The research group “Alternative method development for environmental toxicity testing” is offering a position for a
for a Master Thesis project
According to the World Health Organization (WHO), an estimated 6% of newborns worldwide are born with a developmental defect in the form of a structural or functional abnormality. It is believed that about 3% of the developmental disorders can be attributed to exposure to chemicals. However, due to the considerable lack of data in the area of risk assessment for existing chemicals, it is assumed that this proportion is underestimated and could in fact be significantly higher. At present, internationally standardized guidelines are used to estimate and evaluate embryotoxic effects using animal experiments. However, conducting animal experiments is time-consuming and costly and harbors ethical concerns. In addition, there are problems with the reproducibility of the experiments and the interspecies predictability. For this reason, there is great interest in the development of alternative test models and in vitro test systems for risk assessment of embryotoxicity from both the pharmaceutical and chemical industries.
The aim of this project is to establish an in-vitro test for embryotoxicity, which will be based on the potential of human induced pluripotent stem cells (hiPSC) to differentiate into cells of all three germ layers.
Our working group is looking for a motivated employee (f/m/d) with a high level of commitment, fun at work, motivation, communication skills and team spirit. The applicant should have a completed bachelor’s degree in the field of toxicology/pharmacology/biology or similar. Good knowledge of English and experience with aseptic cell culture techniques (especially stem cells) are a plus.
We are an interdisciplinary, international team with a pleasant working atmosphere. We offer thorough training in a highly topical, challenging area of research. We have up-to-date cell culture models and a thorough knowledge in test method development.
As early as possible.
Please address your application (incl. a short cover letter, your complete CV as one single PDF file) to:
Prof. Dr. Ellen Fritsche, Dr. Julia Tigges
IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.