Publikationen 2017

Hellack B, Nickel C, Schins RPF:  Oxidative potential of silver nanoparticles measured by electron paramagnetic resonance spectroscopy. J Nanopart Res 19: 404, 2017. doi: 10.1007/s11051-017-4084-3

Hüls A, Krämer U, Carlsten C, Schikowski T, Ickstadt K, Schwender K: Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies. BMC Genetics 18: 115, 2017. doi: 10.1186/s12863-017-0586-3

Uphoff EP, Bird PK, Antó JM, Basterrechea M, von Berg A, Bergström A, Bousquet J, Chatzi L, Fantini MP, Ferrero A, Gehring U, Gori D, Heinrich J, Keil T, Kull I, Lau S, Maier D, Momas I, Narduzzi S, Porta D, Ranciere F, Roumeliotaki T, Schikowski T, Smit HA, Standl M, Sunyer J, Wright J: Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res 3: 00150-2016, 2017. doi: 10.1183/23120541.00150-2016

Jendrossek M, Standl M, Koletzko S, Lehmann I, Bauer CP, Schikowski T, von Berg A, Berdel D, Heinrich J, Markevych I: Residential air pollution, road traffic, greenness and maternal hypertension: Results from GINIplus and LISAplus. Int J Occup Environ Med 8(3): 131-142, 2017. doi: 10.15171/ijoem.2017.1073

Benvegnù S, Wahle T, Dotti CG: E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget 8(52): 89439-89450, 2017. doi: 10.18632/oncotarget.20143

Larribère L, Galach M, Novak D, Arévalo K, Volz HC, Stark HJ, Boukamp P, Boutros M, Utikal J: An RNAi screen reveals an essential role for HIPK4 in human skin epithelial differentiation from iPSCs. Stem Cell Rep 9(4): 1234-1245, 2017. doi: 10.1016/j.stemcr.2017.08.023

Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E: Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Stem Cell Res 25: 72-82, 2017. doi: 10.1016/j.scr.2017.10.013

Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP: SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging-US 9(10): 2163-2189, 2017. doi: 10.18632/aging.101307

Ding A, Yang Y, Zhao Z, Hüls A, Vierkötter A, Yuan Z, Cai J, Zhang J, Gao W, Li J, Zhang M, Matsui M, Krutmann J, Kan H, Schikowski T, Jin L, Wang S: Indoor PM_2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep 7(1): 15329, 2017. doi: 10.1038/s41598-017-15295-8

Hellack B, Sugiri D, Schins RPF, Schikowski T, Krämer U, Kuhlbusch TAJ, Hoffmann B: Land use regression modeling of oxidative potential of fine particles, NO₂, PM_2.5 mass and association to type two diabetes mellitus. Atmos Environ 171: 181-190, 2017. doi: 10.1016/j.atmosenv.2017.10.017

Daaboul HE, Daher CF, Taleb RI, Boulos J, Bodman-Smith K, Boukamp P, Shebaby WN, Dagher C, El-Sibai M, Mroueh MA: β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo. J Pharm Pharmacol 69(11): 1552-1564, 2017. doi: 10.1111/jphp.12796

Lohan SB, Ahlberg S, Mensch A, Höppe D, Giulbudagian M, Calderón M, Grether-Beck S, Krutmann J, Lademann J, Meinke MC: EPR technology as sensitive method for oxidative stress detection in primary and secondary keratinocytes induced by two selected nanoparticles. Cell Biochem Biophys 75(3-4): 359-367, 2017. doi: 10.1007/s12013-017-0823-4

Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel K, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M: Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun 8: 484, 2017. doi: 10.1038/s41467-017-00604-6

Li H, Kroll T, Moll J, Frappart L, Herrlich P, Heuer H, Ploubidou A: Spindle misorientation of cerebral and cerebellar progenitors is a mechanistic cause of megalencephaly. Stem Cell Rep 9(4): 1071-1080, 2017. doi: 10.1016/j.stemcr.2017.08.013

Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF: Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease. Part Fibre Toxicol 14: 35, 2017. doi: 10.1186/s12989-017-0213-5

Dekkers S, Miller MR, Schins RPF, Römer I, Russ M, Vandebriel RJ, Lynch I, Belinga-Desaunay MF, Valsami-Jones E, Connell S, Smith IP, Duffin R, Boere JAJF, Heusinkveld HJ, Albrecht C, de Jong WH, Cassee FR: The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. Nanotoxicology 11(6): 794-808, 2017. doi: 10.1080/17435390.2017.1357214

Hammerschmidt-Kamper C, Biljes D, Merches K, Steiner I, Daldrup T, Bol-Schoenmakers M, Pieters RHH, Esser C: Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice. Plos One 12(6): e0180321, 2017. doi: 10.1371/journal.pone.0180321

Sthijns MMJPE*, Thongkam W*, Albrecht C, Hellack B, Bast A, Haenen GRMM, Schins RPF: Silver nanoparticles induce hormesis in A549 human epithelial cells. Toxicol In Vitro 40: 223-233, 2017. doi: 10.1016/j.tiv.2017.01.010 (* equal contribution)

Soppa VJ, Schins RPF, Hennig F, Nieuwenhuijsen MJ, Hellack B, Quass U, Kaminski H, Sasse B, Shinnawi S, Kuhlbusch TAJ, Hoffmann B: Arterial blood pressure responses to short-term exposure to fine and ultrafine particles from indoor sources - A randomized sham-controlled exposure study of healthy volunteers. Environ Res 158: 225-232, 2017. doi: 10.1016/j.envres.2017.06.006

Hüls A, Krämer U, Herder C, Fehsel K, Luckhaus C, Stolz S, Vierkötter A, Schikowski T: Genetic susceptibility for air pollution-induced airway inflammation in the SALIA study. Environ Res 152: 43-50, 2017. doi: 10.1016/j.envres.2016.09.028

Hüls A, Fromke C, Ickstadt K, Hille K, Hering J, von MC, Hartmann M, Kreienbrock L: Antibiotic resistances in livestock: A comparative approach to identify an appropriate regression model for count data. Front Vet Sci 4: 71, 2017. doi: 10.3389/fvets.2017.00071

Hüls A, Ickstadt K, Schikowski T, Krämer U: Detection of gene-environment interactions in the presence of linkage disequilibrium and noise by using genetic risk scores with internal weights from elastic net regression. BMC Genet 18(1): 55, 2017. doi: 10.1186/s12863-017-0519-1

Biljes D, Hammerschmidt-Kamper C, Merches K, Esser C: The aryl hydrocarbon receptor in T cells contributes to sustaining oral tolerance against ovalbumin in a mouse model. EXCLI J 16: 291-301, 2017. doi: 10.17179/excli2017-168

Faßbender S, Opitz FV, Johnen S, Förster I, Weighardt H: MyD88 contributes to staphylococcal enterotoxin B-triggered atopic dermatitis-like skin inflammation in mice. J Invest Dermatol 137(8): 1802-1804, 2017. doi: 10.1016/j.jid.2017.04.015

Flexeder C, Thiering E, Koletzko S, Berdel D, Lehmann I, von Berg A, Hoffmann B, Bauer CP, Heinrich J, Schulz H: Higher serum 25(OH)D concentrations are associated with improved FEV1 and FVC in adolescence. Eur Respir J 49(4): 1601804, 2017. doi: 10.1183/13993003.01804-2016

Koch S, Stroisch TJ, Vorac J, Herrmann N, Leib N, Schnautz S, Kirins H, Förster I, Weighardt H, Bieber T: AhR mediates an anti-inflammatory feedback mechanism in human Langerhans cells involving FcεRI and IDO. Allergy 72(11): 1686-1693, 2017. doi: 10.1111/all.13170

Kaisers W, Boukamp P, Stark H-J, Schwender H, Tigges J, Krutmann J, Schaal H: Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts. Plos One 12(5): e0175657, 2017. doi: 10.1371/journal.pone.0175657

Tzivian L, Jokisch M, Winkler A, Weimar C, Hennig F, Sugiri D, Soppa VJ, Dragano N, Erbel R, Jöckel KH, Moebus S, Hoffmann B; Heinz Nixdorf Recall Study Group: Associations of long-term exposure to air pollution and road traffic noise with cognitive function - An analysis of effect measure modification. Environ Int 103: 30-38, 2017. doi: 10.1016/j.envint.2017.03.018

Kälsch H, Lehmann N, Moebus S, Hoffmann B, Stang A, Jöckel KH, Erbel R, Mahabadi AA: Aortic calcification onset and progression: Association with the development of coronary atherosclerosis. J Am Heart Assoc 6(4): e005093, 2017. doi: 10.1161/JAHA.116.005093

Papala A, Sylvester M, Dyballa-Rukes N, Metzger S, D'Haese J: Isolation and characterization of human CapG expressed and post-translationally modified in Pichia pastoris. Protein Expr Purif 134: 25-37, 2017. doi: 10.1016/j.pep.2017.03.017

Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E: BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Sci Rep 7: 44861, 2017. doi: 10.1038/srep44861

Turgoen MO, Silander TL, Doycheva D, Liao XH, Ridgen M, Ongaro L, Zhou X, Joustra SD, Wit JM, Wade MG, Heuer H, Refetoff S, Bernard DJ: TRH action is impaired in pituitaries of male IGSF1-deficient mice. Endocrinol 158 (4): 815-830, 2017. doi: 10.1210/en.2016-1788

Harris C, Buyken A, Koletzko S, von Berg A, Berdel D, Schikowski T, Koletzko B, Heinrich J, Standl M: Dietary fatty acids and changes in blood lipids during adolescence: The role of substituting nutrient intakes. Nutrients  9(2): 127, 2017. doi: 10.3390/nu9020127

Hülsmann S, Hagos L, Heuer H, Schnell C: Limitations of sulforhodamine 101 for brain imaging. Front Cell Neurosci 11: 44, 2017. doi: 10.3389/fncel.2017.00044

Weber J, McInnes J, Kizilirmak C, Rehders M, Qatato M, Wirth EK, Schweizer U, Verrey F, Heuer H, Brix K:  Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland. Eur J Cell Biol 96(5): 440-456, 2017. doi: 10.1016/j.ejcb.2017.02.002

Shebaby WN, Mroueh MA, Boukamp P, Ri RI, Bodman-Smith K, El-Sibai M, Daher CF: Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer. BMC Complement Altern Med 17(1): 36, 2017. doi: 10.1186/s12906-016-1531-0

Markevych I, Maier W, Fuertes E, Lehmann I, von Berg A, Bauer CP, Koletzko S, Berdel D, Sugiri D, Standl M, Heinrich J: Neighbourhood greenness and income of occupants in four German areas: GINIplus and LISAplus. Urban For Urban Green 21: 88-95, 2017. doi: 10.1016/j.ufug.2016.11.011

Thongkam W*, Gerloff K*, van Berlo D, Albrecht C, Schins FPR: Oxidant generation, DNA damage and cytotoxicity by a panel of engineered nanomaterials in three different human epithelial cell lines. Mutagenesis 32(1): 105-115, 2017. doi: 10.1093/mutage/gew056 (* equal contribution)

Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer TC, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E: Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Arch Toxicol 91(2): 827-837, 2017. doi: 10.​1007/​s00204-016-1709-8

Gao W*, Tan J*, Hüls A*, Ding A, Liu Y, Matsui M, Vierkötter A, Krutmann J^#, Schikowski T^#, Jin L^#, Wang S^#: Genetic variants associated with skin aging in Chinese Han population. J Dermatol Sci 86(1): 21-29, 2017. doi: 10.1016/j.jdermsci.2016.12.017 (* equal contribution; ^# Co-senior authors)

Zhang M, Li B, Wu S, Tan J, Yang Y, Marini A, Vierkötter A, Zhang J, Li H, Schikowski T, Jin L, Krutmann J, Wang S: A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol 137(4): 979–982, 2017. doi: 10.1016/j.jid.2016.11.030

Standl M, Tesch F, Baurecht H, Rodríguez E, Müller-Nurasyid M, Gieger C, Peters A, Wang-Sattler R, Prehn C, Adamski J, Kronenberg F, Schulz H, Koletzko S, Schikowski T, von Berg A, Lehmann I, Berdel D, Heinrich J, Schmitt J, Weidinger S: Association of atopic dermatitis with cardiovascular risk factors and diseases. J Invest Dermatol 137(5): 1074-1081, 2017. doi: 10.1016/j.jid.2016.11.031

Schmuck MR, Temme T, Dach K, de Boer D, Barenys M, Bendt F, Mosig A, Fritsche E: Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro. Arch Toxicol 91(4): 2017–2028, 2017. doi: 10.1007/s00204-016-1852-2

Kohlgrüber S, Upadhye A, Dyballa-Rukes N, McNamara CA, Altschmied J: Regulation of transcription factors by reactive oxygen species and nitric oxide in vascular physiology and pathology. Antioxid Redox Signal 26(13):679-699, 2017. doi: 10.1089/ars.2016.6946

Grether-Beck S, Marini A, Jaenicke T, Stahl W, Krutmann J: Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, cross-over study. Br J Dermatol 176(5): 1231-1240, 2017. doi: 10.1111/bjd.15080