Haarmann-Stemmann Archive

Wajda A, Ejma-Multański A, Himida D, Stypińska B, Filipowicz G, Rossi A, Hacheney I, Haarmann-Stemmann T, Paradowska-Gorycka A, Esser C: Evidence for a fibrogenic interaction between the aryl hydrocarbon receptor and the Wnt/β-catenin pathways in human keratinocytes and fibroblasts. Cell Physiol Biochem 60(1): 44-62, 2026. doi: 10.33594/000000846

Krutmann J, Merk HF, Haarmann-Stemmann T: Umweltdermatologie. Dermatologie (Heidelb) 77(2): 71-72, 2026. doi: 10.1007/s00105-025-05629-3

Coumoul X, Barouki R, Esser C, Haarmann-Stemmann T, Lawrence BP, Lehmann J, Moura-Alves P, Murray IA, Opitz CA, Perdew GH, Bourguet W: The aryl hydrocarbon receptor: structure, signaling, physiology and pathology. Signal Transduct Target Ther 11(1): 20, 2026. doi: 10.1038/s41392-025-02500-8

Li X, Rossi A, Haarmann-Stemmann T, Spindel ER, Connolly JC, Ehrlich AK, Pinkerton KE, Vogel CFA: Vitamin E acetate and its aerosol activate aryl hydrocarbon receptor signaling and exacerbate inflammation in human U937-derived macrophages. Toxicol In Vitro 112: 106196, 2026. doi: 10.1016/j.tiv.2026.106196

Esser C, Haarmann-Stemmann T: Per- und Polyfluoralkylsubstanzen – die „Ewigkeitschemikalien“ und Haut. Dermatologie (Heidelb) 77(2): 108-113, 2026 (online 2025). doi: 10.1007/s00105-025-05615-9

Rolfes KM, Haarmann-Stemmann T, Krutmann J: Auswirkungen partikulärer Luftverschmutzung auf die menschliche Haut. Dermatologie (Heidelb) 77(2): 73-79, 2026 (online 2025). doi: 10.1007/s00105-025-05617-7

Rolfes MK, Singh N, Haarmann-Stemmann T, Krutmann J: The toxin of the year: Airborne PM_2.5. Dermatitis, 2026. doi: 10.1177/17103568251385571

Haarmann-Stemmann T, Esser C: “Forever Chemicals” – Cutaneous exposure to per- and polyfluoroalkyl substances (PFAS): Cause for concern? J Invest Dermatol 145(8): 1846-1849, 2025. doi: 10.1016/j.jid.2025.03.030

Nadal Rodríguez P, Hartung F, Pedrola M, Coomar S, Diaz-Moreno A, Hätälä AM, Rolfes KM, Sánchez-Vera I, Gil J, Molins E, Viayna A, Hanzl A, Thomä NH, Haarmann-Stemmann T^#, Luque FJ^#, Lavilla R^#, Ghashghaei O^#: A multicomponent reaction-based platform opens new avenues in aryl hydrocarbon receptor modulation. ACS Cent Sci 11(4): 629-641, 2025. doi: 10.1021/acscentsci.5c00194 (*equal contribution)

Nadal Rodríguez P*, Hartung F*, Pedrola M, Coomar S, Diaz-Moreno A, Hätälä AM, Rolfes KM, Sánchez-Vera I, Gil J, Mol...

Hartung F, Krutmann J, Haarmann-Stemmann T: Evidence that the aryl hydrocarbon receptor orchestrates oxinflammatory responses and contributes to airborne particulate matter-induced skin aging. Free Radic Biol Med 233: 264-278, 2025. doi: 10.1016/j.freeradbiomed.2025.03.040

Haarmann-Stemmann T, Reichert D, Coumoul X, Lawrence BP, Perdew GH, Sherr DH, Weighardt H, Rolfes KM, Esser C: The Janus-facedness of the aryl hydrocarbon receptor pathway Report of the 6th International AHR Meeting: Research, Prevention, Therapy. Biochem Pharmacol 234: 116808, 2025. doi: 10.1016/j.bcp.2025.116808

Eberle OF, Hartung F, Benndorf P, Haarmann-Stemmann T: Skin sensitizers enhance superoxide formation by polycyclic aromatic hydrocarbons via the aldo-keto reductase pathway. Free Radic Biol Med 230: 50-57, 2025. doi: 10.1016/j.freeradbiomed.2025.02.005

Sondermann NC, Vogel CFA, Haarmann-Stemmann T: Dioxins do not only bind to AHR but also team up with EGFR at the cell-surface: A novel mode of action of toxicological relevance? EXCLI Journal 24: 184–197, 2025. doi: 10.17179/excli2024-8038

Sondermann NC, Momin AA, Arold ST, Haarmann-Stemmann T: Polybrominated diphenyl ether flame retardants inhibit growth factor-induced activation of EGFR by binding to its extracellular domain. Arch Toxicol 99(2):745-753, 2024. doi: 10.1007/s00204-024-03926-9

Sondermann NC, Momin AA, Arold ST, Haarmann-Stemmann T: Benzotriazole UV stabilizers disrupt epidermal growth factor receptor signaling in human cells. Environ Int 190: 108886, 2024. doi: 10.1016/j.envint.2024.108886

Haarmann-Stemmann T: The aryl hydrocarbon receptor in environmentally induced cancers. Biochem Pharmacol 225:116304, 2024. doi: 10.1016/j.bcp.2024.116304

Binder S, Ramachandran H, Haslinger D, Hildebrandt B, Dobner J, Haarmann-Stemmann T, Chiocchetti A, Rossi A: CRISPR/Cas9-mediated editing of ACTB in induced pluripotent stem cells: A model for investigating human ACTB loss-of-function and genetic adaptive responses. Stem Cell Res 77:103395, 2024. doi: 10.1016/j.scr.2024.103395

Vogel CFA, Haarmann-Stemmann T: The aryl hydrocarbon receptor as an environmental sensor and mediator of stress and inflammation. In: Giuseppe Valacchi and Andreas Daiber (eds). Environmental Stressors and OxInflammatory tissue responses. CRC Press, Boca Raton, FL, USA, eBook ISBN: 9781003328100, 2023. doi: 10.1201/9781003328100

Vogel CFA, Haarmann-Stemmann T: The aryl hydrocarbon receptor as an environmental sensor and mediator of stress and ...

Kado SY, Bein K, Castaneda AR, Pouraryan AA, Garrity N, Ishihara Y, Rossi A, Haarmann-Stemmann T, Sweeney C, Vogel CFA: Regulation of IDO2 by the aryl hydrocarbon receptor (AhR) in breast cancer. Cells 12(10): 1433, 2023. doi: 10.3390/cells12101433

Ondrová K, Zůvalová I, Vyhlídalová B, Krasulová K, Miková E, Vrzal R, Nádvorník P, Nepal B, Kortagere S, Kopečná M, Kopečný D, Šebela M, Rastinejad F, Pu H, Soural M, Rolfes KM, Haarmann-Stemmann T, Li H, Mani S, Dvořák Z: Monoterpenoid aryl hydrocarbon receptor allosteric antagonists protect against ultraviolet skin damage in female mice. Nat Commun 14(1): 2728, 2023. doi: 10.1038/s41467-023-38478-6

Nojiri Y, Nakamura M, Magara T, Yamamoto A, Ikumi K, Nakamura R, Nishida E, Haarmann-Stemmann T, Morita A: Influence of aldo-keto reductase 1C3 polymorphisms in early-onset female psoriasis patients. Sci Rep 13(1): 3280, 2023. doi: 10.1038/s41598-023-30464-8

Vogeley C, Kress S, Lang D, Vogel CFA, Hartung F, Brenden H, Nakamura M, Grether-Beck S, Rossi A, Krutmann J, Schikowski T, Haarmann-Stemmann T: A gene variant of AKR1C3 contributes to interindividual susceptibilities to atopic dermatitis triggered by particulate air pollution. Allergy 78(5): 1372-1375, 2023 (online 2022). doi: 10.1111/all.15622 (*equal contribution)

Sondermann NC, Faßbender S, Hartung F, Hätälä AM, Rolfes KM, Vogel CFA, Haarmann-Stemmann T: Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway. Biochem Pharmacol 208: 115371, 2023 (online 2022). doi: 10.1016/j.bcp.2022.115371

Vogeley C, Nguyen T, Woeste S, Krutmann J, Haarmann-Stemmann T, Rossi A: Rapid and simple analysis of short and long sequencing reads using Duesselpore^TM. Front Genet 13: 931996, 2022. doi: 10.3389/fgene.2022.931996

Yusuf N, Haarmann-Stemmann T, Nakamura M: Editorial: Environment and skin cancer. Front Oncol 12: 924225, 2022. doi: 10.3389/fonc.2022.924225

Vogeley C, Rolfes KM, Krutmann J, Haarmann-Stemmann T: The aryl hydrocarbon receptor in the pathogenesis of environmentally-induced squamous cell carcinomas of the skin. Front Oncol 12: 841721, 2022. doi: 10.3389/fonc.2022.841721

Ishihara Y, Kado SY, Bein KJ, He Y, Pouraryan AA, Urban A, Haarmann-Stemmann T, Sweeney C and Vogel CFA: Aryl hydrocarbon receptor signaling synergizes with TLR/NF-κB-signaling for induction of IL-22 through canonical and non-canonical AhR pathways. Front Toxicol 3: 787360, 2022. doi: 10.3389/ftox.2021.787360

Fehsel K, Schwanke K, Kappel BA, Fahimi E, Meisenzahl-Lechner E, Esser C, Hemmrich K, Haarmann-Stemmann T, Kojda G, Lange-Asschenfeldt C: Activation of the aryl hydrocarbon receptor by clozapine induces preadipocyte differentiation and contributes to endothelial dysfunction. J Psychopharmacol 36(2): 191-201, 2022. doi: 10.1177/02698811211055811

Vogeley C, Sondermann NC, Woeste S, Momin AA, Gilardino V, Hartung F, Heinen M, Maaß SK, Mescher M, Pollet M, Rolfes KM, Vogel CFA, Rossi A, Lang D, Arold ST, Nakamura M, Haarmann-Stemmann T: Unraveling the differential impact of PAHs and dioxin-like compounds on AKR1C3 reveals the EGFR extracellular domain as a critical determinant of the AHR response. Environ Int 158: 106989, 2022 (online 2021). doi: 10.1016/j.envint.2021.106989

Faßbender S, Sondenheimer K, Majora M, Schindler J, Opitz FV, Pollet M, Haarmann-Stemmann T, Krutmann J, Weighardt H: Keratinocytes counteract UVB-induced immunosuppression in mice via HIF1a signaling. J Invest Dermatol 142(4):1183-1193, 2022 (online 2021). doi: 10.1016/j.jid.2021.07.185

Rolfes KM, Sondermann NC, Vogeley C, Dairou J, Gilardino V, Wirth R, Meller S, Homey B, Krutmann J, Lang D, Nakamura M, Haarmann-Stemmann T: Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity. Redox Biol 46: 102110, 2021. doi: 10.1016/j.redox.2021.102110

Vogel CFA, Lazennec G, Kado SY, Dahlem C, He Y, Castaneda A, Ishihara Y, Vogeley C, Rossi A, Haarmann-Stemmann T, Jugan J, Mori H, Borowsky AD, La Merrill MA, Sweeney C: Targeting the aryl hydrocarbon receptor signaling pathway in breast cancer development. Front Immunol 12: 625346, 2021. doi: 10.3389/fimmu.2021.625346

Haarmann-Stemmann T, Sutter TR, Krutmann J, Esser C: The mode of action of tapinarof may not only depend on the activation of cutaneous aryl hydrocarbon receptor signaling but also on its antimicrobial activity. J Am Acad Dermatol 85(1): e33-e34, 2021. doi: 10.1016/j.jaad.2021.01.103

Fritsche E, Haarmann-Stemmann T, Kapr J, Galanjuk S, Hartmann J, Mertens PR, Kämpfer AAM, Schins RPF, Tigges J, Koch K: Stem cells for next level toxicity testing in the 21st century. Small 17(15): e2006252, 2021 (online 2020). doi: 10.1002/smll.202006252

Dahlem C, Kado SY, He F, Bein K, Wu D, Haarmann-Stemmann T, Kado NY, Vogel CFA: AHR signaling interacting with nutritional factors regulating the expression of markers in vascular inflammation and atherogenesis. Int J Mol Sci 21(21): 8287, 2020. doi: 10.3390/ijms21218287

Ghashghaei O, Pedrola M, Seghetti F, Martin VV, Zavarce R, Babiak M, Novacek J, Hartung F, Rolfes KM, Haarmann-Stemmann T, Lavilla R: Extended multicomponent reactions with indole aldehydes: Access to unprecedented polyheterocyclic scaffolds, ligands of the aryl hydrocarbon receptor. Angew Chem Int Edit 60(5): 2603-2608, 2021 (online 2020). doi: 10.1002/anie.202011253

Esser C, Hochrath K, Schikowski T, Haarmann-Stemmann T: COVID-19 research: toxicological input urgently needed! Arch Toxicol 94(7): 2547-2548, 2020. doi: 10.1007/s00204-020-02803-5

Vogel CFA, Van Winkle LS, Esser C, Haarmann-Stemmann T: The aryl hydrocarbon receptor as a target of environmental stressors – Implications for pollution mediated stress and inflammatory responses. Redox Biol 34: 101530, 2020. doi: 10.1016/j.redox.2020.101530

Ishihara Y, Haarmann-Stemmann T, Kado N, Vogel CFA: Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages. Toxicol Sci 170(2): 404-414, 2019. doi: 10.1093/toxsci/kfz114