AG Fritsche - Publikationen

2022

Tanabe S, Beaton D, Chauhan V, Choi I, Danielsen PH, Delrue N, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant T, Garcia-Reyero N, Helm J, Huliganga E, Jacobsen N, Kay JE, Kim YJ, Klose J, La Rocca C, Luettich K, Mally A, O'Brien J, Poulsen SS, Rudel RA, Sovadinova I, Tollefsen KE, Vogel U, Yepiskoposyan H, Yauk C: Report of the 1st and 2nd Mystery of Reactive Oxygen Species conferences. ALTEX 39(2): 336-338, 2022. doi: 10.14573/altex.2203011

Koch K, Bartmann K, Hartmann J, Kapr J, Klose J, Kuchovská E, Pahl M, Schlüppmann K, Zühr E, Fritsche E: Scientific validation of human neurosphere assays for developmental neurotoxicity evaluation. Front Toxicol 4: 816370, 2022. doi: 10.3389/ftox.2022.816370

Crofton KM, Bassan A, Behl M, Chushak YG, Fritsche E, Gearhart JM, Marty MS, Mumtaz M, Pavan M, Ruiz P, Sachana M, Selvam R, Shafer TJ, Stavitskaya L, Szabo DT, Szabo ST, Tice RR, Wilson D, Woolley D, Myatt GJ: Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches. Comput Toxicol 22: 100223, 2022. doi: 10.1016/j.comtox.2022.100223

Galanjuk S, Zühr E, Dönmez A, Bartsch D, Kurian L, Tigges J, Fritsche E: The human induced pluripotent stem cell test as an alternative method for embryotoxicity testing. Int J Mol Sci 23(6): 3295, 2022. doi: 10.3390/ijms23063295

Westerink RHS, Shafer TJ, Fritsche E, van Thriel C: Translational neurotoxicology - The 17th biennial meeting of the International Neurotoxicology Association. Neurotoxicology 90: 79-80, 2022. doi: 10.1016/j.neuro.2022.02.010

2021

Tigges J, Schikowski T, Fritsche E: Environmental exposures impact the nervous system in a life stage-specific manner. Neuroforum 27(4): 201-212, 2021. doi: 10.1515/nf-2021-0021

Förster N, Butke J, Keßel HE, Bendt F, Pahl M, Li L, Fan X, Leung PC, Klose J, Masjosthusmann S, Fritsche E, Mosig A: Reliable Identification and Quantification of Neural Cells in Microscopic Images of Neurospheres. Cytometry A, 2021. doi: 10.1002/cyto.a.24514

Vinken M, Benfenati E, Busquet F, Castell J, Clevert DA, de Kok TM, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C, Piersma AH: Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology 458: 152846, 2021. doi: 10.1016/j.tox.2021.152846

Kapr J, Petersilie L, Distler T, Lauria I, Bendt F, Sauter CM, Boccaccini AR, Rose CR, Fritsche E: Human induced pluripotent stem cell-derived neural progenitor cells produce distinct neural 3D in vitro models depending on alginate/gellan gum/laminin hydrogel blend properties. Adv Healthc Mater 10(16): e2100131, 2021. doi: 10.1002/adhm.202100131

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer A-K, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl L-C, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery Cell Biol Toxicol 2021. doi: 10.1007/s10565-021-09603-2

Tigges J, Bielec K, Brockerhoff G, Hildebrandt B, Hübenthal U, Kapr J, Koch K, Teichweyde N, Wieczorek D, Rossi A, Fritsche E: Academic application of Good Cell Culture Practice for induced pluripotent stem cells. ALTEX 38(4): 595-614, 2021. doi: 10.14573/altex.2101221

Neuhaus W*: Consensus statement from the European Network of 3R centres (EU3Rnet). ALTEX 38(1): 138-139, 2021. doi: 10.14573/altex.2010061 *Neuhaus has submitted the Consensus Statement on behalf of all participating centres, institutes and societies of EU3Rnet

Distler T, Lauria I, Detsch R, Sauter CM, Bendt F, Kapr J, Rütten S, Boccaccini AR, Fritsche E: Neuronal differentiation from induced pluripotent stem cell-derived neurospheres by the application of oxidized alginate-gelatin-laminin hydrogels. Biomedicines 9(3): 261, 2021. doi: 10.3390/biomedicines9030261

Fritsche E, Haarmann-Stemmann T, Kapr J, Galanjuk S, Hartmann J, Mertens PR, Kämpfer AAM, Schins RPF, Tigges J, Koch K: Stem cells for next level toxicity testing in the 21st century. Small 17(15): e2006252, 2021. doi: 10.1002/smll.202006252

Barenys M, Illa M, Hofrichter M, Loreiro C, Pla L, Klose J, Kühne BA, Gómez-Catalán J, Braun JM, Crispi F, Gratacós E, Fritsche E: Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction. Stem Cells Transl Med 10(2): 209-221, 2021. doi: 10.1002/sctm.20-0223

Strom A, Strassburger K, Schmuck M, Shevalye H, Davidson E, Zivehe F, Bönhof G, Reimer R, Belgardt BF, Fleming T, Biermann B, Burkart V, Müssig K, Szendroedi J, Yorek MA, Fritsche E, Nawroth PP, Roden M, Ziegler D; GDS Group: Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models. Mol Metab 43: 101114, 2021. doi: 10.1016/j.molmet.2020.101114

Klose J, Tigges J, Masjosthusmann S, Schmuck K, Bend F, Hübenthal U, Petzsch P, Köhrer K, Koch K, Fritsche E: TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs. ALTEX 38(2): 215-234, 2021. doi: 10.14573/altex.2007201

2020

Fritsche E, Tigges J, Hartmann J, Kapr J, Serafini MM, Viviani B: Neural in vitro models for studying substances acting on the central nervous system. Handb Exp Pharmacol 2020. doi: 10.1007/164_367

Vargas-Toscano A, Nickel A-C, Li G, Kamp MA, Muhammad S, Leprivier G, Fritsche E, Barker RA, Sabel M, Steiger HJ, Zhang W, Hänggi D, Kahlert UD: Rapalink-1 targets glioblastoma stem cells and acts synergistically with tumor treating fields to reduce resistance against temozolomide. Cancers 12(12): 3859, 2020. doi: 10.3390/cancers12123859

Fischer I, Nickel A-C, Qin N, Taban K, Pauck D, Steiger H-J, Kamp M, Muhammad S, Hänggi D, Fritsche E, Remke M, Kahlert UD: Different calculation strategies are congruent in determining chemotherapy resistance of brain tumors in vitro. Cells 9(12): 2689, 2020. doi: 10.3390/cells9122689

Tsiampali J, Neumann S, Giesen B, Koch K, Maciaczyk D, Janiak C, Hänggi D, Maciaczyk J: Enzymatic activity of CD73 modulates invasion of gliomas via epithelial-mesenchymal transition-like reprogramming. Pharmaceuticals 13(11): 378, 2020. doi: 10.3390/ph13110378

Masjosthusmann S, Blum J, Bartmann K, Dolde X, Holzer A-K, Stürzl L-C, Keßel EH, Förster N, Dönmez A, Klose J, Pahl M, Waldmann T, Bendt F, Kisitu J, Suciu I, Hübenthal U, Mosig A, Leist M, Fritsche E: Establishment of an priori protocol for the implementation and interpretatiom of an in-vitro testing battery for the assessment of developmental neurotoxicity. EFSA Supporting Publications 17(10): 1938E, 2020. doi: 10.2903/sp.efsa.2020.EN-1938

Kolling J, Tigges J, Hellack B, Albrecht C, Schins RP: Evaluation of the NLRP3 inflammasome activating effects of a large panel of TiO2 nanomaterials in macrophages. Nanomaterials 10(9): 1876, 2020. doi: 10.3390/nano10091876

Fritsche E, Hogberg HT: A Brainer on Neurotoxicity. Frontiers in Toxicol 2: 3, 2020. doi: 10.3389/ftox.2020.00003

Lupu D, Andersson P, Bornehag CG, Demeneix B, Fritsche E, Gennings C, Lichtensteiger W, Leist M, Leonards PEG, Ponsonby AL, Scholze M, Testa G, Tresguerres JAF, Westerink RHS, Zalc B, Rüegg J: The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity. Int J Mol Sci 21: 3978, 2020. doi: 10.3390/ijms21113978

Nimtz L, Hartmann J, Tigges J, Masjosthusmann S, Schmuck M, Keßel E, Theiss S, Köhrer K, Petzsch P, Adjaye J, Wigmann C, Wieczorek D, Hildebrandt B, Bendt F, Hübenthal U, Brockerhoff G, Fritsche E: Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation. Stem Cell Res 45: 101761, 2020. doi: 10.1016/j.scr.2020.101761

Barenys M, Reverte I, Masjosthusmann S, Gómez-Catalán J, Fritsche E: Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway. Neurotoxicology 78: 209-241, 2020. doi: 10.1016/j.neuro.2019.12.007

Uhlmann C, Kuhn LM, Tigges J, Fritsche E, Kahlert DU: Efficient modulation of TP53 expression in human induced pluripotent stem cells. Curr Protoc Stem Cell Biol 52(1): e102, 2020. doi: 10.1002/cpsc.102

2019

Krebs A, … , Fritsche E, …, Leist M: Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data. ALTEX 36(4): 682-699, 2019. doi: 10.14573/altex.1909271s

Walter KM*, Dach K*, Hayakawa K*, Giersiefer S, Heuer H, Lein PJ^#, Fritsche E^#: Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Plos One 14(9): e0221230, 2019. doi: 10.1371/journal.pone.0221230

Solecki R, Rauch M, Gall A, Buschmann J, Kellner R, Kucheryavenko O, Schmitt A, Delrue N, Li W, Hu J, Fujiwara M, Kuwagata M, Mantovani A, Makris SL, Paumgartten F, Schönfelder G, Schneider S, Vogl S, Kleinstreuer N, Schneider M, Schulze F, Fritsche E, Clark R, Shiota K, Chahoud I: Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol 89: 124-129, 2019. doi: 10.1016/j.reprotox.2019.07.003

Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H, Wang CC: Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines. Reprod Toxicol 89: 45-53, 2019. doi: 10.1016/j.reprotox.2019.06.001

Masjosthusmann S, Siebert C, Hübenthal U, Bendt F, Baumann J, Fritsche E: Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense. Chemosphere 235: 447-456, 2019. doi: 10.1016/j.chemosphere.2019.06.123

Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M: Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake. Sci Rep 9(1): 2913, 2019. doi: 10.1038/s41598-019-39770-6

Kühne BA, Puig T, Ruiz-Martínez S, Crous-Masó J, Planas M, Feliu L, Cano A, Garcia ML, Fritsche E, Llobet JM, Gómez-Catalán J, Barenys M: Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres. Food Chem Toxicol 123: 195-204, 2019. doi: 10.1016/j.fct.2018.10.055

Ali AAH, Schwarz-Herzke B, Mir S, Sahlender B, Victor M, Görg B, Schmuck M, Dach K, Fritsche E, Kremer A, von Gall C: Deficiency of the clock gene Bmal1 affects neural progenitor cell migration. Brain Struct Funct 224(1): 373-386, 2019. doi: 10.1007/s00429-018-1775-1

2018

Barenys M, Fritsche E: A historical perspective on the use of stem/progenitor cell-based in vitro methods for neurodevelopmental toxicity testing. Toxicol Sci 165(1): 10-13, 2018. doi: 10.1093/toxsci/kfy170

Fritsche E, Barenys M, Klose J, Masjosthusmann S, Nimtz L, Schmuck M, Wuttke S, Tigges J: Current availability of stem cell-based in vitro methods for developmental neurotoxicity (DNT) testing.Toxicol Sci 165(1): 21-30, 2018. doi: 10.1093/toxsci/kfy178

Fritsche E, Barenys M, Klose J, Masjosthusmann S, Nimtz L, Schmuck M, Wuttke S, Tigges J: Development of the concept for stem cell-based developmental neurotoxicity evaluation. Toxicol Sci 165(1): 14-20, 2018. doi: 10.1093/toxsci/kfy175

Bal-Price A, Fritsche E: Editorial: Developmental neurotoxicity. Toxicol Appl Pharmacol 354: 1-2, 2018. doi: 10.1016/j.taap.2018.07.016

Masjosthusmann S, Barenys M, El-gamal M, Geerts L, Gorreja A, Kühne B, Marchetti N, Tigges J, Witters H, Fritsche E: Literature review and appraisal on alternative neurotoxicity testing methods. EFSA Supporting Publications 2018. doi: 10.2903/sp.efsa.2018.EN-1410

Hellwig C, Barenys M, Baumann J, Gassmann K, Casanellas L, Kauer G, Fritsche E: Culture of human neurospheres in 3D scaffolds for developmental neurotoxicity testing. Toxicol In Vitro 52: 106-115, 2018. doi: 10.1016/j.tiv.2018.06.002

Masjosthusmann S, Becker D, Petzuch B, Klose J, Siebert C, Deenen R, Barenys M, Baumann J, Dach K, Tigges J, Hübenthal U, Köhrer K, Fritsche E: A transcriptome comparison of time-matched developing human, mouse and rat neural progenitor cells reveals human uniqueness. Toxicol Appl Pharmacol 354: 40-55, 2018. doi: 10.1016/j.taap.2018.05.009

Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M: Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX 35(3): 306-352, 2018. doi: 10.14573/altex.1712081

Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg H, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A: Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicol Appl Pharmacol 354: 3-6, 2018. doi: 10.1016/j.taap.2018.02.004

Baker N, Boobis A, Burgoon L, Carney E, Currie R, Fritsche E, Knudsen T, Laffont M, Piersma AH, Poole A, Schneider S, Daston G: Building a developmental toxicity ontology. Birth Defects Res Part B-Dev Reprod Toxicol 110(6): 502-518, 2018. doi: 10.1002/bdr2.1189

2017

Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E: Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Stem Cell Res 25: 72-82, 2017. doi: 10.1016/j.scr.2017.10.013

Fritsche E, Crofton KM, Hernandez AF, Hougaard Bennekou S, Leist M, Bal-Price A, Reaves E, Wilks MF, Terron A, Solecki R, Gourmelon A: OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes. ALTEX 34(2): 311-315, 2017. doi: 10.14573/altex.1701171

Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E: BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Sci Rep 7: 44861, 2017. doi: 10.1038/srep44861

Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ: Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. ALTEX 34(1): 49-74, 2017. doi: 10.14573/altex.1604201

Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer TC, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E: Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Arch Toxicol 91(2): 827-837, 2017. doi: 10.1007/s00204-016-1709-8

Schmuck MR, Temme T, Dach K, de Boer D, Barenys M, Bendt F, Mosig A, Fritsche E: Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro. Arch Toxicol 91(4): 2017-2028, 2017. doi: 10.1007/s00204-016-1852-2

Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek ME: Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology 59: 240–255, 2017. doi: 10.1016/j.neuro.2016.05.010

Barenys M, Masjosthusmann S, Fritsche E: Is Intake of flavonoid-based food supplements during pregnancy safe for the developing child? A literature review. Curr Drug Targets 18(2): 196-231, 2017. doi: 10.2174/1389450116666150804110049

2016

Benfenati E, Berggren E, Fritsche E, Hartung T, Slikker W, Spielmann S, Testai E, Tice RR, Tiramani M, Villenave R: Novel chemical hazard characterisation approaches. EFSA Journal 14(S1): s0506, 2016. doi: 10.2903/j.efsa.2016.s0506

Kalfalah F, Janke L, Schiavi A, Tigges J, Ix A, Ventura N, Boege F, Reinke H: Crosstalk of clock gene expression and autophagy in aging. Aging (Albany NY) 8(9): 1876-1895, 2016. doi: 10.18632/aging.101018

Lang A, Grether-Beck S, Singh M, Kuck F, Jacob S, Kefalas A, Altinoluk-Hambüchen S, Graffmann N, Schneider M, Lindecke A, Brenden H, Felsner I, Ezzahoini H, Marini A, Weinhold S, Vierkötter A, Tigges J, Schmidt S, Stühler K, Köhrer K, Uhrberg M, Haendeler J, Krutmann J, Piekorz RP: MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4. Aging (Albany NY) 8(3): 484-509, 2016. doi: 10.18632/aging.100905

Baumann J, Gassmann K, Masjosthusmann S, DeBoer D, Bendt F, Giersiefer S, Fritsche E: Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events. Arch Toxicol 90(6): 1415-1427, 2016. doi: 10.1007/s00204-015-1568-8

Dittmann KH, Rothmund MC, Paasch A, Mayer C, Fehrenbacher B, Schaller M, Frauenstein K, Fritsche E, Haarmann-Stemmann T, Braeuning A, Rodemann HP: The nuclear aryl hydrocarbon receptor is involved in regulation of DNA-repair and cell survival following treatment with ionizing radiation. Toxicol Lett 240(1): 122-129, 2016. doi: 10.1016/j.toxlet.2015.10.017

Boix N, Teixido E, Vila-Cejudo M, Ortiz P, Ibanez E, Gomez-Catalan J, Llobet JM, Barenys M: Risk assessment for human embryonic development of triclabendazole residues in milk and cheese in the diet of a rural population in Cajamarca (Peru): A preliminary approach. In: Muñoz-Torrero D, Domínguez À, Manresa À (Hrsg.): Recent Advances in Pharmaceutical Sciences VI. Research Signpost, Indien, 2016. ISBN ebook 978-81-308-0566-5, S. 37-47.

2015

de Boer J, Fritsche E, Schoeters G, Kimber I: The European Long-range Research Initiative (LRI): A decade of contributions to human health protection, exposure modelling and environmental integrity. Toxicology 337: 83-90, 2015. [pubmed]

Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, Axelstad M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Monnet-Tschudi F, Wilks MF, Ylikomi T, Fritsche E: International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Arch Toxicol 89(2): 269-287, 2015. [pubmed] (open access)

Waldera Lupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, Götz-Rösch C, Bernerd F, Haag L, Huebenthal U, Fritsche E, Boege F, Grabe N, Tigges J, Stühler K*, Krutmann J*: Characterization of skin aging-associated secreted proteins (SAASP) produced by dermal fibroblasts isolated from intrinsically aged human skin. J Invest Dermatol 135(8): 1954-1968, 2015. (* equal contribution) [pubmed]

Frauenstein K*, Tigges J*, Soshilov AA, Kado S, Raab N, Fritsche E, Haendeler J, Denison MS, Vogel CFA, Haarmann-Stemmann T: Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2). Arch Toxicol 89(8): 1329-1336, 2015. (* equal contribution) [pubmed]

Boix N, Teixido E, Vila-Cejudo M, Ortiz P, Ibáñez E, Llobet JM, Barenys M: Triclabendazole Sulfoxide causes Stage-dependent Embryolethality in Zebrafish and Mouse in Vitro. Plos One 10(3): e0121308, 2015. [pubmed] (open access)

Khalfalah F, Seggewiß S, Walter R, Tigges J, Moreno-Villanueva M, Bürkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Boege F, Royer-Pokora B: Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old humans. Aging (Albany NY) 7(2): 110-122, 2015. [pubmed] (open access)

Röck K, Tigges J, Sass S, Schütze A, Florea AM, Fender AC, Theis FJ, Krutmann J, Boege F, Fritsche E, Reifenberger G, Fischer JW: miR-23a-3p causes cellular senescence by targeting hyaluronan synthase2: Possible implication for skin aging. J Invest Dermatol 135(2): 369-377, 2015. [pubmed]

Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, van Thriel C, Whelan M, Fritsche E: Putative Adverse Outcome Pathways (AOP) Relevant to Neurotoxicity. Crit Rev Toxicol 45(1): 83-91, 2015. [pubmed]

Fritsche E: The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity – a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging. In: Roberts SM, Kehrer JP, Klotz L-O (Hrsg.): Studies on Experimental Toxicology and Pharmacology. Humana Press, New York, 2015. ISBN 978-3-319-19095-2.

Fritsche E, Alm H, Baumann J, Geerts L, Håkansson H, Masjosthusmann S, Witters H: Literature Review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods. EFSA supporting publication: EN-778, 2015, 186 Seiten.

2014

Tigges J^*, Haarmann-Stemmann T^*, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J^*, Fritsche E*: The new arylhydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2): 556-559, 2014. (* equal contribution) [pubmed] (open access)

Gassmann K, Schreiber T, Dingemans MML, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman A, Westerink RHS, Rose CR, Fritsche E: BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Arch Toxicol 88: 1537-1548, 2014. [pubmed]

Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K: Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging (Albany NY). 6(10): 856-878, 2014. [pubmed]

Alépée N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX 31(4): 441-477, 2014. [pubmed]

Crofton K, Fritsche E, Ylikomi T, Bal-Price A: International STakeholder NETwork (ISTNET) for Creating a Developmental Neurotoxicity Testing (DNT) Roadmap for Regulatory Purposes. ALTEX 31(2): 223-224, 2014. [pubmed]

Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Körer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F: Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol 56: 59-68, 2014. [pubmed]

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F: The Hallmarks of Fibroblast Ageing. Mech Ageing Dev 138: 26-44, 2014. [pubmed]

Barenys M, Boix N, Farran-Codina A, Palma-Linares I, Roser M, Curto A, Gomez-Catalan J, Ortiz P, Deza N, Llobet JM: Heavy metal and metalloids intake risk assessment in the diet of a rural population living near a gold mine in the Peruvian Andes (Cajamarca). Food Chem Toxicol 71: 254-263, 2014. [pubmed]

Schmuck M, Temme T, Heinz S, Baksmeier C, Mosig A, Colomina MT, Barenys M, Fritsche E: Automatic counting and positioning of 5-bromo-2-deoxyuridine (BrdU) positive cells in cortical layers of rat brain slices. Neurotoxicology 43: 127-133, 2014. [pubmed]

Baumann J, Barenys M, Gassmann K, Fritsche E: Comparative human and rat "neurosphere assay" for developmental neurotoxicity testing. Curr Protoc Toxicol 59: 12.21.1-12.21.24, 2014. [pubmed]

Fritsche E: Human stem/progenitor cell-based assays for neurodevelopmental toxicity testing. In: In vitro toxicology systems. Bal-Price A, Jennings P (Eds.). Humana Press 2014, pp. 351-376.

2013

Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J*, Haarmann-Stemmann T*: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. (* equal contribution) [pubmed] (open access)

Tigges J*, Weighardt H*, Wolff S, Goetz C, Foerster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E: Arylhydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. J Invest Dermatol 133(1): 87-96, 2013. (*equal contribution) [pubmed] (open access)

Navid F, Bruhs A, Schuller W, Fritsche E, Krutmann J, Schwarz T, Schwarz A: The Aryl Hydrocarbon Receptor is Involved in UVR-Induced Immunosuppression. J Invest Dermatol 133(12): 2763-2770, 2013. [pubmed]

Hewitt NJ, Edwards R, Fritsche E, Goebel C, Aeby P, Scheel J, Reisinger K, Ouedraogo G, Duche D, Eilstein J, Latil A, Kenny J, Moore C, Kuehnl J, Barroso J, Fautz R, Pfuhler S: Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations. Toxicol Sci 133(2): 209-217, 2013. [pubmed]

Ono Y, Torii K, Fritsche E, Shintani Y, Nishida E, Nakamura M, Shirakata Y, Haarmann-Stemmann T, Abel J, Krutmann J, Morita A: Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression. Exp Dermatol 22(5): 349-353, 2013. [pubmed]

2012

Haarmann-Stemmann T, Abel J, Fritsche E, Krutmann J: The AhR-Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention? J Invest Dermatol 132 (1): 7-9, 2012. [pubmed]
Stolpmann K, Brinkmann J, Salzmann S, Genkinger D, Fritsche E, Hutzler C, Wajant H, Luch A, Henkler F: Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis. Cell Death & Disease 3:e388, 2012. [pubmed]

Röck K, Meusch M, Fuchs N, Tigges J, Zipper P, Fritsche E, Krutmann J, Homey B, Reifenberger J, Fischer JW: Estradiol protects the dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes. J Biol Chem 287(24): 20056-20069, 2012. [pubmed]

Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AEM, Kreysa J: Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation. Conference Report. ALTEX – Alternatives to Animal Experimentation 29(2): 202-215, 2012.

van Eijl S, Zhu Z, Cupitt J, Gierula M, Götz C, Fritsche E, Edwards RJ: Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling. PLoS One 7(7): e41721, 2012.

Götz C, Pfeiffer R, Tigges T, Ruwiedel K, Hübenthal U, Merk HF, Krutmann J, Edwards RJ, Abel J, Goebel C, Hewitt N, Fritsche E: Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes. Exp Dermatol 21(5): 364-369, 2012. [pubmed]

Goetz C, Pfeiffer R, Tigges T, Blatz V, Jäckh C, Freytag EM, Fabian E, Landsiedel R, Merk HF, Krutmann J, Edwards RJ, Pease C, Goebel C, Hewitt N, Fritsche E: Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (phase I). Exp Dermatol 21(5): 358-363, 2012. [pubmed]

Goetz C, Hewitt NJ, Jermann E, Tigges T, Kohne Z, Huebenthal U, Krutmann J, Merk HF,Fritsche E: Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models. Xenobiotica 42(6): 526-537, 2012. [pubmed]

Gassmann K, Baumann J, Giersiefer S, Schuwald J, Schreiber T, Merk HF, Fritsche E: Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications. Toxicology In Vitro 26(6): 993-1000, 2012. [pubmed]

2011

Tegenge MA, Rockel TD, Fritsche E*, Bicker G*: Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction. Cell Mol Life Sci 68(12): 2089-2099, 2011. (* corresponding authors) [pubmed]

Bothe H*, Gassmann K*, Götz C, Fritsche E, Abel J, Haarmann-Stemmann T: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. Toxicology Letters 203(3): 258-264, 2011. (*equal contribution) [pubmed]

Verner MA, Bouchard M, Fritsche E, Charbonneau M, Haddad S: In vitro neurotoxicity data in human risk assessment of polybrominated diphenyl ethers (PBDEs): Overview and perspectives. Toxicol In Vitro 25 (8): 1509-1515, 2011. [pubmed]

Fritsche E, Gassmann K, Schreiber T: Neurospheres as a model for developmental neurotoxicity testing. In: In Vitro Neurotoxicology: Methods and Protocols, Methods in Molecular Biology, vol. 758. Lucio G. Costa et al. (eds.), Springer Science+Business Media, LLC 2011, pp. 99-114. [pubmed]

2010

Gassmann K, Abel J, Bothe H, Haarmann-Stemmann T, Merk HF, Quasthoff KN, Rockel TD, Schreiber T, Fritsche E: Species-specific differential AhR-expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. Environ Health Perspect 118(11): 1571-1577, 2010.

Schreiber T, Gassmann K, Götz C, Hübenthal U, Moors M, Krause G, Merk HF, Crofton KM, Nguyen NH, Scanlan TS, Abel J, Rose CR, Fritsche E: Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: Evidence for endocrine disruption. Environ Health Perspect 118 (4): 572-578, 2010.

Moors M, Vudattu NK, Abel J, Krämer U, Rane L, Ulfig N, Ceccatelli S, Seyfert-Margolies V, Fritsche E, Maeurer MJ: Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells. Genes Immun 11 (1): 11-20, 2010.

Haarmann-Stemmann T, Sendker J, Götz C, Krug N, Bothe H, Fritsche E, Proksch P, Abel J: Regulation of human dioxin receptor function by different beta-carboline alkaloids. Archives of Toxicology 84 (8): 619-629, 2010.

Bothe H, Götz C, Stobbe-Maicherski N, Fritsche E, Abel J, Haarmann-Stemmann T: Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Archives of Biochemistry and Biophysics 498 (2): 111-118, 2010.

Breier JM, Gassmann K, Kayser R, Stegeman H, De Groot D, Fritsche E, Shafer TJ: Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: State of the science. Neurotoxicol Teratol 32 (1): 4-15, 2010.

2009

Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, Schuwald J, Weinmann N, Fritsche E: Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect 117 (7): 1131-1138, 2009.

2007

Fritsche E, Schäfer C, Calles C, Bernsmann T, Bernshausen T, Wurm M, Hübenthal U, Cline JE, Hajimiragha H, Schroeder P, Klotz LO, Rannug A, Fürst P, Hanenberg H, Abel J, Krutmann J: Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci 104 (21), 8851-8856, 2007.

Moors M, Cline JE, Abel J, Fritsche E: ERK-dependent and independent pathways trigger human neural progenitor cell migration. Tox Appl Pharmacol 221 (1): 57-67, 2007.

Haarmann-Stemmann T, Bothe H, Kohli A, Sydlik U, Abel J, Fritsche E: Analysis of the transcriptional regulation and molecular function of the Aryl Hydrocarbon Receptor Repressor in human cell lines. Drug Metab Dispos 35 (12): 2262-2269, 2007.

2006

Kalmes M, Neumeyer A, Fritsche E, Blömeke B: Impact of the Arylhydrocarbon Receptor on the eugenol and isoeugenol induced cell cycle arrest in human immortalized keratinocytes (HaCaT). Biol Chem 387(9): 1201-1207, 2006.

Bernshausen T, Jux B, Esser C, Abel J, Fritsche E: Tissue distribution and function of the Aryl Hydrocarbon Receptor Repressor (AhRR) in C57BL/6 and Aryl Hydrocarbon Receptor deficient mice. Archives of Toxicology 80(4): 206-211, 2006.

Merk HF, Baron JM, Heise R, Fritsche E, Schroeder P, Abel J, Krutmann J: Concepts in molecular dermatotoxicology. Exp Dermatol. 15(9): 692-704, 2006.

Rannug A, Fritsche E: The aryl hydrocarbon receptor and light. Biol. Chem. 387(9):1149-57, 2006.

IUF – Leibniz-Institut für umwelt-
medizinische Forschung GmbH
Auf'm Hennekamp 50
40225 Düsseldorf
Postfach 10 30 45
40021 Düsseldorf
Telefon: +49- (0)211-3389-0
Telefax: +49- (0)211-3190910