AG Esser - Publikationen


Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, Schiavi A, Steinwachs S, Esser C, Menzel R, Giani Tagliabue S, Bonati L, Cox F, Ale-Agha N, Jakobs P, Altschmied J, Haendeler J, Coumoul X, Ventura N: Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects. Antioxidants (Basel) 11(4): 613, 2022. doi: 10.3390/antiox11040613

Fueldner C, Riemschneider S, Haupt J, Jungnickel H, Schulze F, Zoldan K, Esser C, Hauschildt S, Knauer J, Luch A, Kalkhof S, Lehmann J: Aryl Hydrocarbon Receptor activation by benzo[a]pyrene prevents development of septic shock and fatal outcome in a mouse model of systemic Salmonella enterica infection. Cells 11(4): 737, 2022. doi: 10.3390/cells11040737

Fehsel K, Schwanke K, Kappel BA, Fahimi E, Meisenzahl-Lechner E, Esser C, Hemmrich K, Haarmann-Stemmann T, Kojda G, Lange-Asschenfeldt C: Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction. J Psychopharmacol 36(2): 191-201, 2022. doi: 10.1177/02698811211055811


Martins S, Hacheney I, Teichweyde N, Hildebrandt B, Krutmann J, Rossi A: Generation of an induced pluripotent stem cell line (IUFi001) from a Cockayne syndrome patient carrying a mutation in the ERCC6 gene. Stem Cell Res 55: 102456, 2021. doi: 10.1016/j.scr.2021.102456

van den Bogaard EH, Esser C, Perdew G: The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: a perspective on current knowledge gaps and directions for future research and therapeutic applications. Exp Dermatol 30(10): 1477-1483, 2021. doi: 10.1111/exd.14409

Esser C: Trajectory shifts in interdisciplinary research of the aryl hydrocarbon receptor - a personal perspective on thymus and skin. Int J Mol Sci 22(4): 1844, 2021. doi: 10.3390/ijms22041844

Haarmann-Stemmann T, Sutter TR, Krutmann J, Esser C: The mode of action of tapinarof may not only depend on the activation of cutaneous aryl hydrocarbon receptor signaling but also on its antimicrobial activity. J Am Acad Dermatol 85(1): e33-e34, 2021. doi: 10.1016/j.jaad.2021.01.103


Nothdurft S, Thumser-Henner C, Breitenbücher F, Okimoto RA, Dorsch M, Opitz CA, Sadik A, Esser C, Hölzel M, Asthana S, Forster J, Beisser D, Kalmbach S, Grüner BM, Bivona TG, Schramm A, Schuler M: Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis. Oncogenesis 9(11): 102, 2020. doi: 10.1038/s41389-020-00286-8

Esser C, Boots AM, Caignard A, Ciraci C, Grčević D, Knapp S, Montoya M, Di Rosa F, Saksida T, Stravinskiene D, Deniz G: The impact of COVID-19 lock-downs for European (female) immunologists – our views as members of the EFIS gender and diversity task force. Euro J Immunol 50(12): 1855-1862, 2020. doi: 10.1002/eji.202070125

Esser C, Hochrath K, Schikowski T, Haarmann-Stemmann T: COVID-19 research: toxicological input urgently needed! Arch Toxicol 94(7): 2547-2548, 2020. doi: 10.1007/s00204-020-02803-5

Häselbarth L, Ouwens DM, Teichweyde N, Hochrath K, Merches K, Esser C: The small chain fatty acid butyrate antagonizes the TCR-stimulation-induced metabolic shift in murine epidermal gamma delta T cells. EXCLI J 19: 334-350, 2020. doi: 10.17179/excli2020-1123

Vogel CFA, Van Winkle LS, Esser C, Haarmann-Stemmann T: The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses. Redox Biol 34: 101530, 2020. doi: 10.1016/j.redox.2020.101530

Merches K, Schiavi A, Weighardt H, Steinwachs S, Teichweyde N, Förster I, Hochrath K, Schumak B, Ventura N, Petzsch P, Köhrer K, Esser C: AHR signaling dampens inflammatory signature in neonatal skin γδ T cells. Int J Mol Sci 21(6): 2249, 2020. doi: 10.3390/ijms21062249


Vogeley C, Esser C, Tüting T, Krutmann J, Haarmann-Stemmann T: Role of the aryl hydrocarbon receptor in environmentally induced skin aging and skin carcinogenesis. Int J Mol Sci 20(23): 6005, 2019. doi: 10.3390/ijms20236005

Haupeltshofer S, Leichsenring T, Berg S, Pedreiturria X, Joachim SC, Tischoff I, Otte J-M, Bopp T, Fantini MC, Esser C, Willbold D, Gold R, Faissner S, Kleiter I: Smad7 in intestinal CD4+ T cells determine autoimmunity in a spontaneious model of multiple sclerosis. PNAS 116(51): 25860-25869, 2019. doi: 10.1073/pnas.1905955116

Cossarizza A, … Esser C, … Zychlinsky A: Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49(10): 1457-1973, 2019. doi: 10.1002/eji.201970107

Esser C, Hochrath K, Teichweyde N, Krutmann J, Chang H-D: Beyond sequencing: fast and easy microbiome profiling by flow cytometry. Arch Toxicol 93(9): 2703-2704, 2019. doi: 10.1007/s00204-019-02527-1

Fiala GJ, Schaffer AM, Merches K, Morath A, Swann J, Herr LA, Hils M, Esser C, Minguet S, Schamel WWA: Proximal Lck promoter-driven Cre function is limited in neonatal and ineffective in adult γδ T cell development. J Immunol 203(2): 569-579, 2019. doi: 10.4049/jimmunol.1701521


Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X: Old receptor, new tricks-the ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR Meeting, 29-31 August 2018 in Paris, France. Int J Mol Sci 19(11): 3603, 2018. doi: 10.3390/ijms19113603

Fueldner C, Kohlschmidt J, Riemschneider S, Schulze F, Zoldan K, Esser C, Hauschildt S, Lehmann J: Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner. Toxicology 409: 80-90, 2018. doi: 10.1016/j.tox.2018.07.011

Riemschneider S, Kohlschmidt J, Fueldner C, Esser C, Hauschildt S, Lehmann J: Aryl hydrocarbon receptor activation by benzo(a)pyrene inhibits proliferation of myeloid precursor cells and alters the differentiation state as well as the functional phenotype of murine bone marrow-derived macrophages. Toxicol Lett 296: 106-113, 2018. doi: 10.1016/j.toxlet.2018.07.050

Pollet M*, Shaik S*, Mescher M*, Frauenstein K, Tigges J, Braun S, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CF, Krutmann J, Haarmann-Stemmann T: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 2018. doi: 10.1038/s41418-018-0160-1 (* equal contribution)

Esser C, Haarmann-Stemmann T, Hochrath K, Schikowski T, Krutmann J: AHR and the issue of immunotoxicity. Curr Opinion Toxicol 10: 91-97, 2018. doi: 10.1016/j.cotox.2018.03.001


Cossarizza A, … Esser C, …. et al.: Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol 47: 1584-1797, 2017. doi: 10.1002/eji.201646632

Hammerschmidt-Kamper C, Biljes D, Merches K, Steiner I, Daldrup T, Bol-Schoenmakers M, Pieters RHH, Esser C: Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice. Plos One 12(6): e0180321, 2017. doi: 10.1371/journal.pone.0180321

Biljes D, Hammerschmidt-Kamper C, Merches K, Esser C: The aryl hydrocarbon receptor in T cells contributes to sustaining oral tolerance against ovalbumin in a mouse model. EXCLI J 16: 291-301, 2017. doi: 10.17179/excli2017-168

Merches K, Haarmann-Stemmann T, Weighardt H, Krutmann J, Esser C: AHR in the skin: From the mediator of chloracne to a therapeutic panacea? Current Opinion Toxicol 2: 79-86, 2017. doi: 10.1016/j.cotox.2017.02.002


Haas K, Weighardt H, Deenen R, Köhrer K, Clausen B, Zahner S, Boukamp P, Bloch W, Krutmann J, Esser C: Aryl hydrocarbon receptor in keratinocytes is essential for murine skin barrier integrity. J Invest Dermatol 136(11): 2260-2269, 2016. doi: 10.1016/j.jid.2016.06.627

Berg J, Mahmoudjanlou Y, Duscha A, Massa M, Thöne J, Esser C, Gold R, Haghikia A: The immunomodulatory effect of laquinimod in CNS autoimmunity is mediated by the aryl hydrocarbon receptor. J Neuroimmunol 298: 9-15, 2016. doi: 10.1016/j.jneuroim.2016.06.003

Brandstätter O*, Schanz O*, Vorac J*, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H*, Förster I*: Balancing intestinal and systemic inflammation through cell typespecific expression of the aryl hydrocarbon receptor repressor. Sci Rep 6: 26091, 2016. doi: 10.1038/srep26091 (* equal contribution)

Eckers A, Jakob S, Heiss C, Haarmann-Stemmann T, Goy C, Brinkmann V, Cortese-Krott MM, Sansone R, Esser C, Ale-Agha N, Altschmied J, Ventura N, Haendeler J: The aryl hydrocarbon receptor promotes aging phenotypes. Sci Rep 6: 19618, 2016. doi: 10.1038/srep19618

Pilz C, Feyerabend T, Sonner J, Redaelli C, Peter K, Kunze A, Haas K, Esser C, Schäkel K, Wick W, Rodewald HR, Lanz TV, Platten M: Normal mast cell numbers in the tissues of AhR-deficient mice. Exp Dermatol 25(1): 62-63, 2016. doi: 10.1111/exd.12864

Esser C: The Aryl Hydrocarbon Receptor in Immunity: Tools and Potential. In: Cuturi MC, Anegon I (Hrsg.): Suppression and Regulation of Immune Responses, Methods and Protocols, Volume II. Humana press, New York, 2016. ISBN 978-1-4939-3138-5.


Biljes B, Hammerschmidt-Kamper C, Kadow S, Diel P, Weigt C, Burkart V, Esser C:  Impaired glucose and lipid metabolism in ageing aryl hydrocarbon receptor deficient mice. EXCLI Journal (14): 1153-1163, 2015. [open access]

Haarmann-Stemmann T, Esser C, Krutmann J: The Janus-faced role of Aryl Hydrocarbon Receptor (AHR) signaling in the skin: Consequences for prevention and treatment of skin disorders. J Invest Dermatol 135(11): 2572-2576, 2015. [pubmed]

Esser C, Rannug A: The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology. Pharmacol Rev 67(2): 259-279, 2015. [pubmed]

Hoffmann B, Esser C: Biologische Wirkungsweisen von Partikeln bei der Allergieentstehung. Allergologie 38: 1–7, 2015.


Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A: Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med 211(9): 1807-1819, 2014. [pubmed]

Mangerich A, Esser C: Chemical warfare in the First World War: reflections 100 years later. Arch Toxicol 88(11): 1909-1911, 2014. [pubmed]

Esser C: A fat story - antigen presentation by butyrophilin 3A1 to γδ T cells. Cell Mol Immunol 11(1): 5-7, 2014. [pubmed]

Esser C: The Aryl Hydrocarbon Receptor (AhR) as a Mediator of Adverse Immune Reactions. In: Molecular Immunotoxicology. Corsini E, Van Loveren H (Eds). Wiley Verlag 2014.


Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J, Haarmann-Stemmann T: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. [pubmed]

Esser C, Bargen I, Weighardt H, Haarmann-Stemmann T, Krutmann J: Functions of the Aryl Hydrocarbon Receptor in the skin. Seminars in Immunopathology 35(6): 677-691, 2013. [pubmed]

Esser C, Götz C: Filling the gaps: need for research on cell-specific xenobiotic metabolism in the skin. Arch Toxicol 87(10): 1873-1875, 2013. [pubmed]

Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RPF, Albrecht C. Zinc Oxide Nanoparticles Induce Necrosis and Apoptosis in Macrophages in a p47phox- and Nrf2-Independent Manner. PLoS One 8(6): e65704, 2013. [pubmed]


Esser C: Biology of the aryl hydrocarbon receptor: report of an international and interdisciplinary conference. Arch Toxicol  86(8): 1323-1329, 2012. [pubmed]


Kiss EA, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, Diefenbach A: Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 334 (6062): 1561-1565, 2011. [pubmed]

Jux B, Kadow S, Luecke S, Rannug A, Krutmann J, Esser C: The aryl hydrocarbon receptror mediates UVB adiation-induced skin tanning. J Invest Dermatol 131(1): 203-210, 2011. [pubmed]

Kadow S, Jux B, Zahner SP, Wingerath B, Chmill S, Clausen BE, Hengstler J, Esser C: Aryl hydrocarbon receptor is critical for homeostasis of invariant gamma-delta T cells in the murine epidermis. J Immunology 187 (6): 3104-3110, 2011. [pubmed]

Perner D, Vierkötter A, Sugiri D, Matsui M, Ranft U, Esser C, Ethève S, Goralczyk R, Kaneko N, Yamamoto A, Morita A, Krutmann J, Krämer U: Association between sun-exposure, smoking behaviour and plasma antioxidant levels with the different manifestation of skin ageing signs between Japanese and German women – A pilot study. J Dermatol Sci 62 (2): 138-140, 2011.

Eckers A, Sauerbier E, Anwar-Mohamed A, Hamann I, Esser C, Schroeder P, El-Kadi AO, Klotz LO: Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct. Arch Biochem Biophys 516 (2): 138-145, 2011. [pubmed]


Chmill S, Kadow S, Winter M, Weighardt H, Esser C: 2,3,7,8-Tetrachlorodibenzo-P-dioxin impairs stable establishment of oral tolerance in mice. Toxicol Sci 118(1):98-107, 2010.

Luecke S, Backlund M, Jux B, Esser C, Krutmann J,  Rannug A: The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Pigment Cell & Melanoma Research 23 (6): 828-833, 2010.

Esser C, Krutmann J: UV-Strahlung und Pigmentierung: Arylhydrocarbonrezeptor - "a new kid on the block".
Der Hautarzt 61 (7): 561-566, 2010.


Jux B, Kadow S, Esser C: Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice. J Immunol 182 (11): 6709-6717, 2009.

Esser C, Jux B, Kadow S, Chmill S, Hübinger J, Frericks M: Cell specific action and toxicity of the AhR: Focus immune system. Toxicol Lett 189, Suppl. 1, S55, 2009.

Esser C, Jux B: Small chemicals, bioactivation, and the immune system - a fragile balance of i-tox and benefits? Chemistry & Biodiversity 6 (11): 2138-2143, 2009.

Goergens A, Frericks M, Esser C: The AhR is only marginally involved in the anti-leukemic effects of its ligand curcumin. Anticancer Research 29 (11): 4657-4664, 2009.

Esser C: The immune phenotype of arylhydrocarbon receptor null mouse mutants: not a simple mirror of AhR overactivation. Biochem Pharmacol  77 (4): 597-607, 2009.

Esser C, Rannug A, Stockinger B: The aryl hydrocarbon receptor and immunity. Trends Immunol 30 (9): 447-454, 2009.

Kadow S, Jux B, Chmill S, Esser C: Small molecules as fiends and foes of the immune system. Future Medicinal Chemistry 1 (9): 1583-1591, 2009.


Stutte S*, Jux B*, Esser C, Förster I: CD24a expression levels discriminate Langerhans cells from dermal dendritic cells in murine skin and lymph nodes. J Invest Dermatol 128 (6) 1470-1475, 2008.( * Equal contribution)

Frericks M, Burgoon L, Zacharewsky T, Esser C: Promoter analysis of TCDD-inducible genes in a thymic epithelial cell line indicates the potential for cell-specific transcription factor crosstalk in the AhR response. Tox Appl Pharmacol 232 (2) 268-279, 2008.

Frericks M, Esser C: A toolbox of novel murine housekeeping genes identified by meta-analysis of large scale gene expression profiles. BBA – Gene Regulatory Mechanisms 1779 (12): 830-837, 2008.


Rockel N, Esser C, Grether-Beck S, Warskulat U, Flögel U, Schwarz A, Schwarz T, Yarosh D, Häussinger D, Krutmann J: The osmolyte taurine protects against ultraviolet B radiation-induced immunosuppression. Journal of Immunology 179 (6): 3604-3612, 2007.

Frericks M., Meissner M, Esser C: Microarray analysis of the AHR system: tissue-specific flexibility in signal and target genes.  Tox Appl Pharmacol 220 (3): 320-332, 2007.

Krämer U, Illig T, Grune T, Krutmann J, Esser C: Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype.   Genes and Immunity 8 (6): 513-517, 2007.
Schwenk M, Sack U, Esser C, Klein R: Diagnostic relevance of the determination of lymphocyte subpopulations in environmental medicine. Int J Hyg Environ Health 210, 177-198, 2007. 


Krämer U, Esser C: Cigarette smoking, metabolic gene polymorphism, and psoriasis. J Invest Dermatol 126 (3): 693-694, 2006.

Frericks M, Temchura VV, Majora M, Stutte S, Esser C: Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice.  Biol Chem 387 (9): 1219-1226, 2006.

Bernshausen T, Jux B, Esser C, Abel J, Fritsche E: Tissue distribution and function of the Aryl Hydrocarbon Receptor Repressor (AhRR) in C57BL/6 and Aryl Hydrocarbon Receptor deficient mice. Archives of Toxicology 80(4): 206-211, 2006.

Valet G, Esser C: Data sieving analysis as a novel method to asses immunotoxic exposure to dioxins retrospectively. Int Immunopharmacol 6 (8): 1374-1375, 2006.

Esser C: The arylhydrocarbon receptor: more than a tox story (Guest-Editorial). Biol Chem 387(9): 1147, 2006.

Esser C: Immunotoxicology. In: Comprehensive Medicinal Chemistry II. J. Taylor and D. Triggie (eds.). Vol. 5: Adme-Tox Approaches. Elsevier Science, 2006, pp. 1-15.


Temchura VV, Frericks M, Nacken W, Esser C: Role of the aryl hydrocarbon receptor in thymocyte emigration in vivo. Eur. J. Immunol 35 (9): 2738-2747, 2005.

Esser C, Tomiuk J: Reporting Hardy-Weinberg tests in case-control studies: reasons for caution but not for panic reactions. J. Invest. Dermatol. 124: 1082-1083, 2005.

Esser C, Steinwachs S, Herder C, Majora M, Lai Z.-W: Effects of a single-dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin, given at post-puberty, in senescent mice. Toxicol. Letters 157 (2): 89-98, 2005.

Majora M, Frericks M, Temchura V, Esser C: Detection of a novel population of fetal thymocytes characterized by preferential emigration and a TCR-gamma-delta T cell fate after dioxin exposure. Int. Immunopharmacol. 5: 1659-1674, 2005.

Esser C: Dioxins and the Immune System. In: Encyclopedic Reference of Immunotoxicology. H-W Vohr (Ed.) - Berlin, Heidelberg: Springer, pp. 208-211, 2005.

Schade N, Esser C, Krutmann J: Ultraviolet B radiation-induced immunosuppression: molecular mechanism and cellular alterations. Photochem. Photobiol. Science 4: 699-708, 2005.