Mitochondria are vital organelles. In our lab we primarily exploit the roundworm Caenorhabditis elegans as a model organism to investigate the role of mitochondrial stress responses (MSR) in neuropathologies and ageing (Schiavi et al. Curr Biol 2015, Torgovnick et al. EMBO Reports 2018, Maglioni et al. Nat Commun 2022). More info about the lab can be found here. In this hypothesis driven project you will specifically investigate how mild mitochondrial stress protects animals against aging and neurodegenerative disease (i.e. Alzheimer) based on mechanisms suggested by our recent unbiased multi-OMICS results, with a special focus on redox- and lipid-regulatory processes. The position has to be filled preferably by June 1st 2022 (flexible).
YOUR TASKS
- Combine genetic, neurobehavioral and imaging techniques to investigate the role of selected molecular pathways (suggested by multi-OMICS analyses) as mediators of mitochondrial-stress extension of healthspan
- Utilize state-of-the-art genetic and biochemical assays to identify novel redox- and/or lipid-regulated genes and signals mediating the pro-longevity effect
- Use functional and structural neuronal assays to address the role of newly identified genes in C. elegans age-associated disease models (i.e. Alzheimer)
YOUR PROFILE
- Master of Science (e.g. Biology)
- Interest in aging and age-associated disease
- Enthusiastic and highly motivated
- Excellent communication skills in English (knowledge of German is a plus)
- Eagerness for independent and team work
- Previous experience with C. elegans or imaging techniques
WE OFFER YOU
- A 3-years funded position (salary and social benefits based on TV-L 13 65%)
- Structured PhD program
- Extensive advanced training opportunities
- Support in reconciling work and family life
- Flexible working time models
- An international, diverse and fair working environment
Applications should include a statement of research interest, a curriculum vitae with the names and e-mail addresses of two referees, and proof of the required qualifications with grades and should be sent (one pdf only) to natascia.ventura@uni-duesseldorf.de.
