Aktuelle Publikationen

Originalarbeiten

Vogeley C, Nguyen T, Woeste S, Krutmann J, Haarmann-Stemmann T, Rossi A: Rapid and simple analysis of short and long sequencing reads using DuesselporeTM. Front Genet 13: 931996, 2022. doi: 10.3389/fgene.2022.931996

Dragano N, Reuter M, Peters A, Engels M, Schmidt B, Greiser KH, Bohn B, Riedel-Heller S, Karch A, Mikolajczyk R, Krause G, Lang O, Panreck L, Rietschel M, Brenner H, Fischer B, Franzke CW, Gastell S, Holleczek B, Jöckel KH, Kaaks R, Keil T, Kluttig A, Kuss O, Legath N, Leitzmann M, Lieb W, Meinke-Franze C, Michels KB, Obi N, Pischon T, Feinkohl I, Rospleszcz S, Schikowski T, Schulze MB, Stang A, Völzke H, Willich SN, Wirkner K, Zeeb H, Ahrens W, Berger K: Increase in mental disorders during the COVID-19 Pandemic-The role of occupational and financial strains. Dtsch Arztebl Int 119(11): 179-187, 2022. doi: 10.3238/arztebl.m2022.0133

Martínez-Fernández C, Bergamino M, Schiavi A, Brena D, Ventura N, Honnen S, Villanueva A, Nadal E, Cerón J: Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans. Dis Model Mech 15(3): dmm049161, 2022. doi: 10.1242/dmm.049161

Zhao T, Markevych I, Standl M, Lyu Z, Schikowski T, Berdel D, Koletzko S, von Berg A, Heinrich J: Ambient ozone exposure and bone turnover markers in children: Results from the GINIplus and LISA birth cohorts. Environ Res 214(Pt 1): 113784, 2022. doi: 10.1016/j.envres.2022.113784

Wei Q, Li Z, Gu Z, Liu X, Krutmann J, Wang, Xia J: Shotgun metagenomic sequencing reveals skin microbial variability from different facial sites. Front Microbiol 13: 933189, 2022. doi: 10.3389/fmicb.2022.933189

Busch M, Ramachandran H, Wahle T, Rossi A, Schins RPF: Investigating the role of the NLRP3 inflammasome pathway in acute intestinal inflammation: use of THP-1 knockout cell lines in an advanced triple culture model. Front Immunol 13: 898039, 2022. doi: 10.3389/fimmu.2022.898039

Plitta-Michalak B, Stricker N, Pavez Loriè E, Chen I, Pollet M, Krutmann J, Volkmer B, Greinert R, Boukamp P, Rapp A: Development and characterisation of an irradiation device for biomedical studies covering the solar spectrum with individual regulated spectral bands. Photochem Photobiol Sci, 2022. doi: 10.1007/s43630-022-00252-w

Kress S, Kilanowski A, Wigmann C, Zhao Q, Zhao T, Abramson MJ, Gappa M, Standl M, Unfried K, Schikowski T: Airway inflammation in adolescents and elderly women: Chronic air pollution exposure and polygenic susceptibility. Sci Total Environ 841: 156655, 2022. doi: 10.1016/j.scitotenv.2022.156655

Borror MB, Girotti M, Kar A, Cain MK, Gao X, MacKay VL, Herron B, Bhaskaran S, Becerra S, Novy N, Ventura N, Johnson TE, Kennedy BK, Rea SL: Inhibition of ATR reverses a mitochondrial respiratory insufficiency. Cells 11(11): 1731, 2022. doi: 10.3390/cells11111731

Kämpfer AAM, Shah UK, Chu SL, Busch M, Büttner V, He R, Rothen-Rutishauser B, Schins RPF, Jenkins GJ: Interlaboratory comparison of an intestinal triple culture to confirm transferability and reproducibility. In vitro models, 2022. doi: 10.1007/s44164-022-00025-w

Duteil L, Queille-Roussel C, Aladren S, Bustos X, Trullas C, Granger C, Krutmann J, Passeron T: Prevention of polymorphic light eruption afforded by a very high broad-spectrum protection sunscreen containing Ectoin. Dermatol Ther (Heidelb) 12(7):  1603-1613, 2022. doi: 10.1007/s13555-022-00755-5

Klose J, Li L, Pahl M, Bendt F, Hübenthal U, Jüngst C, Petzsch P, Schauss A, Köhrer K, Leung PC, Wang CC, Koch K, Tigges J, Fan X, Fritsche E: Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro. Cell Biol Toxicol, 2022. doi: 10.1007/s10565-022-09730-4

Nguyen T, Ramachandran H, Martins S, Krutmann J, Rossi A: Identification of genome edited cells using CRISPRnano. Nucleic Acids Res, 2022. doi: 10.1093/nar/gkac440

Larigot L, Bui LC, de Bouvier M, Pierre O, Pinon G, Fiocca J, Ozeir M, Tourette C, Ottolenghi C, Imbeaud S, Pontoizeau C, Blaise BJ, Chevallier A, Tomkiewicz C, Legrand B, Elena-Herrmann B, Néri C, Brinkmann V, Nioche P, Barouki R, Ventura N, Dairou J, Coumoul X: Identification of modulators of the C. elegans aryl hydrocarbon receptor and characterization of transcriptomic and metabolic AhR-1 profiles. Antioxidants (Basel) 11(5): 1030, 2022. doi: 10.3390/antiox11051030

Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, Raimundo N, Meyer JN, Distelmaier F, Ventura N: Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nat Commun 13(1): 2620, 2022. doi: 10.1038/s41467-022-29972-4

Uhlmann C, Nickel AC, Picard D, Rossi A, Li G, Hildebrandt B, Brockerhoff G, Bendt F, Hübenthal U, Hewera M, Steiger HJ, Wieczorek D, Perrakis A, Zhang W, Remke M, Koch K, Tigges J, Croner RS, Fritsche E, Kahlert UD: Progenitor cells derived from gene-engineered human induced pluripotent stem cells as synthetic cancer cell alternatives for in vitro pharmacology. Biotechnol J 17(6): e2100693, 2022. doi: 10.1002/biot.202100693

Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, Schiavi A, Steinwachs S, Esser C, Menzel R, Giani Tagliabue S, Bonati L, Cox F, Ale-Agha N, Jakobs P, Altschmied J, Haendeler J, Coumoul X, Ventura N: Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects. Antioxidants (Basel) 11(4): 613, 2022. doi: 10.3390/antiox11040613

Greimel E, Adams L, Zsigo C, Berdel D, von Berg A, Koletzko S, Bauer CP, Schikowski T, Herberth G, Heinrich J, Schulte-Körne G, Standl M: Psychopathological symptoms as precursors of depressive symptoms in adolescence: a prospective analysis of the GINIplus and LISA birth cohort studies. Soc Psychiatry Psychiatr Epidemiol 2022. doi: 10.1007/s00127-022-02267-1

Lau M, Wigmann C, Kress S, Schikowski T, Schwender H: Evaluation of tree-based statistical learning methods for constructing genetic risk scores. BMC Bioinformatics 23(1): 97, 2022. doi: 10.1186/s12859-022-04634-w

Koch K, Bartmann K, Hartmann J, Kapr J, Klose J, Kuchovská E, Pahl M, Schlüppmann K, Zühr E, Fritsche E: Scientific validation of human neurosphere assays for developmental neurotoxicity evaluation. Front Toxicol  4: 816370, 2022. doi: 10.3389/ftox.2022.816370

Martins S, Erichsen L, Datsi A, Wruck W, Goering W, Chatzantonaki E, de Amorim VCM, Rossi A, Chrzanowska KH, Adjaye J: Impaired p53-mediated DNA damage response contributes to microcephaly in Nijmegen Breakage Syndrome patient-derived cerebral organoids. Cells 11(5): 802, 2022. doi: 10.3390/cells11050802

Marb A, Libuda L, Standl M, Koletzko S, Bauer CP, Schikowski T, Berdel D, von Berg A, Herberth G, Bühlmeier J, Harris CP: Obesogenic eating behaviour and dietary intake in German children and adolescents: results from the GINIplus and LISA birth cohort studies. Eur J Clin Nutr 2022. doi: 10.1038/s41430-022-01125-2

Galanjuk S, Zühr E, Dönmez A, Bartsch D, Kurian L, Tigges J, Fritsche E: The human induced pluripotent stem cell test as an alternative method for embryotoxicity testing. Int J Mol Sci 23(6): 3295, 2022. doi: 10.3390/ijms23063295

Sofranko A, Wahle T, Kolling J, Heusinkveld HJ, Stahlmecke B, Rosenbruch M, Albrecht C, Schins RPF: Effects of subchronic dietary exposure to the engineered nanomaterials SiO2 and CeO2 in C57BL/6J and 5xFAD Alzheimer model mice. Part Fibre Toxicol 19(1): 23, 2022. doi: 10.1186/s12989-022-00461-2

Elberskirch L, Sofranko A, Liebing J, Riefler N, Binder K, Bonatto Minella C, Razum M, Mädler L, Unfried K, Schins RPF, Kraegeloh A, van Thriel C: How structured meta data acquisition contributes to reproducibility of nanosafety studies: Evaluation by a Round-Robin Test. Nanomaterials 12(7): 1053, 2022. doi: 10.3390/nano12071053

Fueldner C, Riemschneider S, Haupt J, Jungnickel H, Schulze F, Zoldan K, Esser C, Hauschildt S, Knauer J, Luch A, Kalkhof S, Lehmann J: Aryl Hydrocarbon Receptor activation by benzo[a]pyrene prevents development of septic shock and fatal outcome in a mouse model of systemic Salmonella enterica infection. Cells 11(4): 737, 2022. doi: 10.3390/cells11040737

Liu W, Jie L, Liu D, Makino ET, Krutmann J, Mehta RC: Protective effects of a day/night dual-antioxidant serum on skin: a randomized, regimen-controlled study in Chinese women exposed to air pollution. J Cosmet Dermatol, 2022. doi: 10.1111/jocd.14839

Neves JR, Grether-Beck S, Krutmann J, Correia P, Gonçalves Junior JE, Sant'Anna B, Kerob D: Efficacy of a topical serum containing l-ascorbic acid, neohesperidin, pycnogenol, tocopherol and hyaluronic acid in relation to skin aging signs. J Cosmet Dermatol, 2022. doi: 10.1111/jocd.14837

Ishihara Y, Kado SY, Bein KJ, He Y, Pouraryan AA, Urban A, Haarmann-Stemmann T, Sweeney C and Vogel CFA: Aryl hydrocarbon receptor signaling synergizes with TLR/NF-κB-signaling for induction of IL-22 through canonical and non-canonical AhR pathways. Front Toxicol 3: 787360, 2022. doi: 10.3389/ftox.2021.787360

Tham M, Stark H-J, Jauch A, Harwood C, Pavez Lorie E, Boukamp P: Adverse effects of Vemurafenib on skin integrity: Hyperkeratosis and skin cancer initiation due to altered MEK/ERK-signaling and MMP activity. Front Oncol 12: 827985, 2022. doi: 10.3389/fonc.2022.827985

Hering I, Le DT, von Mikecz A: How to keep up with the analysis of classic and emerging neurotoxins: Age-resolved fitness tests in the animal model Caenorhabditis elegans: a step-by-step protocol. EXCLI J 21: 344-353, 2022. doi: 10.17179/excli2021-4626

Markevych I, Astell-Burt T, Altug H, Triebner K, Standl M, Flexeder C, Heinrich J, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Feng X: Residential green space and age at menarche in German and Australian adolescent girls: A longitudinal study. Int J Hyg Environ Health 240: 113917, 2022. doi: 10.1016/j.ijheh.2021.113917

Fehsel K, Schwanke K, Kappel BA, Fahimi E, Meisenzahl-Lechner E, Esser C, Hemmrich K, Haarmann-Stemmann T, Kojda G, Lange-Asschenfeldt C: Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction. J Psychopharmacol 36(2): 191-201, 2022. doi: 10.1177/02698811211055811

Übersichtsarbeiten, Buchbeiträge u.a.

Tanabe S, O'Brien J, Tollefsen KE, Kim Y, Chauhan V, Yauk C, Huliganga E, Rudel RA, Kay JE, Helm JS, Beaton D, Filipovska J, Sovadinova I, Garcia-Reyero N, Mally A, Poulsen SS, Delrue N, Fritsche E, Luettich K, La Rocca C, Yepiskoposyan H, Klose J, Danielsen PH, Esterhuizen M, Jacobsen NR, Vogel U, Gant TW, Choi I, FitzGerald R: Reactive oxygen species in the adverse outcome pathway framework: Toward creation of harmonized consensus key events. Front Toxicol 4: 887135, 2022. doi: 10.3389/ftox.2022.887135

Schröter L, Ventura N: Nanoplastic toxicity: Insights and challenges from experimental model systems. Small e2201680, 2022. doi: 10.1002/smll.202201680

Scarcello E, Sofranko A, Wahle T, Schins RP: Neurotoxicity of engineered nanomaterials: testing considerations. Front Public Health 10: 904544, 2022. doi: 10.3389/fpubh.2022.904544

Yusuf N, Haarmann-Stemmann T, Nakamura M: Editorial: Environment and skin cancer. Front Oncol 12: 924225, 2022. doi: 10.3389/fonc.2022.924225

Neuhaus W, ..., Fritsche E, Tigges J, ..., Spielmann H: The rise of three Rs centres and platforms in Europe. Altern Lab Anim 50(2): 90-120, 2022. doi: 10.1177/02611929221099165

Tanabe S, Beaton D, Chauhan V, Choi I, Danielsen PH, Delrue N, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant T, Garcia-Reyero N, Helm J, Huliganga E, Jacobsen N, Kay JE, Kim YJ, Klose J, La Rocca C, Luettich K, Mally A, O'Brien J, Poulsen SS, Rudel RA, Sovadinova I, Tollefsen KE, Vogel U, Yepiskoposyan H, Yauk C: Report of the 1st and 2nd Mystery of Reactive Oxygen Species conferences. ALTEX 39(2): 336-338, 2022. doi: 10.14573/altex.2203011

Crofton KM, Bassan A, Behl M, Chushak YG, Fritsche E, Gearhart JM, Marty MS, Mumtaz M, Pavan M, Ruiz P, Sachana M, Selvam R, Shafer TJ, Stavitskaya L, Szabo DT, Szabo ST, Tice RR, Wilson D, Woolley D, Myatt GJ: Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches. Comput Toxicol 22: 100223, 2022. doi: 10.1016/j.comtox.2022.100223

Doak SH, Clift MJD, Costa A, Delmaar C, Gosens I, Halappanavar S, Kelly S, Pejinenburg WJGM, Rothen-Rutishauser B, Schins RPF, Stone V, Tran L, Vijver MG, Vogel U, Wohlleben W, Cassee FR: The road to achieving the European Commission's chemicals strategy for nanomaterial sustainability-A PATROLS perspective on new approach methodologies. Small 18(17): e2200231, 2022. doi: 10.1002/smll.202200231

Surber C, Krutmann J: Sonnenschutz: Wichtiger denn je! [Sun protection measures: more important than ever!]. Hautarzt 73(4): 249-250, 2022. doi: 10.1007/s00105-022-04964-z

Wolf P, Krutmann J: Sonnenschutz der Zukunft: Herausforderungen und Möglichkeiten [Sunscreens of the future: challenges and opportunities]. Hautarzt 73(4): 257-265, 2022. doi: 10.1007/s00105-022-04959-w

Rossi A, Lickfett S, Martins S, Prigione A: A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells. Stem Cell Rep 17(4): 707-710, 2022. doi: 10.1016/j.stemcr.2022.01.019

Westerink RHS, Shafer TJ, Fritsche E, van Thriel C: Translational neurotoxicology - The 17th biennial meeting of the International Neurotoxicology Association. Neurotoxicology 90: 79-80, 2022. doi: 10.1016/j.neuro.2022.02.010

Vogeley C, Rolfes KM, Krutmann J, Haarmann-Stemmann T: The Aryl Hydrocarbon Receptor in the pathogenesis of environmentally-induced squamous cell carcinomas of the skin. Front Oncol 12: 841721, 2022. doi: 10.3389/fonc.2022.841721

Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, Murphy MP, Yamamoto M, Winterbourn C: Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat Rev Mol Cell Biol 23(7): 499-515, 2022. doi: 10.1038/s41580-022-00456-z

von Mikecz A, Scharf A: Pollution - bring the field into the lab. Nature 602(7897): 386, 2022. doi: 10.1038/d41586-022-00444-5

Elberskirch L, Binder K, Riefler N, Sofranko A, Liebing J, Bonatto Minella C, Mädler L, Razum M, van Thriel C, Unfried K, Schins RPF, Kraegeloh A: Digital research data: from analysis of existing standards to a scientific foundation for a modular metadata schema in Nanosafety. Part Fibre Toxicol 19: 1, 2022. doi: 10.1186/s12989-021-00442-x

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