Aging processes of the respiratory system are often induced by inhaled airborne pollutants. Degenerative processes like cellular senescence and organ aging can be triggered through the interaction of particles with cells of both organ systems or indirectly through the induction of inflammation processes. These processes are investigated experimentally in vivo and in vitro as well as epidemiologically. Intervention studies on humans allow to elucidate connections between exposure and aging processes and to develop molecular preventive strategies for humans.
The following working groups contribute to research field 1: