C, Andres P, Passeron T: New methodology to evaluate sunscreens under outdoor conditions: A double-blind, randomized intra-individual clinical study of a water-based broad-spectrum SPF50+ versus SPF15 (P3) and SPF50+. Dermatol Ther 9(3): 589-599, 2019. doi: 10.1007/s13555-019-00315-4

Esser C, Hochrath K, Teichweyde N, Krutmann J, Chang H-D: Beyond sequencing: fast and easy microbiome profiling by flow cytometry. Arch Toxicol 93(9): 2703-2704, 2019. doi: 10.1007/s00204-019-02527-1

Bernard JJ, Gallo RL, Krutmann J: Photoimmunology: how ultraviolet radiation affects the immune system. Nat Rev Immunol 19(11): 688-701, 2019. doi: 10.1038/s41577-019-0185-9

Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T*, Homey B*, Meller S*: Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events. Allergy 2019. doi: 10.1111/all.13972 (* equal contribution)

Mescher M, Tigges J, Rolfes KM, Shen AL, Yee J, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T: The toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Archiv Toxicol 93(7): 1917-1926, 2019. doi: 10.1007/s00204-019-02488-5

Groten K, Marini A, Grether-Beck S, Jaenicke T, Ibbotson SH, Moseley H, Ferguson J, Krutmann J: Tomato phytonutrients balance UV response: Results from a double blind, randomized, placebo controlled study. Skin Pharmacol Physiol 32(2): 101-108, 2019. doi: 10.1159/000497104

Krutmann J: Luftverschmutzung und Haut. Hautarzt 70(3): 156-157, 2019. doi: 10.1007/s00105-018-4349-5

Fuks K*, Hüls A*, Sugiri D, Altug H, Vierkötter A, Abramson M, Goebel J, Wagner G, Demuth I, Krutmann J*, Schikowski T*: Tropospheric ozone and skin aging: results from two German cohort studies. Environ Int 124: 139-144, 2019. doi: 10.1016/j.envint.2018.12.047 (* equal contribution)

Schikowski T, Krutmann J: Luftverschmutzung (Feinstaub, Stickstoffdioxid) und Hautalterung. Hautarzt 70(3): 158-162, 2019. doi: 10.1007/s00105-018-4338-8 (Leitthema)

Hüls A*, Abramson MJ*, Sugiri D, Fuks K, Krämer U, Krutmann J, Schikowski T: Non-atopic eczema in elderly women - Impact of air pollution and genes. J Allergy Clin Immunol 143(1): 378-385.e9, 2019. doi: 10.1016/j.jaci.2018.09.031 (* equal contribution)

Hüls A, Sugiri D, Fuks K, Krutmann J*, Schikowski T*: Lentigines formation in Caucasian women - Interaction between particulate matter and UVR. J Invest Dermatol 139(4): 974-976, 2019. doi: 10.1016/j.jid.2018.09.034
(* equal contribution)

2018

Wu S, Zhang M, Yang X, Peng F, Tan J, Yang Y, Wang L, Hu Y, Peng X, Li J. Liu Y, Lu D, Lou H, Feng Q, Lu Y, Guan Y, Zhang Z, Jiao X, Hamer M, Nijsten T, Zeng C, Adhikar K, Gallo C, Poletti I, Schuler-Faccini L, Bortolin M, Quinteros S, Rothhammer F, Bedoya G, José R, Li H, Krutmann J, Liu F, Kayser M, Ruiz-Linares A, Tang K, Xu S, Zhang L, Jin L, Wang J: Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. Plos Genet 14(9): e1007640, 2018. doi: 10.1371/journal.pgen.1007640

Majora M, Sondenheimer K, Knechten M, Uthe I, Esser C, Schiavi A, Ventura N, Krutmann J: HDAC inhibition improves autophagic and lysosomal function to prevent loss of subcutaneous fat in a mouse model of Cockayne syndrome. Sci Transl Med 10(456): eaam7510, 2018. doi: 10.1126/scitranslmed.aam7510

Narda M, Peno-Mazzarino L, Krutmann J, Trullas C, Granger C: Novel facial cream containing carnosine inhibits formation of advanced glycation end-products in human skin.Skin Pharmacol Physiol 31(6): 324-331, 2018. doi: 10.1159/000492276

Pollet M*, Shaik S*, Mescher M*, Frauenstein K, Tigges J, Braun S, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CF, Krutmann J, Haarmann-Stemmann T: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 25: 1823-1836, 2018. doi: 10.1038/s41418-018-0160-1 (* equal contribution)

Pollet M, Krutmann J, Haarmann-Stemmann T: Commentary: Usage of mitogen-activated protein kinase small inhibitors: More than just inhibition!” Front Pharmacol 9: 935, 2018. doi: 10.3389/fphar.2018.00935

Schnass W, Hüls A, Vierkötter A, Krämer U, Krutmann J, Schikowski T: Traffic-related air pollution and eczema in the elderly: Findings from the SALIA cohort. Int J Hyg Environ Health 221(6): 861-867, 2018. doi: 10.1016/j.ijheh.2018.06.002

Sondenheimer K, Krutmann J: Novel means for photoprotection. Front Med 5: 162, 2018. doi: 10.3389/fmed.2018.00162

Diepgen TL, Kresken J, Krutmann J, Merk HF, Senger E, Surber C, Szeimies RM; GD Task Force "Licht.Hautkrebs.Prävention" of the Society for Dermopharmacy: Commentary on the "Evidence- and Consensus-Based (S3) Guidelines for the Treatment of Actinic Keratosis" published by the International League of Dermatological Societies in cooperation with the European Dermatology Forum. Skin Pharmacol Physiol 31(3): 144-146, 2018. doi: 10.1159/000486687

Esser C, Haarmann-Stemmann T, Hochrath K, Schikowski T, Krutmann J: AHR and the issue of immunotoxicity. Curr Opinion Toxicol 10: 91-97, 2018. doi: 10.1016/j.cotox.2018.03.001

Nakamura M*, Haarmann-Stemmann T*, Krutmann J, Morita A: Alternative test models for skin aging research. Exp Dermatol 27: 495-500, 2018. doi: 10.1111/exd.13519

Lademann J, Knorr F, Patzelt A, Meinke MC, Richter H, Krutmann J, Rühl E, Doucet O: Laser scanning microscopic investigations of the decontamination of soot nanoparticles from the skin. Skin Pharmacol Physiol 31(2): 87-94, 2018. doi: 10.1159/000485900

Liu W, Pan X, Vierkötter A, Guo Q, Wang X, Wang Q, Seité S, Moyal D, Schikowski T, Krutmann J: A time-series study of the effect of air pollution on outpatient visits for acne vulgaris in Beijing. Skin Pharmacol Physiol 31: 107-113, 2018. doi: 10.1159/000484482

2017

Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E: Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Stem Cell Res 25: 72-82, 2017. doi: 10.1016/j.scr.2017.10.013

Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP: SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging-US 9(10): 2163-2189, 2017. doi: 10.18632/aging.101307

Ding A, Yang Y, Zhao Z, Hüls A, Vierkötter A, Yuan Z, Cai J, Zhang J, Gao W, Li J, Zhang M, Matsui M, Krutmann J, Kan H, Schikowski T, Jin L, Wang S: Indoor PM_2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep 7(1): 15329, 2017. doi: 10.1038/s41598-017-15295-8

Lohan SB, Ahlberg S, Mensch A, Höppe D, Giulbudagian M, Calderón M, Grether-Beck S, Krutmann J, Lademann J, Meinke MC: EPR technology as sensitive method for oxidative stress detection in primary and secondary keratinocytes induced by two selected nanoparticles. Cell Biochem Biophys 75(3-4): 359-367, 2017. doi: 10.1007/s12013-017-0823-4

Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF: Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease. Part Fibre Toxicol 14: 35, 2017. doi: 10.1186/s12989-017-0213-5

Krutmann J, Moyal D, Liu W, Kandahari S, Lee GS, Noppakun N, Xiang LF, Seité S: Pollution and acne: is there a link? Clin Cosmet Investig Dermatol 2017(10): 199-204, 2017. doi: 10.2147/CCID.S131323

Stege H, Krutmann J: Neue Ansätze zur Prävention aktinischer Keratosen. Hautarzt 68(5): 354-358, 2017. doi: 10.1007/s00105-017-3980-x

Kaisers W, Boukamp P, Stark H-J, Schwender H, Tigges J, Krutmann J, Schaal H: Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts. Plos One 12(5): e0175657, 2017. doi: 10.1371/journal.pone.0175657

Merches K, Haarmann-Stemmann T, Weighardt H, Krutmann J, Esser C: AHR in the skin: From the mediator of chloracne to a therapeutic panacea? Current Opinion Toxicol 2: 79-86, 2017. doi: 10.1016/j.cotox.2017.02.002

Gao W*, Tan J*, Hüls A*, Ding A, Liu Y, Matsui M, Vierkötter A, Krutmann J^#, Schikowski T^#, Jin L^#, Wang S^#: Genetic variants associated with skin aging in Chinese Han population. J Dermatol Sci 86(1): 21-29, 2017. doi: 10.1016/j.jdermsci.2016.12.017 (* equal contribution; ^# Co-senior authors)

Zhang M, Li B, Wu S, Tan J, Yang Y, Marini A, Vierkötter A, Zhang J, Li H, Schikowski T, Jin L, Krutmann J, Wang S: A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol 137(4): 979–982, 2017. doi: 10.1016/j.jid.2016.11.030

Krutmann J, Bouloc A, Sore G, Bernard BA, Passeron T: The skin aging exposome. J Dermatol Sci 85(3): 152-161, 2017. doi: 10.1016/j.jdermsci.2016.09.015

Grether-Beck S, Marini A, Jaenicke T, Stahl W, Krutmann J: Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, cross-over study. Br J Dermatol 176(5): 1231-1240, 2017. doi: 10.1111/bjd.15080

2016

Zhang M, Wu S, Zhang J, Yang Y, Tan J, Liu Y, Guan H, Tang K, Krutmann J, Xu S, Jin L, Guan Y, Li H, Wang S: Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. J Genet Genomics 43(12): 702-704, 2016. doi: 10.1016/j.jgg.2016.10.003

Unfried K, Krämer U, Sydlik U, Autengruber A, Bilstein A, Stolz S, Marini A, Schikowski T, Keymel S, Krutmann J: Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals. Int J Chronic Obstr Pulm Dis 11(1): 2573-2583, 2016. doi: 10.2147/COPD.S115061

Haas K, Weighardt H, Deenen R, Köhrer K, Clausen B, Zahner S, Boukamp P, Bloch W, Krutmann J, Esser C: Aryl hydrocarbon receptor in keratinocytes is essential for murine skin barrier integrity. J Invest Dermatol 136(11): 2260-2269, 2016. doi: 10.1016/j.jid.2016.06.627

Humbert P, Dréno B, Krutmann J, Luger TA, Triller R, Meaume S, Seité S: Recommendations for managing cutaneous disorders associated with advancing age. Clin Interv Aging 12(11): 141-148, 2016. doi: 10.2147/CIA.S96232

Wu S, Tan J, Yang Y, Peng Q, Zhang M, Li J, Lu D, Liu Y, Lou H, Feng Q, Lu Y, Guan Y, Zhang Z, Jiao Y, Sabeti P, Krutmann J, Tang K, Jin L, Xu S, Wang S: Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet 135(11): 1279-1286, 2016. doi: 10.1007/s00439-016-1718-y

Vierkötter A*, Hüls A*, Yamamoto A, Stolz S, Krämer U, Matsui MS, Morita A, Wang S, Li Z, Jin L, Krutmann J*, Schikowski T*: Extrinsic skin aging in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and anatomical site. J Dermatol Sci 83(3): 219-225, 2016. doi: 10.1016/j.jdermsci.2016.05.011 (* equal contribution)

Lang A, Grether-Beck S, Singh M, Kuck F, Jakob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP: MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging 8(3): 484-509, 2016. doi: 10.18632/aging.100905

Krutmann J, Schikowski T, Hüls A, Vierkötter A, Grether-Beck S: Umweltinduzierte (extrinsische) Hautalterung. Der Hautarzt 67(2): 99-102, 2016. doi: 10.1007/s00105-015-3750-6

Hüls A*, Vierkötter A*, Gao W*, Krämer U, Yang Y, Ding A, Stolz S, Matsui M, Kan H, Wang S, Jin L*, Krutmann J*, Schikowski T*: Traffic-related air pollution contributes to development of facial lentigines: Further epidemiological evidence from Caucasians and Asians. J Invest Dermatol 136(5): 1053-1056, 2016. doi: 10.1016/j.jid.2015.12.045 (* equal contribution) Commentary by Anne Lynn S. Chang

Grether-Beck S, Marini A., Jaenicke T, Krutmann J: French Maritime Pine Bark Extract (Pycnogenol®) Effects on Human Skin: Clinical and Molecular Evidence. Skin Pharmacol Physiol 29: 13-17, 2016. doi: 10.1159/000441039

2015

Haarmann-Stemmann T, Esser C, Krutmann J: The Janus-faced role of Aryl Hydrocarbon Receptor (AHR) signaling in the skin: Consequences for prevention and treatment of skin disorders. J Invest Dermatol 135(11): 2572-2576, 2015. [pubmed]

Nakamura M, Haarmann-Stemmann T, Krutmann J: COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn. Exp Dermatol 24(10): 734-735, 2015. [pubmed] (open access)

Krutmann J, Berking C, Berneburg M, Diepgen TL, Dirschka T, Szeimies M: New Strategies in the Prevention of Actinic Keratosis: A Critical Review. Skin Pharmacol Physiol 28: 281-289, 2015. [pubmed]

Li M*, Vierkötter A*, Schikowski T*, Hüls A, Ding A, Matsui MS, Deng B, Ma C, Ren A, Zhang J, Tan J, Tan Y, Yang Y, Jin L, Krutmann J*, Li Z*, Wang S*: Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women. J Dermatol Sci 79(2): 148-154, 2015. (* equal contribution) [pubmed]

Thaçi D, Augustin M, Krutmann J, Luger T: Stellenwert der Basistherapie bei Psoriasis. J Dtsch Dermatol Ges 13(5): 415-418, 2015. (abstract)

Waldera Lupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, Götz-Rösch C, Bernerd F, Haag L, Huebenthal U, Fritsche E, Boege F, Grabe N, Tigges J, Stühler K*, Krutmann J*: Characterization of skin aging-associated secreted proteins (SAASP) produced by dermal fibroblasts isolated from intrinsically aged human skin. J Invest Dermatol 135(8): 1954-1968, 2015. (* equal contribution) [pubmed]

Frauenstein K*, Tigges J*, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CFA, Haarmann-Stemmann T: Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol 89(8): 1329-1336, 2015. (* equal contribution) [pubmed]

Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J: Environment-Induced Lentigines (EILs): Formation of solar lentigines beyond ultraviolet radiation. Exp Dermatol 24(6): 407-411, 2015. [pubmed]

Vierkötter A, Schikowski T, Sugiri D, Matsui MS, Krämer U, Krutmann J: MMP-1 and -3 Promoter Variants are Indicative of a Common Susceptibility for Skin and Lung Aging: Results from a Cohort of Elderly Women (SALIA). J Invest Dermatol 135(5): 1268-1274, 2015. [pubmed]

Bruhs A, Haarmann-Stemmann T, Frauenstein K, Krutmann J, Schwarz T, Schwarz A: Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells. J Invest Dermatol 135(2): 435-444, 2015. [pubmed]

Röck K, Tigges J, Sass S, Schütze A, Florea AM, Fender AC, Theis FJ, Krutmann J, Boege F, Fritsche E, Reifenberger G, Fischer JW: miR-23a-3p causes cellular senescence by targeting hyaluronan synthase2: Possible implication for skin aging. J Invest Dermatol 135(2): 369-377, 2015. [pubmed]

Grether-Beck S, Marini A, Jaenicke T, Krutmann J: Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: Results from a vehicle controlled, randomized study. Photodermatol Photoimmunol Photomed 91: 248-250, 2015. [pubmed] (open access)

2014

Marini A, Reinelt K, Krutmann J, Bilstein A: Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis: A randomised, comparator-controlled, intra-individual double-blind, multi-center trial. Skin Pharmacol Physiol 27(2): 57-65, 2014. [pubmed]

Tigges J^*, Haarmann-Stemmann T^*, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J*, Fritsche E*: The new arylhydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2): 556-559, 2014. (* equal contribution) [pubmed] (open access)

Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K: Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging (Albany NY). 6(10): 856-878, 2014. [pubmed]

Grether-Beck S, Felsner I, Koehler T, Farwick M, Lersch P, Rawlings A, Krutmann J: Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis. Exp Dermatol 23: 853-864, 2014. [pubmed]

Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht C, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K: Signalling-dependent adverse health effects of carbon nanoparticles are prevented by the compatible solute beta mannosylglycerate (firoin) in vitro and in vivo. Plos one 9(11): e111485, 2014. [pubmed]

Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Körer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F: Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol 56: 59-68, 2014. [pubmed]

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F: The Hallmarks of Fibroblast Ageing. Mech Ageing Dev 138: 26-44, 2014. [pubmed]

Krutmann J, Liu W, Li L, Pan X, Crawford M, Sore G, Seite S: Pollution and skin: From epidemiological and mechanistic studies to clinical implications. J Dermatol Sci 2014 76(3): 163-168, 2014. [pubmed]

Macpherson L, Ahmed S, Tamblyn L, Krutmann J, Förster I, Weighardt H, Matthews J: Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int J Mol Sci 15(5): 7939-7957, 2014. [pubmed]

Luger T, Seité S, Humbert P, Krutmann J, Triller R, Dreno B: Recommendations for adjunctive basic skin care in patients with psoriasis. Eur J Dermatol 24(2): 194-200, 2014. [pubmed]

Grether-Beck S, Marini A, Jaenicke T, Krutmann J: Photoprotection of human skin beyond ultraviolet radiation. Photodermatol Photoimmunol Photomed 30(2-3): 167-174, 2014. [pubmed]

Krutmann J, Béhar-Cohen F, Baillet G, de Ayguavives T, Ortega Garcia P, Peña-García P, Remé C, Wolffsohn J: Towards standardization of UV eye protection: what can be learned from photodermatology? Photodermatol Photoimmunol Photomed 30(2-3): 128-136, 2014. [pubmed]

Marini A, Jaenicke T, Grether-Beck S, Le Floc'h C, Cheniti A, Piccardi N, Krutmann J: Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, ß-carotene and Lactobacillus johnsonii: Results from a randomized, placebo-controlled, double-blinded study. Photodermatol Photoimmunol Photomed 30(4): 189-194, 2014. [pubmed]

Behar-Cohen F, Baillet G, de Ayguavives T, Garcia PO, Krutmann J, Peña-García P, Reme C, Wolffsohn JS: Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. Clin Ophthalmol 8: 87-104, 2014. [pubmed]

2013

Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J*, Haarmann-Stemmann T*: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. (* equal contribution) [pubmed] (open access)

Haarmann-Stemmann T, Boege F, Krutmann J: Adaptive and maladaptive responses in skin: Mild heat exposure protects against UVB-induced photoaging in mice. J Invest Dermatol 133(4):868-871, 2013. [pubmed]

Tigges J*, Weighardt H*, Wolff S, Goetz C, Foerster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E: Arylhydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. J Invest Dermatol 133(1): 87-96, 2013. (*equal contribution) [pubmed] (open access)

Navid F, Bruhs A, Schuller W, Fritsche E, Krutmann J, Schwarz T, Schwarz A: The Aryl Hydrocarbon Receptor is Involved in UVR-Induced Immunosuppression. J Invest Dermatol 133(12): 2763-2770, 2013. [pubmed]

Sydlik U, Peuschel H, Paunel-Görgülü A, Keymel S, Krämer U, Weissenberg A, Kroker M, Seghrouchni S, Heiss C, Windolf J, Bilstein A, Kelm M, Krutmann J, Unfried K: Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. Eur Respir J 41(2): 433-442, 2013. [pubmed]

Esser C, Bargen I, Weighardt H, Haarmann-Stemmann T, Krutmann J: Functions of the Aryl

Hydrocarbon Receptor in the skin. Seminars in Immunopathology 35(6): 677-691, 2013. [pubmed]
Esser C, Götz C: Filling the gaps: need for research on cell-specific xenobiotic metabolism in the skin. Arch Toxicol 87(10): 1873-1875, 2013. [pubmed]

Gerber PA, Hevezi P, Buhren BA, Martinez C, Schrumpf H, Gasis M, Grether-Beck S, Krutmann J, Homey B., Zlotnik A: Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins. PLoS ONE 8(6): e63949, 2013. [pubmed]

Nehrenheim K, Meyer I, Brenden H, Vielhaber G, Krutmann J, Grether-Beck S: Dihydrodehydrodiisoeugenol enhances adipocyte differentiation and decreases lipolysis in murine and human cells. Exp Dermatol 22(10): 638-643, 2013. [pubmed]

Ono Y, Torii K, Fritsche E, Shintani Y, Nishida E, Nakamura M, Shirakata Y, Haarmann-Stemmann T, Abel J, Krutmann J, Morita A: Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression. Exp Dermatol 22(5): 349-353, 2013. [pubmed]

Dreno B, Bensadoun RJ, Humbert P, Krutmann J, Luger T, Triller R, Rougier A, Seité S: Algorithm for dermocosmetic use in the management of cutaneous side-effects associated with targeted therapy in oncology.J Eur Acad Dermatol Venereol 27(9): 1071-1080, 2013. [pubmed]

Farris P, Krutmann J, Li YH, McDaniel D, Krol Y: Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin. J Drugs Dermatol 12(12): 1389-1394, 2013. [pubmed]

Peter RU, Krutmann J: Strahlenerkrankungen der Haut. Hautarzt 64: 893, 2013.

2012

Peuschel H, Sydlik U, Grether-Beck S, Felsner I, Stöckmann D, Jakob S, Kroker M, Haendeler J, Gotic M, Bieschke C, Krutmann J, Unfried K: Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation. Part Fibre Toxicol 9(1): 48, 2012. [pubmed]

Grether-Beck S, Felsner I, Brenden B, Kohne Z, Majora M, Marini A, Jaenicke J, Rodriguez-Martin M, Trullas C, Hupe M, Elias PE, Krutmann J: Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression. J Invest Dermatol 132(6): 1561-1572, 2012. [pubmed]

Haarmann-Stemmann T, Abel J, Fritsche E, Krutmann J: The AhR-Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention? J Invest Dermatol 132 (1): 7-9, 2012. [pubmed]

Krutmann J, Morita A, Chung JH: Sun exposure – what molecular photodermatology tells us about its good and bad sides. J Invest Dermatol 132 (3 Pt 2): 976-984, 2012. [pubmed]

Vierkötter A, Krämer U, Sugiri D, Morita A, Yamamoto A, Kaneko N, Matsui M, Krutmann J: Development of lentigines in German and Japanese women correlates with variants in the SLC45A2 gene (Letter to the Editor). J Invest Dermatol 132(3): 733-736, 2012.

Röck K, Meusch M, Fuchs N, Tigges J, Zipper P, Fritsche E, Krutmann J, Homey B, Reifenberger J, Fischer JW: Estradiol protects the dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes. J Biol Chem 287(24): 20056-20069, 2012. [pubmed]

Götz C, Pfeiffer R, Tigges T, Ruwiedel K, Hübenthal U, Merk HF, Krutmann J, Edwards RJ, Abel J, Goebel C, Hewitt N, Fritsche E: Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes. Exp Dermatol 21(5): 364-369, 2012. [pubmed]

Götz C, Pfeiffer R, Tigges T, Blatz V, Jäckh C, Freytag EM, Fabian E, Landsiedel R, Merk HF, Krutmann J, Edwards RJ, Pease C, Goebel C, Hewitt N, Fritsche E: Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (phase I). Exp Dermatol 21(5): 358-363, 2012. [pubmed]

Kaneko N, Vierkoetter A, Kraemer U, Sugiri D, Matsui M, Yamamoto A, Krutmann J, Morita A: Mitochondrial common deletion mutation and extrinsic skin ageing in German and Japanese women. Exp Dermatol 21 Suppl 1: 26-30, 2012. [pubmed]

Marini A, Farwick M, Grether-Beck S, Brenden H, Felsner I, Jaenicke T, Weber M, Schild J, Maczkiewitz U, Köhler T, Bonfigli A, Pagani V, Krutmann J: Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects. Exp Dermatol 21(2): 140-146, 2012. [pubmed]

Marini A*, Grether-Beck S*, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J: Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacology & Physiology 25(2): 86-92, 2012. (*equal contribution) [pubmed]

Goetz C, Hewitt NJ, Jermann E, Tigges T, Kohne Z, Huebenthal U, Krutmann J, Merk HF, Fritsche E: Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models. Xenobiotica 42(6): 526-537, 2012. [pubmed]

Elsner P, Fluhr JW, Gehring W, Kerscher MJ, Krutmann J, Lademann J, Makrantonaki E, Wilhelm KP, Zouboulis CC: Anti-aging data and support claims – consensus statement. J Dtsch Dermatol Ges 9, Suppl 3: S1-S32, 2011.
Krutmann J: Pre- and probiotics for human skin. Clin Plast Surg 39(1): 59-64, 2012. [pubmed]

Seité S, Reinhold K, Jaenicke T, Brenden H, Krutmann J, Grether-Beck S: Broad-spectrum moisterizing sunscreen effectivity prevents molecular reactions to ultraviolet A radiation. Cutis 90:321-326, 2012. [pubmed]

Zouboulis CC, Krutmann J: Gerontodermatologie. Hautarzt 63(12): 929-931, 2012.
Vierkötter A, Krutmann J. Environmental influences on skin aging and ethnic specific manifestations. Dermato-Endocrinology 4 (4): 1-5, 2012.

Kochevar I, Taylor R, Krutmann J: Fundamentals of Cutaneous Photobiology and Photoimmunology. In: Fitzpatrick´s Dermatology in General Medicine (Wolff K, Goldsmith L.A, Katz S, Gilchrest B, Paller AS, Leffell DJ eds) eighth edition, McGraw-Hill, New York, pp 1031-1049, 2012.

Marini A, Krutmann J: Pre- and probiotics for human skin. In: Handbook of diet, nutrition and the skin. V.R. Preedy (ed.), Wageningen Academic Publishers, Wageningen NL, pp 319-332, 2012.

2011

Jux B, Kadow S, Luecke S, Rannug A, Krutmann J, Esser C: The Aryl Hydrocarbon Receptor Mediates UVB Radiation-Induced Skin Tanning. J Invest Dermatol 131(1): 203-210, 2011. [pubmed]
Röck K, Grandoch M, Majora M, Krutmann J, Fischer JW: Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to UVB: New insights into mechanisms of matrix remodelling. J Biol Chem 286 (20): 18268-18276, 2011. [pubmed]

Bayer M, Proksch P, Felsner I, Brenden H, Kohne Z, Walli R, Duong TN, Götz C, Krutmann J, Grether-Beck S: Photoprotection against UVAR: Effective triterpenoids require a lipid raft stabilizing chemical structure. Exp Dermatol 20 (11): 955-958, 2011. [pubmed]

Farwick M, Grether-Beck S, Marini A, Maczkiewitz U, Lange J, Köhler T, Lersch P, Falla T, Felsner I, Brenden H, Jaenicke T, Franke S, Krutmann J: Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof. Exp Dermatol 20 (7): 602-604, 2011. [pubmed]

Marionnet C, Grether-Beck S, Seité S, Marini A, Jaenicke T, Lejeune F, Bastien P, Rougier A, Bernerd F, Krutmann J: A broad-spectrum sunscreen prevents UVA radiation-induced gene expression in reconstructed skin in vitro and in human skin in vivo. Exp Dermatol 20(6): 477-482, 2011. [pubmed]

Perner D, Vierkötter A, Sugiri D, Matsui M, Ranft U, Esser C, Ethève S, Goralczyk R, Kaneko N, Yamamoto A, Morita A, Krutmann J, Krämer U: Association between sun-exposure, smoking behaviour and plasma antioxidant levels with the different manifestation of skin ageing signs between Japanese and German women – A pilot study. J Dermatol Sci 62 (2):138-140, 2011.

Humbert P, Binda D, Robin S, Krutmann J: Beauty from inside: Nutrition-based strategies in cosmetic dermatology. In: Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Krutmann J, Humbert P (eds.). Springer 2011, pp. 189-196.

Krutmann J: Pre- and probiotics for human skin. Clin Plast Surg 39(1): 59-64, 2012. [pubmed]

Krutmann J: Hautalterung / Anti-Aging-Strategien. Editorial. Hautarzt 62(8): 576, 2011.

Krutmann J: Wie die Sonne unsere Haut altern lässt. Die Dermis als treibende Kraft. Hautarzt 62(8): 588-590, 2011.
Krutmann J: Hautalterung / Anti-Aging-Strategien. Editorial. Hautarzt 62(8): 576, 2011.

Krutmann J: Wie die Sonne unsere Haut altern lässt. Die Dermis als treibende Kraft. Hautarzt 62(8): 588-590, 2011.

Krutmann J. Skin aging. In: Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Krutmann J, Humbert P (eds.). Springer 2011, pp.15-24.

Krutmann J, Humbert P (Eds.): Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Springer 2011, 208 pp.

Krutmann J, Luger T: Empfindliche Haut. Hautarzt 62 (12) 892, 2011.
Mang R, Stege H, Krutmann J: Mechanisms in phototoxic and photoallergic reactions. In: Contact Dermatitis, 5^th ed, (Menné T, Frosch P, eds), Springer Berlin, Heidelberg 2011, pp. 155-163.

Marini, A: Schönheit in innen – Funktioniert das wirklich? Hautarzt 62(8): 614-617, 2011.
Monastier C, Mac-Mary S, Krutmann J: How to prove safety and efficacy in nutrition based intervention studies for human skin. In: Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Krutmann J, Humbert P (eds.). Springer 2011, pp. 181-188.

Schroeder P, Krutmann J: Infrared A radiation effects on the skin. Piel 26 (6): 259-262, 2011.

2010

Kamenisch Y*, Fousteri M*, Knoch J, von Thaler AK Fehrenbacher B, Dolle M, Kuiper R, Majora M, Schaller M, van Steeg H, Röcken M, Krutmann J* , Mullenders LH*, Berneburg M: Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med 207(2): 379-390, 2010. (* equal contribution)

Calles C, Schneider M, Macaluso F, Benesova T, Krutmann J, Schroeder P: Infrared-A radiation influences the skin fibroblast transcriptome: mechanisms and consequences. J Invest Dermatol 130 (6): 1524-1536, 2010.

Vierkötter A, Schikowski T, Ranft U , Sugiri D, Matsui M, Krämer U, Krutmann J: Airborne particle exposure and extrinsic skin aging. J Invest Dermatol 130(12): 2719-2726, 2010.

Fernau NS, Fugmann D, Leyendecker M, Reimann K, Grether-Beck S, Galban S, Ale-Agha N, Krutmann J, Klotz LO: Role of HuR and p38-MAP kinase in ultraviolet B-induced posttranscriptional regulation of cyclooxygenase-2 expression in the human keratinocyte cell line HaCaT. J Biol Chem 285 (6): 3896-3904, 2010.

Luecke S, Backlund M, Jux B, Esser C, Krutmann J, Rannug A: The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Pigment Cell & Melanoma Research 23 (6): 828-833, 2010.

Schroeder P, Calles C, Benesova T, Macaluso F, Krutmann J: Photoprotection beyond UV – effective sun protection has to include protection against infrared A radiation induced skin damage. Skin Physiology and Pharmacology 23 (1): 15-17, 2010.

Krutmann J, Lademann J, Merk HF: Main highlights of International Dermatotoxicology Symposium, Netherlands-Vaals. Skin Pharmacol Physiol 23 (1): 5, 2010.

Esser C, Krutmann J: UV-Strahlung und Pigmentierung: Arylhydrocarbonrezeptor - "a new kid on the block". Der Hautarzt 61(7): 561-566, 2010.

Grether-Beck S, Krutmann J: Fettgewebe – Zelluläre und molekulare Grundlagen. Der Hauarzt 61: 838-846, 2010.

Krutmann J, Berking C: Pigmentstörungen. Der Hautarzt 61: 553, 2010.

Krutmann J, Steinert M: Fettgewebe in Dermatologie und Ästhetik. Der Hautarzt 61: 837, 2010.

Schroeder P, Krutmann J: What is needed for a sunscreen to provide complete protection. Skin Therapy Lett 15 (4): 4-5, 2010.

Krutmann J, Welzel J: Innovative physikalische Verfahren in der Dermatologie. Der Hautarzt 61 (5): 386, 2010.

Humbert P, Robin S, Binda D, Krutmann J: Beauty from inside: Nutrition-based strategies in cosmetic dermatology. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 189-196.

Krutmann J: Pathomechanisms of photoaged skin. In: Textbook of aging skin. Farage MA, Miller KW, Maibach HI (eds.). Springer 2010, pp. 101-108.

Krutmann J: Skin Aging. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 15-24.

Montastier Ch, Mac-Mary S, Humbert P, Krutmann J: How to prove safety and efficacy in nutrition-based interventional studies for human skin. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 181-188.

Schröder P, Krutmann J: Infrared-A induced skin aging. In: Textbook of aging skin. Farage MA, Miller KW, Maibach HI (eds.). Springer 2010.

2009

Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO: Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. Nucleic Acids Res 37 (19): 6414-6428, 2009.

Majora M, Wittkampf T, Schürmann B, Bernerd F, Schroeder P, Krutmann J: Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: Increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity. Am J Pathol 175 (3): 1019-1029, 2009.

Catalgol B, Ziaja I, Breusing N, Jung T, Hoehn A, Alpertunga B, Schroeder P, Chondrogianni N, Gonos ES, Petropoulos I, Friguet B, Klotz LO, Krutmann J, Grune T: The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem 284 (44): 30076-30086, 2009.

Vierkötter A, Ranft U, Krämer U, Sugiri D, Reimann V, Krutmann J: The SCINEXA: A novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing. J Dermatol Sci 53 (3):207-11, 2009.

Krutmann J, Schroeder P: Role of mitochondria in photoageing of human skin: The defective powerhouse model. J Invest Dermatol Symp Proc 14 (1), 44-49, 2009.

Grether-Beck S, Krutmann J: Involment of lipid rafts and caveolins in UVA signaling. The Open Dermatology Journal 3: 153-159, 2009.

Schroeder P, Calles C, Krutmann J: Prevention of Infrared-A radiation mediated detrimental effects in human skin. Skin Therapy Letters 14 (5): 4-5, 2009.

Krutmann J: Pre- and probiotics for human skin. J Dermatol Sci 54 (1): 1-5, 2009.

Krutmann J: Moderner Lichtschutz in der ästhetischen Dermatologie. Hautarzt 60 (4): 284, 2009.

Krutmann J: Actives - Zentraler Bestandteil des modernen Lichtschutzes. Hautarzt 60 (4): 294-300, 2009.

Krutmann J: Pro- und Präbiotika in der Dermatologie. Der Hautarzt 60 (10): 794, 2009.

Schroeder P, Krutmann J: Infrarot A-Schutz – Notwendigkeit und Möglichkeiten. Hautarzt 60 (4): 301-304, 2009.

Krutmann J, Schroeder P: Role of mitochondria in photoageing of human skin: The defective powerhouse model. J Invest Dermatol Symp Proc 14 (1): 44-49, 2009.

Krutmann J: Premature aging of skin from environmental assaults. In: Nutritional Cosmetics: Beauty from within. Tabor A, Blair R (eds), William Andrew Inc, Norwich, 2009, pp. 79- 92.

2008

Grether-Beck S, Salahshour-Fard M, Timmer A, Brenden H, Felsner I, Walli R, Füllekrug J, Krutmann J: Ceramide and raft signaling are linked with each other in UVA radiation-induced gene expression. Oncogene 27 (35): 4768-4778, 2008.

Reimann V, Krämer U, Sugiri D, Schroeder P, Hoffman B, Medve-Koenigs K, Jöckel KH, Ranft U, Krutmann J: Sunbed use induces the photoaging-associated mitochondrial Common Deletion. J Invest Dermatol 128 (5): 1294-1297, 2008.

Schröder P, Gremmel T, Berneburg M, Krutmann J: Partial depletion of mitochondrial DNA from human skin fibroblasts induces a gene expression profile reminiscent of photoaged skin. J Invest Dermatol 128 (9): 2297-2303, 2008.

Schröder P, Lademann J, Darvin M, Stege H, Marks C, Bruhnke S, Krutmann J: Analysis of the in vivo relevance of infrared radiation-induced signaling in human skin: Evidence for skin damage and implications for photoprotection. J Invest Dermatol 128 (10): 2491-2497, 2008.

Schröder P, Krutmann J: In vivo relevance of infrared a radiation-induced skin damage: Reply to Piazena and Kelleher. Letter to the Editor. Free Radic Biol Med 44(10): 1870-1871, 2008.

Dong KK, Damaghi N, Picart SD, Markova NG, Obayashi K, Okano Y, Masaki H, Grether-Beck S, Krutmann J, Smiles KA, Yarosh DB: UV-induced DNA damage initiates release of MMP-1 in human skin. Exp Dermatol 17: 1037-1044, 2008.

Grether-Beck S, Mühlberg K, Brenden H, Felsner I, Brynjólfsdóttir A, Einarsson S, Krutmann J: Bioactive molecules from the Blue Lagoon: in vitro and in vivo assessment of silica mud and microalgae extracts for their effects on skin barrier function and prevention of skin ageing. Exp Dermatol 17 (9): 771-779, 2008.

Buechner N, Schroeder P, Jakob S, Kunze K, Maresch T, Calles C, Krutmann J, Haendeler J: Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1. Exp Gerontol 43: 633-637, 2008.

Schröder P, Haendeler J, Krutmann J: The role of near infrared radiation in photoaging of the skin. Exp Gerontol 43 (7): 629-632, 2008.

Köpcke W, Krutmann J: Protection from sunburn with beta-carotene – a meta-analysis. Photochem Photobiol 84: 284-288, 2008.

Gremmel T, Wild S, Schuller W, Kürten V, Dietz K, Krutmann J, Berneburg M: Six genes associated with the clinical phenotypes of individuals with deficient and proficient DNA repair. Translational Oncogenomics 3, 1–13, 2008.

Farwick M, Santonnat B, Lersch P, Korevaaar K, Rawlings AV, Grether-Beck S, Medve-Koenigs K, Krutmann J: An Aquaporin-inspired lipid concentrate for mature skin. Cosmetics & Toiletries magazine 123: 69-74, 2008.

Grether-Beck S, Mühlberg K, Brenden H, Krutmann J: Topische Applikation von Vitaminen, Phytosterolen und Ceramiden schützt vor vermehrter Expression der interstitiellen Kollagenase und verminderter Kollagen I Expression nach einmaliger UVA-Bestrahlung. Der Hautarzt 59 (7): 557-562, 2008.

Grether-Beck S, Mühlberg K, Brenden H, Krutmann J: Untersuchungen zur Verbesserung eines harnstoffhaltigen Externums durch den Zusatz von Ceramiden und Vitaminen. Der Hautarzt 59 (9): 717-718, 720-723, 2008.

Kochevar I, Taylor R, Krutmann J: Fundamentals of Cutaneous Photobiology and Photoimmunology. In: Fitzpatrick´s Dermatology in General Medicine (Eds. Wolff K, Goldsmith L.A, Katz S, Gilchrest B, Paller AS, Leffell DJ) seventh edition, McGraw-Hill, New York, pp 797-808, 2008.

Krutmann J: Prävention der Hautalterung durch kosmetische Strategien: UV-Filter, Antioxidantien und Actives. In: Hautalterung: Grundlagen - Prävention – Therapie. 2nd Edition, (Krutmann J, Diepgen T, Billmann-Krutmann C, Hrsg.), Springer Verlag, Heidelberg, 2008, S. 229-240.

Krutmann J, Morita A: Therapeutic Photomedicine: Phototherapy. In: Fitzpatrick´s Dermatology in General Medicine (Eds. Wolff K, Goldsmith L.A, Katz S, Gilchrest B, Paller AS, Leffell DJ) seventh edition, McGraw-Hill, New York, pp. 2243-2249, 2008.

Krutmann J, Morita A: Photo(chemo)therapy for Atopic Dermatitis. In: Dermatological Phototherapy and Photodiagnostic Methods. (Krutmann J, Hönigsmann H, Elmets CA, eds) 2nd edition. Springer, New York, pp. 103-118, 2008.

Krutmann J, Morita A, Elmets CA: Mechanisms of photo(chemo)therapy. In: Dermatological Phototherapy and Photodiagnostic Methods. (Krutmann J, Hönigsmann H, Elmets CA, eds) 2nd edition. Springer, New York, pp. 63-77, 2008.

Krutmann J, Schroeder P, Morita A: Molekulare Mechanismen der Hautalterung durch UV-Strahlung und andere exogene Noxen. In: Hautalterung: Grundlagen - Prävention – Therapie. 2nd Edition, (Krutmann J, Diepgen T, Billmann-Krutmann C, Hrsg.), Springer Verlag, Heidelberg, 2008, S. 23-36.

Krutmann J, Stahl W: Schönheit von Innen: Zur Bedeutung von Nahrungsmitteln für die Photoprotektion und den Zustand der menschlichen Haut. In: Hautalterung: Grundlagen - Prävention – Therapie. 2nd Edition, (Krutmann J, Diepgen T, Billmann-Krutmann C, Hrsg.), Springer Verlag, Heidelberg, 2008, S. 219-227.

Krutmann J, Stege H, Morita A: Ultraviolet A-1 Phototherapy: Indications and Mode of Actions. In: Dermatological Phototherapy and Photodiagnostic Methods. (Krutmann J, Hönigsmann H, Elmets CA, eds) 2nd edition. Springer, New York, pp. 295-310, 2008.

2007

Bruch-Gerharz D, Gerharz CD, Stege H, Krutmann J, Pohl M, Koester R, Ruzicka T: Cutaneous lymphatic malformations in disappearing bone (Gorham-Stout) disease: A novel clue to the pathogenesis of a rare syndrome. J Am Acad Dermatol 56 (2 Suppl): S21-S25, 2007. doi: 10.1016/j.jaad.2006.01.063

Dai G, Freudenberger T, Zipper P, Melchior A, Grether-Beck S, Rabausch B, de Groot J, Twarock S, Hanenberg H, Homey B, Krutmann J, Reifenberger J, Fischer JW: Chronic UVB-irradiation causes loss of hyaluronic acid from mouse dermis due to downregulation of hyaluronic acid synthases. American Journal of Pathology 171(5): 1451-1461, 2007. doi: 10.2353/ajpath.2007.070136

Elsner P, Hölzle E, Diepgen T, Grether-Beck S, Hönigsmann H, Krutmann J, Scharffetter-Kochanek K, Schwarz T, Luger T: Recommendation: daily sun protection in the prevention of chronic UV-induced skin damage. J Dtsch Dermatol Ges 5(2): 166-173, 2007. doi: 10.1111/j.1610-0387.2007.06099.x

Fritsche E, Schäfer C, Calles C, Bernsmann T, Bernshausen T, Wurm M, Hübenthal U, Cline JE, Hajimiragha H, Schroeder P, Klotz LO, Rannug A, Fürst P, Hanenberg H, Abel J, Krutmann J: Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci 104(21): 8851-8856, 2007. doi: 10.1073/pnas.0701764104

Herrmann M, Grether-Beck S, Meyer I, Franke H, Joppe H, Krutmann J, Vielhaber G: Blackberry leaf extract: A multifunctional anti-aging active. IFSCC Magazine 10: 41-45, 2007. doi: 10.1111/j.1468-2494.2007.00389_5.x

Jünger M, Krutmann J: Ästhetische Dermatologie. Der Hautarzt 58(3): 198, 2007. doi: 10.1007/s00105-007-1306-0

Krämer U, Illig T, Grune T, Krutmann J, Esser C: Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype. Genes Immun 8(6): 513-517, 2007. doi: 10.1038/sj.gene.6364404

Krutmann J, Medve-Königs K, Hansen P: Oraler Sonnenschutz bei Sonnenempfindlichkeit. Deutsche Apotheker Zeitung 147(21): 2421-2424, 2007.

Rockel N, Esser C, Grether-Beck S, Warskulat U, Flögel U, Schwarz A, Schwarz T, Yarosh D, Häussinger D, Krutmann J: The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression. J Immunol 179(6): 3604-3612, 2007. doi: 10.4049/jimmunol.179.6.3604

Schröder P, Hertel I, Schneider M, Krutmann J: The effect of processed water on constitutive and ultraviolet-A-radiation-induced level of mitochondrial DNA mutations in human dermal fibroblasts. Skin Pharmacol Physiol 20(2): 116-119, 2007. doi: 10.1159/000097984

Schröder P, Pohl C, Calles C, Marks C, Wild S, Krutmann J: Cellular response to infrared radiation involves retrograde mitochondrial signaling. Free Radic Biol Med 43(1): 128-135, 2007. doi: 10.1016/j.freeradbiomed.2007.04.002

Schröder P, Hertel I, Schneider M, Krutmann J: The effect of processed water on constitutive and ultraviolet-A-radiation-induced level of mitochondrial DNA muations in human dermal fibroblasts. Skin Pharmacol Physiol 20(2), 116-120, 2007. doi: 10.1159/000097984

Szeimies RM, Krutmann J: Photodynamische Therapie. Der Hautarzt 58(7): 576, 2007. doi: 10.1007/s00105-007-1368-z

Krutmann J and Morita A: Ultraviolet-A1 and Visible Light Therapy. In: Principles and Practice of Photodermatology (Lim HW, Hönigsmann H, Hawk JLM, eds.), Taylor and Francis Group, LLC, Health Science Division, New York, pp. 317-328, 2007.

2006

Berneburg M, Kamenisch Y, Krutmann J, Rocken M: 'To repair or not to repair - no longer a question': repair of mitochondrial DNA shielding against age and cancer. Exp Dermatol 15 (12): 1005-15, 2006.

Krutmann J: The interaction of UVA and UVB wavebands with particular emphasis on signalling. Prog Biophys Mol Biol. 92 (1):105-107, 2006.

Merk HF, Baron JM, Heise R, Fritsche E, Schroeder P, Abel J, Krutmann J: Concepts in molecular dermatotoxicology. Exp Dermatol. 15(9): 692-704, 2006.

Berneburg M, Kamenisch Y, Krutmann J: Repair of mitochondrial DNA in aging and carcinogenesis. Photochem Photobiol Sci. 5(2): 190-198, 2006.

Stahl W, Krutmann J: Systemische Photoprotektion durch Karotinoide. Hautarzt 57 (4): 281-285, 2006.

Gilchrest BA, Krutmann J: Skin Aging. Berlin, Heidelberg: Springer 2006, 198 S.

Krutmann J, Gilchrest BA: Photoaging of skin. In: Skin aging. Gilchrest BA, Krutmann J (Eds.) – Berlin/Heidelberg: Springer 2006, pp. 33-44.

Krutmann J, Yarosh D: Modern photoprotection of human skin. In: Skin aging. Gilchrest BA, Krutmann J (Eds.) – Berlin/Heidelberg: Springer 2006, pp. 103-112.

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