The KAUVIR project
For some time the group has performed research concerning the role of UV irradiation in skin carcinogenesis and skin aging. A first consortium project funded by the BMBF (The German Federal Ministry of Education and Research) specifically addressed the role of UVA. Using additional UVB or IRA demonstrated that radiation with UVA in combination with UVB or IRA caused a different “damage profile” than UVA alone. Therefore, the newly funded BMBF project KAUVIR (combination instead of addition: UV to IR radiation in skin cancer and skin aging) concentrates on the consequences of irradiation with a novel light source that combines UV, visible light (VIS), and IR, thus mimicking sun light to a large extent. These studies are essential in order to get a better understanding of the “damaging” effects of “sun light” and in consequence more relevant risk estimation and prevention. The team is also very interested to determine the consequences and regulation induced by this combinatorial radiation (KAUVIR) on the skin cells in OTCs, i.e. in the tissue context. An important aspect in this context is the influence of Cyclosporine A (CsA). This drug is frequently used as immunosuppressant for organ transplant patients. Unfortunately, however, immunosuppression is strongly associated with an increased risk of skin cancer (carcinomatous catastrophe). Therefore, it is of our interest to establish a molecular and mechanistic link between CsA treatment and UV radiation. In addition, UV-induced skin cancer is a cancer of old age and with the help of our new OTC-based aging model we aim to elucidate also the relationship of UV radiation and skin aging.
Prof. Petra Boukamp coordinates the KAUVIR project. Co-operation partners are Prof. Jean Krutmann from IUF, Dr. Rüdiger Greinert and Dr. Beate Volkmer from the Elbeklinik Buxtehude and Dr. Alexander Rapp from the University Darmstadt.
Inflammatory response studies of the skin
Inflammatory cells are supposed to contribute to skin diseases and skin cancer. Therefore, we will implement as a new research focus the complementation respectively development of OTCs with inflammatory cells in order to address their role in UV-dependent skin cancer and aging. This is an IUF trans-research field approach where we collaborate closely with Prof. Esser’s group.