Recent publications

Original articles

Rolfes KM, Sondermann NC, Vogeley C, Dairou J, Gilardino V, Wirth R, Meller S, Homey B, Krutmann J, Lang D, Nakamura M, Haarmann-Stemmann T: Inhibition of 6-formylindolo[3,2-b]carbazole metabolism sensitizes keratinocytes to UVA-induced apoptosis: Implications for vemurafenib-induced phototoxicity. Redox Biol 46: 102110, 2021. doi: 10.1016/j.redox.2021.102110

Bredeck G, Kämpfer AAM, Sofranko A, Wahle T, Lison D, Ambroise J, Stahlmecke B, Albrecht C, Schins RPF: Effects of dietary exposure to the engineered nanomaterials CeO2, SiO2, Ag, and TiO2 on the murine gut microbiome. Nanotoxicology, 2021. doi: 10.1080/17435390.2021.1940339

Grether-Beck S, Marini A, Jaenicke T, Brenden H, Felsner I, Aue N, Brynjolsdottir A, Krutmann J: Blue Lagoon Algae improve uneven skin pigmentation: Results from in vitro studies and from a monocenter, randomized, double blind, vehicle controlled, split-face study. Skin Pharmacol Physiol, 2021. doi: 10.1159/000518781

Breuckmann P, Meinke MC, Jaenicke T, Krutmann J, Rasulev U, Keck CM, Müller RH, Klein AL, Lademann J, Patzelt A: Influence of nanocrystal size on the in vivo absorption kinetics of caffeine after topical application. Eur J Pharm Biopharm S0939-6411(21)00186-7, 2021. doi: 10.1016/j.ejpb.2021.07.006

Martins S, Hacheney I, Teichweyde N, Hildebrandt B, Krutmann J, Rossi A: Generation of an induced pluripotent stem cell line (IUFi001) from a Cockayne syndrome patient carrying a mutation in the ERCC6 gene. Stem Cell Res 55: 102456, 2021. doi: 10.1016/j.scr.2021.102456

Li B, Cheng Y, Tan Y, Wang F, Hu W, Wang X, Liu W, Krutmann J, Wang S, Zou Y: Analysis of factors influencing patch test reactions: Results from a large-scale population-based study in Chinese. J Cosmet Dermatol, 2021. doi: 10.1111/jocd.14338

Uekoetter K, Ebert N, Stoffels A, Wigmann C, Schikowski T: Validation of the TeleForm scan workflow in the GNC health study on the example of the questionnaire on physical activity. GMS Med Inform Biom Epidemiol 17(1): Doc03, 2021. doi: 10.3205/mibe000217

Zhao T, Triebner K, Markevych I, Standl M, Altug H, de Hoogh K, Schikowski T, Berdel D, Koletzko S, Bauer CP, von Berg A, Nowak D, Heinrich J: Outdoor air pollution and hormone-assessed pubertal development in children: Results from the GINIplus and LISA birth cohorts. Environ Int 152: 106476, 2021. doi: 10.1016/j.envint.2021.106476

Kapr J, Petersilie L, Distler T, Lauria I, Bendt F, Sauter CM, Boccaccini AR, Rose CR, Fritsche E: Human induced pluripotent stem cell-derived neural progenitor cells produce distinct neural 3D in vitro models depending on alginate/gellan gum/laminin hydrogel blend properties. Adv Healthc Mater, 2021. doi: 10.1002/adhm.202100131

Busch M, Kämpfer A, Schins R: An inverted in vitro triple culture model of the healthy and inflamed intestine: adverse effects of polyethylene particles. Chemosphere 284: 131345, 2021. doi: 10.1016/j.chemosphere.2021.131345

Granger C, Ong G, Andres P, Trullàs C, Hosenally M, Lai W, Liu W, Krutmann J, Passeron T, Lim HW: Outdoor Sunscreen Testing with High-intensity Solar Exposure in a Chinese and Caucasian Population. Photodermatol Photoimmunol Photomed, 2021. doi: 10.1111/phpp.12710

Dalecká A, Wigmann C, Kress S, Altug H, Jiřík V, Heinrich J, Abramson MJ, Schikowski T: The mediating role of lung function on air pollution-induced cardiopulmonary mortality in elderly women: The SALIA cohort study with 22-year mortality follow-up. Int J Hyg Environ Health 233: 113705, 2021. doi: 10.1016/j.ijheh.2021.113705

Zhao Q, Wigmann C, Areal AT, Altug H, Schikowski T: Effect of non-optimum ambient temperature on cognitive function of elderly women in Germany. Environ Pollut 285: 117474, 2021. doi: 10.1016/j.envpol.2021.117474

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer A-K, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl L-C, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery Cell Biol Toxicol 2021. doi: 10.1007/s10565-021-09603-2

Budden T, Gaudy-Marqueste C, Porter A, Kay E, Gurung S, Earnshaw CH, Roeck K, Craig S, Traves V, Krutmann J, Muller P, Motta L, Zanivan S, Malliri A, Furney SJ, Nagore E, Virós A: Ultraviolet light-induced collagen degradation inhibits melanoma invasion. Nat Commun 12(1): 2742, 2021.  doi: 10.1038/s41467-021-22953-z

Grether-Beck S, Felsner I, Brenden H, Marini A, Jaenicke T, Aue N, Welss T, Uthe I, Krutmann J: Air pollution-induced tanning of human skin. Br J Dermatol 2021. doi: 10.1111/bjd.20483

Tigges J, Bielec K, Brockerhoff G, Hildebrandt B, Hübenthal U, Kapr J, Koch K, Teichweyde N, Wieczorek D, Rossi A, Fritsche E: Academic application of Good Cell Culture Practice for induced pluripotent stem cells. ALTEX 2021. doi: 10.14573/altex.2101221

Ramachandran H, Martins S, Kontarakis Z, Krutmann J, Rossi A: Fast but not furious: a streamlined selection method for genome edited cells. Life Sci Alliance 4(6): e202101051, 2021. doi: 10.26508/lsa.202101051

Correia Carreira S, Taghavi M, Pavez Loriè E, Rossiter J: FleXert: A soft, actuatable multiwell plate insert for cell culture under stretch. ACS Biomater Sci Eng 7(6): 2225-2245, 2021. doi: 10.1021/acsbiomaterials.0c01448

Coppari S, Colomba M, Fraternale D, Brinkmann V, Romeo M, Rocchi MBL, Di Giacomo B, Mari M, Guidi L, Ramakrishna S, Ventura N, Albertini MC: Antioxidant and anti-inflammaging ability of prune (Prunus Spinosa L.) extract result in improved wound healing efficacy. Antioxidants 10(3): 374, 2021. doi: 10.3390/antiox10030374

Sofranko A, Wahle T, Heusinkveld HJ, Stahlmecke B, Dronov M, Pijnenburg D, Hilhorst R, Lamann K, Albrecht C, Schins RPF: Evaluation of the neurotoxic effects of engineered nanomaterials in C57BL/6J mice in 28-day oral exposure studies. Neurotoxicology 84: 155-171, 2021. doi: 10.1016/j.neuro.2021.03.005

Tacu I, Kokalari I, Abollino O, Albrecht C, Malandrino M, Ferretti AM, Schins RPF, Fenoglio I: Mechanistic insights into the role of iron, copper and carbonaceous component on the oxidative potential of ultrafine particulate matter. Chem Res Toxicol 34(3): 767-779, 2021. doi: 10.1021/acs.chemrestox.0c00399

Vogel CFA, Lazennec G, Kado SY, Dahlem C, He Y, Castaneda A, Ishihara Y, Vogeley C, Rossi A, Haarmann-Stemmann T, Jugan J, Mori H, Borowsky AD, La Merrill MA, Sweeney C: Targeting the aryl hydrocarbon receptor signaling pathway in breast cancer development. Front Immunol 12: 62534, 2021. doi: 10.3389/fimmu.2021.625346

Distler T, Lauria I, Detsch R, Sauter CM, Bendt F, Kapr J, Rütten S, Boccaccini AR, Fritsche E: Neuronal differentiation from induced pluripotent stem cell-derived neurospheres by the application of oxidized alginate-gelatin-laminin hydrogels. Biomedicines 9(3): 261, 2021. doi: 10.3390/biomedicines9030261

Li Z*, Xia J*, Jiang L, Tan Y, An Y, Zhu X, Ruan J, Chen Z, Zhen H, Ma Y, Jie Z, Xiao L, Yang H, Wang J, Kristiansen K, Xu X, Jin L, Nie C, Krutmann J*, Liu X*, Wang J*: Characterization of the human skin resistome and identification of two microbiota cutotypes. Microbiome 9(1): 47, 2021. doi: 10.1186/s40168-020-00995-7 (*equal contribution)

Zhao Q, Kress S, Markevych I, Berdel D, von Berg A, Gappa M, Koletzko S, Bauer CP, Schulz H, Standl M, Heinrich J, Schikowski T: Long-term air pollution exposure under European Union limits and adolescents' lung function: Modifying effect of abnormal weight in the GINIplus and LISA birth cohorts. Chest 160(1): 249-258, 2021. doi: 10.1016/j.chest.2021.02.007

Haarmann-Stemmann T, Sutter TR, Krutmann J, Esser C: The mode of action of tapinarof may not only depend on the activation of cutaneous aryl hydrocarbon receptor signaling but also on its antimicrobial activity. J Am Acad Dermatol 85(1): e33-e34, 2021. doi: 10.1016/j.jaad.2021.01.103

Zhao H, Wu J, Wang N, Grether-Beck S, Krutmann J, Wei L: Oral Pycnogenol® intake benefits the skin in urban Chinese outdoor workers: A randomized, placebo-controlled, double blind, and crossover intervention study. Skin Pharmacol Physiol 34: 135-145, 2021. doi: 10.1159/000514323

Kämpfer AAM, Busch B, Büttner V, Bredeck G, Stahlmecke B, Hellack B, Masson I, Albrecht C, Schins RP: Model complexity as determining factor for in vitro nanosafety studies – Effects of silver and titanium dioxide nanomaterials in intestinal models. Small 17(15): e2004223, 2021. doi: 10.1002/smll.202004223

Gappa M, Filipiak-Pittroff B, Libuda L, von Berg A, Koletzko S, Bauer CP, Heinrich J, Schikowski T, Berdel D, Standl M: Long-term effects of hydrolyzed formulae on atopic diseases in the GINI study. Allergy 76(6): 1903-1907, 2021. doi: 10.1111/all.14709

Lambert KA, Markevych I, Yang B-Y, Bauer C-P, Berdel D, von Berg A, Bergmann K-C, Lodge C, Koletzko S, Prendergast LA, Schikowski T, Schulz H, Werchan M, Heinrich J, Standl M, Erbas B: Association of early life and acute pollen exposure with lung function and exhaled nitric oxide (FeNO). A prospective study up to adolescence in the GINIplus and LISA cohort. Sci Total Environ 763: 143006, 2021. doi: 10.1016/j.scitotenv.2020.143006

Barenys M, Illa M, Hofrichter M, Loreiro C, Pla L, Klose J, Kühne BA, Gómez-Catalán J, Braun JM, Crispi F, Gratacós E, Fritsche E: Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction. Stem Cells Transl Med 10(2): 209-221, 2021. doi: 10.1002/sctm.20-0223

Mekic S, Wigmann C, Gunn DA, Kayser M, Jacobs LC, Schikowski T, Nijsten T, Pardo LM: Genetics of facial telangiectasia in the Rotterdam study; a genome-wide association study and candidate gene approach. J Eur Acad Dermatol Venereol 35(3): 749-754, 2021. doi: 10.1111/jdv.17014

Ghashghaei O, Pedrola M, Seghetti F, Martin VV, Zavarce R, Babiak M, Novacek J, Hartung F, Rolfes KM, Haarmann-Stemmann T, Lavilla R:  Extended multicomponent reactions with indole aldehydes: Access to unprecedented polyheterocyclic scaffolds, ligands of the Aryl Hydrocarbon Receptor. Angew Chem Int Edit 60(5): 2603-2608, 2021. doi: 10.1002/anie.202011253

Melén E, Standl M, Gehring U, Altug H, Antó JM, Berdel D, Bergström A, Bousquet J, Heinrich J, Koppelman GH, Kull I, Lupinek C, Markevych I, Schikowski T, Thiering E, Valenta R, van Hage M, von Berg A, Vonk JM, Wickman M, Wijga A, Gruzieva O: Air pollution and IgE sensitization in 4 European birth cohorts - the MeDALL project. J Allergy Clin Immunol 47(2): 713-722, 2021. doi: 10.1016/j.jaci.2020.08.030

Busch M, Bredeck G, Kämpfer AAM, Schins RPF: Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine. Environ Res 193: 110536, 2021. doi: 10.1016/j.envres.2020.110536

Strom A, Strassburger K, Schmuck M, Shevalye H, Davidson E, Zivehe F, Bönhof G, Reimer R, Belgardt BF, Fleming T, Biermann B, Burkart V, Müssig K, Szendroedi J, Yorek MA, Fritsche E, Nawroth PP, Roden M, Ziegler D; GDS Group: Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models. Mol Metab 43: 101114, 2021. doi: 10.1016/j.molmet.2020.101114

Zhao Q, Kress S, Markevych I, Berdel D, von Berg A, Gappa M, Koletzko S, Bauer CP, Schulz H, Standl M, Heinrich J, Schikowski T: Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study. Environ Int 146: 106195, 2021. doi: 10.1016/j.envint.2020.106195

Klose J, Tigges J, Masjosthusmann S, Schmuck K, Bend F, Hübenthal U, Petzsch P, Köhrer K, Koch K, Fritsche E: TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs. ALTEX 38(2): 215-234, 2021. doi: 10.14573/altex.2007201

Reviews, contributions to books, etc.

Luger T, Amagai M, Dreno B, Dagnelie MA, Liao W, Kabashima K, Schikowski T, Proksch E, Elias PM, Simon M, Simpson E, Grinich E, Schmuth M: Atopic dermatitis: Role of the skin barrier, environment, microbiome, and therapeutic agents. J Dermatol Sci 102(3): 142-157, 2021. doi: 10.1016/j.jdermsci.2021.04.007

Vinken M, Benfenati E, Busquet F, Castell J, Clevert DA, de Kok TM, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C, Piersma AH: Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology, 2021. doi: 10.1016/j.tox.2021.152846

Sies H, Ursini F: Homeostatic control of redox status and health. IUBMB Life, 2021. doi: 10.1002/iub.2519

van den Bogaard EH, Esser C, Perdew G: The aryl hydrocarbon receptor at the forefront of host-microbe interactions in the skin: a perspective on current knowledge gaps and directions for future research and therapeutic applications. Exp Dermatol, 2021. doi: 10.1111/exd.14409

Krutmann J, Granger C, Trullàs C, Passeron T: Daily Photoprotection: What Does it Really Mean? Photodermatol Photoimmunol Photomed, 2021. doi: 10.1111/phpp.12707

Sies H: Oxidative eustress: On constant alert for redox homeostasis. Redox Biol 41: 101867, 2021. doi: 10.1016/j.redox.2021.101867

Passeron T, Zouboulis CC, Tan J, Andersen ML, Katta R, Lyu X, Aguilar L, Kerob D, Morita A, Krutmann J, Peters EMJ: Adult skin acute stress responses to short-term environmental and internal aggression from exposome factors. J Eur Acad Dermatol Venereol 2021. doi: 10.1111/jdv.17432

Lim H, Kohli I, Granger C, Trullas C, Piquero-Casals J, Narda M, Masson P, Krutmann J, Passeron T: Photoprotection of the skin from visible light-induced pigmentation: Current testing methods and proposed harmonization. J Invest Dermatol 2021. doi: 10.1016/j.jid.2021.03.012

Pavez Loriè E: Open, connective, flexible and innovative research is the way to fight new global challenges; A lesson learned from our first year of the COVID-19 pandemic. Clin Sci Res Rep 4: 1-2, 2021. doi: 10.15761/CSRR.1000131

Baswan SM, Klosner AE, Weir C, Salter-Venzon D, Gellenbeck KW, Leveret J, Krutmann J: Role of ingestible carotenoids in skin protection: A review of clinical evidence. Photodermatol Photoimmunol Photomed 2021. doi: 10.1111/phpp.12690

Krutmann J, Schalka S, Watson REB, Liu W, Morita A: Daily photoprotection to prevent photoaging. Photodermatol Photoimmunol Photomed 2021. doi: 10.1111/phpp.12688

Polidori MC, Sies H, Ferrucci L, Benzing T: COVID-19 mortality as a fingerprint of biological age. Ageing Res Rev 67: 101308, 2021. doi: 10.1016/j.arr.2021.101308

Annesi-Maesano I, Forastiere F, Balmes J, Garcia E, Harkema J, Holgate S, Kelly F, Khreis H, Hoffmann B, Maesano CN, McConnell R, Peden D, Pinkerton K, Schikowski T, Thurston G, Van Winkle LS, Carlsten C: The clear and persistent impact of air pollution on chronic respiratory diseases: a call for interventions. Eur Respir J 57(3): 2002981, 2021. doi: 10.1183/13993003.02981-2020

Esser C: Trajectory shifts in interdisciplinary research of the aryl hydrocarbon receptor - a personal perspective on thymus and skin. Int J Mol Sci 22(4): 1844, 2021. doi: 10.3390/ijms22041844

Neuhaus W*: Consensus statement from the European Network of 3R centres (EU3Rnet). ALTEX 38(1): 138-139, 2021. doi: 10.14573/altex.2010061 *Neuhaus has submitted the Consensus Statement on behalf of all participating centres, institutes and societies of EU3Rnet

Passeron T, Lim HW, Goh CL, Kang HY, Ly F, Morita A, Ocampo Candiani J, Puig S, Schalka S, Wei L, Dréno B, Krutmann J: Photoprotection according to skin phototype and dermatoses: Practical recommendations from an expert panel. J Eur Acad Dermatol Venereol 35(7): 1460-1469, 2021. doi: 10.1111/jdv.17242

Krutmann J, Schikowski T, Morita A, Berneburg M: Environmentally-induced (extrinsic) skin aging: Exposomal factors and underlying mechanisms. J Invest Dermatol 141(4S): 1096-1103, 2021. doi: 10.1016/j.jid.2020.12.011

Llewellyn SV, Kämpfer AAM, Keller JG, Vilsmeier K, Büttner V, Seleci DA, Schins RPF, Doak SH, Wohlleben W: Simulating nanomaterial transformation in cascaded biological compartments to enhance the physiological relevance of in vitro dosing regimes: Optional or required? Small 17(15): e2004630, 2021. doi: 10.1002/smll.202004630

Neale RE, Barnes PW, Robson TM, Neale PJ, Williamson CE, Zepp RG, Wilson SR, Madronich S, Andrady AL, Heikkilä AM, Bernhard GH, Bais AF, Aucamp PJ, Banaszak AT, Bornman JF, Bruckman LS, Byrne SN, Foereid B, Häder DP, Hollestein LM, Hou WC, Hylander S, Jansen MAK, Klekociuk AR, Liley JB, Longstreth J, Lucas RM, Martinez-Abaigar J, McNeill K, Olsen CM, Pandey KK, Rhodes LE, Robinson SA, Rose KC, Schikowski T, Solomon KR, Sulzberger B, Ukpebor JE, Wang QW, Wängberg SÅ, White CC, Yazar S, Young AR, Young PJ, Zhu L, Zhu M: Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2020. Photochem Photobiol Sci 20(1): 1-67, 2021. doi: 10.1007/s43630-020-00001-x

Tham R, Schikowski T: The role of traffic-related air pollution on neurodegenerative diseases in older people: An epidemiological perspective. J Alzheimers Dis 79(3): 949-959, 2021. doi: 10.3233/JAD-200813

Krutmann J, Berneburg M: Photodermatologie. Hautarzt 72(1): 1, 2021. doi: 10.1007/s00105-020-04746-5

Krutmann J, Berneburg M: Lichtalterung (Photoaging) der Haut: Was gibt es Neues? Hautarzt 72(1): 2-5, 2021. doi: 10.1007/s00105-020-04747-4

Fritsche E, Haarmann-Stemmann T, Kapr J, Galanjuk S, Hartmann J, Mertens PR, Kämpfer AAM, Schins RPF, Tigges J, Koch K: Stem cells for next level toxicity testing in the 21st century. Small 17(15): e2006252, 2021. doi: 10.1002/smll.202006252

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