FF3 Archive

Lislien M, Kuchovska E, Kapr J, Duale N, Andersen JM, Dirven H, Myhre O, Fritsche E, Koch K, Wojewodzic MW: Transcriptomic characterization of 2D and 3D human induced pluripotent stem cell-based in vitro models as New Approach Methodologies for developmental neurotoxicity testing. Toxicology 510:154000, 2024. doi: 10.1016/j.tox.2024.154000

Klinkhammer H, Staerk C, Maj C, Krawitz PM, Mayr A: Genetic Prediction Modeling in large cohort studies via boosting targeted loss functions. Stat Med 43(28):5412-5430, 2024. doi: 10.1002/sim.10249

Dobner J, Diecke S, Krutmann J, Prigione A, Rossi A: Reassessment of marker genes in human induced pluripotent stem cells for enhanced quality control. Nat Commun 15(1):8547, 2024. doi: 10.1038/s41467-024-52922-1

Kontarakis Z, Revah O, Rossi A: CRISPR-Cas13d: RNA’s own Jedi Master in the fight against viral darkness. Mol Ther Nucleic Acids 35(4):102321, 2024. doi: 10.1016/j.omtn.2024.102321

Cediel-Ulloa A, Awoga R, Dönmez A, Yu X, Gliga A, Attoff K, Forsby A, Rüegg J: Characterization of the C17.2 cell line as testing system for endocrine disruption-induced developmental neurotoxicity. ALTEX, 2024. doi: 10.14573/altex.2404131

Kapr J, Scharkin I, Ramachandran H, Westhoff P, Pollet M, Dangeleit S, Brockerhoff G, Rossi A, Koch K, Krutmann J, Fritsche E: HiPSC-derived 3D neural models reveal neurodevelopmental pathomechanisms of the Cockayne Syndrome B. Cell Mol Life Sci 81(1):368, 2024. doi: 10.1007/s00018-024-05406-w

Piragine E, De Felice M, Germelli L, Brinkmann V, Flori L, Martini C, Calderone V, Ventura N, Da Pozzo E, Testai L: The Citrus flavanone naringenin prolongs the lifespan in C. elegans and slows signs of brain aging in mice. Exp Gerontol 194:112495, 2024. doi: 10.1016/j.exger.2024.112495

Piragine E, De Felice M, Germelli L, Brinkmann V, Flori L, Martini C, Calderone V, Ventura N, Da Pozzo E, Testai L: ...

Dugershaw-Kurzer B, Bossart J, Buljan M, Hannig Y, Zehnder S, Gupta G, Kissling VM, Nowak-Sliwinska P, van Beijnum JR, Griffioen AW, Masjosthusmann S, Zühr E, Fritsche E, Hornung R, Rduch T, Buerki-Thurnherr T: Nanoparticles dysregulate the human placental secretome with consequences on angiogenesis and vascularization. Adv Sci (Weinh) 20: e2401060, 2024. doi: 10.1002/advs.202401060

Fehsel K, Bouvier M-L, Capobianco L, Lunetti P, Klein B, Oldiges M, Majora M, Löffler S: Neuroreceptor inhibition by Clozapine triggers mitohormesis and metabolic reprogramming in human blood cells. Cells 13(9): 762, 2024. doi: 10.3390/cells13090762

Tal T, Myhre O, Fritsche E, Rüegg J, Craenen K, Aiello-Holden K, Agrillo C, Babin PJ, Escher BI, Dirven H, Hellsten K, Dolva K, Hessel E, Heusinkveld HJ, Hadzhiev Y, Hurem S, Jagiello K, Judzinska B, Klüver N, Knoll-Gellida A, Kühne BA, Leist M, Lislien M, Lyche JL, Müller F, Colbourne JK, Neuhaus W, Pallocca G, Seeger B, Scharkin I, Scholz S, Spjuth O, Torres-Ruiz M, Bartmann K: New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project. Front Toxicol 6: 1359507, 2024. doi: 10.3389/ftox.2024.1359507

Holz A, Obi N, Ahrens W, Berger K, Bohn B, Brenner H, Fischer B, Fricke J, Führer A, Gastell S, Greiser KH, Harth V, Heise JK, Holleczek B, Keil T, Klett-Tammen CJ, Leitzmann M, Lieb W, Meinke-Franze C, Michels KB, Mikolajczyk R, Nimptsch K, Peters A, Pischon T, Riedel O, Schikowski T, Schipf S, Schmidt B, Schulze MB, Stang A, Hellwig K, Riemann-Lorenz K, Heesen C, Becher H: Childhood and adolescence factors and multiple sclerosis: results from the German National Cohort (NAKO). BMC Neurol 24(1): 123, 2024. doi: 10.1186/s12883-024-03620-4

Szepanowski LP, Wruck W, Kapr J, Rossi A, Fritsche E, Krutmann J, Adjaye J: Cockayne syndrome patient iPSC-derived brain organoids and neurospheres show early transcriptional dysregulation of biological processes associated with brain development and metabolism. Cells 13(7): 591, 2024. doi: 10.3390/cells13070591

Dobner J, Nguyen T, Pavez-Giani MG, Cyganek L, Distelmaier F, Krutmann J, Prigione A, Rossi A: mtDNA Analysis using Mitopore. Mol Ther Methods Clin Dev 32(2): 101231, 2024. doi: 10.1016/j.omtm.2024.101231

Jaylet T, Coustillet T, Smith NM, Viviani B, Lindeman B, Vergauwen L, Myhre O, Yarar N, Gostner JM, Monfort-Lanzas P, Jornod F, Holbech H, Coumoul X, Sarigiannis DA, Antczak P, Bal-Price A, Fritsche E, Kuchovska E, Stratidakis AK, Barouki R, Kim MJ, Taboureau O, Wojewodzic MW, Knapen D, Audouze K: Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps. Front Toxicol 6: 1285768, 2024. doi: 10.3389/ftox.2024.1285768

Dobner J, Nguyen T, Dunkel A, Prigione A, Krutmann J, Rossi A: Mitochondrial DNA integrity and metabolome profile are preserved in the human induced pluripotent stem cell reference line KOLF2.1J. Stem Cell Rep 19(3): 343-350, 2024. doi: 10.1016/j.stemcr.2024.01.009

Cibelli A, Mola MG, Saracino E, Barile B, Abbrescia P, Mogni G, Spray DC, Scemes E, Rossi A, Spennato D, Svelto M, Frigeri A, Benfenati V, Nicchia GP: Aquaporin-4 and transient receptor potential vanilloid 4 balance in early postnatal neurodevelopment. Glia 72(5): 938-959, 2024. doi: 10.1002/glia.24512

Diemar MG, Vinken M, Teunis M, Krul CAM, Busquet F, Zajac JD, Kandarova H, Corvi R, Rosso MZ, Kharina A, Bryndum LS, Santillo M, Bloch D, Kucheryavenko O, Panagiotakos D, Rogiers V, Beekhuijzen M, Giusti A, Najjar A, Courage C, Koenig T, Kolle S, Boonen H, Dhalluin S, Boberg J, Müller BP, Kukic P, Ritskes-Hoitinga M, Grasselli E, Zietek T, Stoddart G, Heusinkveld HJ, Castell JV, Benfenati E, Yang H, Perera S, Paini A, Kramer NI, Hartung T, Janssen M, Fritsche E, Jennen DGJ, Piumatti M, Rathman J, Marusczyk J, Milec L, Roggen EL: Report of the first ONTOX stakeholder network meeting: Digging under the surface of ONTOX together with the stakeholders. Altern Lab Anim 52(2): 117-131, 2024. doi: 10.1177/02611929231225730

Liu BP, Huxley RR, Schikowski T, Hu KJ, Zhao Q, Jia CX: Exposure to residential green and blue space and the natural environment is associated with a lower incidence of psychiatric disorders in middle-aged and older adults: findings from the UK Biobank. BMC Med 22: 15, 2024. https://doi.org/10.1186/s12916-023-03239-1

Limke A, Poschmann G, Stühler K, Petzsch P, Wachtmeister T, von Mikecz A: Silica nanoparticles disclose a detailed neurodegeneration profile throughout the life span of a model organism. J Xenobiotics 14(1): 135-153, 2024. doi: 10.3390/jox14010008

Binder S, Ramachandran H, Hildebrandt B, Dobner J, Rossi A: Prime-Editing of human ACTB in induced pluripotent stem cells to model human ACTB Loss-of-Function diseases and compensatory mechanisms. Stem Cell Res 75:103304, 2024. doi: 10.1016/j.scr.2024.103304

Bloch S, Lévêque L, Hertz-Picciotto I, Puschner B, Fritsche E, Klose J, I Kramer N, Bouchard MF, Chandrasekera PC, Verner MA: Using in vitro data to derive acceptable exposure levels: A case study on PBDE developmental neurotoxicity. Environ Int 183: 108411, 2024 (online 2023). doi: 10.1016/j.envint.2023.108411

Schröter L, Jentsch L, Maglioni S, Muñoz-Juan A, Wahle T, Limke A, von Mikecz A, Laromaine A, Ventura N: A multisystemic approach revealed aminated polystyrene nanoparticles-induced neurotoxicity. Small e2302907, 2024. doi: 10.1002/smll.202302907

von Mikecz A: Elegant nematodes improve our understanding of human neuronal diseases, the role of pollutants and strategies of resilience. Environ Sci Technol 57(44):16755-16763, 2023. doi: 10.1021/acs.est.3c04580

Tanabe S, Beaton D, Chauhan V, Choi I, Choi J, Clerbaux LA, Coppola L, Dumont AF, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Garcia-Reyero N, Goralczyk A, Huliganga E, Kim YJ, Klose J, La Rocca C, Landesmann B, Mally A, Murugadoss S, Omeragic E, Ouédraogo G, Pereira JM, Sadi B, Schaffert A, Song Y, Sovadinova I, Stöger T, Tollefsen KE, Wittwehr C, Yauk C: Report of the 3rd and 4th mystery of reactive oxygen species conference. ALTEX 40(4):689-693, 2023. doi: 10.14573/altex.2307041

Schiavi A, Cirotti C, Gerber LS, Di Lauro G, Petzsch P, Köhrer KE, Schins RPF, Wahle T, Barilà D, Ventura N: Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species. Cell Death Discov 9 (1): 376, 2023. doi: 10.1038/s41420-023-01592-x

Romero NG, Gutierrez G, Teixidó E, Li L, Klose J, Leung PC, Cañigueral S, Fritsche E, Barenys M: Developmental neurotoxicity evaluation of three Chinese herbal medicines in zebrafish larvae by means of two behavioral assays: Touch-evoked response and light/dark transition. Reprod Toxicol 121: 108469, 2023. doi: 10.1016/j.reprotox.2023.108469

Schumann G, Andreassen OA, Banaschewski T, Calhoun VD, Clinton N, Desrivieres S, Brandlistuen RE, Feng J, Hese S, Hitchen E, Hoffmann P, Jia T, Jirsa V, Marquand AF, Nees F, Nöthen MM, Novarino G, Polemiti E, Ralser M, Rapp M, Schepanski K, Schikowski T, Slater M, Sommer P, Stahl BC, Thompson PM, Twardziok S, van der Meer D, Walter H, Westlye L; environMENTAL Consortium: Addressing global environmental challenges to mental health using population neuroscience: A review. JAMA Psychiatry 80(10): 1066-1074, 2023. doi: 10.1001/jamapsychiatry.2023.2996

De Castelbajac T, Aiello K, Arenas CG, Svingen T, Ramhøj L, Zalko D, Barouki R, Vanhaecke T, Rogiers V, Audebert M, Oelgeschlaeger M, Braeuning A, Blanc E, Tal T, Rüegg J, Fritsche E, Marx-Stoelting P, Rivière G: Innovative tools and methods for toxicity testing within PARC work package 5 on hazard assessment. Front Toxicol 5:1216369, 2023. doi: 10.3389/ftox.2023.1216369

Vonneilich N, Becher H, Bohn B, Brandes B, Castell S, Deckert A, Dragano N, Franzke C-W, Führer A, Gastell S, Greiser H, Keil T, Klett-Tammen C, Koch-Gallenkamp L, Krist L, Leitzmann M, Meinke-Franze C, Mikolajczyk R, Moreno Velasquez I, Obi N, Peters A, Pischon T, Reuter M, Schikowski T, Schmidt B, Schulze M, Sergeev D, Stang A, Völzke H, Wiessner C, Zeeb H, Lüdecke D, von dem Knesebeck O: Associations of migration, socioeconomic position and social relations with depressive symptoms – Analyses of the German national cohort baseline data. Int J Public Health 68: 1606097, 2023. doi: 10.3389/ijph.2023.1606097

Kessel HE, Masjosthusmann S, Bartmann K, Blum J, Dönmez A, Förster N, Klose J, Mosig A, Pahl M, Leist M, Scholze M, Fritsche E: The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays. ALTEX 40(4): 619–634, 2023. doi: 10.14573/altex.2210171

Bartmann K, Bendt F, Dönmez A, Haag D, Keßel HE, Masjosthusmann S, Noel C, Wu J, Zhou P, Fritsche E: A human iPSC-based in vitro neural network formation assay to investigate neurodevelopmental toxicity of pesticides. ALTEX 40(3): 452–470, 2023. doi: 10.14573/altex.2206031

Hartmann J, Henschel N, Bartmann K, Dönmez A, Brockerhoff G, Koch K, Fritsche E: Molecular and functional characterization of different BrainSphere models for use in neurotoxicity testing on microelectrode arrays. Cells 12(9): 1270, 2023. doi: 10.3390/cells12091270

Limke A, Scharpf I, Blesing F, von Mikecz A: **Tire components, age and temperature accelerate neurodegeneration in C. elegans models of Alzheimer’s and Parkinson’s disease**. Environ Pollut 328: 121660, 2023. doi: 10.1016/j.envpol.2023.121660

Schiavi A, Salveridou E, Brinkmann V, Shaik A, Menzel R, Kalyanasundaram S, Nygård S, Nilsen H, Ventura N: **Mitochondria hormesis delays aging and associated diseases in Caenorhabditis elegans impacting on key ferroptosis players**. iScience 26(4): 106448, 2023. doi: 10.1016/j.isci.2023.106448

Dönmez A: On the ambiguity in classification. NeurIPS Workshop on Symmetry and Geometry in Neural Representations, Proc Mach Learn Res 197: 158-170, 2023

Koch K: Editorial: Rising stars in neurotoxicology: 2021. Front Toxicol 5: 1172417, 2023. doi: 10.3389/ftox.2023.1172417

Haendeler J* and Ventura N: Role of mitochondria in environmentally and dietary modulated age-associated diseases. Cells* 12: 404, 2023. doi:10.3390/cells12030404

Lettieri-Barbato D, Ventura N, Faraonio K, Aquilano K: Advances in metabolic mechanisms of aging and its related diseases, Volume II. Front Physiol 14: 1145165, 2023. doi:10.3389/fphys.2023.1145165

Hartmann J, Lauria I, Bendt F, Rütten S, Koch K, Blaeser A, Fritsche E: Alginate-laminin hydrogel supports long-term neuronal activity in 3D human induced pluripotent stem cell-derived neuronal networks. Adv Mater Interfaces 10(6): 2200580, 2023 (online 2022). doi: 10.1002/admi.202200580

Neuhaus W, …, Fritsche E, Tigges J, Kuchovská E, …, Spielmann H: The current status and work of three Rs centres and platforms in Europe. Altern Lab Anim 50(6): 381-413, 2022. doi: 10.1177/02611929221140909

Sies H: Oxidativer Stress, Eustress und Distress: H₂O₂ als Signalmolekül. Biospektrum 28: 685–690, 2022. doi: 10.1007/s12268-022-1862-y

Valente O, Dobner J, Ramachandran H, Hildebrandt B, Distelmaier F, Ventura N, Rossi A: Generation of an induced pluripotent stem cell line (IUFi002-A) from a Leigh syndrome patient carrying mutations in the NDUFS1 gene. Stem Cell Res 65: 102971, 2022. doi: 10.1016/j.scr.2022.102971 (*equal contribution)

Kühne BA, Teixidó E, Ettcheto M, Puig T, Planas M, Feliu L, Pla L, Campuzano V, Gratacós E, Fritsche E, Illa M, Barenys M: Application of the adverse outcome pathway to identify molecular changes in prenatal brain programming induced by IUGR: Discoveries after EGCG exposure. Food Chem Toxicol 170: 113506, 2022. doi: 10.1016/j.fct.2022.113506

Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E: Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals. Chemosphere 311(Pt 2): 137035, 2022. doi: 10.1016/j.chemosphere.2022.137035

Bajard L, Adamovsky O, Audouze K, Baken K, Barouki R, Beltman JB, Beronius A, Bonefeld-Jørgensen EC, Cano-Sancho G, de Baat ML, Di Tillio F, Fernández MF, FitzGerald RE, Gundacker C, Hernández AF, Hilscherova K, Karakitsios S, Kuchovska E, Long M, Luijten M, Majid S, Marx-Stoelting P, Mustieles V, Negi CK, Sarigiannis D, Scholz S, Sovadinova I, Stierum R, Tanabe S, Tollefsen KE, van den Brand AD, Vogs C, Wielsøe M, Wittwehr C, Blaha L: Application of AOPs to assist regulatory assessment of chemical risks – Case studies, needs and recommendations. Environ Res 217: 114650, 2023 (online 2022). doi: 10.1016/j.envres.2022.114650

Schiavi A, Runci A, Maiorino T, Naso FD, Barenys M, Fritsche E, Strappazzon F, Ventura N: Cobalt chloride has beneficial effects across species through a hormetic mechanism. Front Cell Dev Biol 10: 986835, 2022. doi: 10.3389/fcell.2022.986835

Gerber LS, Heusinkveld HJ, Langendoen C, Stahlmecke B, Schins RP, Westerink RH: Acute, sub-chronic and chronic exposures to TiO₂ and Ag nanoparticles differentially affects neuronal function in vitro. Neurotoxicology 93: 311-323, 2022. doi: 10.1016/j.neuro.2022.10.010

Fritsche E, Barenys M, Hogberg HT: Editorial: Methods and protocols in neurotoxicology. Front Toxicol 4: 1031667, 2022. doi: 10.3389/ftox.2022.1031667

Scharpf I, Cichocka S, Le DT, von Mikecz A: Peripheral neuropathy, protein aggregation and serotonergic neurotransmission: Distinctive bio-interactions of thiacloprid and thiamethoxam in the nematode Caenorhabditis elegans. Environ Pollut 314: 120253, 2022. doi: 10.1016/j.envpol.2022.120253

Steiner T, Zink A, Henke MT, Cecchetto G, Buenning M, Rossi A, Schuelke M, Prigione A: RNA-based generation of iPSCs from a boy carrying the mutation m.9185 T>C in the mitochondrial gene MT-ATP6 and from his healthy mother. Stem Cell Res 64: 102920, 2022. doi: 10.1016/j.scr.2022.102920

Scharf A, Limke A, Guehrs KH, von Mikecz A: Pollutants corrupt resilience pathways of aging in the nematode C. elegans. iScience 25(9): 105027, 2022. doi: 10.1016/j.isci.2022.105027

von Mikecz A: Exposome, molecular pathways and one health: The invertebrate Caenorhabditis elegans. Int J Mol Sci 23(16): 9084, 2022. doi: 10.3390/ijms23169084

Dobner J, Ramachandran H, Rossi A: Genome editing in translational medicine: An inventory. Front Biosci (Landmark Ed) 27(8): 241, 2022. doi: 10.31083/j.fbl2708241

Vogeley C, Nguyen T, Woeste S, Krutmann J, Haarmann-Stemmann T, Rossi A: Rapid and simple analysis of short and long sequencing reads using Duesselpore^TM. Front Genet 13: 931996, 2022. doi: 10.3389/fgene.2022.931996

Scarcello E, Sofranko A, Wahle T, Schins RP: Neurotoxicity of engineered nanomaterials: testing considerations. Front Public Health 10: 904544, 2022. doi: 10.3389/fpubh.2022.904544

Schröter L, Ventura N: Nanoplastic toxicity: Insights and challenges from experimental model systems. Small 18(31): e2201680, 2022. doi: 10.1002/smll.202201680

Tanabe S, O’Brien J, Tollefsen KE, Kim Y, Chauhan V, Yauk C, Huliganga E, Rudel RA, Kay JE, Helm JS, Beaton D, Filipovska J, Sovadinova I, Garcia-Reyero N, Mally A, Poulsen SS, Delrue N, Fritsche E, Luettich K, La Rocca C, Yepiskoposyan H, Klose J, Danielsen PH, Esterhuizen M, Jacobsen NR, Vogel U, Gant TW, Choi I, FitzGerald R: Reactive oxygen species in the adverse outcome pathway framework: Toward creation of harmonized consensus key events. Front Toxicol 4: 887135, 2022. doi: 10.3389/ftox.2022.887135

Klose J, Li L, Pahl M, Bendt F, Hübenthal U, Jüngst C, Petzsch P, Schauss A, Köhrer K, Leung PC, Wang CC, Koch K, Tigges J, Fan X, Fritsche E: Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro. Cell Biol Toxicol 39(1): 319-343, 2023 (online 2022). doi: 10.1007/s10565-022-09730-4 (*equal contribution)

Nguyen T, Ramachandran H, Martins S, Krutmann J, Rossi A: Identification of genome edited cells using CRISPRnano. Nucleic Acids Res 50(W1): W199–203, 2022. doi: 10.1093/nar/gkac440

Larigot L, Bui LC, de Bouvier M, Pierre O, Pinon G, Fiocca J, Ozeir M, Tourette C, Ottolenghi C, Imbeaud S, Pontoizeau C, Blaise BJ, Chevallier A, Tomkiewicz C, Legrand B, Elena-Herrmann B, Néri C, Brinkmann V, Nioche P, Barouki R, Ventura N, Dairou J, Coumoul X: **Identification of modulators of the C. elegans aryl hydrocarbon receptor and characterization of transcriptomic and metabolic AhR-1 profiles**. Antioxidants (Basel) 11(5): 1030, 2022. doi: 10.3390/antiox11051030

Neuhaus W, …, Fritsche E, Tigges J, …, Spielmann H: The rise of three Rs centres and platforms in Europe. Altern Lab Anim 50(2): 90-120, 2022. doi: 10.1177/02611929221099165

Maglioni S, Schiavi A, Melcher M, Brinkmann V, Luo Z, Laromaine A, Raimundo N, Meyer JN, Distelmaier F, Ventura N: Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans. Nat Commun 13: 2620, 2022. doi: 10.1038/s41467-022-29972-4

Greimel E, Adams L, Zsigo C, Berdel D, von Berg A, Koletzko S, Bauer CP, Schikowski T, Herberth G, Heinrich J, Schulte-Körne G, Standl M: Psychopathological symptoms as precursors of depressive symptoms in adolescence: a prospective analysis of the GINIplus and LISA birth cohort studies. Soc Psychiatry Psychiatr Epidemiol 57(8): 1627-1639, 2022. doi: 10.1007/s00127-022-02267-1

Tanabe S, Beaton D, Chauhan V, Choi I, Danielsen PH, Delrue N, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant T, Garcia-Reyero N, Helm J, Huliganga E, Jacobsen N, Kay JE, Kim YJ, Klose J, La Rocca C, Luettich K, Mally A, O’Brien J, Poulsen SS, Rudel RA, Sovadinova I, Tollefsen KE, Vogel U, Yepiskoposyan H, Yauk C: Report of the 1st and 2nd Mystery of Reactive Oxygen Species conferences. ALTEX 39(2): 336-338, 2022. doi: 10.14573/altex.2203011

Brinkmann V, Romeo M, Larigot L, Hemmers A, Tschage L, Kleinjohann J, Schiavi A, Steinwachs S, Esser C, Menzel R, Giani Tagliabue S, Bonati L, Cox F, Ale-Agha N, Jakobs P, Altschmied J, Haendeler J, Coumoul X, Ventura N: Aryl hydrocarbon receptor-dependent and -independent pathways mediate curcumin anti-aging effects. Antioxidants (Basel) 11(4): 613, 2022. doi: 10.3390/antiox11040613

Dragano N, Reuter M, Peters A, Engels M, Schmidt B, Greiser KH, Bohn B, Riedel-Heller S, Karch A, Mikolajczyk R, Krause G, Lang O, Panreck L, Rietschel M, Brenner H, Fischer B, Franzke CW, Gastell S, Holleczek B, Jöckel KH, Kaaks R, Keil T, Kluttig A, Kuss O, Legath N, Leitzmann M, Lieb W, Meinke-Franze C, Michels KB, Obi N, Pischon T, Feinkohl I, Rospleszcz S, Schikowski T, Schulze MB, Stang A, Völzke H, Willich SN, Wirkner K, Zeeb H, Ahrens W, Berger K: Increase in mental disorders during the COVID-19 pandemic-The role of occupational and financial strains. Dtsch Arztebl Int 119(11): 179-187, 2022. doi: 10.3238/arztebl.m2022.0133

Galanjuk S, Zühr E, Dönmez A, Bartsch D, Kurian L, Tigges J, Fritsche E: The human induced pluripotent stem cell test as an alternative method for embryotoxicity testing. Int J Mol Sci 23(6): 3295, 2022. doi: 10.3390/ijms23063295

Crofton KM, Bassan A, Behl M, Chushak YG, Fritsche E, Gearhart JM, Marty MS, Mumtaz M, Pavan M, Ruiz P, Sachana M, Selvam R, Shafer TJ, Stavitskaya L, Szabo DT, Szabo ST, Tice RR, Wilson D, Woolley D, Myatt GJ: Current status and future directions for a neurotoxicity hazard assessment framework that integrates in silico approaches. Comput Toxicol 22: 100223, 2022. doi: 10.1016/j.comtox.2022.100223

Rossi A, Lickfett S, Martins S, Prigione A: A call for consensus guidelines on monitoring the integrity of nuclear and mitochondrial genomes in human pluripotent stem cells. Stem Cell Rep 17(4): 707-710, 2022. doi: 10.1016/j.stemcr.2022.01.019

Koch K, Bartmann K, Hartmann J, Kapr J, Klose J, Kuchovská E, Pahl M, Schlüppmann K, Zühr E, Fritsche E: Scientific validation of human neurosphere assays for developmental neurotoxicity evaluation. Front Toxicol 4: 816370, 2022. doi: 10.3389/ftox.2022.816370

Martínez-Fernández C, Bergamino M, Schiavi A, Brena D, Ventura N, Honnen S, Villanueva A, Nadal E, Cerón J: Insights into cisplatin-induced neurotoxicity and mitochondrial dysfunction in Caenorhabditis elegans. Dis Model Mech 15(3): dmm049161, 2022. doi: 10.1242/dmm.049161

Westerink RHS, Shafer TJ, Fritsche E, van Thriel C: Translational neurotoxicology – The 17th biennial meeting of the International Neurotoxicology Association. Neurotoxicology 90: 79-80, 2022. doi: 10.1016/j.neuro.2022.02.010

Martins S, Erichsen L, Datsi A, Wruck W, Goering W, Chatzantonaki E, de Amorim VCM, Rossi A, Chrzanowska KH, Adjaye J: Impaired p53-mediated DNA damage response contributes to microcephaly in Nijmegen Breakage Syndrome patient-derived cerebral organoids. Cells 11(5): 802, 2022. doi: 10.3390/cells11050802

Sies H, Belousov VV, Chandel NS, Davies MJ, Jones DP, Mann GE, Murphy MP, Yamamoto M, Winterbourn C: Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat Rev Mol Cell Biol 23(7): 499-515, 2022. doi: 10.1038/s41580-022-00456-z

von Mikecz A, Scharf A: Pollution – bring the field into the lab. Nature 602(7897): 386, 2022. doi: 10.1038/d41586-022-00444-5

Hering I, Le DT, von Mikecz A: How to keep up with the analysis of classic and emerging neurotoxins: Age-resolved fitness tests in the animal model Caenorhabditis elegans: a step-by-step protocol. EXCLI J 21: 344-353, 2022. doi: 10.17179/excli2021-4626

Maglioni S, Arsalan N, Hamacher A, Afshar S, Schiavi A, Beller M, Ventura N: High-content C. elegans screen identifies natural compounds impacting mitochondria-lipid homeostasis and promoting healthspan. Cells 11(1): 100, 2021. doi: 10.3390/cells11010100

Martikainen MV, Aakko-Saksa P, van den Broek L, Cassee FR, Carare RO, Chew S, Dinnyes A, Giugno R, Kanninen KM, Malm T, Muala A, Nedergaard M, Oudin A, Oyola P, Pfeiffer TV, Rönkkö T, Saarikoski S, Sandström T, Schins RPF, Topinka J, Yang M, Zeng X, Westerink RHS, Jalava PI: TUBE project: Transport-derived Ultrafines and the Brain Effects. Int J Environ Res Public Health 19(1): 311, 2021. doi: 10.3390/ijerph19010311

Rossi A, Kontarakis Z: Beyond Mendelian inheritance: genetic buffering and phenotype variability. Phenomics 2: 79-87, 2022 (online 2021). doi: 10.1007/s43657-021-00030-1

Koch K, Hartmann R, Suwala AK, Rios DH, Kamp MA, Sabel M, Steiger HJ, Willbold D, Sharma A, Kahlert UD, Maciaczyk J: Overexpression of cystine/glutamate antiporter xCT correlates with nutrient flexibility and ZEB1 expression in highly clonogenic glioblastoma stem-like cells (GSCs). Cancers (Basel), 13(23): 6001, 2021. doi: 10.3390/cancers13236001

Förster N, Butke J, Keßel HE, Bendt F, Pahl M, Li L, Fan X, Leung PC, Klose J, Masjosthusmann S, Fritsche E, Mosig A: Reliable identification and quantification of neural cells in microscopic images of neurospheres. Cytometry A 101(5): 411-422, 2022 (online 2021). doi: 10.1002/cyto.a.24514

Tigges J, Schikowski T, Fritsche E: Environmental exposures impact the nervous system in a life stage-specific manner. Neuroforum 27(4): 201-212, 2021. doi: 10.1515/nf-2021-0021

Wellenberg A, Brinkmann V, Bornhorst J, Ventura N, Honnen S, Fritz G: Cisplatin-induced neurotoxicity involves the disruption of serotonergic neurotransmission. Pharmacol Res 174: 105921, 2021. doi: 10.1016/j.phrs.2021.105921

Berger K, Riedel-Heller S, Pabst A, Rietschel M, Richter D; NAKO-Konsortium: Einsamkeit während der ersten Welle der SARS-CoV-2-Pandemie – Ergebnisse der NAKO-Gesundheitsstudie [Loneliness during the first wave of the SARS-CoV-2 pandemic-results of the German National Cohort (NAKO)] Bundesgesundheitsblatt-Gesund 64(9): 1157-1164, 2021. doi: 10.1007/s00103-021-03393-y

Sies H, Ursini F: Homeostatic control of redox status and health. IUBMB Life 74(1): 24-28, 2022 (online 2021). doi: 10.1002/iub.2519

Kapr J, Petersilie L, Distler T, Lauria I, Bendt F, Sauter CM, Boccaccini AR, Rose CR, Fritsche E: Human induced pluripotent stem cell-derived neural progenitor cells produce distinct neural 3D in vitro models depending on alginate/gellan gum/laminin hydrogel blend properties. Adv Healthc Mater 10(16): e2100131, 2021. doi: 10.1002/adhm.202100131

Vinken M, Benfenati E, Busquet F, Castell J, Clevert DA, de Kok TM, Dirven H, Fritsche E, Geris L, Gozalbes R, Hartung T, Jennen D, Jover R, Kandarova H, Kramer N, Krul C, Luechtefeld T, Masereeuw R, Roggen E, Schaller S, Vanhaecke T, Yang C, Piersma AH: Safer chemicals using less animals: kick-off of the European ONTOX project. Toxicology 458: 152846, 2021. doi: 10.1016/j.tox.2021.152846

Zhao Q, Wigmann C, Areal AT, Altug H, Schikowski T: Effect of non-optimum ambient temperature on cognitive function of elderly women in Germany. Environ Pollut 285: 117474, 2021. doi: 10.1016/j.envpol.2021.117474

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E: Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol 38(5): 781-807, 2022 (online 2021). doi: 10.1007/s10565-021-09603-2

Tigges J, Bielec K, Brockerhoff G, Hildebrandt B, Hübenthal U, Kapr J, Koch K, Teichweyde N, Wieczorek D, Rossi A, Fritsche E: Academic application of Good Cell Culture Practice for induced pluripotent stem cells. ALTEX 38(4): 595-614, 2021. doi: 10.14573/altex.2101221

Ramachandran H, Martins S, Kontarakis Z, Krutmann J, Rossi A: Fast but not furious: a streamlined selection method for genome edited cells. Life Sci Alliance 4(6): e202101051, 2021. doi: 10.26508/lsa.202101051

Masjosthusmann S, Tigges J, Fritsche E, Koch K: Arsenic-mediated developmental neurotoxicity: Recent advances in understanding the adverse outcomes and underlying mechanisms. Advances in Neurotoxicology 5: 35-80, 2021. doi: 10.1016/bs.ant.2020.12.002

Sofranko A, Wahle T, Heusinkveld HJ, Stahlmecke B, Dronov M, Pijnenburg D, Hilhorst R, Lamann K, Albrecht C, Schins RPF: Evaluation of the neurotoxic effects of engineered nanomaterials in C57BL/6J mice in 28-day oral exposure studies. Neurotoxicology 84: 155-171, 2021. doi: 10.1016/j.neuro.2021.03.005

Distler T, Lauria I, Detsch R, Sauter CM, Bendt F, Kapr J, Rütten S, Boccaccini AR, Fritsche E: Neuronal differentiation from induced pluripotent stem cell-derived neurospheres by the application of oxidized alginate-gelatin-laminin hydrogels. Biomedicines 9(3): 261, 2021. doi: 10.3390/biomedicines9030261

Tham R, Schikowski T: The role of traffic-related air pollution on neurodegenerative diseases in older people: An epidemiological perspective. J Alzheimers Dis 79(3): 949-959, 2021. doi: 10.3233/JAD-200813

Sies H: Oxidative eustress: On constant alert for redox homeostasis. Redox Biol 41: 101867, 2021. doi: 10.1016/j.redox.2021.101867

Neuhaus W: Consensus statement from the European Network of 3R centres (EU3Rnet). ALTEX* 38(1): 138-139, 2021. doi: 10.14573/altex.2010061 *Neuhaus has submitted the Consensus Statement on behalf of all participating centres, institutes and societies of EU3Rnet

Fritsche E, Haarmann-Stemmann T, Kapr J, Galanjuk S, Hartmann J, Mertens PR, Kämpfer AAM, Schins RPF, Tigges J, Koch K: Stem cells for next level toxicity testing in the 21st century. Small 17(15): e2006252, 2021 (online 2020). doi: 10.1002/smll.202006252

Fischer I, Nickel A-C, Qin N, Taban K, Pauck D, Steiger H-J, Kamp M, Muhammad S, Hänggi D, Fritsche E, Remke M, Kahlert UD: Different calculation strategies are congruent in determining chemotherapy resistance of brain tumors in vitro. Cells 9(12): 2689, 2020. doi: 10.3390/cells9122689

Brinkmann V, Schiavi A, Shaik A, Puchta DR, Ventura N: **Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan.** Aging (Albany NY) 13(1): 104-133, 2020. doi: 10.18632/aging.202316

Peters A, Rospleszcz S, Greiser KH, Dallavalle M, …, Schikowski T, …, Berger K; Complete list of authors available under: Collaborators. The impact of the COVID-19 pandemic on self-reported health. Dtsch Arztebl Int 117(50): 861-867, 2020. doi: 10.3238/arztebl.2020.0861

Tsiampali J, Neumann S, Giesen B, Koch K, Maciaczyk D, Janiak C, Hänggi D, Maciaczyk J: Enzymatic activity of CD73 modulates invasion of gliomas via epithelial-mesenchymal transition-like reprogramming. Pharmaceuticals 13(11): 378, 2020. doi: 10.3390/ph13110378

White A, Kanninen K, Malm T, Schins RPF: Editorial: Air pollution and brain health. Neurochem Int 141: 104900, 2020. doi: 10.1016/j.neuint.2020.104900

Strom A, Strassburger K, Schmuck M, Shevalye H, Davidson E, Zivehe F, Bönhof G, Reimer R, Belgardt BF, Fleming T, Biermann B, Burkart V, Müssig K, Szendroedi J, Yorek MA, Fritsche E, Nawroth PP, Roden M, Ziegler D; GDS Group: Interaction between magnesium and methylglyoxal in diabetic polyneuropathy and neuronal models. Mol Metab 43: 101114, 2021 (online 2020). doi: 10.1016/j.molmet.2020.101114

Esser C, Boots AM, Caignard A, Ciraci C, Grčević D, Knapp S, Montoya M, Di Rosa F, Saksida T, Stravinskiene D, Deniz G: The impact of COVID-19 lock-downs for European (female) immunologists – our views as members of the EFIS gender and diversity task force. Euro J Immunol 50(12): 1855-1862, 2020. doi: 10.1002/eji.202070125

Masjosthusmann S, Blum J, Bartmann K, Dolde X, Holzer A-K, Stürzl L-C, Keßel EH, Förster N, Dönmez A, Klose J, Pahl M, Waldmann T, Bendt F, Kisitu J, Suciu I, Hübenthal U, Mosig A, Leist M, Fritsche E: Establishment of an priori protocol for the implementation and interpretation of an in-vitro testing battery for the assessment of developmental neurotoxicity. EFSA Supporting Publications 17(10): 1938E, 2020. doi: 10.2903/sp.efsa.2020.EN-1938

Klose J, Tigges J, Masjosthusmann S, Schmuck K, Bend F, Hübenthal U, Petzsch P, Köhrer K, Koch K, Fritsche E: TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs. ALTEX 38(2): 215-234, 2021 (online 2020). doi: 10.14573/altex.2007201

Lettieri-Barbato D, Ventura N, Faraonio K, Aquilano K: Editorial: Advances in metabolic mechanisms of aging and its related diseases. Front Physiol 11: 594974, 2020. doi: 10.3389/fphys.2020.594974

Barenys M, Illa M, Hofrichter M, Loreiro C, Pla L, Klose J, Kühne BA, Gómez-Catalán J, Braun JM, Crispi F, Gratacós E, Fritsche E: Rabbit neurospheres as a novel in vitro tool for studying neurodevelopmental effects induced by intrauterine growth restriction. Stem Cells Transl Med 10(2): 209-221, 2021 (online 2020). doi: 10.1002/sctm.20-0223

Sies H: Findings in redox biology: from H₂O₂ to oxidative stress. J Biol Chem 295(39): 13458-13473, 2020. doi: 10.1074/jbc.X120.015651

Sies H: Oxidative stress: Concept and some practical aspects. Antioxidants 9(9): 852, 2020. doi: 10.3390/antiox9090852

von Mikecz A, Schikowski T: Effects of airborne nanoparticles on the nervous system: amyloid protein aggregation, neurodegeneration and neurodegenerative diseases. Nanomaterials 10(7): 1349, 2020. doi: 10.3390/nano10071349

Feng X, Flexeder C, Markevych I, Standl M, Heinrich J, Schikowski T, Koletzko S, Herberth G, Bauer CP, von Berg A, Berdel D, Astell-Burt T: Impact of residential green space on sleep quality and sufficiency in children and adolescents residing in Australia and Germany. Int J Environ Res Public Health 17(13): 4894, 2020. doi: 10.3390/ijerph17134894

Fritsche E, Hogberg HT: A brainer on neurotoxicity. Frontiers in Toxicol 2: 3, 2020. doi: 10.3389/ftox.2020.00003

Esser C, Hochrath K, Schikowski T, Haarmann-Stemmann T: COVID-19 research: toxicological input urgently needed! Arch Toxicol 94(7): 2547-2548, 2020. doi: 10.1007/s00204-020-02803-5

Lupu D, Andersson P, Bornehag CG, Demeneix B, Fritsche E, Gennings C, Lichtensteiger W, Leist M, Leonards PEG, Ponsonby AL, Scholze M, Testa G, Tresguerres JAF, Westerink RHS, Zalc B, Rüegg J: The ENDpoiNTs project: Novel testing strategies for endocrine disruptors linked to developmental neurotoxicity. Int J Mol Sci 21: 3978, 2020. doi: 10.3390/ijms21113978

Wahle T, Sofranko A, Dekkers S, Miller MR, Heusinkveld HJ, Albrecht C, Cassee FR, Schins RPF: Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer’s and vascular disease. Neurochem Int 138: 104755, 2020. doi: 10.1016/j.neuint.2020.104755

Sies H: Schrödingers Koffer. BIOspektrum 26: 345-346, 2020. doi: 10.1007/s12268-020-1364-8

Schiavi A, Strappazzon F, Ventura N: Mitophagy and iron: two actors sharing the stage in age-associated neuronal pathologies. Mech Ageing Dev 188: 111252, 2020. doi: 10.1016/j.mad.2020.111252

Sies H, Jones DP: Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 21(7): 363-383, 2020. doi: 10.1038/s41580-020-0230-3

Negele L, Flexeder C, Koletzko S, Bauer CP, von Berg A, Berdel D, Schikowski T, Standl M, Peters A, Schulz H: Association between objectively assessed physical activity and sleep quality in adolescence. Results from the GINIplus and LISA studies. Sleep Med 72: 65-74, 2020. doi: 10.1016/j.sleep.2020.03.007

Nimtz L, Hartmann J, Tigges J, Masjosthusmann S, Schmuck M, Keßel E, Theiss S, Köhrer K, Petzsch P, Adjaye J, Wigmann C, Wieczorek D, Hildebrandt B, Bendt F, Hübenthal U, Brockerhoff G, Fritsche E: Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation. Stem Cell Res 45: 101761, 2020. doi: 10.1016/j.scr.2020.101761

Schikowski T, Altug H: The role of air pollution in cognitive impairment and decline. Neurochem Int 136: 104708, 2020. doi: 10.1016/j.neuint.2020.104708

Brinkmann V, Ale-Agha N, Haendeler J, Ventura N: The Aryl hydrocarbon Receptor (AhR) in the aging process: Another puzzling role for this highly conserved transcription factor. Front Physiol 10: 1561, 2020. doi: 10.3389/fphys.2019.01561

Altuğ H, Fuks KB, Hüls A, Mayer AK, Tham R, Krutmann J, Schikowski T: Air pollution is associated with depressive symptoms in elderly women with cognitive impairment. Environ Int 136: 105448, 2020. doi: 10.1016/j.envint.2019.105448