Publications of Natascia Ventura's group

2021

Wellenberg A, Brinkmann V, Bornhorst J, Ventura N, Honnen S, Fritz G: Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission. Pharmacol Res 174: 105921, 2021. doi: 10.1016/j.phrs.2021.105921

Coppari S, Colomba M, Fraternale D, Brinkmann V, Romeo M, Rocchi MBL, Di Giacomo B, Mari M, Guidi L, Ramakrishna S, Ventura N, Albertini MC: Antioxidant and anti-inflammaging ability of prune (Prunus Spinosa L.) extract result in improved wound healing efficacy. Antioxidants 10(3): 374, 2021. doi: 10.3390/antiox10030374

2020

Brinkmann V, Schiavi A, Shaik A, Puchta DR, Ventura N: Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan. Aging (Albany NY) 13(1): 104-133, 2020. doi: 10.18632/aging.202316

Lettieri-Barbato D, Ventura N, Faraonio K, Aquilano K: Editorial: Advances in metabolic mechanisms of aging and its related diseases. Front Physiol 11: 594974, 2020. doi: 10.3389/fphys.2020.594974

Schiavi A, Strappazzon F, Ventura N: Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies. Mech Ageing Dev 188: 111252, 2020. doi: 10.1016/j.mad.2020.111252

Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster I, Hochrath K, Schumak B, Ventura N, Petzsch P, Köhrer K, Esser C: AHR signaling dampens inflammatory signature in neonatal skin γδ T cells. Int J Mol Sci 21(6): 2249, 2020. doi: 10.3390/ijms21062249

Brinkmann V, Ale-Agha N, Haendeler J, Ventura N: The Aryl hydrocarbon Receptor (AhR) in the aging process: Another puzzling role for this highly conserved transcription factor. Front Physiol 10: 1561, 2020. doi: 10.3389/fphys.2019.01561

2019

Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N: Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11(16): 6535-6554, 2019. doi: 10.18632/aging.102208

Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F: The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun 10(1): 651, 2019. doi: 10.1038/s41467-019-08555-w

2018

Stork B, Ventura N: Targeting the BECN1-BCL2 autophagy regulatory complex to promote longevity. Biotarget 2: 16, 2018. doi: 10.21037/biotarget.2018.10.01

Torgovnick A*, Schiavi A*, Shaik A#, Kassahun H#, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N: BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans. EMBO Rep 19(12): e45856, 2018. doi: 10.15252/embr.201845856 (*,# equal contribution)

Kassahun H, SenGupta T, Schiavi A, Maglioni S, Skjeldam HK, Arczewska K, Brockway NL, Estes S, Eide L, Ventura N, Nilsen H: Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans. DNA Repair (Amst) 61: 46-55, 2018. doi: 10.1016/j.dnarep.2017.11.009

2016

Kalfalah F, Janke L, Schiavi A, Tigges J, Ix A, Ventura N, Boege F, Reinke H: Crosstalk of clock gene expression and autophagy in agingAging (Albany NY) 8(9): 1876-1895, 2016. doi: 10.18632/aging.101018

Maglioni M, Arsalan N, Ventura N: C. elegans screening strategies to identify pro-longevity interventions. Mech Ageing Dev 157: 60-69, 2016. doi: 10.1016/j.mad.2016.07.010

Maglioni S, Ventura N: C. elegans as a model organism for human mitochondrial associated disordersMitochondrion 30: 117-125, 2016. doi: 10.1016/j.mito.2016.02.003

Klionski DJ et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)Autophagy 12(1): 1-222, 2016. doi: 10.1080/15548627.2015.1100356

Shaik A, Schiavi A, Ventura N: Mitochondrial autophagy promotes healthy aging (Editorial). Cell Cycle 15(4): 1805-1806, 2016. doi: 10.1080/15384101.2016.1181876

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J: The aryl hydrocarbon receptor promotes aging phenotypesSci Rep 6: 19618, 2016. doi: 10.1038/srep19618

Schiavi A and Ventura N: Mitochondrial longevity pathways. In: Olsen A, Gill MS (Hrsg.): Ageing: Lessons from C. elegans. Springer International Publishing, Switzerland, 2016. ISBN print: 978-3-319-44701-8, S. 83-108.

2015

Van den Ecker D, Hoffmann M, Müting G, Maglioni S, Herebian D, Mayatepek E, Ventura N, Distelmaier F: C. elegans ATAD-3 modulates mitochondrial iron and heme homeostasisBiochem Biophys Res Commun 467(2): 389-394, 2015. [pubmed]

Schiavi A, Maglioni S, Palikaras K, Shaik A, Strapazzon F, Brinkmann V, Torgovnick A, Castelein N, De Henau S, Braeckman BP, Cecconi F, Tavernarakis N, Ventura N: Iron starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Curr Biol 25(14): 1810-1822, 2015. [pubmed]

Maglioni S, Arsalan N, Franchi L, Hurd A, Opipari AW, Glick GD, Ventura N: An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegansBiochim Biophys Acta-Bioenerg  1847(11): 1469-1478, 2015. [pubmed]

2014

Maglioni S, Schiavi A, Runci A, Shaik A, Ventura N: Mitochondrial stress extends lifespan in C. elegans through neuronal hormesisExp Gerontol 56: 89-98, 2014. [pubmed]
Schiavi A, Ventura N: The interplay between mitochondria and autophagy and its role in the aging process. Exp Gerontol 56: 147-153, 2014. [pubmed]

Trifunovic A, Ventura N: Mitochondria and metabolic control of the aging process (editorial). Exp Gerontol 56: 1-2, 2014. [pubmed]

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F: The Hallmarks of Fibroblast AgeingMech Ageing Dev 138: 26-44, 2014. [pubmed]

2013

Arczewska KD, Tomazella GG, Lindvall JM, Kassahun H, Maglioni S, Torgovnick A, Henriksson J, Matilainen O, Marquis BJ, Nelson BC, Jaruga P, Babaie E, Holmberg CI, Bürglin TR, Ventura N, Thiede B, Nilsen H: Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Nucleic Acids Res 41(10): 5368-5381, 2013. [pubmed]

Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A: A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasiaJ Med Genet 50(8): 543-551, 2013. [pubmed]

Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condo I, Bei R, Rea S, Braeckman BP, Tavernarakis N, Testi R, Ventura N: Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. Exp Gerontol 48(2): 191-201, 2013. [pubmed]

Torgovnick A, Schiavi A, Maglioni S, Ventura N: Healthy aging: what can we learn from C. elegans? Z Gerontol Geriat 46(7): 623-628, 2013. [pubmed]

Publikationen vor 2012

Ottaviani E, Ventura N, Mandrioli M, Candela M, Franchini A, and Franceschi C. Gut microbiota as a candidate for lifespan extension: an ecological/evolutionary perspective targeted on living organisms as metaorganisms. Biogerontology. 2011 Dec;12(6): 599-609.

Guccini I, Serio D, Condò I, Rufini A, Tomassini B, Mangiola A, Maira G, Anile C, Fina D, Pallone F, Mongiardi MP, Levi A, Ventura N@, Testi R@, Malisan F@Frataxin participates to the hypoxia-induced response in tumors. Cell Death Dis. 2011 Feb 24;2:e123.

Rufini A*, Fortuni S*, Arcuri G, Condo’ I, Serio D, Incani O, Malisan M, Ventura N, Testi R. Preventing the ubiquitin/proteasome-dependent degradation of frataxin, the protein defective in Friedreich’s AtaxiaHum Mol Genet. 2011 Apr 1;20(7):1253-61

Butler JA, Ventura NJohnson TE, Rea SL. The Long-lived mitochondrial (MIT) mutants of C. elegans utilize a novel metabolismFASEB J. 2010 Dec;24(12):4977-88

Torgovnick A, Schiavi A, Testi R, Ventura N. A role for p53 in mitochondrial stress response control of longevity in C. elegans. Exp Gerontol. 2010 Aug;45(7-8):550-7

Ventura N@, Rea SL, Schiavi A, Torgovnick A, Testi R, Johnson TE. p53/cep-1 increases or decreases  C. elegans lifespan depending on level of mitochondrial bioenergetic stress. Aging Cell. 2009 Aug;8(4):380-93

Rea SL*, Ventura N*, Johnson TE. Relationship Between Mitochondrial Inhibition, Development and Life Extension in C. elegans. PloS Biology. 2007 Oct 2;5(10):e259

Kell A, Ventura NJohnson TE. Activation of Skn-1 by novel kinases in Caenorhabditis elegansFree Radic Biol Med. 2007 Dec 1;43(11):1560-6.

Ventura N*@, Rea SL*. C. elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. Biotechnol J. 2007 May;2(5):584-95

Condò I, Ventura N, Malisan F, Rufini A, Tomassini B, Testi R. In vivo maturation of human frataxin. Hum Mol Genet 2007 Jul 1;16(13):1534-40

Condò I*Ventura N*, Malisan F, Tomassini B, Testi R. A pool of extramitochondrial frataxin that protect from apopotsisJ Biol Chem. 2006 Jun16;281(24):16750-6

Ventura N, Rea SL, Henderson ST, Condo I, Testi R, Johnson TE. C. elegans as a model for Friedreich AtaxiaFASEB J 2006 May; 20(7):1029-30.

Ventura N@, Rea SL, Testi R. Long-lived C. elegans mitochondrial mutants as a model for human mitochondrial-associated diseases. Exp Gerontol 2006 Oct;41(10):974-91

Ventura N, Rea S, Henderson ST, Condo I, Johnson TE, Testi R. Reduced Expression of Frataxin Extends the Life Span of Caenorhabditis elegans. Aging Cell 2005 Apr;4(2):109-12.

Barilà D, Rufini A, Condò I, Ventura N, Dorey K, Superti-Furga G and Testi R.  Caspase-dependent cleavage of c-Abl contributes to apoptosis. Mol Cell Biol 2003 Apr;23(8):2790-9.

Cicconi S, Ventura N, Pastore D, Bonini P, Pierucci D, Merlo D, Di Nardo P, Lauro R, Borboni P. Marlier NJL. Characterization of apoptosis signal transduction pathways in HL-5 cardiomyocytes exposed to ischemia/reperfusion oxidative stress model. J Cell Physiol 2003 Apr;195(1):27-37

Malisan F, Franchi L, Tomassini B, Ventura N, Condo' I, Rippo MR, Rufini A, Liberati L, Nachtigall C, Kniep B, Testi R. Acetylation suppresses the pro-apoptotic activity of GD3 gangliosideJ Exp Med 2002 196(12):1535-41
*equal contribution; @corresponding author

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