The research group “Alternative method development for environmental toxicity testing” is offering a position for a
for a Master Thesis with the title:
Establishment of a machine readable database of thyroid effects observed in in vivo studies of pesticides for the establishment of read across.
The identification of endocrine disruptors as possible threats to humans and the environment is an important and relevant European goal. One speaks of an endocrine disruptor if adverse effects (according to the adverse outcome pathways (AOPs)) can be plausibly associated with endocrine activity. The thyroid hormones and possible effects that result from hormone disruption are a relevant part of this assessment. Thyroid hormones play an important role in many physiological processes in humans and animals, such as temperature control and control of energy metabolism. In addition, the thyroid hormones play a central role in development and influence, for example, growth and neural and cognitive development. Chemicals can interfere with thyroid hormone homeostasis through a variety of mechanisms, but for many chemicals and most thyroid MIEs (molecular initiating events), there is a lack of sufficient data on KEs (key events) and KERs (key event relationships) and AOs (adverse outcomes) to assess a possible effect on thyroid hormone regulation. Corresponding experimental investigations, both with regard to adverse effects and with regard to possible endocrine activity and the relevant KEs, are resource-intensive. Therefore, attempts are increasingly being made to digitally compile and analyze the existing database for chemical structures and biological effects cumulatively and to analyze structural relationships in the sense of prioritized resource use to recognize connections. The aim of the thesis it to digitize the publicly available information on in vivo effects of plant protection products in such a way that they are machine-readable and either easy to use in read-across or can actually be incorporated into (Q) SAR models. To achieve this, it is necessary to identify the observed adverse effects with underlying information on the MIE and KEs of one or more possible AOPs. An analysis of the processed data with regard to identifiable differences or similarities related to observed effects, affected species, affected sexes, evidence on the underlying mechanism and connections with the chemical structures would be a further focus of the work.
Our working group is looking for a motivated employee (f/m/d) with a high level of commitment, fun at work, motivation, communication skills and team spirit. The applicant (f/m/d) should have a completed bachelor’s degree in life sciences and additional (master) training in the field of toxicology or pharmacology. A high affinity to computer-based working is necessary. Good knowledge of English and experience with different database software are desirable.
We are an interdisciplinary, international team with a pleasant working atmosphere. We offer thorough training in a highly topical, challenging area of research. The project takes place in a team with other scientists, in part from industry, with whom there will be an intensive exchange of content on project-relevant results.
As early as possible.
Please address your application (incl. a short cover letter, your complete CV as one single PDF file) to:
Prof. Dr. Ellen Fritsche
IUF – Leibniz-Institut für umweltmedizinische Forschung
Auf’m Hennekamp 50
Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.