Publications of Anna von Mikecz's group


Scharf A, Limke A, Guehrs KH, von Mikecz A: Pollutants corrupt resilience pathways of aging in the nematode C. elegans. iScience 25(9): 105027, 2022. doi: 10.1016/j.isci.2022.105027

von Mikecz A: Exposome, molecular pathways and one health: the invertebrate Caenorhabditis elegans. Int J Mol Sci 23(16): 9084, 2022. doi: 10.3390/ijms23169084

von Mikecz A, Scharf A: Pollution - bring the field into the lab. Nature 602(7897): 386, 2022. doi: 10.1038/d41586-022-00444-5

Hering I, Le DT, von Mikecz A: How to keep up with the analysis of classic and emerging neurotoxins: Age-resolved fitness tests in the animal model Caenorhabditis elegans: a step-by-step protocol. EXCLI J 21: 344-353, 2022. doi: 10.17179/excli2021-4626


Piechulek A, Berwanger L, Hemmerich P, von Mikecz A: The nucleus of intestinal cells of the bacterivore nematode Caenorhabditis elegans as a sensitive sensor of environmental pollutants. Methods Mol Biol 2175: 207-217, 2020. doi: 10.1007/978-1-0716-0763-3_15

von Mikecz A, Schikowski T: Effects of airborne nanoparticles on the nervous system: amyloid protein aggregation, neurodegeneration and neurodegenerative diseases. Nanomaterials 10(7): 1349, 2020. doi: 10.3390/nano10071349


Piechulek A, Scharf A, Berwanger L, von Mikecz A: Life span-resolved nanotoxicology identifies nuclear amyloid, altered metabolism and neurodegenerative processes in the nematode Caenorhabditis elegans. Biopolym Cell 35(3): 194-195, 2019. doi: 10.7124/bc.0009CB

Piechulek A, Berwanger L, Scharf A, von Mikecz A: The cell nucleus as sensor of environmental pollution: Amyloid, neurodegeneration and aging. Biopolym Cell 35: 195-196, 2019. doi: 10.7124/bc.0009CC

Piechulek A, Berwanger L, von Mikecz A: Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium. Nanotoxicology 13(8): 1133-1148, 2019. doi: 10.1080/17435390.2019.1643048

Piechulek A, von Mikecz A: Aging by pollutants: Introducing the aging dose (AD)50. Environ Sci Eur 31: 23, 2019. doi: 10.1186/s12302-019-0205-1


von Mikecz A: Lifetime eco-nanotoxicology in an adult organism: where and when is the invertebrate C. elegans vulnerable? Environ Sci-Nano 5: 616-622, 2018. doi: 10.1039/C7EN01061C

Piechulek A, von Mikecz A: Life span-resolved nanotoxicology enables identification of age-associated neuromuscular vulnerabilities in the nematode Caenorhabditis elegans. Environ Pollut 233: 1095-1103, 2018. doi: 10.1016/j.envpol.2017.10.012


Scharf A, Gührs KH, von Mikecz A: Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans. Nanotoxicology 10(4): 426-435, 2016. doi: 10.3109/17435390.2015.1073399


Arnhold F, Gührs KH, von Mikecz A: Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity. PeerJ 3: e754, 2015. [pubmed] (open access)

Arnhold F, Scharf A, von Mikecz A: Imaging and quantification of amyloid fibrillation in the cell nucleus. In: Hancock R (Hrsg.): The Nucleus. Methods in Molecular Biology, Vol. 1228. Springer, New York, 2015. S. 187-202, ISBN 978-1-4939-1679-5. [pubmed]


von Mikecz A: Pathology and function of nuclear amyloid: protein homeostasis matters. Nucleus 5(4): 311-317, 2014. [pubmed]

Arnhold F, von Mikecz A: Intranuclear amyloid – local and quantitative analysis of protein fibrillation in the cell nucleus. In: Bionanoimaging: Insights into protein misfolding and aggregation. Vladimir Uversky & Yuri Lyubchenko (eds), Elsevier 2014, pp. 475-483.


Scharf A, Piechulek A, von Mikecz A: The effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans. ACS Nano 7(12):10695-10703, 2013. [pubmed]

Hemmerich PH, von Mikecz A: Defining the subcellular interface of nanoparticles by live-cell imaging. PLoS one 8(4): e62018, 2013. [pubmed]

von Mikecz A, Scharf A: Isochronal visualization of transcription and proteasomal proteolysis in cell culture or in the modelorganism Caenorhabditis elegans. Methods Mol Biol 1042: 257-273, 2013. [pubmed]


Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P: PML promotes MHC class II gene expression by stabilizing the class II transactivator. J Cell Biol 199(1): 49-63, 2012.


Scharf A, Grozdanov PN, Veith R, Kubitscheck U, Meier UT, von Mikecz A: Distant positioning of proteasomal proteolysis relative to actively transcribed genes. Nucleic Acids Research 39(11): 4612-4627, 2011. [pubmed]

Vordenbäumen S, Braukmann A, Petermann K, Scharf A, Bleck E, von Mikecz A, Jose J, Schneider M: Casein alpha s1 is expressed by human monocytes and upregulates the production of GM-CSF via p38 MAPK. J Immunol 186(1): 592-601, 2011. [pubmed]

Arnhold F, von Mikecz A: Quantitative feature extraction reveals the status quo of protein fibrillation in the cell nucleus. Integrative Biology 3(7): 761-769, 2011. [pubmed]


Chen M, von Mikecz A: Nanoparticle-induced cell culture models for neurodegenerative protein aggregation diseases. Inhalation Toxicology 21 (S1): 110-114, 2009.

Pluskota A, Horzowski E, Bossinger O, von Mikecz A: In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: Silica-nanoparticles induce reproductive senescence. PLoS One 4 (8) e6622, 2009.

von Mikecz A: PolyQ fibrillation in the cell nucleus: Who’s bad? Trends Cell Biol 19 (12): 685-691, 2009.

von Mikecz, A: Nuclear protein aggregates: Structure, function, and topology. Open Biology 2: 193-199, 2009.


Chen M, Singer L, Scharf A, von Mikecz A: Nuclear polyglutamine-containing protein aggregates as active proteolytic centers. Journal of Cell Biology 180 (4): 697-704, 2008. [highlighted in: Nature Chemical Biology 4: 231 (2008)]

von Mikecz A, Chen M, Rockel T, Scharf  A: Localization of the nuclear ubiquitin proteasome system (nUPS), protein aggregation and proteasomal proteolysis in the cell nucleus. In: The nucleus: principles and protocols. R. Hancock (ed). Humana Press, Totowa, NJ, USA 2008, pp. 191-202.


Scharf A, Rockel T, von Mikecz A: Localization of proteasomes and proteasomal proteolysis in the mammalian cell nucleus by systematic application of cytochemistry. Histochem Cell Biol 127: 591-601, 2007.

Unfried K, Albrecht C, Klotz LO, von Mikecz A, Grether-Beck S, Schins RPF: Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1: 52-71, 2007.


Hippe A, Bylaite M, Chen M, von Mikecz A, Wolf R, Ruzicka T, Walz M: Expression and tissue distribution of mouse Hax1. Gene 379: 116-126, 2006.

Chen M, von Mikecz A: Uptake and cytotoxicity of nanoparticles. In: Nanotoxicology - Interactions of Nanomaterials with Biological Systems. Yuliang Zhao, Hari Singh Nalwa (eds). American Scientific Publishers, Stevenson Ranch, CA, USA, 2006, pp. 75-94.

von Mikecz, A: The nuclear ubiquitin-proteasome system (nUPS). J Cell Sci 119 (Pt 10): 1977-1984, 2006.