Originalarbeiten
Uhlmann C, Kuhn LM, Tigges J, Fritsche E, Kahlert DU: Efficient modulation of TP53 expression in human induced pluripotent stem cells. Curr Protoc Stem Cell Biol 52(1): e102, 2020 (online 2019). doi: 10.1002/cpsc.102
Thyssen JP, Ahluwalia TS, Paternoster L, Ballardini N, Bergström A, Melén E, Chawes B, Stokholm J, Hourihane JO, O'Sullivan DM, Bager P, Maelbye M, Bustamante M, Torrent M, Esplugues A, Duijts L, Hu C, Elbert NJ, Pasmans SGMA, Nijsten TEC, von Berg A, Standl M, Schikowski T, Herberth G, Heinrich J, Lee YA, Marenholz I, Lau S, Curtin JA, Simpson A, Custovic A, Pennell CE, Wang CA, Holt PG, Bisgaard H, Bønnelykke K: Interaction between filaggrin mutations and neonatal cat exposure in atopic dermatitis. Allergy 75(6): 1481-1485, 2020 (online 2019). doi: 10.1111/all.14162
Mekic S, Hamer MA, Wigmann C, Gunn DA, Kayser M, Jacobs LC, Schikowski T, Nijsten T, Pardo LM: Epidemiology and determinants of facial telangiectasia: a cross-sectional study. J Eur Acad Dermatol Venereol 34(4): 821-826, 2020 (online 2019). doi: 10.1111/jdv.15996
Grether-Beck S, Marini A, Jaenicke T, Goessens-Rück P, McElwee KJ, Hoffmann R, Krutmann J: Autologous cell therapy for aged human skin: a randomized, placebo-controlled, phase-I study. Skin Pharmacol Physiol 33: 9-16, 2020 (online 2019). doi: 10.1159/000502240
Trullàs C, Granger C, Lim HW, Krutmann J, Masson P: Linear and exponential sunscreen behaviours as an explanation for observed discrepancies in sun protection factor testing. Photodermatol Photoimmunol Photomed 36(5): 351-356, 2020 (online 2019). doi: 10.1111/phpp.12500
Piechulek A, Scharf A, Berwanger L, von Mikecz A: Life span-resolved nanotoxicology identifies nuclear amyloid, altered metabolism and neurodegenerative processes in the nematode Caenorhabditis elegans. Biopolym Cell 35(3): 194-195, 2019. doi: 10.7124/bc.0009CB
Piechulek A, Berwanger L, Scharf A, von Mikecz A: The cell nucleus as sensor of environmental pollution: Amyloid, neurodegeneration and aging. Biopolym Cell 35: 195-196, 2019. doi: 10.7124/bc.0009CC
Vogeley C, Esser C, Tüting T, Krutmann J, Haarmann-Stemmann T: Role of the aryl hydrocarbon receptor in environmentally induced skin aging and skin carcinogenesis. Int J Mol Sci 20(23): 6005, 2019. doi: 10.3390/ijms20236005
Haupeltshofer S, Leichsenring T, Berg S, Pedreiturria X, Joachim SC, Tischoff I, Otte J-M, Bopp T, Fantini MC, Esser C, Willbold D, Gold R, Faissner S, Kleiter I: Smad7 in intestinal CD4+ T cells determine autoimmunity in a spontaneious model of multiple sclerosis. PNAS 116(51): 25860-25869, 2019. doi: 10.1073/pnas.1905955116
Cossarizza A, … Esser C, … Zychlinsky A: Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Eur J Immunol 49(10): 1457-1973, 2019. doi: 10.1002/eji.201970107
Zhao T, Markevych I, Standl M, Schikowski T, Berdel D, Koletzko S, Jörres RA, Nowak D, Heinrich J: Short-term exposure to ambient ozone and inflammatory biomarkers in cross-sectional studies of children and adolescents: Results of the GINIplus and LISA birth cohorts. Environ Pollut 255(Pt 2): 113264, 2019. doi: 10.1016/j.envpol.2019.113264
Liu Y, Gao W, Koellmann C, Le Clerc S, Hüls A, Li B, Peng Q, Wu S, Ding A, Yang Y, Jin L, Krutmann J, Schikowski T, Zagury JF, Wang S: Genome-wide scan identified genetic variants associated with skin aging in a Chinese female population. J Dermatol Sci 96(1): 42-49, 2019. doi: 10.1016/j.jdermsci.2019.08.010
Walter KM*, Dach K*, Hayakawa K*, Giersiefer S, Heuer H, Lein PJ#, Fritsche E#: Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. Plos One 14(9): e0221230, 2019. doi: 10.1371/journal.pone.0221230
Jorcano A, Lubczyńska MJ, Pierotti L, Altug H, Ballester F, Cesaroni G, El Marroun H, Fernández-Somoano A, Freire C, Hanke W, Hoek G, Ibarluzea J, Iñiguez C, Jansen PW, Lepeule J, Markevych I, Polańska K, Porta D, Schikowski T, Slama R, Standl M, Tardon A, Vrijkotte TGM, von Berg A, Tiemeier H, Sunyer J, Guxens M: Prenatal and postnatal exposure to air pollution and emotional and aggressive symptoms in children from 8 European birth cohorts. Environ Int 2019 131: 104927, 2019. doi: 10.1016/j.envint.2019.104927
Harris CP, von Berg A, Berdel D, Bauer CP, Schikowski T, Koletzko S, Heinrich J, Schulz H, Standl M: Dietary saturated fat and low-grade inflammation modified by accelerometer-measured physical activity in adolescence: results from the GINIplus and LISA birth cohorts. BMC Public Health 19(1): 818, 2019. doi: 10.1186/s12889-019-7113-6
Soppa VJ, Shinnawi S, Hennig F, Sasse B, Hellack B, Kaminski H, Quass U, Schins RPF, Kuhlbusch TAJ, Hoffmann B: Effects of short-term exposure to fine and ultrafine particles from indoor sources on arterial stiffness – a randomized sham-controlled exposure study. Int J Hyg Environ Health 222(8): 1115-1132, 2019. doi: 10.1016/j.ijheh.2019.08.002
Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N: Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span. Aging-US 11(16): 6535-6554, 2019. doi: 10.18632/aging.102208
Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H, Wang CC: Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines. Reprod Toxicol 89: 45-53, 2019. doi: 10.1016/j.reprotox.2019.06.001
Granger C, Krutmann J, Bustos J, Sola Y, Hosenally M, Trullàs C, Andres P, Passeron T: New methodology to evaluate sunscreens under outdoor conditions: A double-blind, randomized intra-individual clinical study of a water-based broad-spectrum SPF50+ versus SPF15 (P3) and SPF50+. Dermatol Ther 9(3): 589-599, 2019. doi: 10.1007/s13555-019-00315-4
Piechulek A, Berwanger L, von Mikecz A: Silica nanoparticles disrupt OPT-2/PEP-2-dependent trafficking of nutrient peptides in the intestinal epithelium. Nanotoxicology 13(8): 1133-1148, 2019. doi: 10.1080/17435390.2019.1643048
Esser C, Hochrath K, Teichweyde N, Krutmann J, Chang H-D: Beyond sequencing: fast and easy microbiome profiling by flow cytometry. Arch Toxicol 93(9): 2703-2704, 2019. doi: 10.1007/s00204-019-02527-1
Fiala GJ, Schaffer AM, Merches K, Morath A, Swann J, Herr LA, Hils M, Esser C, Minguet S, Schamel WWA: Proximal Lck promoter-driven Cre function is limited in neonatal and ineffective in adult γδ T cell development. J Immunol 203(2): 569-579, 2019. doi: 10.4049/jimmunol.1701521
Ishihara Y, Haarmann-Stemmann T, Kado N, Vogel CFA: Interleukin 33 expression induced by aryl hydrocarbon receptor in macrophages. Toxicol Sci 170(2): 404-414, 2019. doi: 10.1093/toxsci/kfz114
Piechulek A, von Mikecz A: Aging by pollutants: Introducing the aging dose (AD)50. Environ Sci Eur 31: 23, 2019. doi: 10.1186/s12302-019-0205-1
Hawerkamp HC, Kislat A, Gerber PA, Pollet M, Rolfes KM, Soshilov AA, Denison MS, Momin AA, Arold ST, Datsi A, Braun SA, Oláh P, Lacouture ME, Krutmann J, Haarmann-Stemmann T*, Homey B*, Meller S*: Vemurafenib acts as an aryl hydrocarbon receptor antagonist: Implications for inflammatory cutaneous adverse events. Allergy 74(12): 2437-2448, 2019. doi: 10.1111/all.13972
Mescher M, Tigges J, Rolfes KM, Shen AL, Yee J, Vogeley C, Krutmann J, Bradfield CA, Lang D, Haarmann-Stemmann T: The toll-like receptor agonist imiquimod is metabolized by aryl hydrocarbon receptor-regulated cytochrome P450 enzymes in human keratinocytes and mouse liver. Archiv Toxicol 93(7): 1917-1926, 2019. doi: 10.1007/s00204-019-02488-5
Fuks KB, Wigmann C, Altug H, Schikowski T: Road traffic noise at the residence, annoyance, and cognitive function in elderly women. Int J Environ Res Public Health 16(10): 1790, 2019. doi: 10.3390/ijerph16101790
Weigel C, Chaisaingmongkol J, Assenov Y, Kuhmann C, Winkler V, Santi I, Bogatyrova O, Kaucher S, Bermejo JL, Leung SY, Chan TL, Lasitschka F, Bohrer MH, Marx A, Haußen RH, Herold-Mende C, Dyckhoff G, Boukamp P, Delank KW, Hörmann K, Lippert BM, Baier G, Dietz A, Oakes CC, Plass C, Becher H, Schmezer P, Ramroth H, Popanda O: DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer. Clin Epigenetics 11(1): 67, 2019. doi: 10.1186/s13148-019-0666-5
Masjosthusmann S, Siebert C, Hübenthal U, Bendt F, Baumann J, Fritsche E: Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense. Chemosphere 235: 447-456, 2019. doi: 10.1016/j.chemosphere.2019.06.123
Vogel CFA, Ishihara Y, Campbell C, Kado S, Nguyen-Chi A, Sweeney C, Pollet M, Haarmann-Stemmann T*, Tuscano JM*: A protective role of aryl hydrocarbon receptor repressor in inflammation and tumor growth. Cancers 1(5): 589, 2019. doi: 10.3390/cancers11050589 (*equal contribution)
El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR: Genetic compensation triggered by mutant mRNA degradation. Nature 568(7751): 193-197, 2019. doi: 10.1038/s41586-019-1064-z
Yang BY, Markevych I, Harris C, Standl M, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Dong GH, Heinrich J: High-sensitivity C-reactive protein and allergic endpoints in German adolescents. Int Arch Allergy Immunol 179(2): 152-157, 2019. doi: 10.1159/000497320
Guo Q, Liang F, Tian L, Schikowski T, Liu W, Pan X: Ambient air pollution and the hospital outpatient visits for eczema and dermatitis in Beijing: a time-stratified case-crossover analysis. Environ Sci Process Impacts 21(1): 163-173, 2019. doi: 10.1039/c8em00494c
Groten K, Marini A, Grether-Beck S, Jaenicke T, Ibbotson SH, Moseley H, Ferguson J, Krutmann J: Tomato phytonutrients balance UV response: Results from a double blind, randomized, placebo controlled study. Skin Pharmacol Physiol 32(2): 101-108, 2019. doi: 10.1159/000497104
Carmona-Gutierrez D, Zimmermann A, Kainz K, Pietrocola F, Chen G, Maglioni S, Schiavi A, Nah J, Mertel S, Beuschel CB, Castoldi F, Sica V, Trausinger G, Raml R, Sommer C, Schroeder S, Hofer SJ, Bauer MA, Pendl T, Tadic J, Dammbrueck C, Hu Z, Ruckenstuhl C, Eisenberg T, Durand S, Bossut N, Aprahamian F, Abdellatif M, Sedej S, Enot DP, Wolinski H, Dengjel J, Kepp O, Magnes C, Sinner F, Pieber TR, Sadoshima J, Ventura N, Sigrist SJ, Kroemer G, Madeo F: The flavonoid 4,4'-dimethoxychalcone promotes autophagy-dependent longevity across species. Nat Commun 10(1): 651, 2019. doi: 10.1038/s41467-019-08555-w
Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M: Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake. Sci Rep 9(1): 2913, 2019. doi: 10.1038/s41598-019-39770-6
Çakmak G, Ertürk Ari P, Emerce E, Arı A, Odabası M, Schins RPF, Burgaz S, Gaga EO: Investigation of spatial and temporal variation of particulate matter in vitro genotoxicity and cytotoxicity in relation to the elemental composition. Mutat Res Gen Tox En 842: 22-34, 2019. doi: 10.1016/j.mrgentox.2019.01.009
Hüls A, Sugiri D, Abramson MJ, Hoffmann B, Schwender H, Ickstadt K, Krämer U, Schikowski T: Benefits of improved air quality on aging lungs - Impacts of genetics and obesity. Eur Respir J 53: 1801780, 2019. doi: 10.1183/13993003.01780-2018
Tran B-H, Dao V-A, Bilstein A, Unfried K, Shah-Hosseini K, Mösges R: Ectoine-containing inhalation solution versus saline inhalation solution in the treatment of acute bronchitis and acute respiratory infections: A prospective, controlled, observational study. Biomed Res Int 2019: 7945091, 2019. doi: 10.1155/2019/7945091
Fuks K*, Hüls A*, Sugiri D, Altug H, Vierkötter A, Abramson M, Goebel J, Wagner G, Demuth I, Krutmann J*, Schikowski T*: Tropospheric ozone and skin aging: results from two German cohort studies. Environ Int 124: 139-144, 2019. doi: 10.1016/j.envint.2018.12.047 (* equal contribution)
Zhao T, Markevych I, Standl M, Schulte-Körne G, Schikowski T, Berdel D, Koletzko S, Bauer CP, von Berg A, Nowak D, Heinrich J: Ambient ozone exposure and depressive symptoms in adolescents: Results of the GINIplus and LISA birth cohorts. Environ Res 170: 73-81, 2019. doi: 10.1016/j.envres.2018.12.014
Steinbrenner H, Micoogullari M, Hoang NA, Bergheim I, Klotz L-O, Sies H: Selenium-binding protein 1 (SELENBP1) is a marker of mature adipocytes. Redox Biol 20: 489-495, 2019. doi: 10.1016/j.redox.2018.11.004
Markevych I, Feng X, Astell-Burt T, Standl M, Sugiri D, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Heinrich J: Residential and school greenspace and academic performance: Evidence from the GINIplus and LISA longitudinal studies of German adolescents. Environ Pollut 245: 71-76, 2019. doi: 10.1016/j.envpol.2018.10.053
Hüls A*, Abramson MJ*, Sugiri D, Fuks K, Krämer U, Krutmann J, Schikowski T: Non-atopic eczema in elderly women - Impact of air pollution and genes. J Allergy Clin Immunol 143(1): 378-385.e9, 2019. doi: 10.1016/j.jaci.2018.09.031 (* equal contribution)
Kühne BA, Puig T, Ruiz-Martínez S, Crous-Masó J, Planas M, Feliu L, Cano A, Garcia ML, Fritsche E, Llobet JM, Gómez-Catalán J, Barenys M: Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres. Food Chem Toxicol 123: 195-204, 2019. doi: 10.1016/j.fct.2018.10.055
Hüls A, Sugiri D, Fuks K, Krutmann J*, Schikowski T*: Lentigines formation in Caucasian women - Interaction between particulate matter and solar UVR. J Invest Dermatol 139(4): 974-976, 2019. doi: 10.1016/j.jid.2018.09.034 (* equal contribution)
Ali AAH, Schwarz-Herzke B, Mir S, Sahlender B, Victor M, Görg B, Schmuck M, Dach K, Fritsche E, Kremer A, von Gall C: Deficiency of the clock gene Bmal1 affects neural progenitor cell migration. Brain Struct Funct 224(1): 373-386, 2019. doi: 10.1007/s00429-018-1775-1
Übersichtsarbeiten, Buchbeiträge u.a.
Barenys M, Reverte I, Masjosthusmann S, Gómez-Catalán J, Fritsche E: Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway. Neurotoxicology 78: 209-241, 2020 (online 2019). doi: 10.1016/j.neuro.2019.12.007
Sies H, Reichert AS: Selectively addressing mitochondrial glutathione and thioredoxin redox systems. Cell Chem Biol 26: 316-318, 2019. doi: 10.1016/j.chembiol.2019.02.017
Penzel T, Krämer U, Höger R, Zimmermann S, Wichmann HE: Aktueller Wissensstand zu Fluglärm und Gesundheit - einschließlich WHO-Reviews und neuer Literatur bis Ende 2018. Umweltmed - Hygiene - Arbeitsmed 24(4): 187-218, 2019.
Krebs A, … , Fritsche E, …, Leist M: Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data. ALTEX 36(4): 682-699, 2019. doi: 10.14573/altex.1909271s
Pavan C, Delle Piane M, Gullo M, Filippi F, Fubini B, Hoet P, Horwell CJ, Huaux F, Lison D, Lo Giudice C, Martra G, Montfort E, Schins RPF, Sulpizi M, Wegner K, Wyart-Remy M, Ziemann C, Turci F: The puzzling issue of silica toxicity: are silanols bridging the gaps between surface states and pathogenicity? Part Fibre Toxicol 16(1): 32, 2019. doi: 10.1186/s12989-019-0315-3
Solecki R, Rauch M, Gall A, Buschmann J, Kellner R, Kucheryavenko O, Schmitt A, Delrue N, Li W, Hu J, Fujiwara M, Kuwagata M, Mantovani A, Makris SL, Paumgartten F, Schönfelder G, Schneider S, Vogl S, Kleinstreuer N, Schneider M, Schulze F, Fritsche E, Clark R, Shiota K, Chahoud I: Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol 89: 124-129, 2019. doi:
10.1016/j.reprotox.2019.07.003
Bernard JJ, Gallo RL, Krutmann J: Photoimmunology: how ultraviolet radiation affects the immune system. Nat Rev Immunol 19(11): 688-701, 2019. doi: 10.1038/s41577-019-0185-9
Bruckmann P, Krämer U, Wichmann HE: Wissenschaft trifft Politik - die Basis der europäischen Grenzwerte für Stickstoffdioxid und Feinstaub. Umwelt - Hygiene – Arbeitsmed 24(2): 83-100, 2019.
Krutmann J: Luftverschmutzung und Haut. Hautarzt 70(3): 156-157, 2019. doi: 10.1007/s00105-018-4349-5
Krämer U, Behrendt H: Luftverschmutzung und atopisches Ekzem. Hautarzt 70(3): 169-184, 2019. doi: 10.1007/s00105-018-4330-3
Schikowski T, Krutmann J: Luftverschmutzung (Feinstaub, Stickstoffdioxid) und Hautalterung. Hautarzt 70(3): 158-162, 2019. doi: 10.1007/s00105-018-4338-8 (Leitthema)
Fuks KB, Woodby B, Vallacchi G: Hautschäden durch troposphärisches Ozon. Hautarzt 70(3): 163-168, 2019. doi: 10.1007/s00105-018-4319-y (Leitthema)
Reinke H, Asher G: Crosstalk between metabolism and circadian clocks. Nat Rev Mol Cell Biol 20: 227-241, 2019. doi: 10.1038/s41580-018-0096-9
Originalarbeiten
Torgovnick A*, Schiavi A*, Shaik A#, Kassahun H#, Maglioni S, Rea SL, Johnson TE, Reinhardt HC, Honnen S, Schumacher B, Nilsen H, Ventura N: BRCA1 and BARD1 mediate apoptotic resistance but not longevity upon mitochondrial stress in Caenorhabditis elegans. EMBO Rep 19(12): e45856, 2018. doi: 10.15252/embr.201845856 (*,# equal contribution)
Dekkers S, Ma-Hock L, Lynch I, Russ M, Miller MR, Schins RPF, Keller J, Römer I, Küttler K, Strauss V, De Jong WH, Landsiedel R, Cassee FR: Differences in the toxicity of cerium dioxide nanomaterials after inhalation can be explained by lung deposition, animal species and nanoforms. Inhal Toxicol 30(7-8): 273-286, 2018. doi: 10.1080/08958378.2018.1516834
Harris CP, von Berg A, Berdel D, Bauer CP, Schikowski T, Koletzko S, Heinrich J, Schulz H, Standl M: Association of dietary fatty acids with blood lipids is modified by physical activity in adolescents: Results from the GINIplus and LISA birth cohort studies. Nutrients 10(10): 1372, 2018. doi: 10.3390/nu10101372
Wu S, Zhang M, Yang X, Peng F, Tan J, Yang Y, Wang L, Hu Y, Peng X, Li J. Liu Y, Lu D, Lou H, Feng Q, Lu Y, Guan Y, Zhang Z, Jiao X, Hamer M, Nijsten T, Zeng C, Adhikar K, Gallo C, Poletti I, Schuler-Faccini L, Bortolin M, Quinteros S, Rothhammer F, Bedoya G, José R, Li H, Krutmann J, Liu F, Kayser M, Ruiz-Linares A, Tang K, Xu S, Zhang L, Jin L, Wang J: Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans. Plos Genet 14(9): e1007640, 2018. doi: 10.1371/journal.pgen.1007640
Singh M, Bergmann L, Lang A, Pexa K, Kuck F, Stibane D, Janke L, Ezzahoini H, Lindecke A, Wiek C, Hanenberg H, Köhrer K, von Gall C, Reinke H, Piekorz RP: Gαi3 signaling is associated with sexual dimorphic expression of the clock-controlled output gene Dbp in murine liver. Oncotarget 9(54): 30213-30224, 2018. doi: 10.18632/oncotarget.25727
Narda M, Peno-Mazzarino L, Krutmann J, Trullas C, Granger C: Novel facial cream containing carnosine inhibits formation of advanced glycation end-products in human skin. Skin Pharmacol Physiol 31(6): 324-331, 2018. doi: 10.1159/000492276
Fueldner C, Kohlschmidt J, Riemschneider S, Schulze F, Zoldan K, Esser C, Hauschildt S, Lehmann J: Benzo(a)pyrene attenuates the pattern-recognition-receptor induced proinflammatory phenotype of murine macrophages by inducing IL-10 expression in an aryl hydrocarbon receptor-dependent manner. Toxicology 409: 80-90, 2018. doi: 10.1016/j.tox.2018.07.011
Riemschneider S, Kohlschmidt J, Fueldner C, Esser C, Hauschildt S, Lehmann J: Aryl hydrocarbon receptor activation by benzo(a)pyrene inhibits proliferation of myeloid precursor cells and alters the differentiation state as well as the functional phenotype of murine bone marrow-derived macrophages. Toxicol Lett 296: 106-113, 2018. doi: 10.1016/j.toxlet.2018.07.050
Majora M, Sondenheimer K, Knechten M, Uthe I, Esser C, Schiavi A, Ventura N, Krutmann J: HDAC inhibition improves autophagic and lysosomal function to prevent loss of subcutaneous fat in a mouse model of Cockayne syndrome. Sci Transl Med 10(456): eaam7510, 2018. doi: 10.1126/scitranslmed.aam7510
Full text link: http://stm.sciencemag.org/cgi/content/full/10/456/eaam7510?ijkey=sac1p.cDd82iU&keytype=ref&siteid=scitransmed
Pollet M*, Shaik S*, Mescher M*, Frauenstein K, Tigges J, Braun S, Sondenheimer K, Kaveh M, Bruhs A, Meller S, Homey B, Schwarz A, Esser C, Douki T, Vogel CF, Krutmann J, Haarmann-Stemmann T: The AHR represses nucleotide excision repair and apoptosis and contributes to UV-induced skin carcinogenesis. Cell Death Differ 25: 1823-1836, 2018. doi: 10.1038/s41418-018-0160-1 (* equal contribution)
Forns J, Sunyer J, Garcia-Esteban R, Porta D, Ghassabian A, Giorgis-Allemand L, Gong T, Gehring U, Sørensen M, Standl M, Sugiri D, Almqvist C, Andiarena A, Badaloní C, Beelen R, Berdel D, Cesaroni G, Charles M-A, Eriksen KT, Estarlich M, Fernandez MF, Forhan A, Jaddoe VWV, Korek M, Lichtenstein P, Lertxundi A, Lopez-Espinosa MJ, Markevych I, de Nazelle A, Raaschou-Nielsen O, Nieuwenhuijsen M, Pérez-Lobato R, Philippat C, Slama R, Tiesler CM, Verhulst FC, von Berg A, Vrijkotte T, Nybo Andersen AM, Heude B, Krämer U, Heinrich J, Tiemeier H, Forastiere F, Pershagen G, Brunekreef B, Guxens M: Air pollution exposure during pregnancy and symptoms of attention deficit and hyperactivity disorder in children in Europe. Epidemiology 29(5): 618-626, 2018. doi: 10.1097/EDE.0000000000000874
Hellwig C, Barenys M, Baumann J, Gassmann K, Casanellas L, Kauer G, Fritsche E: Culture of human neurospheres in 3D scaffolds for developmental neurotoxicity testing. Toxicol In Vitro 52: 106-115, 2018. doi: 10.1016/j.tiv.2018.06.002
Schnass W, Hüls A, Vierkötter A, Krämer U, Krutmann J, Schikowski T: Traffic-related air pollution and eczema in the elderly: Findings from the SALIA cohort. Int J Hyg Environ Health 221(6): 861-867, 2018. doi: 10.1016/j.ijheh.2018.06.002
Hanžić N, Horvat A, Bibić J, Unfried K, Jurkin T, Dražić G, Marijanović I, Slade N, Gotić M: Syntheses of gold nanoparticles and their impact on the cell cycle in breast cancer cells subjected to megavoltage X-ray irradiation. Mater Sci Eng C 91: 486-495, 2018. doi: 10.1016/j.msec.2018.05.066
Bauer C, Abdul Pari AA, Umansky V, Utikal J, Boukamp P, Augustin HG, Goerdt S, Géraud C, Felcht M: T-lymphocyte profiles differ between keratoacanthomas and invasive squamous cell carcinomas of the human skin. Cancer Immunol Immunother 67(7): 1147-1157, 2018. doi: 10.1007/s00262-018-2171-7
Bowatte G, Markevych I, Standl M, Dharmage SC, Koletzko S, Lehmann I, Bauer CP, Schikowski T, von Berg A, Berdel D, Heinrich J: Hygienic behavior and allergic sensitization in German adolescents. Allergy 73(9):1915-1918, 2018. doi: 10.1111/all.13492
Masjosthusmann S, Becker D, Petzuch B, Klose J, Siebert C, Deenen R, Barenys M, Baumann J, Dach K, Tigges J, Hübenthal U, Köhrer K, Fritsche E: A transcriptome comparison of time-matched developing human, mouse and rat neural progenitor cells reveals human uniqueness. Toxicol Appl Pharmacol 354: 40-55, 2018. doi: 10.1016/j.taap.2018.05.009
Bühlmeier J, Harris C, Koletzko S, Lehmann I, Bauer CP, Schikowski T, von Berg A, Berdel D, Heinrich J, Hebebrand J, Föcker M, Standl M, Libuda L: Dietary acid load and mental health outcomes in children and adolescents: Results from the GINIplus and LISA birth cohort studies. Nutrients 2018 10(5): E582. doi: 10.3390/nu10050582
Mayerl S, Schmidt M, Doycheva D, Darras VM, Hüttner SS, Boelen A, Visser TJ, Kaether C, Heuer H, von Maltzahn J: Thyroid hormone transporters MCT8 and OATP1C1 control skeletal muscle regeneration. Stem Cell Rep 10(6): 1959-1974, 2018. doi: 10.1016/j.stemcr.2018.03.021
Kotz S, Kullmann M, Kalayda GV, Dyballa-Rukes N, Jaehde U, Metzger S: Optimized two-dimensional gel electrophoresis in an alkaline pH range improves the identification of intracellular CFDA-cisplatin-protein adducts in ovarian cancer cells. Electrophoresis 39(12): 1488-1496, 2018. doi: 10.1002/elps.201700377
Thacher JD, Gehring U, Gruzieva O, Standl M, Pershagen G, Bauer CP, Berdel D, Keller T, Koletzko S, Koppelman GH, Kull I, Lau S, Lehmann I, Maier D, Schikowski T, Wahn U, Wijga AH, Heinrich J, Bousquet J, Anto JM, von Berg A, Melén E, Smit HA, Keil T, Bergström A: Maternal smoking during pregnancy and early childhood and development of asthma and rhinoconjunctivitis - a MeDALL project. Environ Health Perspect 126(4): 047005, 2018. doi: 10.1289/EHP2738
Smith MP, Standl M, Berdel D, von Berg A, Bauer CP, Schikowski T, Koletzko S, Lehmann I, Krämer U, Heinrich J, Schulz H: Handgrip strength is associated with improved spirometry in adolescents. Plos One 13(4): e0194560, 2018. doi: 10.1371/journal.pone.0194560
Hüls A, Klümper C, MacIntyre EA, Brauer M, Melén E, Bauer M, Berdel D, Bergström A, Brunekreef B, Chan-Yeung M, Fuertes E, Gehring U, Gref A, Heinrich J, Standl M, Lehmann I, Kerkhof M, Koppelman GH, Kozyrskyj AL, Pershagen G, Carlsten C, Krämer U, Schikowski T; TAG Study Group: Atopic dermatitis: Interaction between genetic variants of GSTP1, TNF, TLR2, and TLR4 and air pollution in early life. Pediatr Allergy Immunol 29(6): 596-605, 2018. doi: 10.1111/pai.12903
Perkins TN, Peeters PM, Albrecht C, Schins RPF, Dentener MA, Mossman BT, Wouters EFM, Reynaert NL: Crystalline silica alters Sulfatase-1 expression in rat lungs which influences hyper-proliferative and fibrogenic effects in human lung epithelial cells. Toxicol Appl Pharmacol 348: 43-53, 2018. doi: 10.1016/j.taap.2018.04.011
Lanzinger S, Rosenbauer J, Sugiri D, Schikowski T, Treiber B, Klee D, Rathmann W, Holl RW: Impact of long-term air pollution exposure on metabolic control in children and adolescents with type 1 diabetes: results from the DPV registry. Diabetologia 61(6): 1354-1361, 2018. doi: 10.1007/s00125-018-4580-8
Lademann J, Knorr F, Patzelt A, Meinke MC, Richter H, Krutmann J, Rühl E, Doucet O: Laser scanning microscopic investigations of the decontamination of soot nanoparticles from the skin. Skin Pharmacol Physiol 31(2): 87-94, 2018. doi: 10.1159/000485900
Ermakova YG, Pak VV, Bogdanova YA, Kotlobay AA, Yampolsky IV, Shokhina AG, Panova AS, Marygin RA, Staroverov DB, Bilan DS, Sies H, Belousov VV: SypHer3s: a genetically encoded fluorescent ratiometric probe with enhanced brightness and an improved dynamic range. Chem Commun (Camb) 54(23): 2898-2901, 2018. doi: 10.1039/c7cc08740c
Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M: Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX 2018. doi: 10.14573/altex.1712081
Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg H, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A: Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicol Appl Pharmacol 2018. doi: 10.1016/j.taap.2018.02.004
Baker N, Boobis A, Burgoon L, Carney E, Currie R, Fritsche E, Knudsen T, Laffont M, Piersma AH, Poole A, Schneider S, Daston G: Building a developmental toxicity ontology. Birth Defects Res Part B-Dev Reprod Toxicol 110(6): 502-518, 2018. doi: 10.1002/bdr2.1189
Harder L, Dudazy-Gralla S, Müller-Fielitz H, Hjerling Leffler J, Vennström B, Heuer H, Mittag J: Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area. J Neuroendocrinol 30(3): e12573, 2018. doi: 10.1111/jne.12573
Liu W, Pan X, Vierkötter A, Guo Q, Wang X, Wang Q, Seité S, Moyal D, Schikowski T, Krutmann J: A time-series study of the effect of air pollution on outpatient visits for acne vulgaris in Beijing. Skin Pharmacol Physiol 31: 107-113, 2018. doi: 10.1159/000484482
Hüls A, Vierkötter A, Sugiri D, Abramson MJ, Ranft U, Krämer U, Schikowski T: The role of air pollution and lung function on cognitive impairment. Eur Respir J 51: 1701963, 2018. doi: 10.1183/13993003.01963-2017
Ispanixtlahuatl-Meráz O, Schins RPF, Chirino YI: Cell type specific cytoskeleton disruption induced by engineered nanoparticles. Environ Sci Nano 5: 228-245, 2018. doi: 10.1039/C7EN00704C
Piechulek A, von Mikecz A: Life span-resolved nanotoxicology enables identification of age-associated neuromuscular vulnerabilities in the nematode Caenorhabditis elegans. Environ Pollut 233: 1095-1103, 2018. doi: 10.1016/j.envpol.2017.10.012
Filipiak-Pittroff B, Koletzko S, Krämer U, Standl M, Bauer C-P, Berdel D, von Berg A: Full breastfeeding and allergies from infancy until adolescence in the GINIplus cohort. Pediatr Allergy Immunol 29(1): 96-101, 2018. doi: 10.1111/pai.12798
Kassahun H, SenGupta T, Schiavi A, Maglioni S, Skjeldam HK, Arczewska K, Brockway NL, Estes S, Eide L, Ventura N, Nilsen H: Constitutive MAP-kinase activation suppresses germline apoptosis in NTH-1 DNA glycosylase deficient C. elegans. DNA Repair (Amst) 61: 46-55, 2018. doi: 10.1016/j.dnarep.2017.11.009
Tischer C, Dadvand P, Basagana X, Fuertes E, Bergström A, Gruzieva O, Melen E, Berdel D, Heinrich J, Koletzko S, Markevych I, Standl M, Sugiri D, Cirugeda L, Estarlich M, Fernández-Somoano A, Ferrero A, Ibarlueza J, Lertxundi A, Tardón A, Sunyer J, Anto JM: Urban upbringing and childhood respiratory and allergic conditions: A multi-country holistic study. Environ Res 161: 276-283, 2018. doi: 10.1016/j.envres.2017.11.013
Proquin H, Jetten MJ, Jonkhout MCM, Garduño-Balderas LG, Briedé JJ, de Kok TM, Chirino YI, van Loveren H: Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171). Food Chem Toxicol 111: 153-165, 2018. doi: 10.1016/j.fct.2017.11.011
Fülle L, Steiner N, Funke M, Gondorf F, Pfeiffer F, Siegl J, Opitz FV, Haßel SK, Erazo AB, Schanz O, Stunden HJ, Blank M, Gröber C, Händler K, Beyer M, Weighardt H, Latz E, Schultze JL, Mayer G, Förster I: RNA aptamers recognizing murine CCL17 inhibit T cell chemotaxis and reduce contact hypersensitivity in vivo. Mol Ther 26(1): 95-104, 2018. doi: 10.1016/j.ymthe.2017.10.005
Übersichtsarbeiten, Buchbeiträge u.a.
Esser C, Lawrence BP, Sherr DH, Perdew GH, Puga A, Barouki R, Coumoul X: Old receptor, new tricks-the ever-expanding universe of aryl hydrocarbon receptor functions. Report from the 4th AHR Meeting, 29-31 August 2018 in Paris, France. Int J Mol Sci 19(11): 3603, 2018. doi: 10.3390/ijms19113603
Stork B, Ventura N: Targeting the BECN1-BCL2 autophagy regulatory complex to promote longevity. Biotarget 2: 16, 2018. doi: 10.21037/biotarget.2018.10.01
Barenys M, Fritsche E: A historical perspective on the use of stem/progenitor cell-based in vitro methods for neurodevelopmental toxicity testing. Toxicol Sci 165(1): 10-13, 2018. doi: 10.1093/toxsci/kfy170
Fritsche E, Barenys M, Klose J, Masjosthusmann S, Nimtz L, Schmuck M, Wuttke S, Tigges J: Current availability of stem cell-based in vitro methods for developmental neurotoxicity (DNT) testing. Toxicol Sci 165(1): 21-30, 2018. doi: 10.1093/toxsci/kfy178
Fritsche E, Barenys M, Klose J, Masjosthusmann S, Nimtz L, Schmuck M, Wuttke S, Tigges J: Development of the concept for stem cell-based developmental neurotoxicity evaluation. Toxicol Sci 165(1): 14-20, 2018. doi: 10.1093/toxsci/kfy175
Sies H: On the history of oxidative stress: Concept and some aspects of current development. Curr Opinion Toxicol 7: 122-126, 2018. doi: 10.1016/j.cotox.2018.01.002
Bal-Price A, Fritsche E: Editorial: Developmental neurotoxicity. Toxicol Appl Pharmacol 354: 1-2, 2018. doi: 10.1016/j.taap.2018.07.016
Pollet M, Krutmann J, Haarmann-Stemmann T: Commentary: Usage of mitogen-activated protein kinase small inhibitors: More than just inhibition!” Front Pharmacol 9: 935, 2018. doi: 10.3389/fphar.2018.00935
Masjosthusmann S, Barenys M, El-gamal M, Geerts L, Gorreja A, Kühne B, Marchetti N, Tigges J, Witters H, Fritsche E: Literature review and appraisal on alternative neurotoxicity testing methods. EFSA Supporting Publications 2018. doi: 10.2903/sp.efsa.2018.EN-1410
Sondenheimer K, Krutmann J: Novel means for photoprotection. Front Med 5: 162, 2018. doi: 10.3389/fmed.2018.00162
Schneider A, Rückerl R, Standl M, Markevych I, Hoffmann B, Moebus S, Jöckel KH, Weber A, Herr C, Heißenhuber A, Nennstiel-Ratzel U, Heinze S, Schulz C, Kolossa-Gehring M, Niemann H, Gößwald A, Schikowski T, Hüls A, Sugiri D, Peters A: Epidemiologische Studien mit Umweltbezug in Deutschland. Bundesgesundheitsblatt-Gesund 61(6): 697-709, 2018. doi: 10.1007/s00103-018-2740-0
Mescher M, Haarmann-Stemmann T: Modulation of CYP1A1 metabolism: From adverse health effects to chemoprevention and therapeutic options. Pharmacol Ther 187: 71-87, 2018. doi: 10.1016/j.pharmthera.2018.02.012
Diepgen TL, Kresken J, Krutmann J, Merk HF, Senger E, Surber C, Szeimies RM; GD Task Force "Licht.Hautkrebs.Prävention" of the Society for Dermopharmacy: Commentary on the "Evidence- and Consensus-Based (S3) Guidelines for the Treatment of Actinic Keratosis" published by the International League of Dermatological Societies in cooperation with the European Dermatology Forum. Skin Pharmacol Physiol 31(3): 144-146, 2018. doi: 10.1159/000486687
Heinrich J, Schikowski T: COPD patients as vulnerable subpopulation for exposure to ambient air pollution. Curr Environ Health Rep 5(1): 70-76, 2018. doi: 10.1007/s40572-018-0178-z
Esser C, Haarmann-Stemmann T, Hochrath K, Schikowski T, Krutmann J: AHR and the issue of immunotoxicity. Curr Opinion Toxicol 10: 91-97, 2018. doi: 10.1016/j.cotox.2018.03.001
Nakamura M*, Haarmann-Stemmann T*, Krutmann J, Morita A: Alternative test models for skin aging research. Exp Dermatol 27: 495-500, 2018. doi: 10.1111/exd.13519
Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T, Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M: Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX 35(3): 306-352, 2018. doi: 10.14573/altex.1712081
Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg H, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A: Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicol Appl Pharmacol 354: 3-6, 2018. doi: 10.1016/j.taap.2018.02.004
von Mikecz A: Lifetime eco-nanotoxicology in an adult organism: where and when is the invertebrate C. elegans vulnerable? Environ Sci-Nano 5: 616-622, 2018. doi: 10.1039/C7EN01061C
Krutmann J, Sondenheimer K, Grether-Beck S, Haarmann-Stemmann T: Combined, simultaneous exposure to radiation within and beyond the UV spectrum: A novel approach to better understand skin damage by natural sunlight. In: Merk J, Krutmann J (Eds.): Environment and skin. Springer International Publishing, Switzerland, 2018. ISBN: 9783319431000, pp 11-16.
Pavez Loriè E, Stark H-J, Berning M, Boukamp P: Skin squamous cell carcinoma models: The role in combating the disease. In: Marques A, Pirraco RP, Cerqueria MT, Reis RL (Eds.): Skin tissue models. Elsevier, London, UK. ISBN 9780128105450, pp 151-173.
Reinke H, Asher G: Liver Size: Waning by day, waxing by night. Hepatology 67(1): 441-443, 2018. doi: 10.1002/hep.29506
Originalarbeiten
Hellack B, Nickel C, Schins RPF: Oxidative potential of silver nanoparticles measured by electron paramagnetic resonance spectroscopy. J Nanopart Res 19: 404, 2017. doi: 10.1007/s11051-017-4084-3
Hüls A, Krämer U, Carlsten C, Schikowski T, Ickstadt K, Schwender K: Comparison of weighting approaches for genetic risk scores in gene-environment interaction studies. BMC Genetics 18: 115, 2017. doi: 10.1186/s12863-017-0586-3
Uphoff EP, Bird PK, Antó JM, Basterrechea M, von Berg A, Bergström A, Bousquet J, Chatzi L, Fantini MP, Ferrero A, Gehring U, Gori D, Heinrich J, Keil T, Kull I, Lau S, Maier D, Momas I, Narduzzi S, Porta D, Ranciere F, Roumeliotaki T, Schikowski T, Smit HA, Standl M, Sunyer J, Wright J: Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res 2017. doi: 10.1183/23120541.00150-2016
Jendrossek M, Standl M, Koletzko S, Lehmann I, Bauer CP, Schikowski T, von Berg A, Berdel D, Heinrich J, Markevych I: Residential air pollution, road traffic, greenness and maternal hypertension: Results from GINIplus and LISAplus. Int J Occup Environ Med 8(3): 131-142, 2017. doi: 10.15171/ijoem.2017.1073
Benvegnù S, Wahle T, Dotti CG: E3 ligase mahogunin (MGRN1) influences amyloid precursor protein maturation and secretion. Oncotarget 8(52): 89439-89450, 2017. doi: 10.18632/oncotarget.20143
Larribère L, Galach M, Novak D, Arévalo K, Volz HC, Stark HJ, Boukamp P, Boutros M, Utikal J: An RNAi screen reveals an essential role for HIPK4 in human skin epithelial differentiation from iPSCs. Stem Cell Rep 9(4): 1234-1245, 2017. doi: 10.1016/j.stemcr.2017.08.023
Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E: Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Stem Cell Res 25: 72-82, 2017. doi: 10.1016/j.scr.2017.10.013
Lang A, Anand R, Altinoluk-Hambüchen S, Ezzahoini H, Stefanski A, Iram A, Bergmann L, Urbach J, Böhler P, Hänsel J, Franke M, Stühler K, Krutmann J, Scheller J, Stork B, Reichert AS, Piekorz RP: SIRT4 interacts with OPA1 and regulates mitochondrial quality control and mitophagy. Aging-US 9(10): 2163-2189, 2017. doi: 10.18632/aging.101307
Ding A, Yang Y, Zhao Z, Hüls A, Vierkötter A, Yuan Z, Cai J, Zhang J, Gao W, Li J, Zhang M, Matsui M, Krutmann J, Kan H, Schikowski T, Jin L, Wang S: Indoor PM2.5 exposure affects skin aging manifestation in a Chinese population. Sci Rep 7(1): 15329, 2017. doi: 10.1038/s41598-017-15295-8
Hellack B, Sugiri D, Schins RPF, Schikowski T, Krämer U, Kuhlbusch TAJ, Hoffmann B: Land use regression modeling of oxidative potential of fine particles, NO2, PM2.5 mass and association to type two diabetes mellitus. Atmos Environ 171: 181-190, 2017. doi: 10.1016/j.atmosenv.2017.10.017
Daaboul HE, Daher CF, Taleb RI, Boulos J, Bodman-Smith K, Boukamp P, Shebaby WN, Dagher C, El-Sibai M, Mroueh MA: β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo. J Pharm Pharmacol 69(11): 1552-1564, 2017. doi: 10.1111/jphp.12796
Lohan SB, Ahlberg S, Mensch A, Höppe D, Giulbudagian M, Calderón M, Grether-Beck S, Krutmann J, Lademann J, Meinke MC: EPR technology as sensitive method for oxidative stress detection in primary and secondary keratinocytes induced by two selected nanoparticles. Cell Biochem Biophys 75(3-4): 359-367, 2017. doi: 10.1007/s12013-017-0823-4
Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel K, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M: Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun 8: 484, 2017. doi: 10.1038/s41467-017-00604-6
Li H, Kroll T, Moll J, Frappart L, Herrlich P, Heuer H, Ploubidou A: Spindle misorientation of cerebral and cerebellar progenitors is a mechanistic cause of megalencephaly. Stem Cell Rep 9(4): 1071-1080, 2017. doi: 10.1016/j.stemcr.2017.08.013
Hullmann M, Albrecht C, van Berlo D, Gerlofs-Nijland ME, Wahle T, Boots AW, Krutmann J, Cassee FR, Bayer TA, Schins RPF: Diesel engine exhaust accelerates plaque formation in a mouse model of Alzheimer’s disease. Part Fibre Toxicol 14: 35, 2017. doi: 10.1186/s12989-017-0213-5
Dekkers S, Miller MR, Schins RPF, Römer I, Russ M, Vandebriel RJ, Lynch I, Belinga-Desaunay MF, Valsami-Jones E, Connell S, Smith IP, Duffin R, Boere JAJF, Heusinkveld HJ, Albrecht C, de Jong WH, Cassee FR: The effect of zirconium doping of cerium dioxide nanoparticles on pulmonary and cardiovascular toxicity and biodistribution in mice after inhalation. Nanotoxicology 11(6): 794-808, 2017. doi: 10.1080/17435390.2017.1357214
Hammerschmidt-Kamper C, Biljes D, Merches K, Steiner I, Daldrup T, Bol-Schoenmakers M, Pieters RHH, Esser C: Indole-3-carbinol, a plant nutrient and AhR-Ligand precursor, supports oral tolerance against OVA and improves peanut allergy symptoms in mice. Plos One 12(6): e0180321, 2017. doi: 10.1371/journal.pone.0180321
Sthijns MMJPE*, Thongkam W*, Albrecht C, Hellack B, Bast A, Haenen GRMM, Schins RPF: Silver nanoparticles induce hormesis in A549 human epithelial cells. Toxicol In Vitro 40: 223-233, 2017. doi: 10.1016/j.tiv.2017.01.010 (* equal contribution)
Soppa VJ, Schins RPF, Hennig F, Nieuwenhuijsen MJ, Hellack B, Quass U, Kaminski H, Sasse B, Shinnawi S, Kuhlbusch TAJ, Hoffmann B: Arterial blood pressure responses to short-term exposure to fine and ultrafine particles from indoor sources - A randomized sham-controlled exposure study of healthy volunteers. Environ Res 158: 225-232, 2017. doi: 10.1016/j.envres.2017.06.006
Hüls A, Krämer U, Herder C, Fehsel K, Luckhaus C, Stolz S, Vierkötter A, Schikowski T: Genetic susceptibility for air pollution-induced airway inflammation in the SALIA study. Environ Res 152: 43-50, 2017. doi: 10.1016/j.envres.2016.09.028
Hüls A, Fromke C, Ickstadt K, Hille K, Hering J, von MC, Hartmann M, Kreienbrock L: Antibiotic resistances in livestock: A comparative approach to identify an appropriate regression model for count data. Front Vet Sci 4: 71, 2017. doi: 10.3389/fvets.2017.00071
Hüls A, Ickstadt K, Schikowski T, Krämer U: Detection of gene-environment interactions in the presence of linkage disequilibrium and noise by using genetic risk scores with internal weights from elastic net regression. BMC Genet 18(1): 55, 2017. doi: 10.1186/s12863-017-0519-1
Biljes D, Hammerschmidt-Kamper C, Merches K, Esser C: The aryl hydrocarbon receptor in T cells contributes to sustaining oral tolerance against ovalbumin in a mouse model. EXCLI J 16: 291-301, 2017. doi: 10.17179/excli2017-168
Faßbender S, Opitz FV, Johnen S, Förster I, Weighardt H: MyD88 contributes to staphylococcal enterotoxin B-triggered atopic dermatitis-like skin inflammation in mice. J Invest Dermatol 137(8): 1802-1804, 2017. doi: 10.1016/j.jid.2017.04.015
Flexeder C, Thiering E, Koletzko S, Berdel D, Lehmann I, von Berg A, Hoffmann B, Bauer CP, Heinrich J, Schulz H: Higher serum 25(OH)D concentrations are associated with improved FEV1 and FVC in adolescence. Eur Respir J 49(4): 1601804, 2017. doi: 10.1183/13993003.01804-2016
Koch S, Stroisch TJ, Vorac J, Herrmann N, Leib N, Schnautz S, Kirins H, Förster I, Weighardt H, Bieber T: AhR mediates an anti-inflammatory feedback mechanism in human Langerhans cells involving FcεRI and IDO. Allergy 72(11): 1686-1693, 2017. doi: 10.1111/all.13170
Kaisers W, Boukamp P, Stark H-J, Schwender H, Tigges J, Krutmann J, Schaal H: Age, gender and UV-exposition related effects on gene expression in in vivo aged short term cultivated human dermal fibroblasts. Plos One 12(5): e0175657, 2017. doi: 10.1371/journal.pone.0175657
Tzivian L, Jokisch M, Winkler A, Weimar C, Hennig F, Sugiri D, Soppa VJ, Dragano N, Erbel R, Jöckel KH, Moebus S, Hoffmann B; Heinz Nixdorf Recall Study Group: Associations of long-term exposure to air pollution and road traffic noise with cognitive function - An analysis of effect measure modification. Environ Int 103: 30-38, 2017. doi: 10.1016/j.envint.2017.03.018
Kälsch H, Lehmann N, Moebus S, Hoffmann B, Stang A, Jöckel KH, Erbel R, Mahabadi AA: Aortic calcification onset and progression: Association with the development of coronary atherosclerosis. J Am Heart Assoc 6(4): e005093, 2017. doi: 10.1161/JAHA.116.005093
Papala A, Sylvester M, Dyballa-Rukes N, Metzger S, D'Haese J: Isolation and characterization of human CapG expressed and post-translationally modified in Pichia pastoris. Protein Expr Purif 134: 25-37, 2017. doi: 10.1016/j.pep.2017.03.017
Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E: BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Sci Rep 7: 44861, 2017. doi: 10.1038/srep44861
Turgoen MO, Silander TL, Doycheva D, Liao XH, Ridgen M, Ongaro L, Zhou X, Joustra SD, Wit JM, Wade MG, Heuer H, Refetoff S, Bernard DJ: TRH action is impaired in pituitaries of male IGSF1-deficient mice. Endocrinol 158 (4): 815-830, 2017. doi: 10.1210/en.2016-1788
Harris C, Buyken A, Koletzko S, von Berg A, Berdel D, Schikowski T, Koletzko B, Heinrich J, Standl M: Dietary fatty acids and changes in blood lipids during adolescence: The role of substituting nutrient intakes. Nutrients 9(2): 127, 2017. doi: 10.3390/nu9020127
Hülsmann S, Hagos L, Heuer H, Schnell C: Limitations of sulforhodamine 101 for brain imaging. Front Cell Neurosci 11: 44, 2017. doi: 10.3389/fncel.2017.00044
Weber J, McInnes J, Kizilirmak C, Rehders M, Qatato M, Wirth EK, Schweizer U, Verrey F, Heuer H, Brix K: Interdependence of thyroglobulin processing and thyroid hormone export in the mouse thyroid gland. Eur J Cell Biol 96(5): 440-456, 2017. doi: 10.1016/j.ejcb.2017.02.002
Shebaby WN, Mroueh MA, Boukamp P, Ri RI, Bodman-Smith K, El-Sibai M, Daher CF: Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer. BMC Complement Altern Med 17(1): 36, 2017. doi: 10.1186/s12906-016-1531-0
Markevych I, Maier W, Fuertes E, Lehmann I, von Berg A, Bauer CP, Koletzko S, Berdel D, Sugiri D, Standl M, Heinrich J: Neighbourhood greenness and income of occupants in four German areas: GINIplus and LISAplus. Urban For Urban Green 21: 88-95, 2017. doi: 10.1016/j.ufug.2016.11.011
Thongkam W*, Gerloff K*, van Berlo D, Albrecht C, Schins FPR: Oxidant generation, DNA damage and cytotoxicity by a panel of engineered nanomaterials in three different human epithelial cell lines. Mutagenesis 32(1): 105-115, 2017. doi: 10.1093/mutage/gew056 (* equal contribution)
Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer TC, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E: Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Arch Toxicol 91(2): 827-837, 2017. doi: 10.1007/s00204-016-1709-8
Gao W*, Tan J*, Hüls A*, Ding A, Liu Y, Matsui M, Vierkötter A, Krutmann J#, Schikowski T#, Jin L#, Wang S#: Genetic variants associated with skin aging in Chinese Han population. J Dermatol Sci 86(1): 21-29, 2017. doi: 10.1016/j.jdermsci.2016.12.017 (* equal contribution; # Co-senior authors)
Zhang M, Li B, Wu S, Tan J, Yang Y, Marini A, Vierkötter A, Zhang J, Li H, Schikowski T, Jin L, Krutmann J, Wang S: A genome-wide association study of basal transepidermal water loss finds variants at 9q34.3 to be associated with skin barrier function. J Invest Dermatol 137(4): 979–982, 2017. doi: 10.1016/j.jid.2016.11.030
Standl M, Tesch F, Baurecht H, Rodríguez E, Müller-Nurasyid M, Gieger C, Peters A, Wang-Sattler R, Prehn C, Adamski J, Kronenberg F, Schulz H, Koletzko S, Schikowski T, von Berg A, Lehmann I, Berdel D, Heinrich J, Schmitt J, Weidinger S: Association of atopic dermatitis with cardiovascular risk factors and diseases. J Invest Dermatol 137(5): 1074-1081, 2017. doi: 10.1016/j.jid.2016.11.031
Schmuck MR, Temme T, Dach K, de Boer D, Barenys M, Bendt F, Mosig A, Fritsche E: Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro. Arch Toxicol 91(4): 2017–2028, 2017. doi: 10.1007/s00204-016-1852-2
Kohlgrüber S, Upadhye A, Dyballa-Rukes N, McNamara CA, Altschmied J: Regulation of transcription factors by reactive oxygen species and nitric oxide in vascular physiology and pathology. Antioxid Redox Signal 26(13):679-699, 2017. doi: 10.1089/ars.2016.6946
Grether-Beck S, Marini A, Jaenicke T, Stahl W, Krutmann J: Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: Results from a double-blinded, placebo-controlled, cross-over study. Br J Dermatol 176(5): 1231-1240, 2017. doi: 10.1111/bjd.15080
Übersichtsarbeiten, Buchbeiträge u.a.
Sies H, Feinendegen LE: Radiation hormesis: The link to nanomolar hydrogen peroxide. Antioxid Redox Signal 27(9): 596-598, 2017. doi: 10.1089/ars.2017.7233
Siegrist J, Sies H: Disturbed redox homeostasis in oxidative distress - A molecular link from chronic psychosocial work stress to coronary heart disease? Circ Res 121: 103-105, 2017. doi: 10.1161/CIRCRESAHA.117.311182
Cossarizza A, … Esser C, …. et al.: Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol 47: 1584-1797, 2017. doi: 10.1002/eji.201646632
Hellack B, Nickel C, Albrecht C, Kuhlbusch TAJ, Boland S, Baeza-Squiban A, Wohlleben W, Schins RPF: Analytical methods to assess the oxidative potential of nanoparticles: a review. Environ Sci Nano 4: 1920-1934, 2017. doi: 10.1039/c7en00346c
Kraegeloh A, Unfried K: The safety of nanomaterials on molecular and cellular scale. In: Gogotsi Y (Editor) Nanomaterials handbook 2nd edition, CRC Press, USA, 2017. ISBN 9781498703062, pp 629-652.
Hüls A, Schikowski T: Ambient particulate matter and COPD in China: a challenge for respiratory health research. Thorax 72(9): 771-772, 2017. doi: 10.1136/thoraxjnl-2016-209687
Krutmann J, Moyal D, Liu W, Kandahari S, Lee GS, Noppakun N, Xiang LF, Seité S: Pollution and acne: is there a link? Clin Cosmet Investig Dermatol 2017(10): 199-204, 2017. doi: 10.2147/CCID.S131323
Stege H, Krutmann J: Neue Ansätze zur Prävention aktinischer Keratosen. Hautarzt 68(5): 354-358, 2017. doi: 10.1007/s00105-017-3980-x
Fritsche E, Crofton KM, Hernandez AF, Hougaard Bennekou S, Leist M, Bal-Price A, Reaves E, Wilks MF, Terron A, Solecki R, Gourmelon A: OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes. ALTEX 34(2): 311-315, 2017. doi: 10.14573/altex.1701171
Vogel CFA, Haarmann-Stemmann T: The aryl hydrocarbon receptor repressor - More than a simple feedback inhibitor of AHR signaling: Clues for its role in inflammation and cancer. Current Opinion Toxicol 2: 109-119, 2017. doi: 10.1016/j.cotox.2017.02.004
Merches K, Haarmann-Stemmann T, Weighardt H, Krutmann J, Esser C: AHR in the skin: From the mediator of chloracne to a therapeutic panacea? Current Opinion Toxicol 2: 79-86, 2017. doi: 10.1016/j.cotox.2017.02.002
Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ: Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. ALTEX 34(1): 49-74, 2017. doi: 10.14573/altex.1604201
Stone V, Miller MR, Clift MJD, Elder A, Mills NL, Møller P, Schins RPF, Vogel U, Kreyling WG, Jensen KA, Kuhlbusch TAJ, Schwarze PE, Hoet P, Pietroiusti A, De Vizcaya-Ruiz A, Baeza-Squiban A, Tran CL, Cassee FR: Nanomaterials vs ambient ultrafine particles: an opportunity to exchange toxicology knowledge. Environ Health Perspect 125(10): 106002, 2017. doi: 10.1289/EHP424
Krutmann J, Bouloc A, Sore G, Bernard BA, Passeron T: The skin aging exposome. J Dermatol Sci 85(3): 152-161, 2017. doi: 10.1016/j.jdermsci.2016.09.015
Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek ME: Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology 59: 240-255, 2017. doi: 10.1016/j.neuro.2016.05.010
Barenys M, Masjosthusmann S, Fritsche E: Is intake of flavonoid-based food supplements during pregnancy safe for the developing child? A literature review. Curr Drug Targets 18(2): 196-231, 2017. doi: 10.2174/1389450116666150804110049
Martin WF, Sies H: Physiological evolution: Genomic redox footprints. Nat Plants 3: 17071, 2017. doi: 10.1038/nplants.2017.71
Sies H, Berndt C, Jones DP: Oxidative Stress. Annu Rev Biochem 86: 715-748, 2017. doi: 10.1146/annurev-biochem-061516-045037
Sies H: Hydrogen peroxide as a central redox signaling molecule in physiological oxidative stress: Oxidative eustress. Redox Biol 11: 613-619, 2017. doi: 10.1016/j.redox.2016.12.035
Originalarbeiten
Müller-Fielitz H, Stahr M, Bernau M, Richter M, Abele S, Krajka V, Benzin A, Wenzel K, Kalies K, Mittag J, Heuer H, Offermanns S, Schwaninger M: Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun 8: 484, 2017. doi: 10.1038/s41467-017-00604-6
Li H, Kroll T, Moll J, Frappart L, Herrlich P, Heuer H, Ploubidou A: Spindle misorientation of cerebral and cerebellar progenitors is a mechanistic cause of megalencephaly. Stem Cell Rep 2017. doi: 10.1016/j.stemcr.2017.08.013
Tzivian L, Dlugaj M, Winkler A, Hennig F, Fuks K, Sugiri D, Schikowski T, Jakobs H, Erbel R, Jockel KH, Moebus S, Hoffmann B, Weimar C, Heinz Nixdorf Recall study Investigative Group: Long-term air pollution and traffic noise exposures and cognitive function: A cross-sectional analysis of the Heinz Nixdorf Recall study. J Toxicol Environ Health A 79(22-23): 1057-1069, 2016. doi: 10.1080/15287394.2016.1219570
Zhang M, Wu S, Zhang J, Yang Y, Tan J, Liu Y, Guan H, Tang K, Krutmann J, Xu S, Jin L, Guan Y, Li H, Wang S: Large-scale genome-wide scans do not support petaloid toenail as a Mendelian trait. J Genet Genomics 43(12): 702-704, 2016. doi: 10.1016/j.jgg.2016.10.003
Li H, Frappart L, Moll J, Winkler A, Kroll T, Hamann J, Kufferath I, Groth M, Taudien S, Schütte M, Yaspo ML, Heuer H, Lange BM, Platzer M, Zatloukal K, Herrlich P, Ploubidou A: Impaired planar germ cell division in the testis, caused by dissociation of RHAMM from the spindle, results in hypofertility and seminoma. Cancer Res 76(21): 6382-6395, 2016. doi: 10.1158/0008-5472.CAN-16-0179
Fuertes E, Standl M, Forns J, Berdel D, Garcia-Aymerich J, Markevych I, Schulte-Koerne G, Sugiri D, Schikowski T, Tiesler CM, Heinrich J: Traffic-related air pollution and hyperactivity/inattention, dyslexia and dyscalculia in adolescents of the German GINIplus and LISAplus birth cohorts. Environ Int 97: 85-92. doi: 10.1016/j.envint.2016.10.017
Cinotti E, Perrot JL, Labeille B, Biron AC, Vierkötter A, Heusèle C, Nizard C, Schnebert S, Barthelemy JC, Cambazard F: Skin tumours and skin aging in 209 French elderly people: the PROOF study. Eur J Dermatol 26(5): 470-476, 2016. doi: 10.1684/ejd.2016.2838
Unfried K, Krämer U, Sydlik U, Autengruber A, Bilstein A, Stolz S, Marini A, Schikowski T, Keymel S, Krutmann J: Reduction of neutrophilic lung inflammation by inhalation of the compatible solute ectoine: a randomized trial with elderly individuals. Int J Chronic Obstr Pulm Dis 11(1): 2573-2583, 2016. doi: 10.2147/COPD.S115061
Haas K, Weighardt H, Deenen R, Köhrer K, Clausen B, Zahner S, Boukamp P, Bloch W, Krutmann J, Esser C: Aryl hydrocarbon receptor in keratinocytes is essential for murine skin barrier integrity. J Invest Dermatol 136(11): 2260-2269, 2016. doi: 10.1016/j.jid.2016.06.627
Ingenwerth M, Noichl E, Stahr A, Korf HW, Reinke H, von Gall C: Heat shock factor 1 deficiency affects systemic body temperature regulation. Neuroendocrinology 103(5): 605-615, 2016. doi: 10.1159/000441947
Fehsel K, Schikowski T, Jänner M, Hüls A, Voussoughi M, Schulte T, Vierkötter A, Teichert T, Herder C, Sugiri D, Krämer U, Luckhaus C: Estrogen receptor beta polymorphisms and cognitive performance in women: associations and modifications by genetic and environmental influences. J Neural Transm (Vienna) 123(12): 1369-1379, 2016. doi: 10.1007/s00702-016-1620-8
Kalfalah F, Janke L, Schiavi A, Tigges J, Ix A, Ventura N, Boege F, Reinke H: Crosstalk of clock gene expression and autophagy in aging. Aging (Albany NY) 8(9): 1876-1895, 2016. doi: 10.18632/aging.101018
Markevych I, Standl M, Sugiri D, Harris C, Maier W, Berdel D, Heinrich J: Residential greenness and blood lipids in children: A longitudinal analysis in GINIplus and LISAplus. Short communication. Environ Res 151: 168-173, 2016. doi: 10.1016/j.envres.2016.07.037
Wu S, Tan J, Yang Y, Peng Q, Zhang M, Li J, Lu D, Liu Y, Lou H, Feng Q, Lu Y, Guan Y, Zhang Z, Jiao Y, Sabeti P, Krutmann J, Tang K, Jin L, Xu S, Wang S: Genome-wide scans reveal variants at EDAR predominantly affecting hair straightness in Han Chinese and Uyghur populations. Hum Genet 135(11): 1279-1286, 2016. doi: 10.1007/s00439-016-1718-y
Fehrenbach S, Novak D, Bernhardt M, Larribere L, Boukamp P, Umansky V, Utikal J: Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage. Sci Rep 6: 28891, 2016. doi: 10.1038/srep28891
de Hoogh K, Gulliver J, Donkelaar AV, Martin RV, Marshall JD, Bechle MJ, Cesaroni G, Pradas MC, Dedele A, Eeftens M, Forsberg B, Galassi C, Heinrich J, Hoffmann B, Jacquemin B, Katsouyanni K, Korek M, Künzli N, Lindley SJ, Lepeule J, Meleux F, de Nazelle A, Nieuwenhuijsen M, Nystad W, Raaschou-Nielsen O, Peters A, Peuch VH, Rouil L, Udvardy O, Slama R, Stempfelet M, Stephanou EG, Tsai MY, Yli-Tuomi T, Weinmayr G, Brunekreef B, Vienneau D, Hoek G: Development of West-European PM2.5 and NO2 land use regression models incorporating satellite-derived and chemical transport modelling data. Environ Res 151: 1-10, 2016. doi: 10.1016/j.envres.2016.07.005
Hüls A, Krämer U, Gappa M, Müller-Brandes C, Schikowski T, von Berg A, Hoffmann B, Schuster A, Wisbauer M, Flexeder C, Heinrich J, Schulz H, Berdel D: Age dependency of GLI reference values compared with paediatric lung function data in two German studies (GINIplus and LUNOKID). Plos One 11(7): e0159678. doi: 10.1371/journal.pone.0159678
Berg J, Mahmoudjanlou Y, Duscha A, Massa M, Thöne J, Esser C, Gold R, Haghikia A: The immunomodulatory effect of laquinimod in CNS autoimmunity is mediated by the aryl hydrocarbon receptor. J Neuroimmunol 298: 9-15, 2016. doi: 10.1016/j.jneuroim.2016.06.003
Hennig F, Sugiri D, Tzivian L, Fuks K, Moebus S, Jöckel K-H, Vienneau D, Kuhlbusch TAJ, de Hoogh K, Memmesheimer M, Jakobs H, Quass U, Hoffmann B: Comparison of land-use regression modeling with dispersion and chemistry transport modeling to assign air pollution concentrations within the Ruhr area. Atmosphere 7(3): 48, 2016. doi: 10.3390/atmos7030048
Hüls A, Krämer U, Stolz S, Hennig F, Hoffmann B, Ickstadt K, Vierkötter A, Schikowski T: Applicability of the global lung initiative 2012 reference values for spirometry for longitudinal data of elderly women. Plos One 11(6): e0157569, 2016. doi: 10.1371/journal.pone.0157569
Vierkötter A*, Hüls A*, Yamamoto A, Stolz S, Krämer U, Matsui MS, Morita A, Wang S, Li Z, Jin L, Krutmann J*, Schikowski T*: Extrinsic skin aging in German, Chinese and Japanese women manifests differently in all three groups depending on ethnic background, age and anatomical site. J Dermatol Sci 83(3): 219-225, 2016. doi: 10.1016/j.jdermsci.2016.05.011 (* equal contribution)
Brandstätter O*, Schanz O*, Vorac J*, König J, Mori T, Maruyama T, Korkowski M, Haarmann-Stemmann T, von Smolinski D, Schultze JL, Abel J, Esser C, Takeyama H, Weighardt H*, Förster I*: Balancing intestinal and systemic inflammation through cell typespecific expression of the aryl hydrocarbon receptor repressor. Sci Rep 6: 26091, 2016. doi: 10.1038/srep26091 (* equal contribution)
Curjuric I, Imboden M, Bridevaux PO, Gerbase MW, Haun M, Keidel D, Kumar A, Pons M, Rochat T, Schikowski T, Schindler C, von Eckardstein A, Kronenberg F, Probst-Hensch NM: Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline. Age 38(3): 52, 2016. doi: 10.1007/s11357-016-9917-y
Abramson MJ, Schindler C, Schikowski T, Bircher AJ, Burdet L, Gerbase MW, Imboden M, Rochat T, Schmid-Grendelmeier P, Turk AJ, Zemp E, Künzli N, Probst-Hensch N: Rhinitis in Swiss adults is associated with asthma and early life factors, but not second hand tobacco smoke or obesity. Allergol Int 65(2): 192-198, 2016. doi: 10.1016/j.alit.2015.11.004
Hammer-Fomuki E, Mba Okwen P, Ranft U, Gardemann J, Schikowski T: Attitudes of health care professionals towards Mutual Health Organizations: evidence from two regions in the Northwest Province of Cameroon. J Public Health 24(3): 175-183, 2016. doi: 10.1007/2Fs10389-016-0716-9
Ohlwein S, Klümper C, Vossoughi M, Sugiri D, Stolz S, Vierkötter A, Schikowski T, Kara K, Germing A, Quass U, Krämer U, Hoffmann B: Air pollution and diastolic function in elderly women - Results from the SALIA study cohort. Int J Hyg Environ Health 219(4-5): 356-363, 2016. doi: 10.1016/j.ijheh.2016.02.006
Tzivian L, Dlugaj M, Winkler A, Weinmayr G, Hennig F, Fuks KB, Vossoughi M, Schikowski T, Weimar C, Erbel R, Jöckel KH, Moebus S, Hoffmann B, on behalf of the Heinz Nixdorf Recall Study Investigative Group: Long-term air pollution and traffic noise exposures and mild cognitive impairment in older adults: A cross-sectional analysis of the Heinz Nixdorf Recall study. Environ Health Perspect 124(9): 1361-1368, 2016. doi: 10.1289/ehp.1509824
Fuertes E, Markevych I, Bowatte G, Gruzieva O, Gehring U, Becker A, Berdel D, von Berg A, Bergström A, Brauer M, Brunekreef B, Brüske I, Carlsten C, Chan-Yeung M, Dharmage SC, Hoffmann B, Klümper C, Koppelman GH, Kozyrskyj A, Korek M, Kull I, Lodge C, Lowe A, MacIntyre E, Pershagen G, Standl M, Sugiri D, Wijga A, Heinrich J: Residential greenness is differentially associated with childhood allergic rhinitis and aeroallergen sensitization in seven birth cohorts. Allergy 71(10): 1461-1471, 2016. doi: 10.1111/all.12915
Geisel MH, Coassin S, Heßler N, Bauer M, Eisele L, Erbel R, Haun M, Hennig F, Moskau-Hartmann S, Hoffmann B, Jöckel KH, Kedenko L, Kiechl S, Kollerits B, Mahabadi AA, Moebus S, Nürnberg G, Nürnberg P, Paulweber B, Vens M, Willeit J, Willeit K, Klockgether T, Ziegler A, Scherag A, Kronenberg F: Update of the effect estimates for common variants associated with carotid intima media thickness within four independent samples: The Bonn IMT Family Study, the Heinz Nixdorf Recall Study, the SAPHIR Study and the Bruneck Study. Atherosclerosis 249: 83-87, 2016. doi: 10.1016/j.atherosclerosis.2016.03.042
Markevych I, Smith MP, Jochner S, Standl M, Brüske I, von Berg A, Bauer CP, Fuks K, Koletzko S, Berdel D, Heinrich J, Schulz H: Neighbourhood and physical activity in German adolescents: GINIplus and LISAplus. Environ Res 147: 284-293, 2016. doi: 10.1016/j.envres.2016.02.023
Rosenbauer J, Tamayo T, Bächle C, Stahl-Pehe A, Landwehr S, Sugiri D, Krämer U, Maier W, Hermann JM, Holl RW, Rathmann W: Re: Ambient air pollution and early manifestation of type 1 diabetes. Epidemiology 27(4): e25-26, 2016. doi: 10.1097/EDE.0000000000000495
Smith MP, von Berg A, Berdel D, Bauer CP, Hoffmann B, Koletzko S, Nowak D, Heinrich J, Schulz H: Physical activity is not associated with spirometric indices in lung-healthy German youth. Eur Respir J 48(2): 428-440, 2016. doi: 10.1183/13993003.01408-2015
Tamayo T, Rathmann W, Stahl-Pehe A, Landwehr S, Sugiri D, Krämer U, Hermann J, Holl RW, Rosenbauer J: No adverse effect of outdoor air pollution on HbA in children and young adults with type 1 diabetes. Int J Hyg Environ Health 219(4-5): 349-355, 2016. doi: 10.1016/j.ijheh.2016.02.002
Thiering E, Markevych I, Brüske I, Fuertes E, Kratzsch J, Sugiri D, Hoffmann B, von Berg A, Bauer CP, Koletzko S, Berdel D, Heinrich J: Associations of residential long-term air pollution exposures and satellite-derived greenness with insulin resistance in German adolescents. Environ Health Perspect 124(8): 1291-1298, 2016. doi: 10.1289/ehp.1509967
Heusinkveld HJ, van Vliet AC, Nijssend PCG, Westerink RHS: In vitro neurotoxic hazard characterisation of dinitrophenolic herbicides. Toxicol Lett 252: 62-69, 2016. doi: 10.1016/j.toxlet.2016.04.014
Hüls A, Krämer U, Schuster A, Gappa M, Wisbauer M, Müller-Brandes C, Schikowski T, Hoffmann B, von Berg A, Berdel D: Inclusion of children with airway disease for the development of spirometry reference data. Eur Respir J 47(4): 1290-1292, 2016. doi: 10.1183/13993003.01465-2015
Nöske K, Stark H-J, Nevaril L, Berning M, Langbein L, Goyal A, Diederichs S, Boukamp P: Mitotic diversity in homeostatic human interfollicular epidermis. Int J Mol Sci 17(2): 167, 2016. doi: 10.3390/ijms17020167
Vogel CFA, Chang WLW, Kado S, McKulloh K, Vogel H, Wu D, Haarmann-Stemmann T, Yang GX, Leung PSC, Matsumura F, Gershwin ME: Transgenic overexpression of aryl hydrocarbon receptor repressor (AhRR) and AhR-mediated induction of CYP1A1, cytokines and acute toxicity. Environ Health Perspect 124(7): 1071-1083, 2016. doi: 10.1289/ehp.1510194
Orban E, McDonald K, Sutcliffe R, Hoffmann B, Fuks KB, Dragano N, Viehmann A, Erbel R, Jöckel KH, Pundt N, Moebus S: Residential road traffic noise and high depressive symptoms after five years of follow-up: Results from the Heinz Nixdorf Recall study. Environ Health Perspect 124(5): 578-585, 2016. doi: 10.1289/ehp.1409400
Hüls A*, Vierkötter A*, Gao W*, Krämer U, Yang Y, Ding A, Stolz S, Matsui M, Kan H, Wang S, Jin L*, Krutmann J*, Schikowski T*: Traffic-related air pollution contributes to development of facial lentigines: Further epidemiological evidence from Caucasians and Asians. J Invest Dermatol 136(5): 1053-1056, 2016. doi: 10.1016/j.jid.2015.12.045 (* equal contribution) Commentary by Anne Lynn S. Chang
Didovic S*, Opitz FV*, Holzmann B, Förster I, Weighardt H: Requirement of MyD88 signaling in keratinocytes for Langerhans cell migration and initiation of atopic dermatitis-like symptoms in mice. Eur J Immunol 46(4): 981-992, 2016. doi: 10.1002/eji.201545710 (* equal contribution)
Baumann J, Gassmann K, Masjosthusmann S, DeBoer D, Bendt F, Giersiefer S, Fritsche E: Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events. Arch Toxicol 90(6): 1415-1427, 2016. doi: 10.1007/s00204-015-1568-8
Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, Ordóñez-Gutiérrez L, Wandosell F, Viña J, Dotti CG, Hall RA, Pulido R, Gerges NZ, Chan AM, Spaller MR, Serrano M, Venero C, Esteban JA: PTEN recruitment controls synaptic and cognitive function in Alzheimer’s models. Nat Neurosci 19(3): 443-453, 2016. doi: 10.1038/nn.4225
Scharf A, Gührs KH, von Mikecz A: Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans. Nanotoxicology 10(4): 426-435, 2016. doi: 10.3109/17435390.2015.1073399
Raaschou-Nielsen O, Beelen R, Wang M, Hoek G, Andersen ZJ, Hoffmann B, Stafoggia M, Samoli E, Weinmayr G, Dimakopoulou K, Nieuwenhuijsen M, Xun WW, Fischer P, Eriksen KT, Sørensen M, Tjønneland A, Ricceri F, de Hoogh K, Key T, Eeftens M, Peeters PH, Bueno-de-Mesquita HB, Meliefste K, Oftedal B, Schwarze PE, Nafstad P, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Penell J, De Faire U, Korek M, Pedersen N, Östenson CG, Pershagen G, Fratiglioni L, Concin H, Nagel G, Jaensch A, Ineichen A, Naccarati A, Katsoulis M, Trichpoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Brunekreef B, Sokhi RS, Katsouyanni K, Vineis P: Particulate matter air pollution components and risk for lung cancer. Environ Int 87: 66-73, 2016. doi: 10.1016/j.envint.2015.11.007
De Spirt S, Eckers A, Wehrend C, Micoogullari M, Sies H, Stahl W, Steinbrenner H: Interplay between the chalcone cardamonin and selenium in the biosynthesis of Nrf2- regulated antioxidant enzymes in intestinal Caco-2 cells. Free Radic Biol Med 91: 164-171, 2016. doi: 10.1016/j.freeradbiomed.2015.12.011
von Berg A, Filipiak-Pittroff B, Schulz H, Hoffmann U, Link E, Sußmann M, Schnappinger M, Brüske I, Standl M, Krämer U, Hoffmann B, Heinrich J, Bauer CP, Koletzko S, Berdel D, for the GINIplus Study Group: Allergic manifestation 15 years after early intervention with hydrolyzed formulas – the GINI Study. Allergy 71(2): 210-219, 2016. doi: 10.1111/all.12790
Flexeder C, Thiering E, von Berg A, Berdel D, Hoffmann B, Koletzko S, Bauer CP, Koletzko B, Heinrich J, Schulz H: Peak weight velocity in infancy is negatively associated with lung function in adolescence. Pediatr Pulmonol Pediatr Pulmonol 51(2): 147-156, 2016. doi: 10.1002/ppul.23216
Dittmann KH, Rothmund MC, Paasch A, Mayer C, Fehrenbacher B, Schaller M, Frauenstein K, Fritsche E, Haarmann-Stemmann T, Braeuning A, Rodemann HP: The nuclear aryl hydrocarbon receptor is involved in regulation of DNA-repair and cell survival following treatment with ionizing radiation. Toxicol Lett 240(1): 122-129, 2016. doi: 10.1016/j.toxlet.2015.10.017
Pilz C, Feyerabend T, Sonner J, Redaelli C, Peter K, Kunze A, Haas K, Esser C, Schäkel K, Wick W, Rodewald HR, Lanz TV, Platten M: Normal mast cell numbers in the tissues of AhR-deficient mice. Exp Dermatol 25(1): 62-63, 2016. doi: 10.1111/exd.12864
Hornstein T, Lehmann S, Philipp D, Detmer S, Hoffmann M, Peter C, Wesselborg S, Unfried K, Windolf J, Flohé S, Paunel-Görgülü A: Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase- and proteasome-mediated Mcl-1 degradation. J Leukoc Biol 99(1):163-174, 2016. doi: 10.1189/jlb.3A1114-537RR
Pedersen M, Gehring U, Beelen R, Wang M, Giorgis-Allemand L, Andersen AM, Basagana X, Bernard C, Cirach M, Forastiere F, de Hoogh K, Grazuleviciene R, Gruzieva O, Hoek G, Jedynska A, Klümper C, Kooter IM, Krämer U, Kukkonen J, Porta D, Postma DS, Raaschou-Nielsen O, van Rossem L, Sunyer J, Sørensen M, Tsai MY, Vrijkotte TG, Wilhelm M, Nieuwenhuijsen MJ, Pershagen G, Brunekreef B, Kogevinas M, Slama R: Elemental constituents of particulate matter and newborn's size in eight European cohorts. Environ Health Perspect 124(1): 141-150, 2016. doi: 10.1289/ehp.1409546
Grether-Beck S, Marini A., Jaenicke T, Krutmann J: French maritime pine bark extract (Pycnogenol®) effects on human skin: Clinical and molecular evidence. Skin Pharmacol Physiol 29: 13-17, 2016. doi: 10.1159/000441039
Übersichtsarbeiten, Buchbeiträge u.a.
Boukamp P, Stark H-J: Nischenprodukt Stammzelle? In: Baden-Württemberg Stiftung (Ed.): 100! Was die Wissenschaft vom Altern weiß. Hirzel-Verlag, Stuttgart, 2016. ISBN: 978-3-7776-2574-4, pp 60-66.
Benfenati E, Berggren E, Fritsche E, Hartung T, Slikker W, Spielmann S, Testai E, Tice RR, Tiramani M, Villenave R: Novel chemical hazard characterisation approaches. EFSA Journal 14(S1): s0506, 2016. doi: 10.2903/j.efsa.2016.s0506
Boix N, Teixido E, Vila-Cejudo M, Ortiz P, Ibanez E, Gomez-Catalan J, Llobet JM, Barenys M: Risk assessment for human embryonic development of triclabendazole residues in milk and cheese in the diet of a rural population in Cajamarca (Peru): A preliminary approach. In: Muñoz-Torrero D, Domínguez À, Manresa À (Eds.): Recent Advances in Pharmaceutical Sciences VI. Research Signpost, Indien, 2016. ISBN ebook 978-81-308-0566-5, pp 37-47.
Schiavi A and Ventura N: Mitochondrial longevity pathways. In: Olsen A, Gill MS (Eds.): Ageing: Lessons from C. elegans. Springer International Publishing, Switzerland, 2016. ISBN print: 978-3-319-44701-8, pp 83-108.
Humbert P, Dréno B, Krutmann J, Luger TA, Triller R, Meaume S, Seité S: Recommendations for managing cutaneous disorders associated with advancing age. Clin Interv Aging 12(11): 141-148, 2016. doi: 10.2147/CIA.S96232
Maglioni M, Arsalan N, Ventura N: C. elegans screening strategies to identify pro-longevity interventions. Mech Ageing Dev 157: 60-69, 2016. doi: 10.1016/j.mad.2016.07.010
Heusinkveld HJ, Wahle T, Campbell A, Westerink RHS, Tran L, Johnston H, Stone V, Cassee FR, Schins RPF: Neurodegenerative and neurological disorders by small inhaled particles. Neurotoxicology 56: 94-106, 2016. doi: 10.1016/j.neuro.2016.07.007
Maglioni S, Ventura N: C. elegans as a model organism for human mitochondrial associated disorders. Mitochondrion 30: 117-125, 2016. doi: 10.1016/j.mito.2016.02.003
Klionski DJ et al.: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1): 1-222, 2016. doi: 10.1080/15548627.2015.1100356
Zwighaft Z, Reinke H, Asher G: The Liver in the Eyes of a Chronobiologist. J Biol Rhythms 31(2): 115-124, 2016. doi: 10.1177/0748730416633552
Nehr S, Gladtke D, Hellack B, Hermann H, Hoffmann B, Kuhlbusch TAJ, Schins RPF, Wiesen P, Zellner R: Tropospheric aerosols – Current research and future air quality policy. Gefahrst Reinh Luft 76(6): 231-237, 2016. (abstract)
Shaik A, Schiavi A, Ventura N: Mitochondrial autophagy promotes healthy aging (Editorial). Cell Cycle 15(4): 1805-1806, 2016. doi: 10.1080/15384101.2016.1181876
Visser WE, Heuer H, Visser TJ: Triiodothyroacetic Acid Treatment in MCT8 Deficiency: A Word of Nuance (Editorial). Thyroid 26(5): 615-617, 2016. doi: 10.1089/thy.2016.0191
Kermanizadeh A, Gosens G, Johnston H, Danielsen PH, Jacobsen NR, Lenz AG, Fernandes T, Schins RPF, Cassee FR, Wallin H, Kreyling W, Stoeger T, Loft S, Møller P, Tran L, Stone V: A multi-laboratory toxicological assessment of a panel of ten engineered nanomaterials to human health - ENPRA project - the highlights, the limitations and the current and future challenges. J Toxicol Environ Health B Crit Rev 19(1): 1-28, 2016. doi: 10.1080/10937404.2015.112621
Reinke H, Asher G: Circadian Clock Control of Liver Metabolic Functions. Gastroenterology 150(3): 574–580, 2016. doi: 10.1053/j.gastro.2015.11.043
Krutmann J, Schikowski T, Hüls A, Vierkötter A, Grether-Beck S: Umweltinduzierte (extrinsische) Hautalterung. Der Hautarzt 67(2): 99-102, 2016. doi: 10.1007/s00105-015-3750-6
Esser C: The Aryl Hydrocarbon Receptor in Immunity: Tools and Potential. In: Cuturi MC, Anegon I (Hrsg.): Suppression and Regulation of Immune Responses, Methods and Protocols, Volume II. Humana press New York, 2016. ISBN 978-1-4939-3138-5
Originalarbeiten
Bürkel K, Krämer U, Möllers M, Falkenberg MK, Klockenbusch W, Schmitz R: 3D ultrasound evaluation of the fetal ear - comparison of an xMatrix probe with a conventional mechanical probe. Ultraschall Med 2015. doi: 10.1055/s-0041-108567. [pubmed]
Randag AC, Graaff R, Dreise MM, Vierkötter A, Werker PMN, Stenekes MW: Body mass index, chronological age and hormonal status are better predictors of biological skin age than arm skin autofluorescence in healthy women who have never smoked. Br J Dermatol 73(5): 1199-1204, 2015. [pubmed]
Thiering E, Brüske I, Kratzsch J, Hofbauer LC, Berdel D, von Berg A, Lehmann I, Hoffmann B, Bauer CP, Koletzko S, Heinrich J: Associations between serum 25-hydroxyvitamin D and bone turnover markers in a population based sample of German children. Sci Rep 5: 18138, 2015. [pubmed] (open access)
Gehring U, Wijga A, Hoek G, Bellander T, Berdel D, Brüske I, Fuertes E, Gruzieva O, Heinrich J, Hoffmann B, de Jongste JC, Klümper C, Koppelman GH, Korek M, Krämer U, Maier D, Melén E, Pershagen G, Postma DS, Standl M, von Berg A, Anto JM, Bousquet J, Keil T, Smit HA, Brunekeef B: Exposure to air pollution and development of asthma and rhinoconjunctivitis throughout childhood and adolescence: a population-based birth cohort study. Lancet Resp Med 3(12): 933-942, 2015. [abstract]
Biljes B, Hammerschmidt-Kamper C, Kadow S, Diel P, Weigt C, Burkart V, Esser C: Impaired glucose and lipid metabolism in ageing aryl hydrocarbon receptor deficient mice. EXCLI Journal (14): 1153-1163, 2015. [open access]
Kullmann M, Kalayda GV, Hellwig M, Kotz S, Hilger AH, Metzger S, Jaehde U: Assessing the contribution of the two protein disulfide isomerases PDIA1 and PDIA3 to cisplatin resistance. J Inorg Biochem 153: 247-252, 2015. [pubmed]
Schmohl KA, Müller AM, Wechselberger A, Rühland S, Salb N, Schwenk N, Heuer H, Carlsen J, Göke B, Nelson PJ, Spitzweg C: Thyroid hormones and tetrac - new regulators of stroma tumour formation via integrin. Endocrine-Related Cancer 22(6): 941-952, 2015. [pubmed]
Zwighaft Z, Aviram R, Shalev M, Rousso-Noori L, Kraut-Cohen J, Golik M, Brandis A, Reinke H, Aharoni A, Kahana C, Asher G: Circadian clock control by polyamine levels through a mechanism that declines with age. Cell Metab 15: 468-574, 2015. [pubmed]
Van den Ecker D, Hoffmann M, Müting G, Maglioni S, Herebian D, Mayatepek E, Ventura N, Distelmaier F: C. elegans ATAD-3 modulates mitochondrial iron and heme homeostasis. Biochem Biophys Res Commun 467(2): 389-394, 2015. [pubmed]
de Boer J, Fritsche E, Schoeters G, Kimber I: The European Long-range Research Initiative (LRI): A decade of contributions to human health protection, exposure modelling and environmental integrity. Toxicology 337: 83-90, 2015. [pubmed]
Haarmann-Stemmann T, Esser C, Krutmann J: The Janus-faced role of Aryl Hydrocarbon Receptor (AHR) signaling in the skin: Consequences for prevention and treatment of skin disorders. J Invest Dermatol 135(11): 2572-2576, 2015. [pubmed]
Tsai M-Y, Hoek G, Eeftens M, de Hoogh K, Beelen R, Beregszaszi T, Cesaroni G, Cirach M, Cyrys J, de Nazelle A, de Vocht F, Ducret-Stich R, Eriksen K, Galassi C, Grazuleviciene R, Grazulevicius T, Grivas G, Gryparis A, Heinrich J, Hoffmann B, Iakovides M, Keuken M, Krämer U, Künzli N, Lanki T, Madsen C, Meliefste K, Merritt A-S, Mosler G, Nieuwenhuijsen M, Pershagen G, Phuleria H, Quass U, Ranzi A, Schaffner E, Sokhi R, Stempfelet M, Stephanou E, Sugiri D, Taimisto P, Tewis M, Udvardy O, Wang M, Brunekreef B: Spatial variation of PM elemental composition between and within 20 European study areas - Results of the ESCAPE project. Environ Int 84: 181-192, 2015. [pubmed]
Fuertes E, Bracher J, Flexeder C, Markevych I, Klümper C, Hoffmann B, Krämer U, von Berg A, Bauer CP, Koletzko S, Berdel D, Heinrich J, Schulz H: Long-term air pollution exposure and lung function in 15 year-old adolescents living in an urban and rural area in Germany: The GINIplus and LISAplus cohorts. Int J Hyg Environ Health 218(7): 656-665 2015. [pubmed]
Luzak A, Flexeder C, von Berg A, Berdel D, Klümper C, Koletzko S, Bauer CP, Heinrich J, Nowak D, Schulz H: Relation of lung function and current inhalant allergen-specific immunoglobulin E concentrations in adolescents (GINIplus cohort). Ann Allergy Asthma Immunol 115(3): 183-190, 2015. [pubmed]
Schmohl KA, Müller, AM, Schwenk N, Knoop K, Reijntjes E, Köhrle J, Heuer H, Bartenstein P, Göke B, Nelson PJ, Spitzweg C: Establishment of an effective radioiodine thyroid ablation protocol in mice. Eur Thyroid J 4 (suppl 1): 74-80, 2015. (abstract)
Weimar C, Winkler A, Dlugaj M, Lehmann N, Hennig F, Bauer M, Kröger K, Kälsch H, Mahabadi AA, Dragano N, Moebus S, Hoffmann B, Jöckel KH, Erbel R, and on behalf of the Heinz Nixdorf Recall Study Investigative Group: Ankle-Brachial Index but Neither Intima Media Thickness Nor Coronary Artery Calcification is Associated With Mild Cognitive Impairment. J Alzheimers Dis 47(2): 433-442, 2015. [pubmed]
Weighardt H, Förster I: Bcl-3 puts the brakes on contact hypersensitivity. Eur J Immunol 45(4): 971-974, 2015. [pubmed]
Zoch A, Mayerl S, Schulz A, Greither T, Frappart L, Rübsam J, Heuer H, Giovannini M, Morrison H: Merlin Isoforms 1 and 2 Both Act as Tumour Suppressors and Are Required for Optimal Sperm Maturation. Plos One 10(8): e0129151, 2015. [pubmed] (open access)
Kotz S, Kullmann M, Crone B, Kalayda GV, Jaehde U, Metzger S: Combination of two-dimensional gel electrophoresis and a fluorescent carboxyfluorescein diacetate labeled cisplatin analogue allows the identification of intracellular cisplatin-protein adducts. Electrophoresis 36(21-22): 2811-2819, 2015. [pubmed]
Hampel R, Peters A, Beelen R, Brunekreef B, Cyrys J, De Faire U, de Hoogh K, Fuks K, Hoffmann B, Hüls A, Imboden M, Jedynska A, Kooter I, Koenig W, Künzli N, Leander K, Magnusson P, Männistö S, Penell J, Pershagen G, Phuleria H, Probst-Hensch N, Pundt N, Schaffner E, Schikowski T, Sugiri D, Tiittanen P, Tsai M-Y, Wang M, Wolf K, Lanki T, for the ESCAPE TRANSPHORM study groups: Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environ Int 82: 76-84, 2015. [pubmed]
Li M, Vierkötter A, Schikowski T, Hüls A, Ding A, Matsui MS, Deng B, Ma C, Ren A, Zhang J, Tan J, Yang Y, Jin L, Krutmann J, Li Z, Wang S: Epidemiological evidence that indoor air pollution from cooking with solid fuels accelerates skin aging in Chinese women. J Dermatol Sci 79(2): 148-154, 2015. [pubmed]
Schikowski T, Vossoughi M, Vierkötter A, Schulte T, Teichert T, Sugiri D, Fehsel K, Tzivian L, Bae IS, Ranft U, Hoffmann B, Probst-Hensch N, Herder C, Krämer U, Luckhaus C: Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women. Environ Res 142: 10-16, 2015. [pubmed]
Teichert T, Hellwig A, Peßler A, Hellwig M, Vossoughi M, Sugiri D, Vierkötter A, Schulte T, Freund J, Roden M, Hoffmann B, Schikowski T, Luckhaus C, Krämer U, Henle T, Herder C: Association between Advanced Glycation End Products and Impaired Fasting Glucose: Results from the SALIA Study. Plos One 10(5): e0128293, 2015. [pubmed] (open access)
Viehmann A, Hertel S, Fuks K, Eisele L, Moebus S, Möhlenkamp S, Nonnemacher M, Jakobs H, Erbel R, Jöckel KH, Hoffmann B, on behalf of the Heinz Nixdorf Recall Investigator Group: Long-term residential exposure to urban air pollution and repeated measures of systemic blood markers of inflammation and coagulation. Occup Environ Med 72(9): 656-663, 2015. [pubmed]
Weinmayr G, Hennig F, Fuks K, Nonnemacher M, Jakobs H, Möhlenkamp S, Erbel R, Jöckel KH, Hoffmann B, Moebus S, on behalf of the Heinz Nixdorf Recall Investigator Group: Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. Environ Health 14(1): 53, 2015. [pubmed] (open access)
Weinreich G, Wessendorf TE, Pundt N, Weinmayr G, Hennig F, Moebus S, Möhlenkamp S, Erbel R, Jöckel KH, Teschler H, Hoffmann B, on behalf of the Heinz Nixdorf Recall study group: Association of short-term ozone and temperature with sleep-disordered breathing. Eur Respir J 46(5): 1361-1369, 2015. [pubmed]
Wolf K, Stafoggia M, Cesaroni G, Andersen ZJ, Beelen R, Galassi C, Hennig F, Migliore E, Penell J, Ricceri F, Sørensen M, Turunen AW, Hampel R, Hoffmann B, Kälsch H, Laatikainen T, Pershagen G, Raaschou-Nielsen O, Sacerdote C, Vineis P, Badaloni C, Cyrys J, de Hoogh K, Eriksen KT, Jedynska A, Keuken M, Kooter I, Lanki T, Ranzi A, Sugiri D, Tsai MY, Wang M, Hoek G, Brunekreef B, Peters A, Forastiere F: Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts. Epidemiology 26(4): 565-74, 2015. [pubmed]
Wrona M, Jöckel KH, Pannier F, Bock E, Hoffmann B, Rabe E: Association of Venous Disorders with Leg Symptoms: Results from the Bonn Vein Study 1. Eur J Vasc Endovasc Surg 50(3): 360-367, 2015. [pubmed]
Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, Axelstad M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Monnet-Tschudi F, Wilks MF, Ylikomi T, Fritsche E: International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Arch Toxicol 89(2): 269-287, 2015. [pubmed] (open access)
Schiavi A, Maglioni S, Palikaras K, Shaik A, Strapazzon F, Brinkmann V, Torgovnick A, Castelein N, De Henau S, Braeckman BP, Cecconi F, Tavernarakis N, Ventura N: Iron starvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans. Curr Biol 25(14): 1810-1822, 2015. [pubmed]
Maglioni S, Arsalan N, Franchi L, Hurd A, Opipari AW, Glick GD, Ventura N: An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans. Biochim Biophys Acta-Bioenerg 1847(11): 1469-1478, 2015. [pubmed]
Kroker M, Sydlik U, Autengruber A, Cavelius C, Weighardt H, Kraegeloh A, Unfried K: Preventing carbon nanoparticle-induced lung inflammation reduces antigen-specific sensitization and subsequent allergic reactions in a mouse model. Part Fibre Toxicol 12(1): 20, 2015. [pubmed] (open access)
Hellack B, Quass U, Beuck H, Wick G, Kuttler W, Schins RPF, Kuhlbusch TAJ: Elemental composition and radical formation potency of PM10 at an urban background station in Germany in relation to origin of air masses. Atmos Environ 105: 1–6, 2015. (abstract)
Bekki K, Vogel H, Li W, Ito T, Sweeney C, Haarmann-Stemmann T, Matsumura F, Vogel CF: The aryl hydrocarbon receptor (AhR) mediates resistance to apoptosis induced in breast cancer cells. Pestic Biochem Physiol 120: 5-13, 2015. [pubmed]
Waldera Lupa DM, Kalfalah F, Safferling K, Boukamp P, Poschmann G, Volpi E, Götz-Rösch C, Bernerd F, Haag L, Huebenthal U, Fritsche E, Boege F, Grabe N, Tigges J, Stühler K*, Krutmann J*: Characterization of skin aging-associated secreted proteins (SAASP) produced by dermal fibroblasts isolated from intrinsically aged human skin. J Invest Dermatol 135(8): 1954-1968, 2015. (* equal contribution) [pubmed]
Berning M, Prätzel-Wunder S, Bickenbach JR, Boukamp P: Three-dimensional in vitro skin and skin cancer models based on human fibroblast-derived matrix. Tissue Eng Part C Methods 21(9): 958-970, 2015. [pubmed]
Brüske I, Pei Z, Thiering E, Flexeder C, Berdel D, von Berg A, Koletzko S, Bauer CP, Hoffmann B, Heinrich J, Schulz H, and for the GINIplus Study Group: Caesarean Section has no impact on lung function at the age of 15 years. Pediatr Pulmonol 50(12): 1262-1269, 2015. [pubmed]
Idler N, Teuner CM, Hunger M, Holle R, Ortlieb S, Schulz H, Bauer CP, Hoffmann U, Koletzko S, Lehmann I, von Berg A, Berdel D, Hoffmann B, Schaaf B, Heinrich J, Wolfenstetter SB, for the GINIplus and LISAplus Study Groups: The association between physical activity and healthcare costs in children - results from the GINIplus and LISAplus cohort studies. BMC Public Health 15(1): 437, 2015. [pubmed] (open access)
Jones DP, Sies H: The Redox Code. Antioxid Redox Signal 23(9): 734-746, 2015. [pubmed] (open access)
Chen SY, Wu CF, Lee JH, Hoffmann B, Peters A, Brunekreef B, Chu DC, Chan CC: Associations between Long-Term Air Pollutant Exposures and Blood Pressure in Elderly Residents of Taipei City: A Cross-Sectional Study. Environ Health Perspect 123(8): 779-784, 2015. [pubmed] (open access)
Fuertes E, Standl M, von Berg A, Lehmann I, Hoffmann B, Bauer CP, Koletzko S, Berdel D, Heinrich J: Parental allergic disease before and after child birth poses similar risk for childhood allergies. Allergy 70(7): 873-886, 2015. [pubmed]
Hoffmann B, Weinmayr G, Hennig F, Fuks K, Moebus S, Weimar C, Dragano N, Hermann DM, Kälsch H, Mahabadi AA, Erbel R, Jöckel KH: Luftqualität, Schlaganfall und koronare Ereignisse - Ergebnisse der Heinz Nixdorf Recall Studie aus dem Ruhrgebiet. [Air quality, stroke and coronary events - results of the Heinz Nixdorf Recall Study from the Ruhr region]. Dtsch Arztebl Int 112: 195-201, 2015. [pubmed] (open access)
Iszatt N, Stigum H, Verner MA, White RA, Govarts E, Palkovicova Murinova L, Schoeters G, Trnovec T, Legler J, Pelé F, Botton J, Chevrier C, Wittsiepe J, Ranft U, Vandentorren S, Kasper-Sonnenberg M, Klümper C, Weisglas-Kuperus N, Polder A, Eggesbø M, OBELIX: Prenatal and Postnatal Exposure to Persistent Organic Pollutants and Infant Growth: A Pooled Analysis of Seven European Birth Cohorts. Environ Health Perspect 123(7): 730-736, 2015. [pubmed] (open access)
Lanki T, Hampel R, Tiittanen P, Andrich S, Beelen R, Brunekreef B, Dratva J, De Faire U, Fuks KB, Hoffmann B, Imboden M, Jousilahti P, Koenig W, Mahabadi AA, Künzli N, Pedersen NL, Penell J, Pershagen G, Probst-Hensch NM, Schaffner E, Schindler C, Sugiri D, Swart WJ, Tsai MY, Turunen AW, Weinmayr G, Wolf K, Yli-Tuomi T, Peters A: Air Pollution from Road Traffic and Systemic Inflammation in Adults: A Cross-Sectional Analysis in the European ESCAPE Project. Environ Health Perspect 123(8): 785-791, 2015. [pubmed] (open access)
Beelen R, Hoek G, Raaschou-Nielsen O, Stafoggia M, Andersen ZJ, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer PH, Nieuwenhuijsen MJ, Xun WW, Katsouyanni K, Dimakopoulou K, Marcon A, Vartiainen E, Lanki T, Yli-Tuomi T, Oftedal B, Schwarze PE, Nafstad P, De Faire U, Pedersen NL, Östenson CG, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Sørensen M, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita HB, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Jaensch A, Ineichen A, Tsai MY, Schaffner E, Probst-Hensch NM, Schindler C, Ragettli MS, Vilier A, Clavel-Chapelon F, Declercq C, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Vineis P, Brunekreef B. Natural Cause Mortality and Long-Term Exposure to Particle Components: An Analysis of 19 European Cohorts within the Multi-Center ESCAPE Project. Environ Health Perspect 123(6): 525-533, 2015. [pubmed] (open access)
Jacquemin B, Siroux V, Sanchez M, Carsin AE, Schikowski T, Adam M, Bellisario V, Buschka A, Bono R, Brunekreef B, Cai Y, Cirach M, Clavel-Chapelon F, Declercq C, de Marco R, de Nazelle A, Ducret-Stich RE, Ferretti VV, Gerbase MW, Hardy R, Heinrich J, Janson C, Jarvis D, Al Kanaani Z, Keidel D, Kuh D, Le Moual N, Nieuwenhuijsen MJ, Marcon A, Modig L, Pin I, Rochat T, Schindler C, Sugiri D, Stempfelet M, Temam S, Tsai MY, Varraso R, Vienneau D, Vierkötter A, Hansell AL, Krämer U, Probst-Hensch NM, Sunyer J, Künzli N, Kauffmann F: Ambient Air Pollution and Adult Asthma Incidence in Six European Cohorts (ESCAPE). Environ Health Perspect 123(6): 613-621, 2015. [pubmed] (open access)
Li H, Moll J, Winkler A, Frappart L, Brunet S, Hamann J, Verlhac MH, Heuer H, Herrlich P, Plobidou A: RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility. Biol Open 4(4): 562-571, 2015. [pubmed] (open access)
Perez L, Wolf K, Hennig F, Penell J, Basagana X, Aguilera I, Agis D, Beelen R, Brunekreef B, Cyrys J, Fuks KB, Adam M, Baldassare D, Cirach M, Elosua R, Dratva J, Hampel R, Koenig W, Marrugat J, De Faire U, Pershagen G, Probst-Hensch NM, de Nazelle A, Nieuwenhuijsen MJ, Rathmann W, Rivera M, Seissler J, Schindler C, Thierry J, Hoffmann B, Peters A, Künzli N: Air Pollution and Atherosclerosis: A Cross-Sectional Analysis of Four European Cohort Studies in the ESCAPE Study. Environ Health Perspect 123(6): 597-605, 2015. [pubmed] (open access)
Vierkötter A, Schikowski T, Sugiri D, Matsui MS, Krämer U, Krutmann J: MMP-1 and -3 Promoter Variants are Indicative of a Common Susceptibility for Skin and Lung Aging: Results from a Cohort of Elderly Women (SALIA). J Invest Dermatol 135(5): 1268-1274, 2015. [pubmed]
Boix N, Teixido E, Vila-Cejudo M, Ortiz P, Ibáñez E, Llobet JM, Barenys M: Triclabendazole Sulfoxide causes Stage-dependent Embryolethality in Zebrafish and Mouse in Vitro. Plos One 10(3): e0121308, 2015. [pubmed] (open access)
Kubesch N, De Nazelle A, Guerra S, Westerdahl D, Martinez D, Bouso L, Carrasco-Turigas G, Hoffmann B, Nieuwenhuijsen M: Arterial blood pressure responses to short-term exposure to low and high traffic-related air pollution with and without moderate physical activity. Eur J Prev Cardiol 22(5): 548-557, 2015. [pubmed]
Hellack B, Quass U, Nickel C, Wick G, Schins RPF, Kuhlbusch TAJ. Oxidative potential of particulate matter at a German motorway. Environ Sci Process Impacts 17(4): 868–876, 2015. [pubmed]
Klümper C, Krämer U, Lehmann I, von Berg A, Berdel D, Herberth G, Beckmann C, Link E, Heinrich J, Hoffmann B, Schins RPF (for the GINIplus and LISAplus study groups): Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children. Environ Res 138: 381-390, 2015. [pubmed]
Mölter A, Simpson A, Berdel D, Brunekreef B, Custovic A, Cyrys J, de Jongste J, de Vocht F, Fuertes E, Gehring U, Gruzieva O, Heinrich J, Hoek G, Hoffmann B, Klümper C, Korek M, Kuhlbusch TA, Lindley S, Postma D, Tischer C, Wijga A, Pershagen G, Agius R: A multicentre study of air pollution exposure and childhood asthma prevalence: the ESCAPE project. Eur Respir J 45(3): 610-624, 2015. [pubmed]
Arnhold F, Gührs KH, von Mikecz A: Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity. PeerJ 3: e754, 2015. [pubmed] (open access)
Bruhs A, Haarmann-Stemmann T, Frauenstein K, Krutmann J, Schwarz T, Schwarz A: Activation of the arylhydrocarbon receptor causes immunosuppression primarily by modulating dendritic cells. J Invest Dermatol 135(2): 435-444, 2015. [pubmed]
Khalfalah F, Seggewiß S, Walter R, Tigges J, Moreno-Villanueva M, Bürkle A, Ohse S, Busch H, Boerries M, Hildebrandt B, Boege F, Royer-Pokora B: Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old humans. Aging (Albany NY) 7(2): 110-122, 2015. [pubmed] (open access)
Mayerl S, Liebsch C, Visser TJ, Heuer H: Absence of TRH receptor 1 in male mice affects gastric ghrelin production. Endocrinology 156(2): 755-767, 2015. [pubmed]
Röck K, Tigges J, Sass S, Schütze A, Florea AM, Fender AC, Theis FJ, Krutmann J, Boege F, Fritsche E, Reifenberger G, Fischer JW: miR-23a-3p causes cellular senescence by targeting hyaluronan synthase2: Possible implication for skin aging. J Invest Dermatol 135(2): 369-377, 2015. [pubmed]
Grether-Beck S, Marini A, Jaenicke T, Krutmann J: Effective photoprotection of human skin against infrared A radiation by topically applied antioxidants: Results from a vehicle controlled, randomized study. Photodermatol Photoimmunol Photomed 91: 248-250, 2015. [pubmed] (open access)
Adam M, Schikowski T, Carsin AE, Cai Y, Jacquemin B, Sanchez M, Vierkötter A, Marcon A, Keidel D, Sugiri D, Al Kanani Z, Nadif R, Siroux V, Hardy R, Kuh D, Rochat T, Bridevaux PO, Eeftens M, Tsai MY, Villani S, Phuleria HC, Birk M, Cyrys J, Cirach M, de Nazelle A, Nieuwenhuijsen MJ, Forsberg B, de Hoogh K, Declerq C, Bono R, Piccioni P, Quass U, Heinrich J, Jarvis D, Pin I, Beelen R, Hoek G, Brunekreef B, Schindler C, Sunyer J, Krämer U, Kauffmann F, Hansell AL, Künzli N, Probst-Hensch N: Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis. Eur Respir J 45(1): 38-50, 2015. [pubmed] (open access)
Casas M, Nieuwenhuijsen M, Martinez D, Ballester F, Basagana X, Basterrechea M, Chatzi L, Chevrier C, Eggesbø M, Fernandez MF, Govarts E, Guxens M, Grimalt JO, Hertz-Picciotto I, Iszatt N, Kasper-Sonnenberg M, Kiviranta H, Kogevinas M, Palkovicova L, Ranft U, Schoeters G, Patelarou E, Petersen MS, Torrent M, Trnovec T, Valvi D, Toft GV, Weihe P, Weisglas-Kuperus N, Wilhelm M, Wittsiepe J, Vrijheid M, Bonde JP: Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers. Environ Int 74: 23-31, 2015. [pubmed]
Hou F, Huang X, Liu C, Sun H, Zhou T, Song Y, Rong Y, Zhu B, Chen W, Wang J, Wang J, He M, Miao X, Hoffmann B, Wu T, Chen W, Yuan J: Housing characteristics in relation to exhaled nitric oxide in china. Am J Health Behav 39(1): 88-98, 2015. [pubmed]
Liu C, Fuertes E, Flexeder C, Hofbauer LC, Berdel D, Hoffmann B, Kratzsch J, von Berg A, Heinrich J; for the GINIplus and LISAplus Study Groups: Associations between ambient air pollution and bone turnover markers in 10-year old children: Results from the GINIplus and LISAplus studies. Int J Hyg Environ Health 218(1): 58-65, 2015. [pubmed] (open access)
Schnell C, Shahmoradi A, Wichert SP, Mayerl S, Hagos Y, Heuer H, Rossner MJ*, Hülsmann S*: The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes. Brain Struct Funct 220(1): 193-203, 2015. (* equal contribution) [pubmed] (open access)
Übersichtsarbeiten, Buchbeiträge u.a.
Arnhold F, Scharf A, von Mikecz A: Imaging and quantification of amyloid fibrillation in the cell nucleus. In: Hancock R (Hrsg.): The Nucleus. Methods in Molecular Biology, Vol. 1228. Springer, New York, 2015, S. 187-202, ISBN 978-1-4939-1679-5. [pubmed]
Fritsche E: The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity – a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging. In: Roberts SM, Kehrer JP, Klotz L-O (Hrsg.): Studies on Experimental Toxicology and Pharmacology. Humana Press, New York, 2015. ISBN 978-3-319-19095-2.
Hoffmann B, Esser C: Biologische Wirkungsweisen von Partikeln bei der Allergieentstehung. Allergologie 38: 1–7, 2015.
Fritsche E, Alm H, Baumann J, Geerts L, Håkansson H, Masjosthusmann S, Witters H: Literature Review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods. EFSA supporting publication: EN-778, 2015, 186 Seiten.
Peeters PM, Wouters EF, Reynaert NL: Immune homeostasis in epithelial cells: evidence and role of inflammasome signaling reviewed. J Immunol Res 2015: 828264. [pubmed] (open access)
Nakamura M, Haarmann-Stemmann T, Krutmann J: COX inhibition enhances inflammatory immune cell infiltration in UV-irradiated human skin: implications for the treatment of sunburn. Exp Dermatol 24(10): 734-735, 2015. [pubmed] (open access)
Hoffmann B: A look inside the arteries: moving from event rates to subclinical measures of disease. Occup Environ Med 72(10): 687-688, 2015. [pubmed]
Krutmann J, Berking C, Berneburg M, Diepgen TL, Dirschka T, Szeimies M: New Strategies in the Prevention of Actinic Keratosis: A Critical Review. Skin Pharmacol Physiol 28: 281-289, 2015. [pubmed]
Thaçi D, Augustin M, Krutmann J, Luger T: Stellenwert der Basistherapie bei Psoriasis. J Dtsch Dermatol Ges 13(5): 415-418, 2015. (abstract)
Eze IC, Hemkens LG, Bucher HC, Hoffmann B, Schindler C, Künzli N, Schikowski T, Probst-Hensch NM: Association between Ambient Air Pollution and Diabetes Mellitus in Europe and North America: Systematic Review and Meta-Analysis. Environ Health Perspect 123(5): 381-389, 2015. [pubmed] (open access)
Nakamura M, Morita A, Seité S, Haarmann-Stemmann T, Grether-Beck S, Krutmann J: Environment-Induced Lentigines (EILs): Formation of solar lentigines beyond ultraviolet radiation. Exp Dermatol 24(6): 407-411, 2015. [pubmed]
Esser C, Rannug A: The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology. Pharmacol Rev 67(2): 259-279. [pubmed]
Sies H: Oxidative stress: a concept in redox biology and medicine. Redox Biol 4: 180-183, 2015. [pubmed] (open access)
Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Suñol C, van Thriel C, Whelan M, Fritsche E: Putative Adverse Outcome Pathways (AOP) Relevant to Neurotoxicity. Crit Rev Toxicol 45(1): 83-91, 2015. [pubmed]
Krämer U, Schmitz R, Ring J, Behrendt H: What can Reunification of East and West Germany tell us about the cause of the allergy epidemic? Clin Exp Allergy 45(1): 94-107, 2015. [pubmed] (open access)
Newby DE, Mannucci PM, Tell GS, Baccarelli AA, Brook RD, Donaldson K, Forastiere F, Franchini M, Franco OH, Graham I, Hoek G, Hoffmann B, Hoylaerts MF, Künzli N, Mills N, Pekkanen J, Peters A, Piepoli MF, Rajagopalan S, Storey RF, on behalf of ESC Working Group on Thrombosis, European Association for Cardiovascular Prevention and Rehabilitation, and ESC Heart Failure Association: Expert position paper on air pollution and cardiovascular disease. Eur Heart J 36(2): 83-93, 2015. [pubmed] (open access)
Tzivian L, Winkler A, Dlugaj M, Schikowski T, Vossoughi M, Fuks K, Weinmayr G, Hoffmann B: Effect of long-term outdoor air pollution and noise on cognitive and psychological functions in adults. Int J Hyg Environ Health 218(1): 1-11, 2015. [pubmed]
Originalarbeiten
Meijer M, Hendriks HS, Heusinkveld HJ, Langeveld WT, Westerink RH: Comparison of plate reader-based methods with fluorescence microscopy for measurements of intracellular calcium levels for the assessment of in vitro neurotoxicity. Neurotoxicology 45: 31-37, 2014. [pubmed]
Beelen R, Raaschou-Nielsen O, Stafoggia M, Jovanovic Andersen Z, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Fischer P, Nieuwenhuijsen M, Vineis P, Xun WW, Katsouyanni K, Dimakopoulou K, Oudin A, Forsberg B, Modig L, Havulinna AS, Lanki T, Turunen A, Oftedal B, Nystad W, Nafstad P, De Faire U, Pedersen NL, Östenson CG, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Overvad K, Ellermann T, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita B, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Hampel R, Concin H, Nagel G, Ineichen A, Schaffner E, Probst-Hensch N, Künzli N, Schindler C, Schikowski T, Adam M, Phuleria H, Vilier A, Clavel-Chapelon F, Declercq C, Grioni S, Krogh V, Tsai MY, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Katsoulis M, Trichopoulou A, Brunekreef B, Hoek G: Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project. The Lancet 383(9919): 785-795, 2014. [pubmed]
Cesaroni G, Forastiere F, Stafoggia M, Andersen ZJ, Badaloni C, Beelen R, Caracciolo B, De Faire U, Erbel R, Eriksen KT, Fratiglioni L, Galassi C, Hampel R, Heier M, Hennig F, Hilding A, Hoffmann B, Houthuijs D, Jöckel KH, Korek M, Lanki T, Leander K, Magnusson PKE, Migliore E, Östenson CG, Overvad K: Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project. BMJ 348: f7412, 2014. [pubmed] (open access)
Kälsch H, Hennig F, Moebus S, Möhlenkamp S, Dragano N, Jakobs H, Memmesheimer M, Erbel R, Jöckel KH, Hoffmann B; on behalf of the Heinz Nixdorf Recall Study Investigative Group: Are air pollution and traffic noise independently associated with atherosclerosis: the Heinz Nixdorf Recall Study. Eur Heart J 35(13): 853-860, 2014. [pubmed]
Neumann C, Heinrich F, Neumann K, Junghans V, Mashreghi MF, Ahlers J, Janke M, Rudolph C, Mockel-Tenbrinck N, Kühl AA, Heimesaat MM, Esser C, Im SH, Radbruch A, Rutz S, Scheffold A: Role of Blimp-1 in programing Th effector cells into IL-10 producers. J Exp Med 211(9): 1807-1819, 2014. [pubmed]
Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H: Transporters MCT8 and OATP1C1 maintain thyroid hormone homeostasis in the murine brain. J Clin Invest 124(5): 1987-1999, 2014. [pubmed]
Dimakopoulou K, Samoli E, Beelen R, Stafoggia M, Jovanovic Andersen Z, Hoffmann B, Fischer P, Nieuwenhuijsen M, Vineis P, Xun W, Hoek G, Raaschou-Nielsen O, Oudin A, Forsberg B, Modig L, Jousilahti P, Lanki T, Turunen A, Oftedal B, Nafstad P, Schwarze PE, Penell J, Fratiglioni L, Andersson N, Pedersen N, Korek M, De Faire U, Thorup Eriksen K, Tjønneland A, Becker T, Wang M, Bueno-de-Mesquita B, Tsai MY, Eeftens M, Peeters PH, Meliefste K, Marcon A, Krämer U, Kuhlbusch TA, Vossoughi M, Key T, de Hoogh K, Hampel R, Peters A, Heinrich J, Weinmayr G, Concin H, Nagel G, Ineichen A, Jacquemin B, Stempfelet M, Vilier A, Ricceri F, Sacerdote C, Pedeli X, Katsoulis M, Trichopoulou A, Brunekreef B, Katsouyanni K: Air pollution and non-malignant respiratory mortality in 16 cohorts within the ESCAPE project. Am J Respir Crit Care Med 189(6): 684-696, 2014. [pubmed]
Gruzieva O, Gehring U, Aalberse R, Agius R, Beelen R, Behrendt H, Bellander T, Birk M, de Jongste JC, Fuertes E, Heinrich J, Hoek G, Klümper C, Koppelman G, Korek M, Krämer U, Lindley S, Mölter A, Simpson A, Standl M, van Hage M, von Berg A, Wijga A, Brunekreef B, Pershagen G: Meta-analysis of air pollution exposure association with allergic sensitization in European birth cohorts. J Allergy Clin Immunol 133(3): 767-776, 2014. [pubmed]
Sommer D, Peters A, Wirtz T, Mai M, Ackermann J, Thabet Y, Schmidt J, Weighardt H, Wunderlich FT, Degen J, Schultze JL, Beyer M: Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases. Nat Commun 66C: 97-106, 2014. [pubmed]
Cai Y, Schikowski T, Adam M, Buschka A, Carsin AE, Jacquemin B, Marcon A, Sanchez M, Vierkötter A, Al-Kanaani Z, Beelen R, Birk M, Brunekreef B, Cirach M, Clavel-Chapelon F, Declercq C, de Hoogh K, de Nazelle A, Ducret-Stich RE, Valeria Ferretti V, Forsberg B, Gerbase MW, Hardy R, Heinrich J, Hoek G, Jarvis D, Keidel D, Kuh D, Nieuwenhuijsen MJ, Ragettli MS, Ranzi A, Rochat T, Schindler C, Sugiri D, Temam S, Tsai MY, Varraso R, Kauffmann F, Krämer U, Sunyer J, Künzli N, Probst-Hensch N, Hansell AL: Cross-sectional associations between air pollution and chronic bronchitis: an ESCAPE meta-analysis across five cohorts. Thorax 69(11): 1005-1014, 2014. [pubmed]
Theologidis I, Chelo IM, Goy C, Teotónio H: Reproductive assurance drives transitions to self-fertilization in experimental Caenorhabditis elegans. BMC Biol 12(1): 93, 2014. [pubmed] (open access)
Müller-Brandes C, Krämer U, Gappa M, Seitner-Sorge G, Hüls A, von Berg A, Hoffmann B, Schuster A, Illi S, Wisbauer M, Berdel D: LUNOKID: can numeric ATS/ERS quality criteria replace visual inspection of spirometry? Eur Respir J 43(5): 1347-1356, 2014. [pubmed]
Schikowski T, Mills IC, Anderson HR, Cohen A, Hansell A, Kauffmann F, Krämer U, Marcon A, Perez L, Sunyer J, Probst-Hensch N, Künzli N: Ambient air pollution - a cause for COPD? Eur Respir J 43(1): 250-263, 2014. [pubmed]
Schikowski T, Adam M, Marcon A, Cai Y, Vierkötter A, Carsin AE, Jacquemin B, Al Kanani Z, Beelen R, Birk M, Bridevaux PO, Brunekeef B, Burney P, Cirach M, Cyrys J, de Hoogh K, de Marco R, de Nazelle A, Declercq C, Forsberg B, Hardy R, Heinrich J, Hoek G, Jarvis D, Keidel D, Kuh D, Kuhlbusch T, Migliore E, Mosler G, Nieuwenhuijsen MJ, Phuleria H, Rochat T, Schindler C, Villani S, Tsai MY, Zemp E, Hansell A, Kauffmann F, Sunyer J, Probst-Hensch N, Krämer U, Künzli N: Association of ambient air pollution with the prevalence and incidence of COPD. Eur Respir J 44(3): 614-626, 2014. [pubmed]
Fuks KB, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, Oftedal B, Oudin A, Panasevich S, Penell J, Sommar JN, Sørensen M, Tiittanen P, Wolf K, Xun WW, Aguilera I, Basagaña X, Beelen R, Bots ML, Brunekreef B, Bueno-de-Mesquita HB, Caracciolo B, Cirach M, de Faire U, de Nazelle A, Eeftens M, Elosua R, Erbel R, Forsberg B, Fratiglioni L, Gaspoz JM, Hilding A, Jula A, Korek M, Krämer U, Künzli N, Lanki T, Leander K, Magnusson PK, Marrugat J, Nieuwenhuijsen MJ, Ostenson CG, Pedersen NL, Pershagen G, Phuleria HC, Probst-Hensch NM, Raaschou-Nielsen O, Schaffner E, Schikowski T, Schindler C, Schwarze PE, Søgaard AJ, Sugiri D, Swart WJ, Tsai MY, Turunen AW, Vineis P, Peters A, Hoffmann B: Arterial blood pressure and long-term exposure to traffic-related air pollution: An analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Environ Health Perspect 122(9): 896-905, 2014. [pubmed]
Hennig F, Fuks K, Moebus S, Weinmayr G, Memmesheimer M, Jakobs H, Bröcker-Preuss M, Führer-Sakel D, Möhlenkamp S, Erbel R, Jöckel KH, Hoffmann B: Association between source-specific particulate matter air pollution and hs-CRP: Local traffic and industrial emissions. Environ Health Perspect 122(7): 703-710, 2014. [pubmed]
Macintyre EA, Gehring U, Mölter A, Fuertes E, Klümper C, Krämer U, Quass U, Hoffmann B, Gascon M, Brunekreef B, Koppelman GH, Beelen R, Hoek G, Birk M, de Jongste JC, Smit H, Cyrys J, Gruzieva O, Korek M, Bergström A, Agius RM, de Vocht F, Simpson A, Porta D, Forastiere F, Badaloni C, Cesaroni G, Esplugues A, Fernández-Somoano A, Lerxundi A, Sunyer J, Cirach M, Nieuwenhuijsen MJ, Pershagen G, Heinrich J: Air pollution and respiratory infections during early childhood: An analysis of 10 European birth cohorts within the ESCAPE project. Environ Health Perspect 122(1): 107-113, 2014. [pubmed]
Macintyre EA, Brauer M, Melén E, Bauer CP, Bauer M, Berdel D, Bergström A, Brunekreef B, Chan-Yeung M, Klümper C, Fuertes E, Gehring U, Gref A, Heinrich J, Herbarth O, Kerkhof M, Koppelman GH, Kozyrskyj AL, Pershagen G, Postma DS, Thiering E, Tiesler CM, Carlsten C; TAG Study Group: GSTP1 and TNF gene variants and associations between air pollution and incident childhood asthma: The traffic, asthma and genetics (TAG) study. Environ Health Perspect 122(4): 418-424, 2014. [pubmed]
Stafoggia M, Cesaroni G, Peters A, Andersen ZJ, Badaloni C, Beelen R, Caracciolo B, Cyrys J, de Faire U, de Hoogh K, Eriksen KT, Fratiglioni L, Galassi C, Gigante B, Havulinna AS, Hennig F, Hilding A, Hoek G, Hoffmann B, Houthuijs D, Korek M, Lanki T, Leander K, Magnusson PK, Meisinger C, Migliore E, Overvad K, Ostenson CG, Pedersen NL, Pekkanen J, Penell J, Pershagen G, Pundt N, Pyko A, Raaschou-Nielsen O, Ranzi A, Ricceri F, Sacerdote C, Swart WJ, Turunen AW, Vineis P, Weimar C, Weinmayr G, Wolf K, Brunekreef B, Forastiere F: Long-term exposure to ambient air pollution and incidence of cerebrovascular events: Results from 11 European cohorts within the ESCAPE project. Environ Health Perspect 122(9): 919-925, 2014. [pubmed]
Wang M, Beelen R, Bellander T, Birk M, Cesaroni G, Cirach M, Cyrys J, de Hoogh K, Declercq C, Dimakopoulou K, Eeftens M, Eriksen KT, Forastiere F, Galassi C, Grivas G, Heinrich J, Hoffmann B, Ineichen A, Korek M, Lanki T, Lindley S, Modig L, Mölter A, Nafstad P, Nieuwenhuijsen MJ, Nystad W, Olsson D, Raaschou-Nielsen O, Ragettli M, Ranzi A, Stempfelet M, Sugiri D, Tsai MY, Udvardy O, Varró MJ, Vienneau D, Weinmayr G, Wolf K, Yli-Tuomi T, Hoek G, Brunekreef B: Performance of multi-city land use regression models for nitrogen dioxide and fine particles. Environ Health Perspect 122(8): 843-849, 2014. [pubmed]
Winneke G, Ranft U, Wittsiepe J, Kasper-Sonnenberg M, Fürst P, Krämer U, Seitner G, Wilhelm M: Behavioral sexual dimorphism in school-age children and early developmental exposure to dioxins and PCBs: a follow-up study of the Duisburg cohort. Environ Health Perspect 122(3): 292-298, 2014. [pubmed]
Zanobetti A, Luttmann-Gibson H, Horton ES, Cohen A, Coull BA, Hoffmann B, Schwartz JD, Mittleman MA, Li Y, Stone PH, de Souza C, Lamparello B, Koutrakis P, Gold DR: Brachial artery responses to ambient pollution, temperature, and humidity in people with type 2 diabetes: A repeated-measures study. Environ Health Perspect 122(3): 242-248, 2014. [pubmed]
Peeters PM, Eurlings IMJ, Perkins TN, Wouters EF, Schins RPF, Borm PJA, Drommer W, Reynaert NL, Albrecht C: Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs. Particle and Fibre Toxicology 11(1): 58, 2014. [pubmed] (open access)
Tigges J*, Haarmann-Stemmann T*, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J*, Fritsche E*§: The new arylhydrocarbon receptor (AhR) antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one (BDDI) protects against UVB-induced signal transduction. J Invest Dermatol 134(2): 556-559, 2014. (* equal contribution) [pubmed] (open access)
Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen ZJ, Xun WW, Katsouyanni K, Dimakopoulou K, Brunekreef B, Weinmayr G, Hoffmann B, Wolf K, Samoli E, Houthuijs D, Nieuwenhuijsen M, Oudin A, Forsberg B, Olsson D, Salomaa V, Lanki T, Yli-Tuomi T, Oftedal B, Aamodt G, Nafstad P, De Faire U, Pedersen NL, Östenson CG, Fratiglioni L, Penell J, Korek M, Pyko A, Eriksen KT, Tjønneland A, Becker T, Eeftens M, Bots M, Meliefste K, Wang M, Bueno-de-Mesquita B, Sugiri D, Krämer U, Heinrich J, de Hoogh K, Key T, Peters A, Cyrys J, Concin H, Nagel G, Ineichen A, Schaffner E, Probst-Hensch N, Dratva J, Ducret-Stich R, Vilier A, Clavel-Chapelon F, Stempfelet M, Grioni S, Krogh V, Tsai M-Y, Marcon A, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Katsoulis M, Trichopoulou A, Vineis P, Hoek G: Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts within the ESCAPE project. Epidemiology 23(3): 368-378, 2014. [pubmed]
Eeftens M, Hoek G, Gruzieva O, Mölter A, Agius R, Beelen R, Brunekreef B, Custovic A, Cyrys J, Fuertes E, Heinrich J, Hoffmann B, de Hoogh K, Jedynska A, Keuken M, Klümper C, Kooter I, Krämer U, Korek M, Koppelman GH, Kuhlbusch TA, Simpson A, Smit HA, Tsai MY, Wang M, Wolf K, Pershagen G, Gehring U: Elemental composition of particulate matter and the association with lung function. Epidemiology 25(5): 648-657, 2014. [pubmed]
Gascon M, Sunyer J, Casas M, Martínez D, Ballester F, Basterrechea M, Bonde JP, Chatzi L, Chevrier C, Eggesbø M, Esplugues A, Govarts E, Hannu K, Ibarluzea J, Kasper-Sonnenberg M, Klümper C, Koppen G, Nieuwenhuijsen MJ, Palkovicova L, Pelé F, Polder A, Schoeters G, Torrent M, Trnovec T, Vassilaki M, Vrijheid M: Prenatal exposure to DDE and PCB 153 and respiratory health in early childhood: A meta-analysis. Epidemiology 25(4): 544-553, 2014. [pubmed]
Guxens M, Garcia-Esteban R, Giorgis-Allemand L, Forns J, Badaloni C, Ballester F, Beelen R, Cesaroni G, Chatzi L, de Agostini M, de Nazelle A, Eeftens M, Fernandez MF, Fernández-Somoano A, Forastiere F, Gehring U, Ghassabian A, Heude B, Jaddoe VW, Klümper C, Kogevinas M, Krämer U, Larroque B, Lertxundi A, Lertxuni N, Murcia M, Navel V, Nieuwenhuijsen M, Porta D, Ramos R, Roumeliotaki T, Slama R, Sørensen M, Stephanou EG, Sugiri D, Tardón A, Tiemeier H, Tiesler CM, Verhulst FC, Vrijkotte T, Wilhelm M, Brunekreef B, Pershagen G, Sunyer J: Air pollution during pregnancy and childhood cognitive and pychomotor development: six European birth cohorts. Epidemiology 25(5): 636-647, 2014. [pubmed]
Newson RB, van Ree R, Forsberg B, Janson C, Lötvall J, Dahlén SE, Toskala EM, Baelum J, Brożek GM, Kasper L, Kowalski ML, Howarth PH, Fokkens WJ, Bachert C, Keil T, Krämer U, Bislimovska J, Gjomarkaj M, Loureiro C, Burney PG, Jarvis D: Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA2LEN survey. Allergy 69(5): 643-651, 2014. [pubmed]
Obaseki D, Potts J, Joos G, Baelum J, Haahtela T, Ahlström M, Matricardi P, Kramer U, Gjomarkaj M, Fokkens W, Makowska J, Todo-Bom A, Toren K, Janson C, Dahlen SE, Forsberg B, Jarvis D, Howarth P, Brozek G, Minov J, Bachert C, Burney P; The GALEN network of excellence: The relation of airway obstruction to asthma, chronic rhinosinusitis and age: results from a population survey of adults. Allergy 69(9): 1205-1214, 2014. [pubmed]
de Hoogh K, Korek M, Vienneau D, Keuken M, Kukkonen J, Nieuwenhuijsen MJ, Badaloni C, Beelen R, Bolignano A, Cesaroni G, Pradas MC, Cyrys J, Douros J, Eeftens M, Forastiere F, Forsberg B, Fuks K, Gehring U, Gryparis A, Gulliver J, Hansell AL, Hoffmann B, Johansson C, Jonkers S, Kangas L, Katsouyanni K, Künzli N, Lanki T, Memmesheimer M, Moussiopoulos N, Modig L, Pershagen G, Probst-Hensch N, Schindler C, Schikowski T, Sugiri D, Teixidó O, Tsai MY, Yli-Tuomi T, Brunekreef B, Hoek G, Bellander T: Comparing land use regression and dispersion modelling to assess residential exposure to ambient air pollution for epidemiological studies. Environ Int 73C: 382-392, 2014. [pubmed]
Eze IC, Schaffner E, Fischer E, Schikowski T, Adam M, Imboden M, Tsai M, Carballo D, von Eckardstein A, Künzli N, Schindler C, Probst-Hensch N: Long-term air pollution exposure and diabetes in a population-based Swiss cohort. Environ Int 70C: 95-105, 2014. [pubmed] (open access)
Wang M, Beelen R, Stafoggia M, Raaschou-Nielsen O, Andersen ZJ, Hoffmann B, Fischer P, Houthuijs D, Nieuwenhuijsen M, Weinmayr G, Vineis P, Xun WW, Dimakopoulou K, Samoli E, Laatikainen T, Lanki T, Turunen AW, Oftedal B, Schwarze P, Aamodt G, Penell J, De Faire U, Korek M, Leander K, Pershagen G, Pedersen NL, Ostenson CG, Fratiglioni L, Eriksen KT, Sørensen M, Tjønneland A, Bueno-de-Mesquita B, Eeftens M, Bots ML, Meliefste K, Krämer U, Heinrich J, Sugiri D, Key T, de Hoogh K, Wolf K, Peters A, Cyrys J, Jaensch A, Concin H, Nagel G, Tsai MY, Phuleria H, Ineichen A, Künzli N, Probst-Hensch N, Schaffner E, Vilier A, Clavel-Chapelon F, Declerq C, Ricceri F, Sacerdote C, Marcon A, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Katsoulis M, Trichopoulou A, Keuken M, Jedynska A, Kooter IM, Kukkonen J, Sokhi RS, Brunekreef B, Katsouyanni K, Hoek G: Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: Results from the ESCAPE and TRANSPHORM projects. Environ Int 66C: 97-106, 2014. [pubmed]
Kohlboeck G, Romanos M, Tiesler C, Koletzko S, Kratzsch J, Thiery J, Bauer CP, von Berg A, Berdel D, Hoffmann B, Schaaf B, Lehmann I, Herbarth O, Heinrich J; GINI-plus and LISA-plus study groups. Peer problems are associated with elevated serum leptin levels in children. Psychol Med 44(2): 255-265, 2014. [pubmed]
German National Cohort (GNC) Consortium (Linseisen J, … Hoffmann B, et al.): The German National Cohort: aims, study design and organization. Eur J Epidemiol 29(5): 371-382, 2014. [pubmed] (open access)
Gassmann K, Schreiber T, Dingemans MML, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman A, Westerink RHS, Rose CR, Fritsche E: BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Arch Toxicol 88: 1537-1548, 2014. [pubmed]
Mangerich A, Esser C: Chemical warfare in the First World War: reflections 100 years later. Arch Toxicol 88(11): 1909-1911, 2014. [pubmed]
van Berlo D*, Wilhelmi V*, Boots AW, Hullmann M, Kuhlbusch TAJ, Bast A, Schins RPF, Albrecht C: Apoptotic, inflammatory, and fibrogenic effects of two different types of multi-walled carbon nanotubes in mouse lung. Arch Toxicol 88(9): 1725-1737, 2014. (* equal contribution) [pubmed]
Waldera-Lupa DM, Kalfalah F, Florea AM, Sass S, Kruse F, Rieder V, Tigges J, Fritsche E, Krutmann J, Busch H, Boerries M, Meyer HE, Boege F, Theis F, Reifenberger G, Stühler K: Proteome-wide analysis reveals an age-associated cellular phenotype of in situ aged human fibroblasts. Aging (Albany NY). 6(10): 856-878, 2014. [pubmed]
Müller J, Mayerl S, Visser TJ, Darras VM, Boelen A, Frappart L, Mariotta L, Verrey F, Heuer H: Tissue-specific alterations in thyroid hormone homeostasis in combined Mct10 and Mct8 deficiency. Endocrinology 155(1): 315-325, 2014. [pubmed]
Vogel CFA, Kahn EM, Leung P, Gershwin ME, Chang WLW, Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS: Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for NF-κB. Journal of Biological Chemistry 289(3): 1866-1875, 2014. [pubmed] (open access)
Globisch T, Steiner N, Fülle L, Lukacs-Kornek V, Degrandi D, Dresing P, Alferink J, Lang R, Pfeffer K, Beyer M, Weighardt H, Kurts C, Ulas T, Schultze JL, Förster I: Cytokine-dependent regulation of denditic cell differentiation in the splenic microenvironment. Eur J Immunol 44(2): 500-510, 2014. [pubmed]
Clift MJD, Endes C, Vanhecke D, Wick P, Gehr P, Schins RPF, Petri-Fink A, Rothen-Rutishauser B: A comparative study of different in vitro lung cell culture systems to assess the most beneficial tool for screening the potential adverse effects of carbon nanotubes. Toxicological Sciences 137(1): 55-64, 2014. [pubmed]
Newson R, Jones M, Forsberg B, Janson C, Bossios A, Dahlen SE, Toskala E, Al-Kalemji A, Kowalski M, Rymarczyk B, Salagean E, van Drunen C, Bachert C, Wehrend T, Krämer U, Mota-Pinto A, Burney P, Leynaert B, Jarvis D: The association of asthma, nasal allergies and positive skin prick tests with obesity, leptin and adiponectin. Clin Exp Allergy 44(2): 250-260, 2014. [pubmed]
Kersseboom S, Horn S, Visser WE, Chen J, Friesema ECH, Vaurs-Barrière C, Peeters RP, Heuer H, Visser TJ: In vitro and mouse studies supporting therapeutic utility of triiodothyroacetic acid in MCT8 deficiency. Mol Endocrinol 28: 1961-1970, 2014. [pubmed]
Grether-Beck S, Felsner I, Koehler T, Farwick M, Lersch P, Rawlings A, Krutmann J: Topical ceramides neither enhance UVB-induced apoptosis in normal human keratinocytes nor affect viability in UVB-irradiated reconstructed human epidermis. Exp Dermatol 23: 853-864, 2014. [pubmed]
Teichert T, Vossoughi M, Vierkötter A, Sugiri D, Schikowski T, Hoffmann B, Schulte T, Roden M, Raulf-Heimsoth M, Luckhaus C, Krämer U, Herder C: Investigating the spill-over hypothesis: Analysis of the association between local inflammatory markers in sputum and systemic inflammatory mediators in plasma. Environ Res 134: 24-32, 2014. [pubmed]
Brüske I, Standl M, Weidinger S, Klümper C, Hoffmann B, Schaaf B, Herbarth O, Lehmann I, von Berg A, Berdel D, Bauer CP, Koletzko S, Heinrich J, Lisaplus Study Groups FT: Epidemiology of urticaria in infants and young children in Germany - Results from the German LISAplus and GINIplus Birth Cohort Studies. Pediatr Allergy Immunol 25: 36-42, 2014. [pubmed]
Pei Z, Heinrich J, Fuertes E, Flexeder C, Hoffmann B, Lehmann I, Schaaf B, von Berg A, Koletzko S; Influences of Lifestyle-Related Factors on the Immune System and the Development of Allergies in Childhood plus Air Pollution and Genetics (LISAplus) Study Group: Cesarean delivery and risk of childhood obesity. J Pediatr 164(5): 1068-1073, 2014. [pubmed]
Kohlboeck G, Romanos M, Teuner CM, Holle R, Tiesler CM, Hoffmann B, Schaaf B, Lehmann I, Herbarth O, Koletzko S, Bauer CP, von Berg A, Berdel D, Heinrich J: Healthcare use and costs associated with children's behavior problems. Eur Child Adolesc Psychiatry 23(8): 701-714, 2014. [pubmed]
Kahl S, Straßburger K, Nowotny B, Livingstone R, Klüppelholz B, Keßel K, Hwang JH, Giani G, Hoffmann B, Pacini G, Gastaldelli A, Roden M: Comparison of liver fat indices for the diagnosis of hepatic steatosis and insulin resistance. Plos one 9(4): e94059, 2014. [pubmed] (open access)
Tamayo T, Rathmann W, Krämer U, Sugiri D, Grabert M, Holl RW: Is particle pollution in outdoor air associated with metabolic control in type 2 diabetes? Plos one 9(3): e91639, 2014. [pubmed] (open access)
Autengruber A, Sydlik U, Kroker M, Hornstein T, Ale-Agha N, Stöckmann D, Bilstein A, Albrecht C, Paunel-Görgülü A, Suschek CV, Krutmann J, Unfried K: Signalling-dependent adverse health effects of carbon nanoparticles are prevented by the compatible solute beta mannosylglycerate (firoin) in vitro and in vivo. Plos one 9(11): e111485, 2014. [pubmed]
Kalfalah F, Sobek S, Bornholz B, Götz-Rösch C, Tigges J, Fritsche E, Krutmann J, Körer K, Deenen R, Ohse S, Boerries M, Busch H, Boege F: Inadequate mito-biogenesis in primary dermal fibroblasts from old humans is associated with impairment of PGC1A-independent stimulation. Exp Gerontol 56: 59-68, 2014. [pubmed]
Maglioni S, Schiavi A, Runci A, Shaik A, Ventura N: Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis. Exp Gerontol 56: 89-98, 2014. [pubmed]
Schneider R, Linka RM, Reinke H: HSP90 affects the stability of BMAL1 and circadian gene expression. J Biol Rhythms 29(2): 87-96, 2014. [pubmed]
Fuertes E, Markevych I, von Berg A, Bauer CP, Berdel D, Koletzko S, Sugiri D, Heinrich J: Greenness and allergies: evidence of differential associations in two areas in Germany. J Epidemiol Community Health 68(8): 787-790, 2014. [pubmed] (open access)
Fuertes E, MacIntyre E, Agius R, Beelen R, Brunekreef B, Bucci S, Cesaroni G, Cirach M, Cyrys J, Forastiere F, Gehring U, Gruzieva O, Hoffmann B, Jedynska A, Keuken M, Klümper C, Kooter I, Korek M, Krämer U, Mölter A, Nieuwenhuijsen M, Pershagen G, Porta D, Postma DS, Simpson A, Smit HA, Sugiri D, Sunyer J, Wang M, Heinrich J: Associations between particulate matter elements and early-life pneumonia in seven birth cohorts: Results from the ESCAPE and TRANSPHORM projects. Int J Hyg Environ Health 217(8): 819-829, 2014. [pubmed]
Liu C, Fuertes E, Tiesler CM, Birk M, Babisch W, Bauer CP, Koletzko S, von Berg A, Hoffmann B, Heinrich J; GINIplus; LISAplus; Study Groups: The associations between traffic-related air pollution and noise with blood pressure in children: Results from the GINIplus and LISAplus studies. Int J Hyg Environ Health 217(4-5): 499-505, 2014. [pubmed]
Liu C, Flexeder C, Fuertes E, Cyrys J, Bauer CP, Koletzko S, Hoffmann B, von Berg A, Heinrich J; for the GINIplus and LISAplus Study Groups: Effects of air pollution on exhaled nitric oxide in children: Results from the GINIplus and LISAplus studies. Int J Hyg Environ Health 217(4-5): 483-491, 2014. [pubmed]
Kuhlbusch, TAJ, Quincey P, Fuller GW, Kelly F, Mudway I, Viana M, Querol X, Alastuey A, Katsouyanni K, Weijers E, Borowiak A, Gehrig R, Hueglin C, Bruckmann P, Favez O, Sciare J, Hoffmann B, Yttri KE, Torseth K, Sager U, Asbach C: New Directions: The future of European urban air quality monitoring. Atmospheric Environment 87: 258-260, 2014.
Nonnemacher M, Jakobs H, Viehmann A, Vanberg I, Kessler C, Moebus S, Möhlenkamp S, Erbel R, Hoffmann B, Memmesheimer M, on behalf of the Heinz Nixdorf Recall Study Investigative Group. Spatio-temporal modelling of residential exposure to particulate matter and gaseous pollutants for the Heinz Nixdorf Recall Cohort. Atmospheric Environment 91: 15-23, 2014. (abstract)
Schmuck M, Temme T, Heinz S, Baksmeier C, Mosig A, Colomina MT, Barenys M, Fritsche E: Automatic counting and positioning of 5-bromo-2-deoxyuridine (BrdU) positive cells in cortical layers of rat brain slices. Neurotoxicology 43: 127-133, 2014. [pubmed]
Van Berlo D*, Hullmann M*, Wessels A, Scherbart AM, Cassee FR, Gerlofs-Nijland ME, Albrecht C, Schins RPF. Investigation of the effects of short-term inhalation of carbon nanoparticles on brains and lungs of C57BL/6J and p47phox-/- mice. Neurotoxicology 43: 65-72, 2014. (* equal contribution) [pubmed]
Speckmann B, Bidmon HJ, Borchardt A, Sies H, Steinbrenner H: Intestinal selenoprotein P in epithelial cells and in plasma cells. Arch Biochem Biophys 541: 30-36, 2014. [pubmed]
Flexeder C, Thiering E, Kratzsch J, Klümper C, Koletzko B, Müller MJ, Koletzko S, Heinrich J. Is a child's growth pattern early in life related to serum adipokines at the age of 10 years? Eur J Clin Nutr 68(1): 25-31, 2014. [pubmed]
Hellack B, Yang A, Cassee FR, Janssen NAH, Schins RPF, Kuhlbusch TAJ: Intrinsic hydroxyl radical generation measurements directly from sampled filters as a metric for the oxidative potential of ambient particulate matter. J Aerosol Sci 72: 47-55, 2014.
Rajalin AM, Micoogullari M, Sies H, Steinbrenner H: Upregulation of the thioredoxin-dependent redox system during differentiation of 3T3-L1 cells to adipocytes. Biol Chem 395(6): 667–677, 2014. [pubmed]
Kälsch H, Lehmann N, Berg MH, Mahabadi AA, Mergen P, Möhlenkamp S, Bauer M, Kara K, Dragano N, Hoffmann B, Moebus S, Schmermund A, Stang A, Jöckel KH, Erbel R: Coronary artery calcification outperforms thoracic aortic calcification for the prediction of myocardial infarction and all-cause mortality: The Heinz Nixdorf Recall Study. Eur J Prev Cardiol 21(9): 1163-1170, 2014. [pubmed]
Barenys M, Boix N, Farran-Codina A, Palma-Linares I, Roser M, Curto A, Gomez-Catalan J, Ortiz P, Deza N, Llobet JM: Heavy metal and metalloids intake risk assessment in the diet of a rural population living near a gold mine in the Peruvian Andes (Cajamarca). Food Chem Toxicol 71: 254-263, 2014. [pubmed]
Batscheider A, Rzehak R, Teuner CM, Wolfenstetter SB, Leidl R, von Berg A, Berdel D, Hoffmann B, Heinrich J for the GINIplus and LISAplus study groups. Development of BMI values of German children and their healthcare costs. Econ Hum Biol 12: 56-66, 2014. [pubmed]
Macpherson L, Ahmed S, Tamblyn L, Krutmann J, Förster I, Weighardt H, Matthews J: Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int J Mol Sci 15(5): 7939-7957, 2014. [pubmed]
Markevych I, Thiering E, Fuertes E, Sugiri D, Berdel D, Koletzko S, von Berg A, Bauer CP, Heinrich J: A cross-sectional analysis of the effects of residential greenness on blood pressure in 10 year old children: Results from the GINIplus and LISAplus studies. BMC Public Health 14(1): 477, 2014. [pubmed] (open access)
Vossoughi M, Schikowski T, Vierkötter A, Sugiri D, Hoffmann B, Teichert T, Herder C, Schulte T, Luckhaus C, Raulf-Heimsoth M, Casjens S, Brüning T, Krämer U: Air pollution and subclinical airway inflammation in the SALIA cohort study. Immunity & Ageing 11(1): 5, 2014. (open access)
Soppa VJ, Schins RPF, Hennig F, Hellack B, Quass U, Kaminski H, Kuhlbusch TAJ, Hoffmann B, Weinmayr G: Respiratory effects of fine and ultrafine particles from indoor sources- a randomized sham-controlled exposure study of healthy volunteers. Int J Environ Res Public Health 11(7): 6871-6889, 2014. [pubmed] (open access)
Winkler V, Leitzmann M, Obi N, Ahrens W, Edinger T, Giani G, Linseisen J, Löffler M, Michels K, Nöthlings U, Schipf S, Kluttig A, Wichmann HE, Hoffmann B, Jöckel KH, Becher H: Response in individuals with and without foreign background and application to the National Cohort in Germany: which factors have an effect? Int J Public Health 59(3): 555-563, 2014. [pubmed]
Wawro N, Heinrich J, Thiering E, Kratzsch J, Schaaf B, Hoffmann B, Lehmann I, Bauer CP, Koletzko S, von Berg A, Berdel D, Linseisen J: Serum 25(OH)D concentrations and atopic diseases at age 10: results from the GINIplus and LISAplus birth cohort studies. BMC Pediatr 14(1): 286, 2014. [pubmed] (open access)
Marini A, Jaenicke T, Grether-Beck S, Le Floc'h C, Cheniti A, Piccardi N, Krutmann J: Prevention of polymorphic light eruption by oral administration of a nutritional supplement containing lycopene, ß-carotene and Lactobacillus johnsonii: Results from a randomized, placebo-controlled, double-blinded study. Photodermatol Photoimmunol Photomed 30(4): 189-194, 2014. [pubmed]
Müller J, Heuer H: Expression pattern of thyroid hormone transporters in the postnatal mouse brain. Frontiers in Endocrinology Vol. 5, Article 92, 2014. [pubmed] (open access)
Unfried K, Kroker M, Autengruber A, Gotic M, Sydlik U: The compatible solute ectoine reduces the exacerbating effects of environmental model particles on the immune response of the airways. J Allergy 2014: 708458. [pubmed] (open access)
Baumann J, Barenys M, Gassmann K, Fritsche E: Comparative human and rat "neurosphere assay" for developmental neurotoxicity testing. Curr Protoc Toxicol 59: 12.21.1-12.21.24, 2014. [pubmed]
Übersichtsarbeiten, Buchbeiträge u.a.
Schikowski T, Mills IC, Anderson HR, Cohen A, Hansell A, Kauffmann F, Krämer U, Marcon A, Perez L, Sunyer J, Probst-Hensch N, Künzli N: Ambient air pollution - a cause for COPD? Eur Respir J 43(1): 250-263, 2014. [pubmed]
Sies H: Role of metabolic H2O2 generation: Redox signalling and oxidative stress. J Biol Chem 289(13): 8735-8741, 2014. [pubmed]
Esser C: A fat story - antigen presentation by butyrophilin 3A1 to γδ T cells. Cell Mol Immunol 11(1): 5-7, 2014. [pubmed]
Alépée N, Bahinski T, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG: State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX 31(4): 441-477, 2014. [pubmed]
Crofton K, Fritsche E, Ylikomi T, Bal-Price A: International STakeholder NETwork (ISTNET) for Creating a Developmental Neurotoxicity Testing (DNT) Roadmap for Regulatory Purposes. ALTEX 31(2): 223-224, 2014. [pubmed]
Schiavi A, Ventura N: The interplay between mitochondria and autophagy and its role in the aging process. Exp Gerontol 56: 147-153, 2014. [pubmed]
Trifunovic A, Ventura N: Mitochondria and metabolic control of the aging process (editorial). Exp Gerontol 56: 1-2, 2014. [pubmed]
Krutmann J, Liu W, Li L, Pan X, Crawford M, Sore G, Seite S: Pollution and skin: From epidemiological and mechanistic studies to clinical implications. J Dermatol Sci 76(3): 163-168, 2014. [pubmed]
Luger T, Seité S, Humbert P, Krutmann J, Triller R, Dreno B: Recommendations for adjunctive basic skin care in patients with psoriasis. Eur J Dermatol 24(2): 194-200, 2014. [pubmed]
Grether-Beck S, Marini A, Jaenicke T, Krutmann J: Photoprotection of human skin beyond ultraviolet radiation. Photodermatol Photoimmunol Photomed 30(2-3): 167-174, 2014. [pubmed]
Krutmann J, Béhar-Cohen F, Baillet G, de Ayguavives T, Ortega Garcia P, Peña-García P, Remé C, Wolffsohn J: Towards standardization of UV eye protection: what can be learned from photodermatology? Photodermatol Photoimmunol Photomed 30(2-3): 128-136, 2014. [pubmed]
Behar-Cohen F, Baillet G, de Ayguavives T, Garcia PO, Krutmann J, Peña-García P, Reme C, Wolffsohn JS: Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. Clin Ophthalmol 8: 87-104, 2014. [pubmed]
von Mikecz A: Pathology and function of nuclear amyloid: protein homeostasis matters. Nucleus 5(4): 311-317, 2014. [pubmed]
Birmili W, Rückerl R, Hoffmann B, Weinmayr G, Schins R, Kuhlbusch TAJ, Vogel A, Weber K, Franck U, Cyrys J, Peters A: Ultrafine aerosol particles in ambient air: Perspectives to elucidate their health effects (Ultrafeine Aerosolpartikel in der Außenluft: Perspektiven zur Aufklärung ihrer Gesundheitseffekte). Gefahrst Reinh Luft 74(11/12): 492-500, 2014. (abstract)
Arnhold F, von Mikecz A: Intranuclear amyloid – local and quantitative analysis of protein fibrillation in the cell nucleus. In: Bionanoimaging: Insights into protein misfolding and aggregation. Vladimir Uversky & Yuri Lyubchenko (Eds.), Elsevier 2014, pp. 475-483.
Boland S, Vranic S, Schins RPF, Stöger T: Current in vitro models for nanomaterial testing in pulmonary systems. In: Nanotoxicology (2nd Edition): Progress Towards Nanomedicine. Monteiro-Riviere N, Tran CL (Eds.). CRC Press 2014, pp. 291-314.
Fritsche E: Human stem/progenitor cell-based assays for neurodevelopmental toxicity testing. In: In vitro toxicology systems. Bal-Price A, Jennings P (Eds.). Humana Press 2014, pp. 351-376.
Esser C: The Aryl Hydrocarbon Receptor (AhR) as a Mediator of Adverse Immune Reactions. In: Molecular Immunotoxicology. Corsini E, Van Loveren H (Eds). Wiley Verlag 2014.
Behrendt H, Alessandrini F, Buters J, Krämer, U, Koren H, Ring J: Environmental Pollution and Allergy: Historical Aspects. In: History of Allergy. Chem Immun Allergy, Vol. 100. Bergmann KC, Ring J (Eds.). S. Karger Verlag 2014.
Originalarbeiten
Raaschou-Nielsen O, Andersen ZJ, Beelen R, Samoli E, Stafoggia M, Weinmayr G, Hoffmann B, Fischer P, Nieuwenhuijsen MJ, Brunekreef B, Xun WW, Katsouyanni K, Dimakopoulou K, Sommar J, Forsberg B, Modig L, Oudin A, Oftedal B, Schwarze PE, Nafstad P, De Faire U, Pedersen NL, Ostenson CG, Fratiglioni L, Penell J, Korek M, Pershagen G, Eriksen KT, Sørensen M, Tjønneland A, Ellermann T, Eeftens M, Peeters PH, Meliefste K, Wang M, Bueno-de-Mesquita B, Key TJ, de Hoogh K, Concin H, Nagel G, Vilier A, Grioni S, Krogh V, Tsai MY, Ricceri F, Sacerdote C, Galassi C, Migliore E, Ranzi A, Cesaroni G, Badaloni C, Forastiere F, Tamayo I, Amiano P, Dorronsoro M, Trichopoulou A, Bamia C, Vineis P, Hoek G: Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol 14(9): 813-822, 2013. [pubmed]
Scharf A, Piechulek A, von Mikecz A: The effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans. ACS Nano 7(12): 10695-10703, 2013. [pubmed]
von Berg A, Filipiak-Pittroff B, Krämer U, Hoffmann B, Link E, Beckmann C, Hoffmann U, Reinhardt D, Grübl A, Heinrich J, Wichmann HE, Bauer CP, Koletzko S, Berdel D; GINIplus study group: Allergies in high-risk schoolchildren after early intervention with cow's milk protein hydrolysates: 10-year results from the German Infant Nutritional Intervention (GINI) study. J Allergy Clin Immunol 131(6): 1565-1573, 2013. [pubmed]
Fuertes E, Brauer M, Macintyre E, Bauer M, Bellander T, von Berg A, Berdel D, Brunekreef B, Chan-Yeung M, Gehring U, Herbarth O, Hoffmann B, Kerkhof M, Klümper C, Koletzko S, Kozyrskyj A, Kull I, Heinrich J, Melén E, Pershagen G, Postma D, Tiesler CM, Carlsten C; TAG Study Group: Childhood allergic rhinitis, traffic-related air pollution, and variability in the GSTP1, TNF, TLR2, and TLR4 genes: Results from the TAG Study. J Allergy Clin Immunol 132(2): 342-352, 2013. [pubmed]
Wohn C, Ober-Blöbaum JL, Haak S, Pantelyushin S, Cheong C, Zahner SP, Onderwater S, Kant M, Weighardt H, Holzmann B, Reizis B, Becher B, Prens EP, Clausen BE: Langerinneg conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice. Proc Natl Acad Sci USA 110(26): 10723-10728, 2013. [pubmed]
Frauenstein K, Sydlik U, Tigges J, Majora M, Wiek C, Hanenberg H, Abel J, Esser C, Fritsche E, Krutmann J*, Haarmann-Stemmann T*: Evidence for a novel anti-apoptotic pathway in keratinocytes involving the aryl hydrocarbon receptor, E2F1 and checkpoint kinase 1. Cell Death & Differentiation 20(10): 1425-1434, 2013. (* equal contribution) [pubmed] (open access)
Arczewska KD, Tomazella GG, Lindvall JM, Kassahun H, Maglioni S, Torgovnick A, Henriksson J, Matilainen O, Marquis BJ, Nelson BC, Jaruga P, Babaie E, Holmberg CI, Bürglin TR, Ventura N, Thiede B, Nilsen H: Active transcriptomic and proteomic reprogramming in the C. elegans nucleotide excision repair mutant xpa-1. Nucleic Acids Res 41(10): 5368-5381, 2013. [pubmed]
Gerloff K, Pereira DIA, Faria N, Boots AW, Kolling J, Förster I, Albrecht C, Powell JJ, Schins RPF. Influence of simulated gastro-intestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells. Nanotoxicology 7: 353-366, 2013. [pubmed]
Clift MJD, Raemy DO, Zulqurnain A, Endes C, Lehmann AD, Brandenberger C, Peter-Fink A, Wick P, Parak WJ, Gehr P, Schins RPF, Rothen-Rutushauser B: Can the Ames test provide an insight into nano-object mutagenicity?; Investigating the interaction between nano-objects and bacteria. Nanotoxicology 7: 1373-1385, 2013. [pubmed]
Gehring U, Gruzieva O, Agius RM, Beelen R, Custovic A, Cyrys J, Eeftens M, Flexeder C, Fuertes E, Heinrich J, Hoffmann B, de Jongste JC, Kerkhof M, Klümper C, Korek M, Mölter A, Schultz ES, Simpson A, Sugiri D, Svartengren M, von Berg A, Wijga AH, Pershagen G, Brunekreef B: Air pollution exposure and lung function in children: The ESCAPE project. Environ Health Perspect 121 (11-12): 1357-1364, 2013. [pubmed]
Schikowski T, Schaffner E, Meier F, Phuleria HC, Vierkötter A, Schindler C, Kriemler S, Zemp E, Krämer U, Bridevaux PO, Rochat T, Schwartz J, Künzli N, Probst-Hensch N: Improved air quality and attenuated lung function decline: Modification by obesity in the SAPALDIA cohort. Environ Health Perspect 121(9): 1034-1039, 2013. [pubmed]
Burgoyne JR, Oka S, Ale-Agha N, Eaton P: Hydrogen peroxide sensing and signaling by protein kinases in the cardiovascular system. Antioxid Redox Signal 18(9):1042-1052, 2013. [pubmed]
Thiering E, Cyrys J, Kratzsch J, Meisinger C, Hoffmann B, Berdel D, von Berg A, Koletzko S, Bauer CP, Heinrich J: Long-term exposure to traffic-related air pollution and insulin resistance in children: results from the GINIplus and LISAplus birth cohorts. Diabetologia 56(8): 1696-1704, 2013. [pubmed]
Sydlik U, Peuschel H, Paunel-Görgülü A, Keymel S, Krämer U, Weissenberg A, Kroker M, Seghrouchni S, Heiss C, Windolf J, Bilstein A, Kelm M, Krutmann J, Unfried K: Recovery of neutrophil apoptosis by ectoine: a new strategy against lung inflammation. Eur Respir J 41(2): 433-442, 2013. [pubmed]
Navid F, Bruhs A, Schuller W, Fritsche E, Krutmann J, Schwarz T, Schwarz A: The Aryl Hydrocarbon Receptor is Involved in UVR-Induced Immunosuppression. J Invest Dermatol 133(12): 2763-2770, 2013. [pubmed]
Tigges J*, Weighardt H*, Wolff S, Goetz C, Foerster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E: Arylhydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related to AhRR expression. J Invest Dermatol 133(1): 87-96, 2013. (* equal contribution) [pubmed] (open access)
Tomassen P, Jarvis D, Newson R, Van Ree R, Forsberg B, Howarth P, Janson C, Kowalski ML, Krämer U, Matricardi PM, Middelveld RJ, Todo-Bom A, Toskala E, Thilsing T, Brożek G, Van Drunen C, Burney P, Bachert C: Staphylococcus aureus enterotoxin-specific IgE is associated with asthma in the general population: a GA2LEN study. Allergy 68(10): 1289-1297, 2013. [pubmed]
Di Gregorio E, Bianchi FT, Schiavi A, Chiotto AM, Rolando M, Verdun di Cantogno L, Grosso E, Cavalieri S, Calcia A, Lacerenza D, Zuffardi O, Retta SF, Stevanin G, Marelli C, Durr A, Forlani S, Chelly J, Montarolo F, Tempia F, Beggs HE, Reed R, Squadrone S, Abete MC, Brussino A, Ventura N, Di Cunto F, Brusco A: A de novo X;8 translocation creates a PTK2-THOC2 gene fusion with THOC2 expression knockdown in a patient with psychomotor retardation and congenital cerebellar hypoplasia. J Med Genet 50(8): 543-551, 2013. [pubmed]
de Hoogh K, Wang M, Adam M, Badaloni C, Beelen R, Birk M, Cesaroni G, Cirach M, Declercq C, Dėdelė A, Dons E, de Nazelle A, Eeftens M, Eriksen K, Eriksson C, Fischer P, Gražulevičienė R, Gryparis A, Hoffmann B, Jerrett M, Katsouyanni K, Iakovides M, Lanki T, Lindley S, Madsen C, Mölter A, Mosler G, Nádor G, Nieuwenhuijsen M, Pershagen G, Peters A, Phuleria H, Probst-Hensch N, Raaschou-Nielsen O, Quass U, Ranzi A, Stephanou E, Sugiri D, Schwarze P, Tsai MY, Yli-Tuomi T, Varró MJ, Vienneau D, Weinmayr G, Brunekreef B, Hoek G: Development of land use regression models for particle composition in twenty study areas in europe. Environ Sci Technol 47(11): 5778-5786, 2013. [pubmed]
Wang M, Beelen R, Basagana X, Becker T, Cesaroni G, de Hoogh K, Dedele A, Declercq C, Dimakopoulou K, Eeftens M, Forastiere F, Galassi C, Gražulevičienė R, Hoffmann B, Heinrich J, Iakovides M, Künzli N, Korek M, Lindley S, Mölter A, Mosler G, Madsen C, Nieuwenhuijsen M, Phuleria H, Pedeli X, Raaschou-Nielsen O, Ranzi A, Stephanou E, Sugiri D, Stempfelet M, Tsai MY, Lanki T, Udvardy O, Varró MJ, Wolf K, Weinmayr G, Yli-Tuomi T, Hoek G, Brunekreef B: Evaluation of Land Use Regression Models for NO2 and Particulate Matter in 20 European Study Areas: The ESCAPE Project. Environ Sci Technol 47(9): 4357-4364, 2013. [pubmed]
Macintyre EA, Carlsten C, Macnutt M, Fuertes E, Melén E, Tiesler CM, Gehring U, Krämer U, Klümper C, Kerkhof M, Chan-Yeung M, Kozyrskyj AL, Berdel D, Bauer CP, Herbarth O, Bauer M, Schaaf B, Koletzko S, Pershagen G, Brunekreef B, Heinrich J, Brauer M: Traffic, asthma and genetics: combining international birth cohort data to examine genetics as a mediator of traffic-related air pollution's impact on childhood asthma. Eur J Epidemiol 28: 597–606, 2013. [pubmed]
Maletz S, Floehr T, Beier S, Klümper C, Brouwer A, Behnisch P, Higley E, Giesy JP, Hecker M, Gebhardt W, Linnemann V, Pinnekamp J, Hollert H: In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents. Water Res 47(4): 1545-1557, 2013. [pubmed]
Stobbe-Maicherski N, Wolff S, Wolff C, Abel J, Sydlik U, Frauenstein K, Haarmann-Stemmann T: The IL-6-type cytokine oncostatin M induces AHR expression in a STAT3-dependent manner in human HepG2 hepatoma cells. FEBS Journal 280(24): 6681-6690, 2013. [pubmed]
Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, Marzocchella L, Gelino S, Hansen M, Malisan F, Condo I, Bei R, Rea S, Braeckman BP, Tavernarakis N, Testi R, Ventura N: Autophagy induction extends lifespan and reduces lipids content in response to frataxin silencing in C. elegans. Exp Gerontol 48(2): 191-201, 2013. [pubmed]
Czamara D, Tiesler CM, Kohlböck G, Berdel D, Hoffmann B, Bauer CP, Koletzko S, Schaaf B, Lehmann I, Herbarth O, von Berg A, Müller-Myhsok B, Schulte-Körne G, Heinrich J: Children with ADHD symptoms have a higher risk for reading, spelling and math difficulties in the GINIplus and LISAplus Cohort Studies. PLoS One 8(5): e63859, 2013. [pubmed]
Gerber PA, Hevezi P, Buhren BA, Martinez C, Schrumpf H, Gasis M, Grether-Beck S, Krutmann J, Homey B., Zlotnik A: Systematic identification and characterization of novel human skin-associated genes encoding membrane and secreted proteins. PLoS ONE 8(6): e63949, 2013. [pubmed]
Hemmerich PH, von Mikecz A: Defining the subcellular interface of nanoparticles by live-cell imaging. PLoS one 8(4): e62018, 2013. [pubmed]
Pfitzner R, Gorzelniak L, Heinrich J, von Berg A, Klümper C, Bauer CP, Koletzko S, Berdel D, Horsch A, Schulz H: Physical activity in german adolescents measured by accelerometry and activity diary: introducing a comprehensive approach for data management and preliminary results. PLoS One 8(6): e65192, 2013. [pubmed]
Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K, Jänicke RU: Oppositional Regulation of Noxa by JNK1 and JNK2 during Apoptosis Induced by Proteasomal Inhibitors. PLoS One 8(4): e61438, 2013. [pubmed]
Teichert T, Vossoughi M, Vierkötter A, Sugiri D, Schikowski T, Schulte T, Roden M, Luckhaus C, Herder C, Krämer U: Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: Results from the SALIA study. PLoS One 8(12): e83042, 2013. [pubmed]
Vrzal R*, Frauenstein K*, Proksch P, Abel J, Dvorak Z, Haarmann-Stemmann T: Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells. PLoS One 8(9): e74917, 2013. (*authors contributed equally) [pubmed]
Wilhelmi V, Fischer U, Weighardt H, Schulze-Osthoff K, Nickel C, Stahlmecke B, Kuhlbusch TA, Scherbart AM, Esser C, Schins RPF, Albrecht C. Zinc Oxide Nanoparticles Induce Necrosis and Apoptosis in Macrophages in a p47phox- and Nrf2-Independent Manner. PLoS One 8(6): e65704, 2013. [pubmed]
Nehrenheim K, Meyer I, Brenden H, Vielhaber G, Krutmann J, Grether-Beck S: Dihydrodehydrodiisoeugenol enhances adipocyte differentiation and decreases lipolysis in murine and human cells. Exp Dermatol 22(10): 638-643, 2013. [pubmed]
Ono Y, Torii K, Fritsche E, Shintani Y, Nishida E, Nakamura M, Shirakata Y, Haarmann-Stemmann T, Abel J, Krutmann J, Morita A: Role of the aryl hydrocarbon receptor in tobacco smoke extract-induced matrix metalloproteinase-1 expression. Exp Dermatol 22(5): 349-353, 2013. [pubmed]
Steinbrenner H, Hotze AL, Speckmann B, Pinto A, Sies H, Schott M, Ehlers M, Scherbaum WA, Schinner S: Localization and regulation of pancreatic selenoprotein P. J Mol Endocrinol 50(1): 31-42, 2013. [pubmed]
Kohlboeck G, Koletzko S, Bauer CP, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Heinrich J; GINI-plus Study groups; LISA-plus Study groups: Association of atopic and non-atopic asthma with emotional symptoms in school children. Pediatr Allergy Immunol 24(3): 230-236, 2013. [pubmed]
Heinrich J, Thiering E, Rzehak P, Krämer U, Hochadel M, Rauchfuss KM, Gehring U, Wichmann HE: Long-term exposure to NO2 and PM10 and all-cause and cause-specific mortality in a prospective cohort of women. Occup Environ Med 70(3): 179-186, 2013. [pubmed]
Beelen R, Hoek G, Vienneau D, Eeftens M, Dimakopoulou K, Pedeli X, Tsai M-Y, Künzli N, Schikowski T, Marcon A, Eriksen KT, Raaschou-Nielsen O, Stephanou E, Patelarou E, Lanki T, Yli-Tuomi T, Declercq, Falq G, Stempfelet M, Birk M, Cyrys J, von Klot S, Nádor G, Varró MJ, Dedele A, Grazuleviciene R, Mölter A, Lindley S, Madsen C, Cesaroni G, Ranzi A, Badaloni C, Hoffmann B, Nonnemacher M, Krämer U, Kuhlbusch T, Cirach M, de Nazelle A, Nieuwenhuijsen M, Bellander T, Korek M, Olsson D, Strömgren M, Dons E, Jerrett M, Fischer P, Wang M, Brunekreef B, de Hoogh K: Development of NO2 and NOx land use regression models for estimating air pollution exposure in 36 study areas in Europe - The ESCAPE project. Atmos Environ 72: 10-23, 2013. (abstract)
Casas L, Tiesler C, Thiering E, Brüske I, Koletzko S, Bauer CP, Wichmann HE, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Sunyer J, Heinrich J; for the GINIplus and LISAplus Study Group: Indoor factors and behavioural problems in children: The GINIplus and LISAplus birth cohort studies. Int J Hyg Environ Health 216(2): 146-154, 2013. [pubmed]
Marini A, Reinelt K, Krutmann J, Bilstein A: Ectoine-containing cream in the treatment of mild to moderate atopic dermatitis: A randomised, comparator-controlled, intra-individual double-blind, multi-center trial. Skin Pharmacol Physiol 27(2): 57-65, 2013. [pubmed]
Pei Z, Flexeder C, Fuertes E, Thiering E, Koletzko B, Cramer C, Berdel D, Lehmann I, Bauer CP, Heinrich J: Early life risk factors of being overweight at 10 years of age: results of the German birth cohorts GINIplus and LISAplus. Eur J Clin Nutr 67(8): 855-862, 2013. [pubmed]
Dreno B, Bensadoun RJ, Humbert P, Krutmann J, Luger T, Triller R, Rougier A, Seité S: Algorithm for dermocosmetic use in the management of cutaneous side-effects associated with targeted therapy in oncology. J Eur Acad Dermatol Venereol 27(9): 1071-1080, 2013. [pubmed]
Tiesler CM, Birk M, Kohlböck G, Koletzko S, Bauer CP, Wichmann HE, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Heinrich J, for the GINIplus and LISAplus Study Groups: Residential mobility and behavioural problems in children: results from the GINIplus and LISAplus studies. J Public Health 21: 39-48, 2013. (abstract)
Farris P, Krutmann J, Li YH, McDaniel D, Krol Y: Resveratrol: a unique antioxidant offering a multi-mechanistic approach for treating aging skin. J Drugs Dermatol 12(12): 1389-1394, 2013. [pubmed]
Gotic M, Jurkin T, Music S, Unfried K, Sydlik U, Bauer-Segvic A: Microstructural characterizations of different Mn-oxide nanoparticles used as models in toxicity studies. J Molecular Structure 1044: 248-254, 2013.
Ortlieb S, Schneider G, Koletzko S, Berdel D, von Berg A, Bauer CP, Schaaf B, Herbarth O, Lehmann I, Hoffmann B, Heinrich J, Schulz H; GINIplus and LISAplus Study Groups: Physical activity and its correlates in children: a cross-sectional study (the GINIplus & LISAplus studies). BMC Public Health 13: 349, 2013. [pubmed]
Rabe E, Hertel S, Bock E, Hoffmann B, Jöckel KH, Pannier F: Therapie mit medizinischen Kompressionsstrümpfen in Deutschland - Ergebnisse der Bonner Venenstudien. J Dtsch Dermatol Ges 11(3): 257-262, 2013. (abstract)
Bauer M, Hoffmann B, Möhlenkamp S, Lehmann N, Moebus S, Roggenbuck U, Berg C, Kälsch H, Mahabadi AA, Kara K, Jöckel KH, Erbel R: Verteilung der karotidalen Intima-Media-Dicke bei Männern und Frauen mit und ohne koronare Herzerkrankung. Herz 38(5): 501-508, 2013. [pubmed]
Hüls A, Krämer U, Gappa M, Müller-Brandes C, Seitner-Sorge G, von Berg A, Schuster A, Beckmann C, Illi S, Wisbauer M, Berdel D: Neue spirometrische Referenzwerte für Kinder und Jugendliche in Deutschland unter Berücksichtigung der Größe und nichtlinearer Alterseffekte: Die LUNOKID-Studie. Pneumologie 67(3): 141-149, 2013. [pubmed]
Pedersen M, Giorgis-Allemand L, Bernard C, Aguilera I, Nybo Andersen AM, Ballester F, Beelen RMJ, Chatzi L, Cirach M, Danileviciute A, Dedele A, van Eijsden M, Estarlich M, Fernández-Somoano A, Fernández MF, Forastiere F, Gehring U, Grazuleviciene R, Gruzieva O, Heude B, Hoek G, de Hoogh K, van den Hooven EH, Håberg SE, Jaddoe VWV, Klümper C, Korek M, Krämer U, Lerchundi A, Lepeule J, Nafstad P, Nystad W, Patelarou E, Porta D, Postma D, Raaschou-Nielsen O, Rudnai P, Sunyer J, Stephanou E, Sørensen M, Thiering E, Tuffnell D, Varró MJ, Vrijkotte TGM, Wijga A,Wilhelm M,Wright J, Nieuwenhuijsen MJ, Pershagen G, Brunekreef B, Kogevinas M, Slama R: Ambient air pollution and low birthweight: a European cohort study (ESCAPE). Lancet Respir Med 1(9): 695-704, 2013. (abstract)
Fuertes E, Standl M, Cyrys J, Berdel D, von Berg A, Bauer CP, Krämer U, Sugiri D, Lehmann I, Koletzko S, Carlsten C, Brauer M, Heinrich J: A longitudinal analysis of associations between traffic-related air pollution with asthma, allergies and sensitization in the GINIplus and LISAplus birth cohorts. PeerJ 1: e193, 2013. [pubmed]
Romanos M, Tiesler CM, Koletzko S, Berdel D, von Berg A, Hoffmann B, Schaaf B, Herbarth O, Lehmann I, Bauer CP, Stach B, Gerlach M, Schulte-Körne G, Heinrich J: No cross-sectional and longitudinal association of ferritin and symptoms of attention-deficit-/hyperactivity disorder in a large population-based sample of children: results from the GINIplus and LISAplus studies. Atten Defic Hyperact Disord 5(3): 313-320, 2013. [pubmed]
Übersichtsarbeiten, Buchbeiträge u.a.
Haarmann-Stemmann T, Boege F, Krutmann J: Adaptive and maladaptive responses in skin: Mild heat exposure protects against UVB-induced photoaging in mice. J Invest Dermatol 133(4): 868-871, 2013. [pubmed]
Esser C, Bargen I, Weighardt H, Haarmann-Stemmann T, Krutmann J: Functions of the Aryl Hydrocarbon Receptor in the skin. Seminars in Immunopathology 35(6): 677-691, 2013. [pubmed]
Esser C, Götz C: Filling the gaps: need for research on cell-specific xenobiotic metabolism in the skin. Arch Toxicol 87(10): 1873-1875, 2013. [pubmed]
Hewitt NJ, Edwards R, Fritsche E, Goebel C, Aeby P, Scheel J, Reisinger K, Ouedraogo G, Duche D, Eilstein J, Latil A, Kenny J, Moore C, Kuehnl J, Barroso J, Fautz R, Pfuhler S: Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations. Toxicol Sci 133(2): 209-217, 2013. [pubmed]
Steinbrenner H, Sies H: Selenium homeostasis and antioxidant selenoproteins in brain: Implications for disorders in the central nervous system. Arch Biochem Biophys 536 (2): 152-157, 2013. [pubmed]
Steinbrenner H, Speckmann B, Sies H: Toward understanding success and failures in the use of selenium for cancer prevention. Antioxid Redox Signal 19(2): 181-191, 2013. [pubmed]
Torgovnick A, Schiavi A, Maglioni S, Ventura N: Healthy aging: what can we learn from C. elegans? Z Gerontol Geriat 46(7): 623-628, 2013. [pubmed]
Peter RU, Krutmann J: Strahlenerkrankungen der Haut (editorial). Hautarzt 64: 893, 2013.
von Mikecz A, Scharf A: Isochronal visualization of transcription and proteasomal proteolysis in cell culture or in the modelorganism Caenorhabditis elegans. Methods Mol Biol 1042: 257-273, 2013. [pubmed]
Schins RPF: Genotoxicity of Nanoparticles. In: Deutsche Forschungsgemeinschaft (DFG) (ed). Nanomaterials. Wiley-VCH, Weinheim, Germany, 1st Edition, 2013, pp. 60-64.
Originalarbeiten
Heiseke AF, Faul AC, Lehr HA, Förster I, Schmid RM, Krug A, Reindl W: CCL17 promotes intestinal inflammation in mice and counteracts regulatory T cell-mediated protection from colitis. Gastroenterology 142(2): 335-345, 2012. [pubmed]
Koletzko S, Filipiak-Pittroff B, Koletzko B, von Berg A, Krämer U, Berdel D, Heinrich J; German Infant Nutritional Intervention study group: No reason to change the current guidelines on allergy prevention. J Allergy Clin Immunol 129(1): 262-262, 2012.
Thyssen JP, Thuesen B, Huth C, Standl M, Carson CG, Heinrich J, Krämer U, Kratzsch J, Berg ND, Menné T, Johansen JD, Carlsen BC, Schwab S, Thorand B, Munk M, Wallaschofski H, Heickendorff L, Meldgaard M, Szecsi PB, Stender S, Bønnelykke K, Weidinger S, Bisgaard H, Linneberg A: Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxy vitamin D concentrations. J Allergy Clin Immunol 130(5): 1204-1207, 2012. [pubmed]
Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P: PML promotes MHC class II gene expression by stabilizing the class II transactivator. J Cell Biol 199(1): 49-63, 2012. [pubmed]
Poppensieker K, Otte DM, Schürmann B, Limmer A, Dresing P, Drews E, Schumak B, Klotz L, Raasch J, Mildner A, Waisman A, Scheu S, Knolle P, Förster I, Prinz M, Maier W, Zimmer A, Alferink J: CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci USA 109(10): 3897-3902, 2012. [pubmed]
Winter C, Pfister D, Busch J, Bingol C, Ranft U, Schrader M, Dieckmann KP, Heidenreich A, Albers P: Residual tumor size and IGCCCG risk classification predict additional vascular procedures in patients with germ cell tumors and residual tumor resection: A multicenter analysis of the German testicular cancer study group. Eur Urol 61(2): 403-409, 2012. [pubmed]
Govarts E, Nieuwenhuijsen M, Schoeters G, Ballester F, Bloemen K, de Boer M, Chevrier C, Eggesbø M, Guxens M, Krämer U, Legler J, Martinez D, Palkovicova L, Patelarou E, Ranft U, Rautio A, Skaalum Petersen M, Slama R, Stigum H, Toft G, Trnovec T, Vandentorren S, Weihe P, Weisglas Kuperus N, Wilhelm M, Wittsiepe J, Bonde JP, and OBELIX/ENRIECO: Prenatal Exposure to Polychlorinated Biphenyls (PCB) and Dichlorodiphenyldichloroethylene (DDE) and Birth Weight: A Meta-analysis within 12 European Birth Cohorts. Environ Health Perspect 120(2): 162-170, 2012. [pubmed]
Hoffmann B, Luttmann-Gibson H, Cohen A, Zanobetti A, de Souza C, Foley C, Suh HH, Coull BA, Schwartz J, Mittleman M, Stone P, Horton E, Gold DR: Opposing effects of particle pollution, ozone and ambient temperature on arterial blood pressure. Environmental Health Perspectives 120(2): 241-246, 2012. [pubmed]
Sørensen M, Hoffmann B, Hvidberg M, Ketzel M, Jensen SS, Andersen ZJ, Tjønneland A, Overvad K, Raaschou-Nielsen 0: Long-term exposure to traffic-related air oollution, blood pressure and self-reported hypertension in a Danish cohort. Environ Health Perspect 120(3): 418-424, 2012. [pubmed]
Grether-Beck S, Felsner I, Brenden B, Kohne Z, Majora M, Marini A, Jaenicke J, Rodriguez-Martin M, Trullas C, Hupe M, Elias PE, Krutmann J: Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression. J Invest Dermatol 132(6): 1561-1572, 2012. [pubmed]
Haarmann-Stemmann T, Abel J, Fritsche E, Krutmann J: The AhR-Nrf2 Pathway in Keratinocytes: On the Road to Chemoprevention? J Invest Dermatol 132 (1): 7-9, 2012. [pubmed]
Vierkötter A, Krämer U, Sugiri D, Morita A, Yamamoto A, Kaneko N, Matsui M, Krutmann J: Development of lentigines in German and Japanese women correlates with variants in the SLC45A2 gene (Letter to the Editor). J Invest Dermatol 132(3): 733-736, 2012.
Flexeder C, Thiering E, Brüske I, Koletzko S, Bauer CP, Wichmann HE, Mansmann U, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Heinrich J; for the GINIplus and LISAplus Study Group: Growth velocity during infancy and onset of asthma in school-aged children. Allergy 67(2): 257-264, 2012. [pubmed]
Jarvis D, Newson R, Lötvall J, Hastan D, Tomassen P, Keil T, Gjomarkaj M, Forsberg B, Gunnbjörnsdóttir M, Minov J, Brozek G, Dahlen S, Toskala E, Kowalski ML, Olze H, Howarth PH, Krämer U, Baelum J, Loureiro C, Kaspar L, Bousquet PJ, Bousquet J, Bachert C, Fokkens W, Burney P. Asthma in adults and its association with chronic rhinosinusitis: The GA2LEN survey in Europe. Allergy 67(1): 91-98, 2012. [pubmed]
Standl M, Sausenthaler S, Lattka E, Koletzko S, Bauer CP, Wichmann HE, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Klopp N, Koletzko B, Heinrich J; for the GINIplus and LISAplus Study Group: FADS gene cluster modulates the effect of breastfeeding on asthma. Results from the GINIplus and LISAplus studies. Allergy 67(1): 83-90, 2012. [pubmed]
Gais P, Reim D, Jusek G, Rossmann-Bloeck T, Weighardt H, Pfeffer K, Altmayr F, Janssen KP, Holzmann B: Cutting edge: divergent cell-specific functions of MyD88 for inflammatory responses and organ injury in septic peritonitis. J Immunol 188(12): 5833-5837, 2012. (pubmed]
Pinto A, Juniper DT, Sanil M, Morgan L, Clark L, Sies H, Rayman MP, Steinbrenner H: Supranutritional selenium induces alterations in molecular targets related to energy metabolism in skeletal muscle and visceral adipose tissue of pigs. J Inorg Biochem 114: 47-54. 2012. [pubmed]
Stolpmann K, Brinkmann J, Salzmann S, Genkinger D, Fritsche E, Hutzler C, Wajant H, Luch A, Henkler F: Activation of the aryl hydrocarbon receptor sensitises human keratinocytes for CD95L- and TRAIL-induced apoptosis. Cell Death & Disease 3: e388, 2012. [pubmed]
Eeftens M, Beelen R, de Hoogh K, Bellander T, Cesaroni G, Cirach M, Declercq C, Dedele A, Dons E, de Nazelle A, Dimakopoulou K, Eriksen KT, Falq G, Fischer P, Galassi C, Gražulevičienė R, Heinrich J, Hoffmann B, Jerrett M, Keidel D, Korek M, Lankki T, Lindley S, Madsen C, Molter A, Nador G, Nieuwenhuijsen MJ, Nonnemacher M, Pedeli X, Raaschou Nielsen O, Patelarou E, Quass U, Ranzi A, Schindler C, Stempfelet M, Stephanou EG, Sugiri D, Tsai M, Yli-Tuomi T, Varro MJ, Vienneau D, von Klot S, Wolf K, Brunekreef B, Hoek G: Development of land use regression models for PM2.5, PM2.5 absorbance, PM10 and PMcoarse in 20 European study areas; results of the ESCAPE project. Environ Sci Technol 46(20): 11195-11205, 2012. [pubmed]
Köhler T, Reizis B, Johnson RS, Weighardt H, Förster I: Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration. Eur J Immunol 42(5): 1226-1236, 2012. [pubmed]
Röck K, Meusch M, Fuchs N, Tigges J, Zipper P, Fritsche E, Krutmann J, Homey B, Reifenberger J, Fischer JW: Estradiol protects the dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes. J Biol Chem 287(24): 20056-20069, 2012. [pubmed]
Bhattacharya K, Hoffmann E, Schins RPF, Boertz J, Prantl EM, Alink GM, Byrne HJ, Kuhlbusch TAJ,Rahman Q, Wiggers H, Schulz C, Dopp E: Comparison of micro- and nanoscale Fe+3-containing (hematite) particles for their toxicological properties in human lung cells in vitro. Toxicol Sci 126(1): 173-182, 2012. [pubmed]
Stahl W, Sies H: Photoprotection by dietary carotenoids: Concept, mechanisms, evidence and future development. Mol Nutr Food Res 56(2): 287-95, 2012. [pubmed]
Lødrup Carlsen KC, Roll S, Carlsen KH, Mowinckel P, Wijga AH, Brunekreef B, Torrent M, Roberts G, Arshad SH, Kull I, Krämer U, von Berg A, Eller E, Høst A, Kuehni C, Spycher B, Sunyer J, Chen CM, Reich A, Asarnoj A, Puig C, Herbarth O, Mahachie John JM, Van Steen K, Willich SN, Wahn U, Lau S, Keil T; GALEN WP 1.5 ‘Birth Cohorts’ working group: Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts. PLoS One 7(8): e43214, 2012. [pubmed]
Standl M, Lattka E, Stach B, Koletzko S, Bauer CP, von Berg A, Berdel D, Krämer U, Schaaf B, Röder S, Herbarth O, Buyken A, Drogies T, Thiery J, Koletzko B, Heinrich J; for the GINIplus Study Group; and LISAplus Study Group. FADS1 FADS2 Gene Cluster, PUFA Intake and Blood Lipids in Children: Results from the GINIplus and LISAplus Studies. PLoS One 7(5): e37780, 2012. [pubmed]
van Eijl S, Zhu Z, Cupitt J, Gierula M, Götz C, Fritsche E, Edwards RJ: Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling. PLoS One 7(7): e41721, 2012.
Thiering E, Brüske I, Kratzsch J, Hoffmann B, Herbarth O, von Berg A, Schaaf B, Wichmann HE, Heinrich J; the LISAplus Study Group: Peak growth velocity in infancy is positively associated with blood pressure in school-aged children. J Hypertens 30(6): 1114-1121, 2012. [pubmed]
Gerloff K, Fenoglio I Carella E, Kolling J, Albrecht C, Boots A, Förster I, Schins R: Distinctive toxicity of TiO2 rutile/anatase mixed phases nanoparticles on Caco-2 cells. Chemical Research in Toxicology 25(3): 646-655, 2012. [pubmed]
Götz C, Pfeiffer R, Tigges T, Ruwiedel K, Hübenthal U, Merk HF, Krutmann J, Edwards RJ, Abel J, Goebel C, Hewitt N, Fritsche E: Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes. Exp Dermatol 21(5): 364-369, 2012. [pubmed]
Götz C, Pfeiffer R, Tigges T, Blatz V, Jäckh C, Freytag EM, Fabian E, Landsiedel R, Merk HF, Krutmann J, Edwards RJ, Pease C, Goebel C, Hewitt N, Fritsche E: Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (phase I). Exp Dermatol 21(5): 358-363, 2012. [pubmed]
Kaneko N, Vierkoetter A, Kraemer U, Sugiri D, Matsui M, Yamamoto A, Krutmann J, Morita A: Mitochondrial common deletion mutation and extrinsic skin ageing in German and Japanese women. Exp Dermatol 21 Suppl 1: 26-30, 2012. [pubmed]
Marini A, Farwick M, Grether-Beck S, Brenden H, Felsner I, Jaenicke T, Weber M, Schild J, Maczkiewitz U, Köhler T, Bonfigli A, Pagani V, Krutmann J: Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects. Exp Dermatol 21(2): 140-146, 2012. [pubmed]
Cyrys J, Eeftens M, Heinrich J, Ampe C, Armengaud A, Beelen R, Bellander T, Beregszaszi T, Birk M, Cesaroni G, Cirach M, de Hoogh K, De Nazelle A, de Vocht F, Declercq C, Dėdelė A, Dimakopoulou K, Eriksen K, Galassi C, Graulevičienė R, Grivas G, Gruzieva O, Hagenbjörk Gustafsson A, Hoffmann B, Iakovides M, Ineichen A, Krämer U, Lanki T, Lozano P, Madsen C, Meliefste K, Modig L, Mölter A, Mosler G, Nieuwenhuijsen M, Nonnemacher M, Oldenwening M, Peters A, Pontet S, Probst-Hensch N, Quass U, Raaschou-Nielsen O, Ranzi A, Sugiri D, Stephanou EG, Taimisto P, Tsai M-Y, Vaskövi E, Villani S, Wang M, Brunekreef B, Hoek G: Variation of NO2 and NOx concentrations between and within 36 European study areas: Results from the ESCAPE study. Atmospheric Environment 62: 374-390, 2012.
Eeftens M, Tsai MY, Ampe V, Anwander B, Beelen R, Bellander T, Cesaroni G, Cirach M, Cyrys J, de Hoogh K, De Nazelle A, de Vocht F, Declercq C, Dėdelė A, Eriksen K, Galassi C, Gražulevičienė R, Grivas G, Heinrich J, Hoffmann B, Iakovides M, Ineichen A, Katsouyanni K, Korek K, Krämer U, Kuhlbusch T, Lanki T, Madsen C, Meliefste K, Mölter A, Mosler G, Nieuwenhuijsen M, Oldenwening M, Pennanen A, Probst-Hensch N, Quass U, Raaschou-Nielsen O, Ranzi A, Stephanou E, Sugiri D, Udvardy O, Vaskövi É, Weinmayr G, Brunekreef B, Hoek G: Variation of PM2.5, PM10, PM2.5 absorbance and PMcoarse concentrations between and within 20 European study areas – results of the ESCAPE project. Atmospheric Environment 62: 303-317, 2012.
De Spirt S, Sies H, Tronnier H, Heinrich U: An encapsulated fruit and vegetable juice concentrate increases skin microcirculation in healthy women. Skin Pharmacol Physiol 25(1): 2-8, 2012. [pubmed]
Marini A*, Grether-Beck S*, Jaenicke T, Weber M, Burki C, Formann P, Brenden H, Schönlau F, Krutmann J: Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women. Skin Pharmacology & Physiology 25(2): 86-92, 2012. (*equal contribution) [pubmed]
Gassmann K, Baumann J, Giersiefer S, Schuwald J, Schreiber T, Merk HF, Fritsche E: Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications. Toxicology In Vitro 26(6): 993-1000, 2012. [pubmed]
Wilhelmi V, Fischer U, van Berlo D, Schulze-Osthoff K, Schins RPF, Albrecht C: Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicology in vitro 26(2): 323-334, 2012. [pubmed]
Bauer M, Gräbsch C, Schlink U, Klopp N, Illig T, Krämer U, von Berg A, Schaaf B, Borte M, Heinrich J, Herbarth O, Lehmann I, Röder S; for the LISAplus Study Group: Genetic association between obstructive bronchitis and enzymes of oxidative stress. Metabolism 61(12): 1771-1779, 2012. [pubmed]
Casas L, Tischer C, Tiesler C, Brüske I, Koletzko S, Bauer CP, Wichmann HE, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Heinrich J; for the GINIplus LISAplus Study Group: Association of gas cooking with children's respiratory health: results from GINIplus and LISAplus birth cohort studies. Indoor Air 22(6): 476-482, 2012. [pubmed]
Italia S, Batscheider A, Heinrich J, Wenig C, Bauer CP, Koletzko S, Lehmann I, Herbarth O, von Berg A, Berdel D, Hoffmann B, Schaaf B, Wolfenstetter SB: Utilization and costs of conventional and alternative pharmaceuticals in children: results from the German GINIplus and LISAplus Birth Cohort Studies. Pharmacoepidemiology and Drug Safety 21(10): 1102-1111, 2012. [pubmed]
Mertens J, Stock S, Lüngen M, von Berg A, Krämer U, Filipiak-Pittroff B, Heinrich J, Koletzko S, Grübl A, Wichmann HE, Bauer CP, Reinhardt D, Berdel D, Gerber A: Is prevention of atopic eczema with hydrolyzed formulas cost-effective? A health economic evaluation from Germany. Pediatr Allergy Immunol 23(6): 597-604, 2012. [pubmed]
Kohlboeck G, Sausenthaler S, Standl M, Koletzko S, Bauer CP, von Berg A, Berdel D, Krämer U, Schaaf B, Lehmann I, Herbarth O, Heinrich J: Food intake, diet quality and behavioral problems in children: Results from the GINI-plus/LISA-plus studies. Ann Nutr Metab 60(4): 247-256, 2012. [pubmed]
Rennert A, Wittsiepe J, Kasper-Sonnenberg M, Binder G, Fürst P, Cramer C, Krämer U, Wilhelm M: Prenatal and early life exposure to polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls may influence dehydroepiandrosterone sulfate levels at prepubertal age: Results from the Duisburg birth cohort study. J Toxicol Environ Health A 75(19-20): 1232-1240, 2012. [pubmed]
Goetz C, Hewitt NJ, Jermann E, Tigges T, Kohne Z, Huebenthal U, Krutmann J, Merk HF, Fritsche E: Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDerm™ models. Xenobiotica 42(6): 526-537, 2012. [pubmed]
Batscheider A, Zakrzewska S, Heinrich J, Wenig CM, Menn P, Bauer CP, Hoffmann U, Koletzko S, Lehmann I, Herbarth O, von Berg A, Berdel D, Krämer U, Schaaf B, Wichmann HE, Leidl R: Exposure to second-hand smoke and direct healthcare costs in children — results from two German birth cohorts, GINIplus and LISAplus. BMC Health Serv Res 12(1): 344, 2012. [pubmed]
Seité S, Reinhold K, Jaenicke T, Brenden H, Krutmann J, Grether-Beck S: Broad-spectrum moisterizing sunscreen effectivity prevents molecular reactions to ultraviolet A radiation. Cutis 90: 321-326, 2012. [pubmed]
Hauth EAM, Berkemeyer S, Jaeger H, Forsting M, Hoffmann B, Jöckel KH: Epidemiological follow-up 15 years after the breast cancer scandal in Essen. Geburtsh Frauenheilk 72(6): 513-522, 2012.
Vierkötter A, Krutmann J: Environmental influences on skin aging and ethnic specific manifestations. Dermato-Endocrinology 4(4): 1-5, 2012.
Übersichtsarbeiten, Buchbeiträge
Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AEM, Kreysa J: Advancing the Science of Developmental Neurotoxicity (DNT): Testing for Better Safety Evaluation. Conference Report. ALTEX – Alternatives to Animal Experimentation 29(2): 202-215, 2012.
Cramer C, Link E, Koletzko S, Lehmann I, Herbarth O, Borte M, Schaaf B, Heinrich J, Wichmann HE, Bauer CP, von Berg A, Berdel D, Behrendt H, Krämer U, for the GINIplus and LISAplus Study Group: The hygiene hypothesis does not apply to atopic eczema in childhood. In: Ring J, Darsow U, Behrendt H (eds): Chemical immunology and allergy. New Trends in Allergy and Atopic Eczema, vol 96. Basel, Karger 2012, pp. 15-23 [pubmed]
Esser C: Biology of the aryl hydrocarbon receptor: report of an international and interdisciplinary conference. Arch Toxicol 86(8): 1323-1329, 2012. [pubmed]
Genuneit J, Grabenhenrich L, Krämer U, Cramer C, Schlaud M, für die Arbeitsgruppe „Epidemiologie allergischer und dermatologischer Erkrankungen“ der Deutschen Gesellschaft für Epidemiologie: Epidemiologische Forschung zu allergischen Erkrankungen in Deutschland: eine Chronologie. Allergologie 35(1): 3-10, 2012.
Heinrich J, Brüske I, Schnappinger M, Standl M, Flexeder C, Thiering E, Tischer C, Tiesler CM, Kohlböck G, Wenig CM, Bauer CP, Schaaf B, von Berg A, Berdel D, Krämer U, Cramer C, Lehmann I, Herbarth O, Behrendt H, Ring J, Kühnisch J, Koletzko S: Die zwei deutschen Geburtskohorten GINIplus und LISAplus. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 55(6-7): 864-874, 2012. [pubmed]
Heinrich J, Brüske I, Cramer C, Hoffmann U, Schnappinger M, Schaaf B, von Berg A, Berdel D, Krämer U, Lehmann I, Herbarth O, Borte M, Grübl A, Bauer CP, Beckmann C, Behrendt H, Ring J, Koletzko S: GINIplus und LISAplus. Design und ausgewählte Ergebnisse zweier deutscher Geburtskohorten zum natürlichen Verlauf atopischer Erkrankungen sowie deren Determinanten. Allergologie 35(1): 20-31, 2012.
Jacquemin B, Schikowski T, Carsin AE, Hansell A, Krämer U, Sunyer J, Probst-Hensch N, Kauffmann F, Künzli N: The role of air pollution in adult-onset asthma: A review of the current evidence. Semin Respir Crit Care Med 33(6): 606-619, 2012. [pubmed]
Kochevar I, Taylor R, Krutmann J: Fundamentals of Cutaneous Photobiology and Photoimmunology. In: Fitzpatrick´s Dermatology in General Medicine (Wolff K, Goldsmith L.A, Katz S, Gilchrest B, Paller AS, Leffell DJ eds) eighth edition, McGraw-Hill, New York, pp 1031-1049, 2012.
Krämer U, Vierkötter A, Schikowski T, Sugiri D, Brüning T, Raulf-Heimsoth M: Prävalenz und Inzidenz allergischer Erkrankungen bei Älteren – Ergebnisse der Kohortenstudie SALIA. Allergologie 35(3): 121-130, 2012.
Krutmann J: Pre- and probiotics for human skin. Clin Plast Surg 39(1): 59-64, 2012. [pubmed]
Krutmann J, Morita A, Chung JH: Sun exposure – what molecular photodermatology tells us about its good and bad sides. J Invest Dermatol 132(3 Pt 2): 976-984, 2012. [pubmed]
Künzli N, Hoffmann B: Luft. In: Egger M, Razum O (Hrsg.): Public Health – Sozial- und Präventivmedizin kompakt. Berlin/Boston, de Gruyter, 2012, S. 163-171.
Marini A, Krutmann J: Pre- and probiotics for human skin. In: Handbook of diet, nutrition and the skin. V.R. Preedy (ed.), Wageningen Academic Publishers, Wageningen NL, pp. 319-332, 2012.
Schins RPF, Albrecht C, Gerloff K, Van Berlo D: Genotoxicity of carbon nanotubes. In: (Donaldson K, Poland C, Duffin R, Eds.) The Inhalation Toxicology of Carbon Nanotubes. Cambridge University Press, UK,2012, pp. 150-173.
Sies H, Hollman PC, Grune T, Stahl W, Biesalski HK, Williamson G: Protection by flavanol-rich foods against vascular dysfunction and oxidative damage: 27th Hohenheim Consensus Conference. Adv Nutr 3(2): 217-221, 2012. [pubmed]
Stahl W, Sies H: β-Carotene and other carotenoids in protection from sunlight. Am J Clin Nutr 96(5): 1179S-1184S, 2012. [pubmed]
van Berlo D, Hullmann M, Schins RPF: Toxicology of ambient particulate matter. In: (Luch A, Ed.) Molecular, Clinical and Environmental Toxicology. Volume 3. Molecular Toxicology Series: Experientia Supplementum, Birkhäuser Basel 2012, pp. 165-217.
von Berg A, Filipiak-Pittroff B, Krämer U, Link E, Heinrich J, Koletzko S, Grübl A, Hoffmann U, Beckmann C, Reinhardt D, Bauer CP, Wichmann HE, Berdel D: Die German Infant Nutritional Intervention Study (GINI) zur präventiven Wirkung von Hydrlysatnahrungen bei Kindern mit Allergierisiko. Design und ausgewählte Ergebnisse. Allergologie 35 (1): 32-43, 2012.
Van Berlo D, Clift M, Albrecht C, Schins RPF. Carbon nanotubes: An insight into the mechanisms of their potential genotoxicity. Swiss Medical Weekly 142: w13698, 2012.
Vrijheid M, Casas M, Bergström A, Carmichael A, Cordier S, Eggesbø M, Eller E, Fantini MP, Fernández MF, Fernández-Somoano A, Gehring U, Grazuleviciene R, Hohmann C, Karvonen AM, Keil T, Kogevinas M, Koppen G, Krämer U, Kuehni C, Magnus P, Majewska R, Andersen AM, Patelarou E, Petersen MS, Pierik FH, Polanska K, Porta D, Richiardi L, Santos AC, Slama R, Sram RJ, Thijs C, Tischer C, Toft G, Trnovec T, Vandentorren S, Vrijkotte TG, Wilhelm M, Wright J, Nieuwenhuijsen M: European Birth Cohorts for Environmental Health Research. Environ Health Perspect 120(1): 29-37, 2012. [pubmed]
Zouboulis CC, Krutmann J: Gerontodermatologie. Hautarzt 63(12): 929-931, 2012.
Originalarbeiten
Kiss EA, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, Diefenbach A: Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 334 (6062): 1561-1565, 2011. [pubmed]
Guarda G, Braun M, Staehli F, Tardivel A, Mattmann C, Förster I, Farlik M, Decker T, Du Pasquier RA, Romero P, Tschopp J: Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2): 213-223, 2011. [pubmed]
Weber C, Meiler S, Döring Y, Koch M, Drechsler M, Megens RT, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Förster I, Zenke M, Hieronymus T, Junt T, Zernecke A: CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 121(7): 2898–2910, 2011. [pubmed]
Rey G, Cesbron F, Rougemont J, Reinke H, Brunner M, Naef F: Genome-wide and phase-specific DNA-binding rhythms of BMAL1 control circadian output functions in mouse liver. PLoS Biology 9(2): e1000595, 2011. [pubmed]
Filipiak-Pittroff B, Schnopp C, Berdel D, Naumann A, Sedlmeier S, Onken A, Rodriguez E, Fölster-Holst R, Baurecht H, Ollert M, Ring J, Cramer C, von Berg A, Bauer CP, Herbarth O, Lehmann I, Schaaf B, Koletzko S, Wichmann HE, Heinrich J, Weidinger S, on behalf of the GINIplus and LISAplus study groups. Predictive value of food sensitization 1 and filaggrin mutations in children with eczema. J Allergy Clin Immunol 128(6): 1235-1241, 2011. [pubmed]
Koletzko S, Filipiak-Pittroff B, von Berg A, Grübl A, Heinrich J, Krämer U, Wichmann HE, Bauer CP, Reinhardt D, Berdel D: Supplementation with cow's milk at birth is not recommended. J Allergy Clin Immunology 127(3): 836-838, 2011.
Scharf A, Grozdanov PN, Veith R, Kubitscheck U, Meier UT, von Mikecz A: Distant positioning of proteasomal proteolysis relative to actively transcribed genes. Nucleic Acids Research 39(11): 4612-4627, 2011. [pubmed]
Tegenge MA, Rockel TD, Fritsche E*, Bicker G*: Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction. Cell Mol Life Sci 68(12): 2089-2099, 2011. (* corresponding authors) [pubmed]
Rzehak P, Sausenthaler S, Koletzko B, Reinhardt D, von Berg A, Krämer U, Berdel D, Bollrath C, Grübl A, Bauer C P, Wichmann H-E, Heinrich J, for the GINI-plus study group. Long-term effects of hydrolyzed protein infant formulas on growth-extended follow-up to 10 years of age: results from the German Infant Nutrional Intervention Study (GINI). Am J Clin Nutr 94(6): 1803S-1807S, 2011. [pubmed]
Cramer C, Link E, Bauer CP, Hoffmann U, von Berg A, Lehmann I, Herbarth O, Borte M, Schaaf B, Sausenthaler S, Wichmann H-E, Heinrich J, Krämer U: Association between attendance of day care centres and increased prevalence of eczema in the German birth cohort sutdy LISAplus. Allergy 66(1): 68-75, 2011. [pubmed]
Hastan D, Fokkens WJ, Bachert C, Newson RB, Bislimovska J, Bockelbrink A, Bousquet PJ, Brozek G, Bruno A, Dahlén SE, Forsberg B, Gunnbjörnsdóttir M, Kasper L, Krämer U, Kowalski ML, Lange B, Lundbäck B, Salagean E, Todo-Bom A, Tomassen P, Toskala E, van Drunen CM, Bousquet J, Zuberbier T, Jarvis D, Burney P: Chronic rhinosinusitis in Europe - an underestimated disease. A GA(2) LEN study. Allergy 66(9): 1216-1223, 2011. [pubmed]
Schmitt J, Chen CM, Apfelbacher C, Romanos M, Lehmann I, Herbarth O, Schaaf B, Krämer U, von Berg A, Wichmann HE, Heinrich J, the LISA-plus Study Group: Infant eczema, infant sleeping problems and mental health at 10 years of age: The prospective birth-cohort study LISAplus. Allergy 66(3): 404-411, 2011. [pubmed]
Tischer CG, Hohmann C, Thiering E, Herbarth O, Muller A, Henderson J, Granell R, Fantini MP, Luciano L, Bergstrom A, Kull I, Link E, von BA, Kuehni CE, Strippoli MP, Gehring U, Wijga A, Eller E, Bindslev-Jensen C, Keil T, Heinrich J. Meta-analysis of mould and dampness exposure on asthma and allergy in eight European birth cohorts: an ENRIECO initiative. Allergy 66(12): 1570-1579, 2011. [pubmed]
Tomassen P, Newson RB, Hoffmans R, Lötvall J, Cardell LO, Gunnbjörnsdóttir M, Thilsing T, Matricardi P, Krämer U, Makowska JS, Brozek G, Gjomarkaj M, Howarth P, Loureiro C, Toskala E, Fokkens W, Bachert C, Burney P, Jarvis D: Reliability of EP3OS symptom criteria and nasal endoscopy in the assessment of chronic rhinosinusitis - a GA(2)LEN study. Allergy 66 (4): 556-561, 2011. [pubmed]
Jux B, Kadow S, Luecke S, Rannug A, Krutmann J, Esser C: The Aryl Hydrocarbon Receptor Mediates UVB Radiation-Induced Skin Tanning. J Invest Dermatol 131(1): 203-210, 2011. [pubmed]
Fuks K, Viehmann A, Moebus S, Nonnemacher M, Möhlenkamp S, Dragano N, Jakobs H, Erbel R, Jöckel KH, Hoffmann B on behalf of the Heinz Nixdorf Recall Investigative Group: Long-term urban particulate air pollution, traffic noise and arterial blood pressure. Environ Health Perspect 119(12): 1706-1711, 2011. [pubmed]
Peinemann F, Moebus S, Dragano N, Möhlenkamp S, Lehmann N, Zeeb H, Erbel R, Jöckel KH, Hoffmann B: Second-hand smoke exposure and coronary artery calcification among non-smoking participants of a population-based cohort. Environ Health Perspect 119(11): 1556-1561, 2011. [pubmed]
Tischer C, Gehring U, Chen CM, Kerkhof M, Koppelman G, Sausenthaler S, Herbarth O, Schaaf B, Lehmann I, Krämer U, Berdel D, von Berg A, Bauer CP, Koletzko S, Wichmann HE, Brunekreef B, Heinrich J: Respiratory health in children and indoor exposure to (1,3)-{beta}-D-glucan, EPS mould components, and endotoxin. Eur Respir J 37(5): 1050-1059, 2011. [pubmed]
Kadow S, Jux B, Zahner SP, Wingerath B, Chmill S, Clausen BE, Hengstler J, Esser C: Aryl hydrocarbon receptor is critical for homeostasis of invariant gamma-delta T cells in the murine epidermis. J Immunology 187(6): 3104-3110, 2011. [pubmed]
Vordenbäumen S, Braukmann A, Petermann K, Scharf A, Bleck E, von Mikecz A, Jose J, Schneider M: Casein alpha s1 is expressed by human monocytes and upregulates the production of GM-CSF via p38 MAPK. J Immunol 186(1): 592-601, 2011. [pubmed]
Specht S, Frank JK, Alferink J, Dubben B, Layland LE, Denece G, Bain O, Förster I, Kirschning CJ, Martin C, Hoerauf A: CCL17 controls mast cells for the defense against filarial larval entry. J Immunol 186: 4845-4852, 2011. [pubmed]
Röck K, Grandoch M, Majora M, Krutmann J, Fischer JW: Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to UVB: New insights into mechanisms of matrix remodelling. J Biol Chem 286 (20): 18268-18276, 2011. [pubmed]
Scherbart AM, Langer J, Bushmelev A, van Berlo D, Haberzettl P, van Schooten FJ, Schmidt AM, Rose CR, Schins RPF, Albrecht C: Uptake, inflammatory and oxidative stress responses of titanium dioxide in alveolar macrophages: A question of size? Part Fibre Toxicol 8(1): 31, 2011. [pubmed]
Speckmann B, Bidmon HJ, Pinto A, Anlauf M, Sies H, Steinbrenner H: Induction of glutathione peroxidase 4 expression during enterocytic cell differentiation. J Biol Chem 286(12): 10764-10772, 2011. [pubmed]
Arnhold F, von Mikecz A: Quantitative feature extraction reveals the status quo of protein fibrillation in the cell nucleus. Integrative Biology 3(7): 761-769, 2011. [pubmed]
Krefis AC, Schwarz NG, Nkrumah B, Acquah S, Loag W, Oldeland J, Sarpong N, Adu-Sarkodie Y, Ranft U, May J:
Spatial analysis of land cover determinants of malaria incidence in the ashanti region, ghana. PLoS One 6(3): e17905, 2011. [pubmed]
Tse BW, Russell PJ, Lochner M, Förster I, Power CA: IL-18 inhibits growth of murine orthotopic prostate carcinomas via both adaptive and innate immune mechanisms. PLoS One 6 (9): e24241, 2011. [pubmed]
Bayer M, Proksch P, Felsner I, Brenden H, Kohne Z, Walli R, Duong TN, Götz C, Krutmann J, Grether-Beck S:
Photoprotection against UVAR: Effective triterpenoids require a lipid raft stabilizing chemical structure.
Exp Dermatol 20 (11): 955-958, 2011. [pubmed]
Farwick M, Grether-Beck S, Marini A, Maczkiewitz U, Lange J, Köhler T, Lersch P, Falla T, Felsner I, Brenden H, Jaenicke T, Franke S, Krutmann J: Bioactive tetrapeptide GEKG boosts extracellular matrix formation: in vitro and in vivo molecular and clinical proof. Exp Dermatol 20 (7): 602-604, 2011. [pubmed]
Marionnet C, Grether-Beck S, Seité S, Marini A, Jaenicke T, Lejeune F, Bastien P, Rougier A, Bernerd F, Krutmann J: A broad-spectrum sunscreen prevents UVA radiation-induced gene expression in reconstructed skin in vitro and in human skin in vivo. Exp Dermatol 20(6): 477-482, 2011. [pubmed]
Ghiazza M, Scherbart AM, Fenoglio I, Grendene F, Turci F, Martra G, Albrecht C, Schins RP, Fubini B: Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. Chem Res Toxicol 24(1): 99-110, 2011. [pubmed]
Gerloff K, Albrecht C, Boots AW, Förster I, Schins RPF. Particles which may occur in food or food packaging can exert cytotoxicity and (oxidative) DNA damage in target cells of the human intestine. Letter to the editor. Nanotoxicology 5: 282-283, 2011.
Wessels A, van Berlo D, Boots AW, Gerloff K, Scherbart AM, Cassee F, Gerlofs-Nijland M, Van Schooten F, Albrecht C, Schins RPF: Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles. Nanotoxicology 5: 66-78, 2011. [pubmed]
Winter M, Beer HD, Hornung V, Krämer U, Schins RPF, Förster I: Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells. Nanotoxicology 5: 326-340, 2011. [pubmed]
Perner D, Vierkötter A, Sugiri D, Matsui M, Ranft U, Esser C, Ethève S, Goralczyk R, Kaneko N, Yamamoto A, Morita A, Krutmann J, Krämer U: Association between sun-exposure, smoking behaviour and plasma antioxidant levels with the different manifestation of skin ageing signs between Japanese and German women – A pilot study. J Dermatol Sci 62(2): 138-140, 2011.
Sodenkamp JC, Behrends J, Förster I, Müller W, Ehlers S, Hölscher C: gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis. Eur J Cell Biol 90(6-7): 505-514, 2011. [pubmed]
Bothe H*, Gassmann K*, Götz C, Fritsche E, Abel J, Haarmann-Stemmann T: Epigallocatechin-3-gallate does not affect the activity of enzymes involved in metabolic activation and cellular excretion of benzo[a]pyrene in human colon carcinoma cells. Toxicology Letters 203(3): 258-264, 2011. (*equal contribution) [pubmed]
Kasper-Sonnenberg M, Sugiri D, Wurzler S, Ranft U, Dickel H, Wittsiepe J, Hölzer J, Lemm F, Eberwein G, Altmeyer P, Kraft M, Krämer U, Wilhelm M: Prevalence of nickel sensitization and urinary nickel content of children are increased by nickel in ambient air. Environ Res 111(2): 266-273, 2011. [pubmed]
Tiesler CM, Chen CM, Sausenthaler S, Herbarth O, Lehmann I, Schaaf B, Krämer U, von Berg A, von Kries R, Wichmann HE, Heinrich J; The LISA Study Group: Passive smoking and behavioural problems in children: Results from the LISAplus prospective birth cohort study. Environ Res 111(8): 1173-1179, 2011. [pubmed]
Rzehak P, Koletzko S, Koletzko B, Sausenthaler S, Reinhardt D, Grübl A, Bauer CP, Krämer U, Bollrath C, von Berg A, Berdel D, Wichmann HE, Heinrich J, for the GINI Study Group: Growth of infants fed formula rich in canola oil (low erucic acid rapeseed oil). Clin Nutr 30(3): 339-345, 2011. [pubmed]
Brossette T, Hundsdörfer C, Kröncke KD, Sies H, Stahl W: Direct evidence that (-)-epicatechin increases intric oxide levels in human endothelial cells. Eur J Nutr 50: 595-599, 2011. [pubmed]
Pinto A, Speckmann B, Sies H, Steinbrenner H: Delaying insulin signal transduction in skeletal muscle cells. J Inorganic Biochem 105: 812-820, 2011. [pubmed]
Franck U, Herbarth O, Röder S, Schlink U, Borte M, Diez U, Krämer U, Lehmann I: Respiratory effects of indoor particles in young children are size dependent. Sci Total Environ 409(9):1621-1631, 2011. [pubmed]
Eckers A, Sauerbier E, Anwar-Mohamed A, Hamann I, Esser C, Schroeder P, El-Kadi AO, Klotz LO: Detection of a functional xenobiotic response element in a widely employed FoxO-responsive reporter construct. Arch Biochem Biophys 516(2): 138-145, 2011. [pubmed]
Apfelbacher CJ, Krämer U: Erratum re: prevalence of overweight and obesity in East and West German children in the decade after reunification: population-based series of cross-sectional studies. J Epidemiol Community Health 65(1): 86, 2011.
Thiering E, Brüske I, Kratzsch J, Thiery J, Sausenthaler S, Meisinger C, Koletzko S, Bauer CP, Schaaf B, von Berg A, Berdel D, Lehmann I, Herbarth O, Krämer U, Wichmann HE, Heinrich J; for the GINIplus and LISAplus Study Groups: Prenatal and postnatal tobacco smoke exposure and development of insulin resistance in 10 year old children. Int J Hyg Environ Health 214(5): 361-368, 2011. [pubmed]
Sørensen M, Hvidberg M, Hoffmann B, Andersen ZJ, Nordsborg RB, Lillelund KG, Jakobsen J, Tjønneland A, Overvad K, Raaschou-Nielsen O: Exposure to road traffic and railway noise and associations with blood pressure and self-reported hypertension: a cohort study. Environmental Health 10(1): 92, 2011. [pubmed]
Krefis AC, Schwarz NG, Krüger A, Fobil J, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J:
Modeling the Relationship between Precipitation and Malaria Incidence in Children from a Holoendemic Area in Ghana. Am J Trop Med Hyg 84(2): 285-291, 2011. [pubmed]
Standl M, Sausenthaler S, Lattka E, Koletzko S, Bauer CP, Wichmann HE, von Berg A, Berdel D, Krämer U, Schaaf B, Röder S, Herbarth O, Klopp N, Koletzko B, Heinrich J; for the GINIplus and LISAplus Study Group: FADS gene variants modulate the effect of dietary fatty acid intake on allergic diseases in children. Clin Exp Allergy 41(12): 1757-1766, 2011. [pubmed]
Breitfelder A, Wenig CM, Wolfenstetter SB, Rzehak P, Menn P, John J, Leidl R, Bauer CP, Koletzko S, Röder S, Herbarth O, von Berg A, Berdel D, Krämer U, Schaaf B, Wichmann HE, Heinrich J; the GINI-plus, LISA-plus Study Groups: Relative weight-related costs of healthcare use by children-Results from the two German birth cohorts, GINI-plus and LISA-plus. Econ Hum Biol 9(3): 302-315, 2011. [pubmed]
Leyendecker M, Korsten P, Reinehr R, Speckmann B, Schmoll D, Scherbaum WA, Bornstein SR, Barthel A, Klotz LO:
Ceruloplasmin expression in rat liver cells is attenuated by insulin: Role of FoxO transcription factors. Horm Metab Res 43 (4): 268-274, 2011. [pubmed]
Sausenthaler S, Stadl M, Buyken A, Rzehak P, Koletzko S, Bauer CP, Schaaf B, von Berg A, Berdel D, Borte M, Herbart O, Lehmann I, Krämer U, Wichmann H-E, Heinrich J: Regional and socioeconomic differences in food, nutrient and supplement intake in school-age children in Germany. Results from the GINIplus and the LISAplus Study. Public Health Nutrition 14 (10): 1724-1735, 2011. [pubmed]
Germing A, Gotzmann M, Schikowski T, Vierkötter A, Ranft U, Kramer U, Mugge A: High frequency of diastolic dysfunction in a population-based cohort of elderly women - but poor association with the symptom dyspnea. BMC Geriatrics 11(1): 71, 2011. [pubmed]
Steinbrenner H, Speckmann B, Pinto A, Sies H: High selenium intake and increased diabetes risk: experimental evidence for interplay between selenium and carbohydrate metabolism. J Clin Biochem Nutr 48 (1): 40-45, 2011. [pubmed]
Germing A, Gotzmann M, Schikowski T, Vierkötter A, Ranft U, Mügge A: Diastolic dysfunction without abnormalities in left atrial and left ventricular geometry does not affect quality of life in elderly women. Exp Clin Cardiol 16 (2): 37-39, 2011. [pubmed]
Übersichtsarbeiten, Buchbeiträge u.a.
Elsner P, Fluhr JW, Gehring W, Kerscher MJ, Krutmann J, Lademann J, Makrantonaki E, Wilhelm KP, Zouboulis CC: Anti-aging data and support claims – consensus statement. J Dtsch Dermatol Ges 9, Suppl 3: S1-S32, 2011.
Fritsche E, Gassmann K, Schreiber T: Neurospheres as a model for developmental neurotoxicity testing. In: In Vitro Neurotoxicology: Methods and Protocols, Methods in Molecular Biology, vol. 758. Lucio G. Costa et al. (eds.), Springer Science+Business Media, LLC 2011, pp. 99-114.
Haarmann-Stemmann T, Abel J: Influence of HIF-1a and Nrf2 on AHR mediated gene expression, toxicity and biological functions. In: The AH Receptor in Biology and Toxicology. Raimo Pohjanvirta (ed). Wiley-VCH, Weinheim 2011, ISBN 978-0-470-60182-2.
Humbert P, Binda D, Robin S, Krutmann J: Beauty from inside: Nutrition-based strategies in cosmetic dermatology. In: Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Krutmann J, Humbert P (eds.). Springer 2011, pp. 189-196.
Krutmann J: Hautalterung / Anti-Aging-Strategien (editorial). Hautarzt 62(8): 576, 2011.
Krutmann J: Wie die Sonne unsere Haut altern lässt. Die Dermis als treibende Kraft. Hautarzt 62(8): 588-590, 2011.
Krutmann J. Skin aging. In: Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Krutmann J, Humbert P (eds.). Springer 2011, pp.15-24.
Krutmann J, Luger T: Empfindliche Haut. Hautarzt 62 (12) 892, 2011.
Krutmann J, Humbert P (Eds.): Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Springer 2011, 208 pp.
Mang R, Stege H, Krutmann J: Mechanisms in phototoxic and photoallergic reactions. In: Contact Dermatitis, 5th ed, (Menné T, Frosch P, eds), Springer Berlin, Heidelberg 2011, pp. 155-163.
Marini, A: Schönheit in innen – Funktioniert das wirklich? Hautarzt 62(8): 614-617, 2011.
Monastier C, Mac-Mary S, Krutmann J: How to prove safety and efficacy in nutrition based intervention studies for human skin. In: Nutrition für healthy skin: Strategies for clinical and cosmetic practice. Krutmann J, Humbert P (eds.). Springer 2011, pp. 181-188.
Riedel N, Hoffman B, Fuks K, Jöckel KH, Dragano N: Gesundheitliche Ungleichheit in der Stadt: Eine gemeinsame Bewertung von sozialen und umweltbezogenen Belastungen im Ruhrgebiet - Health inequalities in the city: assessing the concurrence of social and environmental risks in the Ruhr Area. Umwelt und Mensch – Informationsdienst 2: 89-94, 2011.
Verner MA, Bouchard M, Fritsche E, Charbonneau M, Haddad S: In vitro neurotoxicity data in human risk assessment of polybrominated diphenyl ethers (PBDEs): Overview and perspectives. Toxicol In Vitro 25 (8): 1509-1515, 2011. [pubmed]
Vierkötter A: Umweltverschmutzung und Hautalterung. Hautarzt 62(8): 577-581, 2011.
Loft S, Schins RPF, Møller P: Particulates and oxidative stress. In: Cardiovascular Effects of Inhaled Ultrafine and Nano-Sized Particles. Cassee FR, Mills NL, Newby DE (Eds). John Wiley and Sons, New Jersey, USA , pp. 251-271, 2011.
Schroeder P, Krutmann J: Infrared A radiation effects on the skin. Piel 26 (6): 259-262, 2011.
Stutte S, Gerbitzki N, Novak N, Förster I: Expression and function of CCL17 in atopic dermatitis. In: Atopic Dermatitis. Ed. J. Esparza-Gordillo, InTech2011, ISBN 978-953-308-67-5
Originalarbeiten
Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U: Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding. Cell 142 (6): 943-953, 2010.
Semmling V, Lukacs-Kornek V, Thaiss CA, Quast T, Hochheiser K, Panzer U, Rossjohn J, Perlmutter P, Cao J, Godfrey DI, Savage PB, Knolle PA, Kolanus W, Förster I, Kurts C: Alternative cross-priming through CCL17-CCR4-mediated attraction of CTLs toward NKT cell–licensed DCs. Nature Immunology 11(4): 313-320, 2010.
Manolopoulos KN, Klotz LO, Korsten P, Bornstein SR, Barthel A: Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stress. Mol Psychiatry 15(11): 1046-1052, 2010.
Kamenisch Y, Fousteri M, Knoch J, von Thaler AK Fehrenbacher B, Dolle M, Kuiper R, Majora M, Schaller M, van Steeg H, Röcken M, Krutmann J* , Mullenders LH*, Berneburg M: Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med 207(2): 379-390, 2010.(* equal contribution)
Stabenow D, Frings M, Trück C, Gärtner K, Förster I, Kurts C, Tüting T, Odenthal M, Dienes HP, Cederbrand K, Protzer U, Knolle PA: Bioluminescence imaging allows measuring CD8 T cell function in the liver. Hepatology 51 (4): 1430-1437, 2010.
Stutte S, Quast T, Gerbitzki N, Savinko T, Novak N, Reifenberger J, Homey B, Kolanus W, Alenius H, Förster I: Requirement of CCL17 for CCR7- and CXCR4-dependent migration of cutaneous dendritic cells. Proc Natl Acad Sci USA 107 (19): 8736-8741, 2010.
Cramer C, Link E, Horster M, Koletzko S, Bauer CP, Berdel D, von Berg A, Lehmann I, Herbarth O, Borte M, Schaaf B, Behrendt H, Chen CM, Sausenthaler S, Illig T, Wichmann H-E, Heinrich J, Krämer U, for the GINI and LISAplus study group: Elder siblings enhance the effect of filaggrin mutations on childhood eczema – results from the two birth cohort studies LISAplus and GINIplus. J Allergy Clin Immunol 125(6): 1254-1260, 2010.
Schmitt J, Apfelbacher C, Chen CM, Romanos M, Sausenthaler S, Koletzko S, Bauer CP, Hoffmann U, Krämer U, Berdel D, von Berg A, Wichmann HE, Heinrich J, German Infant Nutrition Intervention plus Study Group: Infant onset eczema in relation to mental health problems at age 10 years: Results from a prospective birth cohort study (German Infant Nutrition Intervention plus). J Allergy Clin Immunol 125(2): 404-410, 2010.
Krämer U, Herder C, Sugiri D, Strassburger K, Schikowski T, Ranft U, Rathmann W: Traffic-related air pollution and incident type 2 diabetes: Results from the SALIA cohort study. Environ Health Perspect 118(9): 1273-1279, 2010.
Rückinger S, Rzehak P, Chen CM, Sausenthaler S, Koletzko S, Bauer CP, Hoffmann U, Krämer U, Berdel D, von Berg A, Bayer O, Wichmann HE, von Kries R, Heinrich J, GINIplus Study Group: Prenatal and Postnatal Tobacco Exposure and Behavioural Problems in 10 Year Old Children: Results from the GINI-plus Prospective Birth Cohort Study. Environ Health Perspect 118(1): 150-154, 2010.
Schreiber T, Gassmann K, Götz C, Hübenthal U, Moors M, Krause G, Merk HF, Crofton KM, Nguyen NH, Scanlan TS, Abel J, Rose CR, Fritsche E: Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: Evidence for endocrine disruption. Environ Health Perspect 118(4): 572-578, 2010.
Speckmann B, Pinto A, Winter M, Förster I, Sies H, Steinbrenner H: Proinflammatory cytokines down-regulate intestinal selenoprotein P biosynthesis via NOS-2 induction. Free Radic Biol Med 49(5): 777-785, 2010.
van Berlo D, Wessels A, Boots A, Wilhelmi V, Scherbart A, Gerloff K, van Schooten FJ, Albrecht C, Schins R: Neutrophil-derived ROS contribute to oxidative DNA damage induction by quartz particles. Free Radic Biol Med 49(11): 1685-93, 2010.
Weissenberg A*, Sydlik U*, Peuschel H, Schroeder P, Schneider M, Schins RP, Abel J, Unfried K: Reactive oxygen species as mediators of membrane-dependent signaling induced by ultrafine particles. Free Radic Biol Med 49: 597–605, 2010. (*equal contribution)
Gais P, Tiedje C, Altmayr F, Gaestel M, Weighardt H, Holzmann B: TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2. J Immunol 184(10): 5842-5848, 2010.
Calles C, Schneider M, Macaluso F, Benesova T, Krutmann J, Schroeder P: Infrared-A radiation influences the skin fibroblast transcriptome: mechanisms and consequences. J Invest Dermatol 130(6): 1524-1536, 2010.
Vierkötter A, Schikowski T, Ranft U , Sugiri D, Matsui M, Krämer U, Krutmann J: Airborne particle exposure and extrinsic skin aging. J Invest Dermatol 130(12): 2719-2726, 2010.
Fernau NS, Fugmann D, Leyendecker M, Reimann K, Grether-Beck S, Galban S, Ale-Agha N, Krutmann J, Klotz LO: Role of HuR and p38-MAP kinase in ultraviolet B-induced posttranscriptional regulation of cyclooxygenase-2 expression in the human keratinocyte cell line HaCaT. J Biol Chem 285(6): 3896-3904, 2010.
Chmill S, Kadow S, Winter M, Weighardt H, Esser C: 2,3,7,8-Tetrachlorodibenzo-P-dioxin impairs stable establishment of oral tolerance in mice. Toxicol Sci 118(1): 98-107, 2010.
Wessels A, Birmili W, Albrecht C, Hellack B, Jermann E, Wick G, Harrison RM, Schins RPF: Oxidant generation and toxicity of size-fractionated ambient particles in A549 human lung epithelial cells. Environ Sci Technol 44 (9): 3539-3545, 2010.
Luecke S, Backlund M, Jux B, Esser C, Krutmann J, Rannug A: The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Pigment Cell & Melanoma Research 23(6): 828-833, 2010.
Moors M, Vudattu NK, Abel J, Krämer U, Rane L, Ulfig N, Ceccatelli S, Seyfert-Margolies V, Fritsche E, Maeurer MJ: Interleukin-7 (IL-7) and IL-7 splice variants affect differentiation of human neural progenitor cells. Genes Immun 11(1): 11-20, 2010.
Krämer U, Oppermann H, Ranft U, Schäfer T, Ring J, Behrendt H: Differences in allergy trends between East and West Germany and possible explanations. Clinical Experimental Allergy 40(2): 289-298, 2010.
Schnabel E, Sausenthaler S, Schaaf B, Schäfer T, Lehmann I, Behrendt H, Herbarth O, Borte M, Krämer U, von Berg A, Wichmann HE, Heinrich J; for the LISA Study Group: Prospective association between food sensitization and food allergy: results of the LISA birth cohort study. Clin Exp Allergy 40(3): 450-457, 2010.
von Berg A, Krämer U, Link E, Bollrath C, Heinrich J, Brockow I, Koletzko S, Grübl A, Filipiak-Pittroff B, Wichmann HE, Bauer CP, Reinhardt D, Berdel D, GINIplus Study Group: Impact of early feeding on childhood eczema: Development after nutritional intervention compared with the natural course: The GINIplus study up to the age of six years. Clin Exp Allergy 40(4): 627-636, 2010.
Ghiazza M, Scherbart AM, Fenoglio I, Grendene F, Turci F, Martra G, Albrecht C, Schins RP, Fubini B: Surface iron inhibits quartz-induced cytotoxic and inflammatory responses in alveolar macrophages. Chem Res Toxicol 24(1): 99-110, 2011.
Mann E, Ranft U, Eberwein G, Gladtke D, Sugiri D, Behrendt H, Ring J, Schäfer T, Begerow J, Wittsiepe J, Krämer U, Wilhelm M: Does airborne nickel exposure induce nickel senistization? Contact Dermatitis 62(6): 355-362, 2010.
Demircigil Cakmak G, Coskun E, Vidinli N, Erbas Y, Yilmaz M, Cimrin A, Schins RPF, Borm PJA, Burgaz S: Increased micronucleus frequencies in surrogate and target cells from workers exposed to crystalline silica containing dust. Mutagenesis 25: 163-169, 2010.
Haarmann-Stemmann T, Sendker J, Götz C, Krug N, Bothe H, Fritsche E, Proksch P, Abel J: Regulation of human dioxin receptor function by different beta-carboline alkaloids. Archives of Toxicology 84 (8): 619-629, 2010.
van Berlo D, Albrecht C, Knaapen AM, Cassee FR, Gerlofs-Nijland ME, Kooter IM, Palomero-Gallagher N, Bidmon HJ, van Schooten FJ, Krutmann J, Schins RPF: Comparative evaluation of the effects of short-term inhalation exposure to diesel engine exhaust on rat lung and brain. Arch Toxicol 84(7): 553-562, 2010.
Hammer M, Echtenachter B, Weighardt H, Jozefowski K, Rose-John S, Männel DN, Holzmann B, Lang R: Increased inflammation and lethality of Dusp1-/- mice in polymicrobial peritonitis models. Immunology 131(3): 395-404, 2010.
Sausenthaler S, Koletzko S, Koletzko B, Reinhardt D, Krämer U, von Berg A, Berdel D, Bauer CP, Grübl A, Wichmann HE, Heinrich J; for the GINIplus study group: Effect of hydrolysed formula feeding on taste preferences at 10 years. Data from the German Infant Nutritional Intervention Program Plus Study. Clin Nutr 29(3): 304-306, 2010.
Nicolescu R, Petcu C, Cordeanu A, Fabritius K, Schlumpf M, Krebs R, Krämer U, Winneke G: Environmental exposure to lead, but not other neurotoxic metals, relates to core elements of ADHD in Romanian children: Performance and questionnaire data. Environ Res 110(5): 476-483, 2010.
Schikowski T, Ranft U, Sugiri D, Vierkötter A, Brüning T, Harth V, Krämer U: Decline in air pollution and change in prevalence in respiratory symptoms and chronic obstructive pulmonary disease in elderly women. Respir Res 11(1): 113, 2010.
Bartholome A, Kampkötter A, Tanner S, Sies H, Klotz LO: Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture. Arch Biochem Biophys 501(1): 58-64, 2010.
Bothe H, Götz C, Stobbe-Maicherski N, Fritsche E, Abel J, Haarmann-Stemmann T: Luteolin enhances the bioavailability of benzo(a)pyrene in human colon carcinoma cells. Archives of Biochemistry and Biophysics 498(2): 111-118, 2010.
Klaus V, Hartmann T, Gambini J, Graf P, Stahl W, Hartwig A, Klotz LO: 1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes. Arch Biochem Biophys 496(2): 93-100, 2010.
Krefis AC, Schwarz NG, Nkrumah B, Acquah S, Loag W, Sarpong N, Adu-Sarkodie Y, Ranft U, May J: Principal component analysis of socioeconomic factors and their association with malaria in children from the Ashanti Region, Ghana. Malaria J 9(1): 201, 2010.
Smolders R, Alimonti A, Cerna M, Den Hond E, Kristiansen J, Palkovicova L, Ranft U, Seldén AI, Telišman S, Schoeters G: Availability and comparability of human biomonitoring data across Europe: A case-study on blood-lead levels. Sci Total Environ 408(6): 1437-1445, 2010.
Orru H, Kimmel V, Kikas Ü, Soon A, Künzli N, Schins RPF, Borm PJA, Forsberg B: Elemental Composition and Oxidative Properties of PM2.5 in Estonia in Relation of Origin of Air Masses - results from ERCHS II in Tartu. Sci Tot Environ 408(7): 1515-1522, 2010.
Assfalg V, Hüser N, Reim D, Kaiser-Moore S, Rossmann-Bloeck T, Weighardt H, Novotny AR, Stangl MJ, Holzmann B, Emmanuel KL: Combined immunosuppressive and antibiotic therapyimproves bacterial clearance and survival of polymicrobial septic peritonitis. Shock 33(2): 155-161, 2010.
MacIntyre EA, Chen CM, Herbarth O, Borte M, Schaaf B, Krämer U, von Berg A, Wichmann HE, Heinrich J, LISA Study Group: Early-life otitis media and incident atopic disease at school age in a birth cohort. Pediatr Infect Dis J 29(12): e96-e99, 2010.
Ale-Agha N, Albrecht C, Klotz LO: Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to carbon or silica-based nanoparticles. Biol Chem 391(11): 1333-1339, 2010.
Apfelbacher C, Ollert M, Ring J, Behrendt H, Krämer U: Contact to cat or dog, allergies and parental education. Pediatr Allergy Immunol 21(2 Pt 1): 284-291, 2010.
Herberth G, Daegelmann C, Röder S, Behrendt H, Krämer U, Borte M, Heinrich J, Herbarth O, Lehmann I; for the LISAplus study group: IL-17E but not IL-17A is associated with allergic sensitization: results from the LISA study. Pediatr Allergy Immunol 21(7): 1086-90, 2010.
Schroeder P, Calles C, Benesova T, Macaluso F, Krutmann J: Photoprotection beyond UV – effective sun protection has to include protection against infrared A radiation induced skin damage. Skin Physiology and Pharmacology 23(1): 15-17, 2010.
Rzehak P, Scherag A, Grallert H, Sausenthaler S, Koletzko S, Bauer CP, Schaaf B, von Berg A, Berdel D, Borte M, Herbarth O, Krämer U, Illig T, Wichmann HE, Hebebrand J, Heinrich J, Gini And Lisa Study Group: Associations between BMI with the FTO gene are age dependent: Results from the GINI and LISA Birth Cohort Studies up to age 6 years. Obesity Facts 3(3): 173-180, 2010.
Germing A, Gotzmann M, Rauße R, Brodherr T, Holt S, Lindstaedt M, Dietrich J, Ranft U, Krämer U, Mügge A: Normal values for longitudinal function of the right ventricle in healthy women >70 years of age. Eur J Echocardiogr 11 (8): 725-728, 2010.
Chen CM, Sausenthaler S, Bischof W, Herbarth O, Borte M, Behrendt H, Krämer U, Williams HC, Wichmann HE, Heinrich J; the LISA Study Group: Perinatal exposure to endotoxin and the development of eczema during the first 6 years of life. Clin Exp Dermatol 35(3): 238-244, 2010.
Henry J, Casjens S, Schikowski T, Stachon A, Germing A, Ranft U, Lehnert M, Harth V, Krämer U, Brüning T, Pesch B: Prohepcidin, B-type natriuretic peptide and iron statusin a cohort of elderly women from the Rhine-Ruhr area. Acta Haematol 124(3): 129-133, 2010.
Gerlofs-Nijland M, van Berlo D, Cassee FR, Schins RPF, Wang K, Campbell A: Effects of prolonged exposure to diesel engine exhaust on proinflammatory markers in different regions of the rat brain. Part Fibre Toxicol 7(1): 12, 2010.
van Berlo D, Knaapen AM, van Schooten FJ, Schins RP, Albrecht C: NF-kappaB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells. Part Fibre Toxicol 7 (1): 13, 2010.
Übersichtsarbeiten, Buchbeiträge
Abel J, Haarmann-Stemmann T: An introduction to the molecular basics of Arylhydrocarbon Receptor biology. Biological Chemistry 391(11):1235-48, 2010.
Breier JM, Gassmann K, Kayser R, Stegeman H, De Groot D, Fritsche E, Shafer TJ: Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: State of the science. Neurotoxicol Teratol 32(1): 4-15, 2010.
Donaldson K, Poland C, Schins RPF: Possible genotoxic mechanisms of nanoparticles: criteria for improved test strategies. Nanotoxicology 4: 414-420, 2010.
Entschladen F, Altschmied J, Baumgrass R, Behrmann I, Giehl K, Hermanns H, Huber O, Kieser A, Klotz LO, Kubatzky KF, Hass R, Janssen O, Friedrich K: Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology. Cell Commun Signal 8: 2, 2010.
Esser C, Krutmann J: UV-Strahlung und Pigmentierung: Arylhydrocarbonrezeptor - "a new kid on the block". Der Hautarzt 61(7): 561-566, 2010.
Grether-Beck S, Krutmann J: Fettgewebe – Zelluläre und molekulare Grundlagen. Der Hauarzt 61: 838-846, 2010.
Humbert P, Robin S, Binda D, Krutmann J: Beauty from inside: Nutrition-based strategies in cosmetic dermatology. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 189-196.
Krutmann J: Pathomechanisms of photoaged skin. In: Textbook of aging skin. Farage MA, Miller KW, Maibach HI (eds.). Springer 2010, pp. 101-108.
Krutmann J: Skin Aging. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 15-24.
Krutmann J, Berking C: Pigmentstörungen. Der Hautarzt 61: 553, 2010.
Krutmann J, Lademann J, Merk HF: Main highlights of International Dermatotoxicology Symposium, Netherlands-Vaals. Skin Pharmacol Physiol 23(1): 5, 2010.
Krutmann J, Steinert M: Fettgewebe in Dermatologie und Ästhetik. Der Hautarzt 61: 837, 2010.
Krutmann J, Welzel J: Innovative physikalische Verfahren in der Dermatologie. Der Hautarzt 61(5): 386, 2010.
Luecke S, Backlund M, Jux B, Esser C, Krutmann J, Rannug A: The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis. Pigment Cell & Melanoma Research 23(6): 828-833, 2010.
Montastier Ch, Mac-Mary S, Humbert P, Krutmann J: How to prove safety and efficacy in nutrition-based interventional studies for human skin. In: Nutrion for healthy skin: Strategies for clinical and cosmetic practice. Krutmann J and Humbert S (eds). Springer Berlin, New York 2010, pp. 181-188.
Schroeder P, Krutmann J: What is needed for a sunscreen to provide complete protection. Skin Therapy Lett 15(4): 4-5, 2010.
Schröder P, Krutmann J: Infrared-A induced skin aging. In: Textbook of aging skin. Farage MA, Miller KW, Maibach HI (eds.). Springer 2010, pp. 421-426.
Vierkötter A: Einfluss von Partikeln aus dem Straßenverkehr auf die extrinsische Hautalterung. Der Hautarzt 61: 538-539, 2010.
Originalarbeiten
Ale-Agha N, Galban S, Sobieroy C, Abdelmohsen K, Gorospe M, Sies H, Klotz LO: HuR regulates gap junctional intercellular communication by controlling β-catenin levels and adherens junction integrity. Hepatology 50 (5): 1567-1576, 2009.
Sydlik U, Gallitz I, Albrecht C, Abel J, Krutmann J, Unfried K: The compatible solute ectoine protects against nanoparticle-induced neutrophilic lung inflammation. Am J Respir Crit Care Med 180 (1): 29-35, 2009.
Gros E, Bussmann C, Bieber T, Förster I, Novak N: Expression of chemokines and chemokine receptors in lesional and non-lesional skin of atopic dermatitis. J Allergy Clin Immunol 124 (4): 753-760, 2009.
Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, Schuwald J, Weinmann N, Fritsche E: Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect 117 (7): 1131-1138. 2009.
Dalla Rosa I, Goffart S, Wurm M, Wiek C, Essmann F, Sobek S, Schroeder P, Zhang H, Krutmann J, Hanenberg H, Schulze-Osthoff K, Mielke C, Pommier Y, Boege F, Christensen MO: Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. Nucleic Acids Res 37 (19): 6414-6428, 2009.
Rzehak P, Sausenthaler S, Koletzko S, Reinhardt D, von Berg A, Krämer U, Berdel D, Bollrath C, Grübl A, Bauer CP, Wichmann HE, Heinrich J; German Infant Nutritional Intervention Study Group: Short- and long-term effects of feeding hydrolyzed protein infant formulas on growth at < or = 6 y of age: results from the German Infant Nutritional Intervention Study. Am J Clin Nutr 89 (6): 1846-1856, 2009.
Schwarz C, Ranft U, Piechotowski I, Childs JE, Brockmann SO: Risk Factors for human infection with Puumala virus, Southwestern Germany. Emerging Infectious Diseases 15 (7): 1032-1039, 2009.
Chen CM, Weidinger S, Klopp N, Sausenthaler S, Bischof W, Herbarth O, Bauer M, Borte M, Schaaf B, Lehmann I, Behrendt H, Krämer U, Berdel D, von Berg A, Bauer CP, Koletzko S, Illig T, Wichmann HE, Heinrich J; the LISA and GINI Study Group: Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life. Allergy 64 (9): 1327-1332, 2009.
Jux B, Kadow S, Esser C: Langerhans cell maturation and contact hypersensitivity are impaired in aryl hydrocarbon receptor-null mice. J Immunol 182 (11): 6709-6717, 2009.
Majora M, Wittkampf T, Schürmann B, Bernerd F, Schroeder P, Krutmann J: Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: Increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity. Am J Pathol 175 (3): 1019-1029, 2009.
Catalgol B, Ziaja I, Breusing N, Jung T, Hoehn A, Alpertunga B, Schroeder P, Chondrogianni N, Gonos ES, Petropoulos I, Friguet B, Klotz LO, Krutmann J, Grune T: The proteasome is an integral part of solar ultraviolet a radiation-induced gene expression. J Biol Chem 284 (44): 30076-30086, 2009.
Gerlofs-Nijland ME, Rummelhard M, Boere JF, Leseman DLAC, Duffin R, Schins RPF, Borm PJA, Sillanpää M, Salonen RO, Cassee FR: Particle induced toxicity in relation to Transition Metal and Polycyclic Aromatic Hydrocarbon contents. Environ Sci Technol 43 (13): 4729-4736, 2009.
Gerloff K, Albrecht C, Boots AW, Förster I, Schins RPF: Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology 3 (4): 355-364, 2009.
Van Berlo D, Haberzettl P, Gerloff K, Li H, Scherbart AM, Albrecht C, Schins RPF: Investigation of the cytotoxic and proinflammatory effects of cement dusts in rat alveolar macropages. Chemical Research in Toxicology 22 (9): 1548-1558, 2009.
Tessema TS, Schwamb B, Lochner M, Förster I, Jakobi V, Petry F: Dynamics of gut mucosal and systemic Th1/Th2 cytokine responses in interferon-gamma and interleukin-12p40 knock out mice during primary and challenge Cryptosporidium parvum infection. Immunobiology 214 (6): 454-466, 2009.
Reim D, Westenfelder K, Kaiser-Moore S, Schlautkötter S, Holzmann B, Weighardt H: Role of T cells for cytokine production and outcome in a model of acute septic peritonitis. Shock 31 (3): 245-250, 2009.
Esser C, Jux B, Kadow S, Chmill S, Hübinger J, Frericks M: Cell specific action and toxicity of the AhR: Focus immune system. Toxicol Lett 189, Suppl. 1, S55, 2009.
Ranft U, Schikowski T, Sugiri D, Krutmann J, Krämer U: Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ Res 109 (8): 1004-1011, 2009.
Krämer U, Sugiri D, Ranft U, Krutmann J, von Berg A, Berdel D, Behrendt H, Kuhlbusch T, Hochadel M, Wichmann H-E, Heinrich J: Eczema, respiratory health and traffic related air pollution in birth cohorts from small-town areas.
J Dermatol Sci 56 (2): 99-105, 2009.
Vierkötter A, Ranft U, Krämer U, Sugiri D, Reimann V, Krutmann J: The SCINEXA: A novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing.
J Dermatol Sci 53 (3): 207-11, 2009
Nawrot T, Kuenzli N, Sunyer J, Shi T, Moreno T, Viana M, Heinrich J, Forsberg B, Kelly F, Muhamed SM, Nemery B, Borm P: Oxidative Properties Of Ambient Pm2.5 And Elemental Composition: Heterogeneous Associations In 19 European Cities. Atmospheric Environment 43: 4595-4602, 2009.
Baulig A, Singh S, Marchand A, Schins R, Barouki R, Garlatti M, Marano F, Baeza-Squiban A: Role of Paris PM(2.5) components in the pro-inflammatory response induced in airway epithelial cells. Toxicology 261 (3): 126-135, 2009.
Eckers A, Reimann K, Klotz LO: Nickel and copper ion-induced stress signaling in human hepatoma cells: Analysis of phosphoinositide 3‘-kinase/Akt signaling. Biometals 22 (2): 307-316, 2009.
Herberth G, Gubelt R, Röder S, Krämer U, Schins RP, Diez U, Borte M, Heinrich J, Wichmann HE, Herbarth O, Lehmann I: Increase of inflammatory markers after indoor renovation activities: The LISA birth cohort study. Pediatr Allergy Immunol 20 (6): 563-570, 2009.
Mues C, Zhou J, Manolopoulos KN, Korsten P, Schmoll D, Klotz LO, Bornstein SR, Klein HH, Barthel A: Regulation of glucose-6-phosphatase gene expression by insulin and metformin. Horm Metab Res 41 (10): 730-735, 2009.
Ale-Agha N, Albrecht C, Klotz LO:
Loss of gap junctional intercellular communication in rat lung epithelial cells exposed to quartz particles.
Biochem Biophys Res Commun 390 (1): 44-47, 2009.
Speckmann B, Sies H, Steinbrenner H: Attenuation of hepatic expression and secretion of selenoproteins. Biochem Biophys Res Commun 387: 158-163, 2009.
Rzehak P, Sausenthaler S, Koletzko S, Bauer CP, Schaaf B, von Berg A, Berdel D, Borte M, Herbarth O, Krämer U, Fenske N, Wichmann HE, Heinrich J: Period-specific growth, overweight and modification by breastfeeding in the GINI and LISA birth cohorts up to age 6 years. Eur J Epidemiol 24 (8): 449-467, 2009.
Albrecht C, Scherbart AM, Berlo D, Braunbarth CM, Schins RPF, Scheel J: Evaluation of cytotoxic effects and oxidative stress with hydroxyapatite dispersions of different physicochemical properties in rat NR8383 cells and primary macrophages. Toxicology in Vitro 23 (3): 520-530, 2009.
Chen M, von Mikecz A: Nanoparticle-induced cell culture models for neurodegenerative protein aggregation diseases. Inhalation Toxicology 21 (S1): 110-114, 2009.
Jalava PI, Hirvonen MR, Sillanpää M, Pennanen AS, Happo MS, Hillamo R, Cassee FR, Gerlofs-Nijland M, Borm PJ, Schins RP, Janssen NA, Salonen RO: Associations of urban air particulate composition with inflammatory and cytotoxic responses in RAW 246.7 cell line. Inhalation Toxicology 21 (12): 994-1006, 2009.
Hoffmann B, Kolahgar B, Rauchfuss K, Eberwein G, Franzen-Reuter I, Kraft M, Wilhelm M, Ranft U, Jöckel KH: Childhood social position and associations between environmental exposures and health outcomes. Int J Hyg Environ Health 212 (2): 146-156, 2009.
Eckers A, Klotz LO: Heavy metal ion-induced insulin-mimetic signalling. Redox Rep 14 (4): 141-146, 2009.
Esser C, Jux B: Small chemicals, bioactivation, and the immune system ? a fragile balance of i-tox and benefits? Chemistry & Biodiversity 6 (11): 2138-2143, 2009.
Krutmann J, Schroeder P: Role of mitochondria in photoageing of human skin: The defective powerhouse model.
J Invest Dermatol Symp Proc 14 (1): 44-49, 2009.
Schnabel E, Sausenthaler S, Liese J, Herbarth O, Borte M, Schaaf B, Krämer U, von Berg A, Wichmann HE, Heinrich J; for the LISA-Study-Group: Hospital admission in children up to the age of 2 years. Eur J Pediatr 168 (8): 925-931, 2009.
Schnabel E, Sausenthaler S, Brockow I, Liese J, Herbarth O, Michael B, Schaaf B, Krämer U, von Berg A, Wichmann HE, Heinrich J; for the LISA Study Group: Burden of otitis media and pneumonia in children up to 6 years of age: results of the LISA birth cohort. Eur J Pediatr 168 (10): 1251-1257, 2009.
Brockow I, Zutavern A, Hoffmann U, Grübl A, von Berg A, Koletzko S, Filipiak B, Bauer CP, Wichmann HE, Reinhardt D, Berdel D, Krämer U, Heinrich J; GINIplus Study Group: Early allergic sensitizations and their relevance to atopic diseases in children aged 6 years: results of the GINI study. J Investig Allergol Clin Immunol 19 (3): 180-187, 2009.
Sausenthaler S, Rzehak P, Chen CM, Arck P, Bockelbrink A, Schäfer T, Schaaf B, Borte M, Herbarth O, Krämer U, von Berg A, Wichmann HE, Heinrich J; LISA Study Group: Stress-related maternal factors during pregnancy in relation to childhood eczema: results from the LISA Study. J Investig Allergol Clin Immunol 19 (6): 481-487, 2009.
Bhattacharya K, Davoren M, Boertz J, Schins RP, Hoffmann E, Dopp E: Titanium dioxide nanoparticles induce oxidative stress and DNA adduct formation but not DNA breakage in human lung cells. Part Fibre Toxicol 6 (1): 17, 2009.
Goergens A, Frericks M, Esser C: The AhR is only marginally involved in the anti-leukemic effects of its ligand curcumin. Anticancer Research 29 (11): 4657-4664, 2009.
Grether-Beck S, Krutmann J: Involment of lipid rafts and caveolins in UVA signaling. The Open Dermatology Journal 3: 153-159, 2009.
Herbert OC, Barnetson R, Weninger W, Krämer U, Behrendt H, Ring J: Western lifestyle and increased prevalence of atopic diseases. World Allergy Organization Journal 2: 130-137, 2009.
Pluskota A, Horzowski E, Bossinger O, von Mikecz A: In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: Silica-nanoparticles induce reproductive senescence. PLoS One 4 (8) e6622, 2009.
Schroeder P, Calles C, Krutmann J: Prevention of Infrared-A radiation mediated detrimental effects in human skin. Skin Therapy Letters 14 (5): 4-5, 2009.
Übersichtsarbeiten, Buchbeiträge
Buch T, Schulz A, Förster I: MHC class II deficiency. In: Encyclopedia of Molecular Mechanisms of Disease, Florian Lang (Ed.), Springer 2009, Vol.2, pp.1306-1308.
De-Zolt S, Altschmied J, Ruiz P, von Melchner H, Schnütgen F: Gene-trap vectors and mutagenesis. Methods Mol Biol 530: 29-47, 2009.
Eckers A, Klotz LO: Heavy metal ion-induced insulin-mimetic signalling. Redox Rep 14 (4) 141-146, 2009.
Esser C: The immune phenotype of arylhydrocarbon receptor null mouse mutants: not a simple mirror of AhR overactivation. Biochem Pharmacol 77 (4): 597-607, 2009.
Esser C, Rannug A, Stockinger B: The aryl hydrocarbon receptor and immunity. Trends Immunol 30 (9): 447-454, 2009.
Grether-Beck S, Krutmann J: Involment of lipid rafts and caveolins in UVA signaling. The Open Dermatology Journal 3: 153-159, 2009.
Haarmann-Stemmann T, Bothe H, Abel J: Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways. Biochemical Pharmacology 77 (4): 508-520, 2009.
Kadow S, Jux B, Chmill S, Esser C: Small molecules as fiends and foes of the immune system. Future Medicinal Chemistry 1 (9): 1583-1591, 2009.
Klotz LO, Sies H: Cellular generation of oxidants: relation to oxidative stress. In: Redox Signaling and Regulation in Biology and Medicine. (C. Jacob, P.G. Winyard, eds.), Wiley-VCH Verlag, Weinheim, Germany, pp. 45-61, 2009.
Kroencke KD, Klotz LO: Zinc fingers as biological redox switches? Antioxid Redox Signal 11: 1015-1027, 2009.
Krutmann J: Pre- and probiotics for human skin. J Dermatol Sci 54 (1): 1-5, 2009.
Krutmann J: Premature aging of skin from environmental assaults. In: Nutritional Cosmetics: Beauty from within. Tabor A, Blair R (eds), William Andrew Inc, Norwich, 2009, pp. 79-92.
Krutmann J: Moderner Lichtschutz in der ästhetischen Dermatologie. Der Hautarzt 60 (4): 284, 2009.
Krutmann J: Actives - Zentraler Bestandteil des modernen Lichtschutzes. Der Hautarzt 60 (4): 294-300, 2009.
Krutmann J: Pro- und Präbiotika in der Dermatologie. Der Hautarzt 60 (10): 794, 2009.
Krutmann J, Schroeder P: Role of mitochondria in photoageing of human skin: The defective powerhouse model. J Invest Dermatol Symp Proc 14 (1): 44-49, 2009.
Schroeder P, Krutmann J: Infrarot A-Schutz – Notwendigkeit und Möglichkeiten. Hautarzt 60 (4): 301-304, 2009.
Schroeder P, Krutmann J: Protecting skin from photoaging by near infrared radiation. Household and Personal Care Today 3: 2009.
Steinbrenner H, Sies H: Protection against reactive oxigen species by selenoproteins. Biochim Biophys Acta 1790 (2009)1478-1485.
Stone V, Johnston H, Schins RPF: Development of in vitro systems for Nanotoxicology – Methodological Considerations. Crit Rev Toxicol 39 (7), 613-626, 2009.
von Mikecz A: PolyQ fibrillation in the cell nucleus: Who’s bad? Trends Cell Biol 19 (12): 685-691, 2009.
